LIVIVO - Search results -

Search results

Result 1 - 10 of total 124

Search options

Article: Spontaneous pulmonary herniation in COVID-19.

Macdonald, Andrew / Butcher, Cameron / Nguyen, Thuy Nhu

2023 Volume 11, Issue 5, Page(s) e01145

Abstract: Spontaneous pulmonary hernia (SPH) is a rare condition. We report a case secondary to extreme coughing and COVID-19 infection. The patient displayed several clinical features typical of this diagnosis; difficult to manage pain on coughing, flank ... ...

Abstract	Spontaneous pulmonary hernia (SPH) is a rare condition. We report a case secondary to extreme coughing and COVID-19 infection. The patient displayed several clinical features typical of this diagnosis; difficult to manage pain on coughing, flank haematoma and bulging of the chest wall on coughing. Clinicians should be aware of the risk factors and clinical features of SPH to aid diagnosis of this rare condition.
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1145
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: An unexpected case of broncholithiasis secondary to pulmonary nocardiosis.

Chhor, Louis / Tumali, Reditta Soraya / Östberg, Caroline / Macdonald, Andrew / Wade, Christine

Respirology case reports

2024 Volume 12, Issue 1, Page(s) e01275

Abstract: Persistent productive cough despite appropriate treatment warrants consideration of flexible bronchoscopy to obtain bronchial specimens for culture. Endobronchial examination of airways may reveal signs of infection in the form of purulent secretions, ... ...

Abstract	Persistent productive cough despite appropriate treatment warrants consideration of flexible bronchoscopy to obtain bronchial specimens for culture. Endobronchial examination of airways may reveal signs of infection in the form of purulent secretions, sputum plugs or in this case, an unexpected finding of a calcified broncholithiasis secondary to Nocardia infection.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1275
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies.

Morgan, Ethan L / Macdonald, Andrew

Viruses

2020 Volume 12, Issue 9

Abstract: Human papillomaviruses (HPVs) are small, DNA viruses that cause around 5% of all cancers in humans, including almost all cervical cancer cases and a significant proportion of anogenital and oral cancers. The HPV oncoproteins E5, E6 and E7 manipulate ... ...

Abstract	Human papillomaviruses (HPVs) are small, DNA viruses that cause around 5% of all cancers in humans, including almost all cervical cancer cases and a significant proportion of anogenital and oral cancers. The HPV oncoproteins E5, E6 and E7 manipulate cellular signalling pathways to evade the immune response and promote virus persistence. The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway has emerged as a key mediator in a wide range of important biological signalling pathways, including cell proliferation, cell survival and the immune response. While STAT1 and STAT2 primarily drive immune signalling initiated by interferons, STAT3 and STAT5 have widely been linked to the survival and proliferative potential of a number of cancers. As such, the inhibition of STAT3 and STAT5 may offer a therapeutic benefit in HPV-associated cancers. In this review, we will discuss how HPV manipulates JAK/STAT signalling to evade the immune system and promote cell proliferation, enabling viral persistence and driving cancer development. We also discuss approaches to inhibit the JAK/STAT pathway and how these could potentially be used in the treatment of HPV-associated disease.
MeSH term(s)	Alphapapillomavirus/pathogenicity ; Alphapapillomavirus/physiology ; Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Carcinogenesis ; Female ; Humans ; Immune Evasion ; Interferons/metabolism ; Janus Kinases/antagonists & inhibitors ; Janus Kinases/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/virology ; Papillomavirus Infections/drug therapy ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology ; STAT Transcription Factors/antagonists & inhibitors ; STAT Transcription Factors/metabolism ; Signal Transduction ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/virology ; Viral Proteins/genetics ; Viral Proteins/metabolism
Chemical Substances	Antineoplastic Agents ; Antiviral Agents ; STAT Transcription Factors ; Viral Proteins ; Interferons (9008-11-1) ; Janus Kinases (EC 2.7.10.2)
Language	English
Publishing date	2020-09-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12090977
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies

Morgan, Ethan L / Macdonald, Andrew

Viruses. 2020 Sept. 03, v. 12, no. 9

2020

Abstract	Human papillomaviruses (HPVs) are small, DNA viruses that cause around 5% of all cancers in humans, including almost all cervical cancer cases and a significant proportion of anogenital and oral cancers. The HPV oncoproteins E5, E6 and E7 manipulate cellular signalling pathways to evade the immune response and promote virus persistence. The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway has emerged as a key mediator in a wide range of important biological signalling pathways, including cell proliferation, cell survival and the immune response. While STAT1 and STAT2 primarily drive immune signalling initiated by interferons, STAT3 and STAT5 have widely been linked to the survival and proliferative potential of a number of cancers. As such, the inhibition of STAT3 and STAT5 may offer a therapeutic benefit in HPV-associated cancers. In this review, we will discuss how HPV manipulates JAK/STAT signalling to evade the immune system and promote cell proliferation, enabling viral persistence and driving cancer development. We also discuss approaches to inhibit the JAK/STAT pathway and how these could potentially be used in the treatment of HPV-associated disease.
Keywords	DNA viruses ; animal viruses ; carcinogenesis ; cell proliferation ; cell viability ; human diseases ; immune response ; immune system ; interferons ; non-specific protein-tyrosine kinase ; oncogene proteins ; signal transduction ; therapeutics ; transactivators ; uterine cervical neoplasms ; viruses
Language	English
Dates of publication	2020-0903
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v12090977
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: JAK2 Inhibition Impairs Proliferation and Sensitises Cervical Cancer Cells to Cisplatin-Induced Cell Death.

