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  1. Article ; Online: Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report.

    Huršidić Radulović, Azra / Babić, Željka / Macan, Marija / Macan, Jelena

    Contact dermatitis

    2024  Volume 90, Issue 6, Page(s) 628–630

    MeSH term(s) Humans ; Adamantane/analogs & derivatives ; Adamantane/adverse effects ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/diagnosis ; Olanzapine/adverse effects ; Dermatitis, Occupational/etiology ; Dipeptides/adverse effects ; Patch Tests ; Male ; Antipsychotic Agents/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Middle Aged ; Adult ; Female
    Chemical Substances saxagliptin (9GB927LAJW) ; Adamantane (PJY633525U) ; Olanzapine (N7U69T4SZR) ; Dipeptides ; Antipsychotic Agents ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.14534
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  2. Article ; Online: Body fat and muscle in relation to heart rate variability in young-to-middle age men: a cross sectional study.

    Cvijetic, Selma / Macan, Jelena / Boschiero, Dario / Ilich, Jasminka Z

    Annals of human biology

    2023  Volume 50, Issue 1, Page(s) 108–116

    Abstract: Background: While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear.: Aims: In this cross sectional study, we analysed the association of body fat (four ...

    Abstract Background: While obesity is recognisably associated with changes in heart rate variability (HRV), the association between skeletal muscle mass and HRV is less clear.
    Aims: In this cross sectional study, we analysed the association of body fat (four parameters) and muscle mass (five parameters) with indicators of HRV activity.
    Subjects and methods: Assessment of body composition and HRV was performed in
    Results: Mean values of parameters of fat tissue were above normal/reference values. Muscle tissue indicators were higher or within the reference ranges. Fat tissue parameters were significantly higher in participants with lower parasympathetic nervous system (PNS) indicators. Weight-adjusted skeletal muscle index (wSMI) was significantly lower in men with reduced PNS parameters. Fat tissue parameters were negatively correlated with PNS parameters, while wSMI was positively correlated with PNS parameters.
    Conclusions: Participants with higher fat mass and lower muscle mass had poorer parasympathetic activity. Since mean values of HRV parameters indicated mild parasympathetic dominance, we conclude that physical activity and consequently good muscle mass potentially compensated for the negative interaction between fat tissue and HRV.
    MeSH term(s) Male ; Humans ; Middle Aged ; Heart Rate/physiology ; Cross-Sectional Studies ; Body Mass Index ; Adipose Tissue/physiology ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 186656-4
    ISSN 1464-5033 ; 0301-4460
    ISSN (online) 1464-5033
    ISSN 0301-4460
    DOI 10.1080/03014460.2023.2180089
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  3. Article ; Online: Incidence and prevalence of occupational contact dermatitis in hairdressing apprentices: A 3-year prospective cohort study.

    Franić, Zrinka / Ljubojević Hadžavdić, Suzana / Babić, Željka / Macan, Jelena

    Contact dermatitis

    2023  Volume 89, Issue 3, Page(s) 153–160

    Abstract: Background: It is known that a large number of hairdressing apprentices (HA) develop occupational contact dermatitis (OCD) during schooling, but studies that address prevalence of contact sensitization in HAs with hand eczema are missing.: Objectives!# ...

    Abstract Background: It is known that a large number of hairdressing apprentices (HA) develop occupational contact dermatitis (OCD) during schooling, but studies that address prevalence of contact sensitization in HAs with hand eczema are missing.
    Objectives: To assess the prevalence, incidence rate and clinical characteristics of OCD, including contact sensitization, in a sample of Croatian HAs.
    Materials and methods: A total of 408 HAs from 25 Croatian towns were examined at the beginning of education and monitored at the end of each school year. Clinical evaluation of skin changes was performed using the Osnabrueck Hand Eczema Severity Index (OHSI). Standard patch test (PT) with baseline and hairdresser series of contact allergens was performed in 46 HAs with skin changes lasting ≥3 months.
    Results: The overall incidence rate of OCD was 32.3/100 person-years, and the 3-year prevalence 50.3%. Contact sensitization was found in 14 out of 46 (30.3%) HAs, with 10 of these 14 HAs (71.4%) sensitized to specific hairdressing allergens. The strongest reactions were found to PPD. HAs with positive PT had higher OHSI than HAs with negative patch test (median, IQR: 3, 2-4 vs. 2, 2-4).
    Conclusions: Contact sensitization to specific hairdressing chemicals was found in 71.4% of HAs with a positive patch test, supporting evidence on the early contact sensitization to occupational allergens among HAs.
    MeSH term(s) Humans ; Incidence ; Dermatitis, Allergic Contact/epidemiology ; Dermatitis, Allergic Contact/etiology ; Prospective Studies ; Prevalence ; Dermatitis, Occupational/etiology ; Dermatitis, Occupational/complications ; Allergens/adverse effects ; Eczema/epidemiology ; Patch Tests/adverse effects
    Chemical Substances Allergens
    Language English
    Publishing date 2023-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.14355
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  4. Article ; Online: Evaluation of Skin Barrier Condition Among Physicians and Dentists.

    Babić, Željka / Japundžić-Rapić, Iva / Lugović Mihić, Liborija / Macan, Jelena

    Dermatitis : contact, atopic, occupational, drug

    2023  Volume 35, Issue 1, Page(s) 70–76

    MeSH term(s) Humans ; Male ; Female ; Cross-Sectional Studies ; Skin ; Epidermis ; Water ; Physicians ; Dentists
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2023.0266
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    Zs.A 3680: Show issues Location:
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  5. Article ; Online: Skin barrier function in nursing apprentices during the coronavirus disease 2019 (COVID-19) pandemic.

    Babić, Željka / Šakić, Franka / Franić, Zrinka / Macan, Jelena

    Contact dermatitis

    2022  Volume 86, Issue 6, Page(s) 507–513

    Abstract: Background: Studies investigating simultaneous influence of personal and work-related factors on skin health during the coronavirus disease 2019 (COVID-19) pandemic are missing.: Objectives: To investigate the associations of skin hazards relevant ... ...

    Abstract Background: Studies investigating simultaneous influence of personal and work-related factors on skin health during the coronavirus disease 2019 (COVID-19) pandemic are missing.
    Objectives: To investigate the associations of skin hazards relevant for nursing apprentices with parameters of skin barrier function.
    Methods: A total of 238 nursing apprentices attending the final year of education (median age 19 years) from vocational schools in Zagreb, Croatia, were enrolled in this study. We administered a questionnaire based on the Nordic Occupational Skin Questionnaire to the nursing apprentices, performed clinical examination of skin on the hands, and evaluated transepidermal water loss (TEWL) and stratum corneum (SC) pH on the dorsum of the hand.
    Results: Around half of nursing apprentices had compromised hand skin barrier function, as indicated by TEWL values >25 g/m
    Conclusions: Measurement of SC pH was shown to be less sensitive to field conditions than TEWL, and should be employed more in the field studies. Strengthening of skin health promotion in healthcare workers and apprentices is needed in pandemic conditions.
    MeSH term(s) Adult ; COVID-19 ; Dermatitis, Allergic Contact/diagnosis ; Female ; Humans ; Pandemics ; Skin ; Surveys and Questionnaires ; Water Loss, Insensible ; Young Adult
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.14069
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  6. Article ; Online: Diagnostics and Prevention of Occupational Allergy in Hairdressers.

    Uter, Wolfgang / Johansen, Jeanne D / Macan, Jelena / Symanzik, Cara / John, Swen M

    Current allergy and asthma reports

    2023  Volume 23, Issue 5, Page(s) 267–275

    Abstract: Purpose of review: This study aims to provide an overview on current knowledge on occupational allergic diseases in hairdressers and up-to-date perspectives of prevention.: Recent findings: Hand eczema (dermatitis) is common in hairdressers, often ... ...

    Abstract Purpose of review: This study aims to provide an overview on current knowledge on occupational allergic diseases in hairdressers and up-to-date perspectives of prevention.
    Recent findings: Hand eczema (dermatitis) is common in hairdressers, often caused by contact allergy to one or multiple small molecules (haptens) used, e.g., for dyeing, bleaching, and waving/relaxing or by ancillary substances such as preservatives. Hairdressers, compared to other patch-tested patients, have an up to fivefold increased risk to be found sensitized, e.g., against p-phenylenediamine, ammonium persulfate, and glyceryl thioglycolate. Some of these small molecules may induce respiratory sensitization causing allergic rhinitis and/or asthma, notably persulfate salts. Occupational hazards in hairdressing are well described. This knowledge needs to be put into use for risk reduction, mainly by substitution of allergenic ingredients by less allergenic ones, education, and use of ventilation and suitable single-use gloves.
    MeSH term(s) Humans ; Dermatitis, Occupational/diagnosis ; Dermatitis, Occupational/etiology ; Dermatitis, Occupational/prevention & control ; Hair Dyes/adverse effects ; Hair Preparations/adverse effects ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/prevention & control ; Allergens/adverse effects ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control
    Chemical Substances Hair Dyes ; Hair Preparations ; Allergens
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-023-01076-z
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    Zs.A 5548: Show issues Location:
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  7. Article ; Online: Diagnosing occupational COVID-19 in Croatian healthcare workers.