Morgan, Ethan L / Macdonald, Andrew

Cancers

2019 Volume 11, Issue 12

Abstract: Persistent infection with high-risk human papillomavirus (HPV) is the underlying cause of ~5% of all human cancers, including the majority of cervical carcinomas and many other ano-genital and oral cancers. A major challenge remains to identify key host ... ...

Abstract	Persistent infection with high-risk human papillomavirus (HPV) is the underlying cause of ~5% of all human cancers, including the majority of cervical carcinomas and many other ano-genital and oral cancers. A major challenge remains to identify key host targets of HPV and to reveal how they contribute to virus-mediated malignancy. The HPV E6 oncoprotein aberrantly activates the signal transducer and activator of transcription 3 (STAT3) transcription factor and this is achieved by a virus-driven increase in the levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in HPV positive cervical cancers cells. Crucially, STAT3 activity is essential for the proliferation and survival of cervical cancer cells, suggesting that targeting STAT3 may have therapeutic potential. Unfortunately, the development of direct STAT3 inhibitors has been problematic in the clinic due to toxicity issues identified in early stage trials. To overcome this issue, we focused on the protein Janus kinase 2 (JAK2), which phosphorylates STAT3 and is essential for STAT3 activation. Here, we demonstrate that inhibiting JAK2 reduces cell proliferation and induces apoptosis in HPV transformed cervical cancer cells. We further establish that this is due to inhibition of phosphorylation of the JAK2 substrates STAT3 and STAT5. Finally, we demonstrate that the clinically available JAK2 inhibitor Ruxolitinib synergises with cisplatin in inducing apoptosis, highlighting JAK2 as a promising therapeutic target in HPV-driven cancers.
Language	English
Publishing date	2019-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11121934
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NFκB-IL-6 signalling axis.

Morgan, Ethan L / Macdonald, Andrew

PLoS pathogens

2019 Volume 15, Issue 6, Page(s) e1007835

Abstract: Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Although the fundamental link between HPV infection and oncogenesis is established, the specific mechanisms of virus-mediated transformation are not fully understood. ...

Abstract	Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Although the fundamental link between HPV infection and oncogenesis is established, the specific mechanisms of virus-mediated transformation are not fully understood. We previously demonstrated that the HPV encoded E6 protein increases the activity of the proto-oncogenic transcription factor STAT3 in primary human keratinocytes; however, the molecular basis for STAT3 activation in cervical cancer remains unclear. Here, we show that STAT3 phosphorylation in HPV positive cervical cancer cells is mediated primarily via autocrine activation by the pro-inflammatory cytokine Interleukin 6 (IL-6). Antibody-mediated blockade of IL-6 signalling in HPV positive cells inhibits STAT3 phosphorylation, whereas both recombinant IL-6 and conditioned media from HPV positive cells leads to increased STAT3 phosphorylation within HPV negative cervical cancer cells. Interestingly, we demonstrate that activation of the transcription factor NFκB, involving the small GTPase Rac1, is required for IL-6 production and subsequent STAT3 activation. Our data provides new insights into the molecular re-wiring of cancer cells by HPV E6. We reveal that activation of an IL-6 signalling axis drives the autocrine and paracrine phosphorylation of STAT3 within HPV positive cervical cancers cells and that activation of this pathway is essential for cervical cancer cell proliferation and survival. Greater understanding of this pathway provides a potential opportunity for the use of existing clinically approved drugs for the treatment of HPV-mediated cervical cancer.
MeSH term(s)	Autocrine Communication ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Cell Line, Tumor ; Female ; Human papillomavirus 16 ; Human papillomavirus 18 ; Humans ; Interleukin-6/metabolism ; NF-kappa B/metabolism ; Neoplasm Proteins/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology ; rac1 GTP-Binding Protein/metabolism
Chemical Substances	IL6 protein, human ; Interleukin-6 ; NF-kappa B ; Neoplasm Proteins ; RAC1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2019-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1007835
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways.

Moens, Ugo / Macdonald, Andrew

International journal of molecular sciences

2019 Volume 20, Issue 16

Abstract: Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of ... ...