    Žaja, Roko / Kerner, Ivana / Milošević, Milan / Macan, Jelena

    Arhiv za higijenu rada i toksikologiju

    2021  Volume 72, Issue 4, Page(s) 289–297

    Abstract: Coronavirus disease 2019 (COVID-19) can be diagnosed as occupational disease by an occupational health physician (OHP), if supported by relevant work-related and medical documentation. The aim of this study was to analyse such documentation submitted by ... ...

    Abstract Coronavirus disease 2019 (COVID-19) can be diagnosed as occupational disease by an occupational health physician (OHP), if supported by relevant work-related and medical documentation. The aim of this study was to analyse such documentation submitted by Croatian healthcare workers (HCWs) and discuss its relevance in view of European and Croatian guidelines. The study included 100 Croatian HCWs who were SARS-CoV-2-positive and requested that their infection be diagnosed as occupational disease by their OHPs from 1 May 2020 to 10 March 2021. As participants they were asked to fill out our online Occupational COVID-19 in Healthcare Workers Questionnaire. For the purpose of this study we analysed answers about the type of close contact at the workplace, COVID-19 symptoms, and enclosed work-related (job description, employer statement about exposure to SARS-CoV-2) and medical documentation (positive SARS-CoV-2 polymerase chain reaction test and patient history confirming the diagnosis of COVID-19). Most participants were working in hospitals (N=95), mostly nurses (N=75), who became infected by a patient (N=68) or colleague (N=31), and had at least one COVID-19 symptom (N=87). Eighty participants did not enclose obligatory documents, 41 of whom failed to submit job description and 31 both job description and employer statement. These findings confirm that the major risk of occupational COVID-19 in HCWs is close contact with patients and colleagues, and points out the need for better cooperation between OHPs, occupational safety experts, employers, and diseased workers.
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Occupational Health ; SARS-CoV-2
    Language English
    Publishing date 2021-12-30
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 127289-5
    ISSN 1848-6312 ; 0004-1254
    ISSN (online) 1848-6312
    ISSN 0004-1254
    DOI 10.2478/aiht-2021-72-3603
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  8. Article ; Online: Characteristics of work-related COVID-19 in Croatian healthcare workers: a preliminary report.

    Žaja, Roko / Kerner, Ivana / Macan, Jelena / Milošević, Milan

    Arhiv za higijenu rada i toksikologiju

    2021  Volume 72, Issue 1, Page(s) 36–41

    Abstract: Healthcare workers (HCWs) are considered to run a higher occupational risk of becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and develop coronavirus disease (COVID-19) than the rest of the population. The aim of this ...

    Abstract Healthcare workers (HCWs) are considered to run a higher occupational risk of becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and develop coronavirus disease (COVID-19) than the rest of the population. The aim of this study was to describe and analyse the characteristics of work-related COVID-19 in Croatian HCWs. Study participants were HCWs who contacted their occupational physician between 1 May 2020 and 12 November 2020 with a request for the registration of COVID-19 as an occupational disease. All participants filled out our online Occupational COVID-19 in Healthcare Workers Questionnaire. The study included 59 HCWs (median age 45.0, interquartile range 36.0-56.0 years). Most (78 %) were nurses or laboratory technicians, and almost all (94.9 %) worked in hospitals. Hierarchical cluster analysis revealed three clusters of COVID-19-related symptoms: 1) elevated body temperature with general weakness and fatigue, 2) diarrhoea, and 3) headache, muscle and joint pain, anosmia, ageusia, and respiratory symptoms (nasal symptoms, burning throat, cough, dyspnoea, tachypnoea). Almost half (44.6 %) reported comorbidities. Only those with chronic pulmonary conditions were more often hospitalised than those without respiratory disorders (57.1 % vs. 2.5 %, respectively; P=0.001). Our findings suggest that work-related COVID-19 among Croatian HCWs is most common in hospital nurses/laboratory technicians and takes a mild form, with symptoms clustering around three clinical phenotypes: general symptoms of acute infection, specific symptoms including neurological (anosmia, ageusia) and respiratory symptoms, and diarrhoea as a separate symptom. They also support evidence from other studies that persons with chronic pulmonary conditions are at higher risk for developing severe forms of COVID-19.
    MeSH term(s) Adult ; COVID-19/epidemiology ; Croatia/epidemiology ; Female ; Health Personnel/statistics & numerical data ; Humans ; Male ; Middle Aged ; Occupational Diseases/epidemiology ; Risk Assessment/statistics & numerical data ; SARS-CoV-2
    Language English
    Publishing date 2021-03-30
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 127289-5
    ISSN 1848-6312 ; 0004-1254
    ISSN (online) 1848-6312
    ISSN 0004-1254
    DOI 10.2478/aiht-2021-72-3530
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  9. Article ; Online: Characteristics of hand eczema in final-year apprentice nurses during the COVID-19 pandemic.

    Šakić, Franka / Babić, Željka / Franić, Zrinka / Macan, Jelena

    Contact dermatitis

    2021  Volume 86, Issue 2, Page(s) 98–106

    Abstract: Background: Apprentice nurses are considered at high risk to developing occupational skin diseases.: Objectives: This study assessed the frequency and origin of hand eczema, and work-related risk factors in apprentice nurses.: Methods: The study ... ...

    Abstract Background: Apprentice nurses are considered at high risk to developing occupational skin diseases.
    Objectives: This study assessed the frequency and origin of hand eczema, and work-related risk factors in apprentice nurses.
    Methods: The study involved 240 final-year apprentice nurses (females 75%, median age 19 years) from vocational schools in Zagreb, Croatia. The study was performed in 2020/2021 and included a questionnaire and clinical examination by means of the Osnabrück Hand Eczema Severity Index (OHSI). Skin prick test (SPT) with natural rubber latex (NRL) allergen, and patch test with the basic series of allergens, and disinfectants, were performed in 42 apprentice nurses with hand eczema that lasted more than 3 months.
    Results: Clinically observed and self-reported hand eczema were found in 49% and 46% of apprentice nurses, respectively. Those with observed changes were older and reported more days per month spent on practical work than those with healthy skin (P = .001). Median OHSI was 4 (interquartile range 2-6). There were no positive SPTs to latex, and 11 (26%) apprentice nurses had positive patch test reactions to one or more tested allergens, mostly nickel.
    Conclusions: Hand eczema was common in final-year apprentice nurses during the COVID-19 pandemic. It was mostly of irritative origin, associated with the duration of practical training, confirming cumulative effect of hazards on skin barrier.
    MeSH term(s) COVID-19/nursing ; Croatia ; Dermatitis, Occupational/etiology ; Eczema/etiology ; Female ; Hand Dermatoses/etiology ; Humans ; Male ; Pandemics ; Patch Tests ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Students, Nursing ; Young Adult
    Language English
    Publishing date 2021-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.14006
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  10. Article ; Online: Skin Characteristics of Hairdresser Apprentices at the Beginning of Vocational Training.

    Franić, Zrinka / Babić, Željka / Milić, Mirta / Macan, Jelena

    Dermatitis : contact, atopic, occupational, drug

    2021  Volume 32, Issue 6, Page(s) 437–443

    Abstract: Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis.: Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin ... ...

    Abstract Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis.
    Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin bioengineering methods at the beginning of apprenticeship.
    Methods: During the screening phase of a prospective cohort study, we recruited 352 HAs in 24 Croatian towns. The protocol included the following: questionnaires with self-reported skin and atopy symptoms evaluation, Osnabrueck Hand Eczema Severity Index (OHSI) for clinical skin assessment, genotyping FLG (filaggrin) gene mutations, skin pH, and transepidermal water loss (TEWL) measurements.
    Results: Self-reported skin symptoms were reported by 12%, history of dry hands by 29%, and history of atopy by 46% of HAs. Skin changes were found at the clinical examination in 18% of the HA. The OHSI score was positively correlated with hand TEWL and hand skin pH in multiple regression linear models. An FLG gene mutation was found in 1 apprentice.
    Conclusions: Significant prevalence of clinically observed skin signs on the hands was observed in HAs at the beginning of training. The OHSI score was found to be an independent predictor of higher hand TEWL and skin pH values. The need to ameliorate preventive examinations before the enrolment to hairdressing schools was indicated.
    MeSH term(s) Barbering ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Occupational/diagnosis ; Dermatitis, Occupational/etiology ; Eczema/diagnosis ; Follow-Up Studies ; Hand Dermatoses/diagnosis ; Hand Dermatoses/etiology ; Humans ; Occupational Exposure/adverse effects ; Prospective Studies ; Vocational Education
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000718
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