Abstract	Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the infected cell into a tumor cell. One mechanism viruses employ to reprogram the host cell is through interference with signaling pathways. Polyomaviruses are naked, double-stranded DNA viruses whose genome encodes the regulatory proteins large T-antigen and small t-antigen, and structural proteins that form the capsid. The large T-antigens and small t-antigens can interfere with several host signaling pathways. In this case, we review the interplay between the large T-antigens and small t-antigens with host signaling pathways and the biological consequences of these interactions.
MeSH term(s)	Animals ; Antigens, Viral, Tumor/immunology ; Host-Pathogen Interactions ; Humans ; Polyomavirus/immunology ; Polyomavirus/physiology ; Polyomavirus Infections/immunology ; Signal Transduction
Chemical Substances	Antigens, Viral, Tumor
Language	English
Publishing date	2019-08-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20163914
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Early Total Recanalization of the Prostate Artery and Reperfusion of the Prostate following Particle Embolization for Benign Prostatic Hyperplasia.

Braithwaite, Simon / Boardman, Phil / Tapping, Charles / Macdonald, Andrew

Journal of vascular and interventional radiology : JVIR

2021 Volume 32, Issue 7, Page(s) 1096–1098

MeSH term(s)	Arteries/diagnostic imaging ; Embolization, Therapeutic/adverse effects ; Humans ; Lower Urinary Tract Symptoms/therapy ; Male ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/therapy ; Reperfusion ; Treatment Outcome
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Letter
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2021.03.545
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3720: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Acetamiprid fate in a sandy loam with contrasting soil organic matter contents: A comparison of the degradation, sorption and leaching of commercial neonicotinoid formulations

Potts, Jessica / Jones, Davey L. / Macdonald, Andrew / Ma, Qingxu / Cross, Paul

Science of the total environment. 2022 June 11,

2022

Abstract: The impacts of neonicotinoids have generally focussed on the responses of the pure active ingredient. Using a selection of two commercial formulations and the active ingredient, we ran three laboratory studies using ¹⁴C-labelled acetamiprid to study the ... ...

Abstract	The impacts of neonicotinoids have generally focussed on the responses of the pure active ingredient. Using a selection of two commercial formulations and the active ingredient, we ran three laboratory studies using ¹⁴C-labelled acetamiprid to study the leaching, sorption and mineralisation behaviours of the commercially available neonicotinoid formulations compared to the pure active ingredient. We added ¹⁴C-spiked acetamiprid to a sandy loam soil that had received long-term additions of farmyard manure at two rates (10 t/ha/yr and 25 t/ha/yr) and mineral fertilisers, as a control. We found significant differences in acetamiprid mineralisation across both the SOM and chemical treatments. Sorption was primarily impacted by changes in SOM and any differences in leachate recovery were much less significant across both treatment types. The mineralisation of all pesticide formulations was comparatively slow, with <23 % of any given chemical/soil organic matter combination being mineralised over the experimental period. The highest mineralisation rates occurred in samples with the highest soil organic matter levels. The results also showed that 82.9 % ± 1.6 % of the acetamiprid applied was leached from the soil during repeated simulated rainfall events. This combined with the low sorption values, and the low rates of mineralisation, implies that acetamiprid is highly persistent and mobile within sandy soils. As a highly persistent neurotoxin with high invertebrate selectivity, the presence of neonicotinoids in soil presents a high toxicology risk to various beneficial soil organisms, including earthworms, as well as being at high risk of transfer to surrounding watercourses.
Keywords	acetamiprid ; active ingredients ; animal manures ; environment ; leachates ; mineralization ; neurotoxins ; rainfall simulation ; risk ; sandy loam soils ; soil organic matter ; sorption ; toxicology
Language	English
Dates of publication	2022-0611
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.156711
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 74/341: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation.

Scarth, James A / Patterson, Molly R / Morgan, Ethan L / Macdonald, Andrew

The Journal of general virology

2021 Volume 102, Issue 3

Abstract: Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in over 99 % of cervical cancer cases, and a significant proportion of oropharyngeal and anogenital cancers. The key drivers of HPV-mediated transformation are the ... ...

Abstract	Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in over 99 % of cervical cancer cases, and a significant proportion of oropharyngeal and anogenital cancers. The key drivers of HPV-mediated transformation are the oncoproteins E5, E6 and E7. Together, they act to prolong cell-cycle progression, delay differentiation and inhibit apoptosis in the host keratinocyte cell in order to generate an environment permissive for viral replication. The oncoproteins also have key roles in mediating evasion of the host immune response, enabling infection to persist. Moreover, prolonged infection within the cellular environment established by the HR-HPV oncoproteins can lead to the acquisition of host genetic mutations, eventually culminating in transformation to malignancy. In this review, we outline the many ways in which the HR-HPV oncoproteins manipulate the host cellular environment, focusing on how these activities can contribute to carcinogenesis.
MeSH term(s)	Alphapapillomavirus/genetics ; Alphapapillomavirus/pathogenicity ; Alphapapillomavirus/physiology ; Apoptosis ; Carcinogenesis ; Cell Cycle Checkpoints ; Cell Differentiation ; Cell Proliferation ; Cell Transformation, Viral ; Cellular Reprogramming ; Epigenesis, Genetic ; Genome, Viral ; Humans ; Immune Evasion ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/metabolism ; PDZ Domains ; Papillomavirus Infections/virology ; RNA, Untranslated/genetics ; Signal Transduction ; Virus Replication
Chemical Substances	Oncogene Proteins, Viral ; RNA, Untranslated
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001540
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 610: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito