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  1. Article ; Online: A sex-based analysis of 5-year outcomes following stenting for the treatment of aorto-iliac occlusive disease.

    Mwipatayi, Bibombe Patrice / Barry, Ian Patrick / Hanna, Joseph / Macarulay, Reane / Wong, Jackie / Thomas, Shannon / Vijayan, Vikram / Puttaswamy, Vikram / Ward, Natalie C

    Vascular

    2023  , Page(s) 17085381231194152

    Abstract: Objectives: The aim of this study was to evaluate the impact of sex on mid-term outcomes following stenting for aorto-iliac occlusive disease (AIOD).: Methods: The Covered versus Balloon Expandable Stent Trial (COBEST) compared the safety and ... ...

    Abstract Objectives: The aim of this study was to evaluate the impact of sex on mid-term outcomes following stenting for aorto-iliac occlusive disease (AIOD).
    Methods: The Covered versus Balloon Expandable Stent Trial (COBEST) compared the safety and efficacy of the covered stent (CS) with those of the bare metal stent (BMS) in the treatment of hemodynamically significant AIOD. It was identified that CS provided a significant benefit. The primary endpoint of our analysis was the rate of primary patency 5 years following stenting for AIOD (inclusive of both CS and BMS) in both sexes.
    Results: Of the 168 lesions treated, 103 (61%) were present in men and 65 (39%) were present in women. Of the concomitant comorbidities, diabetes mellitus was significantly more common in women (17.5% vs 41.5%,
    Conclusions: No significant difference was identified in the primary patency rate between the sexes. Further investigation is warranted to ascertain whether sex-specific interventional guidelines are required in this regard.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381231194152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4277: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 590: Show issues

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  2. Article ; Online: Sex-Related Outcomes Following Drug Balloon Angioplasty in Patients from the BIOLUX P-III Registry: A Subgroup Analysis.

    Barry, Ian Patrick / Macarulay, Reane / Brodmann, Marianne / Zeller, Thomas / Moscovic, Matej / Dahm, Johannes / Troisi, Nicola / Tepe, Gunnar / Wong, Jacqueline / Mwipatayi, Bibombe Patrice

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 7, Page(s) 918–928

    Abstract: Purpose: To evaluate the use of drug-coated balloons in a real-world patient population with peripheral arterial disease and analyse the impact of sex on mid-term outcomes following their utilisation.: Methods: The BIOLUX P-III is a prospective, ... ...

    Abstract Purpose: To evaluate the use of drug-coated balloons in a real-world patient population with peripheral arterial disease and analyse the impact of sex on mid-term outcomes following their utilisation.
    Methods: The BIOLUX P-III is a prospective, international, multi-centre, registry of patients with infra-inguinal lesions treated using the Passeo-18 Lux, a drug-coated balloon. Our study is a 24-month subgroup analysis of these patients; primary endpoints were freedom from major adverse events and clinically driven target lesion re-vascularisation within 12 months post-intervention.
    Results: Of the 877 patients in the registry, 561 (64.0%) were male and 316 (36.0%) were female. Chronic limb threatening ischaemia (Rutherford class ≥ 4) occurred in 35.7% of males and 40.6% of females. Rates of freedom from major adverse events and clinically driven target lesion re-vascularisation at 12 months were 87.3% (95% confidence interval [CI] 84.2-89.9) and 90.4% (95% CI 86.5-93.3), and 92.3% (95% CI 89.9-94.1) and 92.9% (95% CI 89.7-95.1) in males and females, respectively. All-cause mortality at 24 months was 12.0% (95% CI 9.4-15.3) in males and 11.9% (95% CI 8.6-16.5) in females. The major target limb amputation rate at 24 months was 9.1% (95% CI 6.9-11.9) in males and 4.0% (95% CI 2.3-7.0) in females.
    Conclusion: Treatment with the Passeo-18 Lux DCB demonstrated high efficacy and low complication rates. Despite the greater proportion of chronic limb threatening ischaemia observed in females, males were at a greater risk of ipsilateral major limb amputation and major adverse events following drug-coated balloon utilisation.
    Clinical trial registration: NCT02276313.
    Level of evidence: Level 4.
    MeSH term(s) Angioplasty, Balloon/adverse effects ; Cardiovascular Agents/adverse effects ; Coated Materials, Biocompatible ; Female ; Femoral Artery ; Humans ; Limb Salvage ; Male ; Paclitaxel/adverse effects ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/therapy ; Popliteal Artery ; Prospective Studies ; Registries ; Treatment Outcome ; Vascular Patency
    Chemical Substances Cardiovascular Agents ; Coated Materials, Biocompatible ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03135-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1378: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation.

    Ochieng, Pius / Nath, Sridesh / Macarulay, Reane / Eden, Edward / Dabo, Abdoulaye / Campos, Michael / Jiang, Xian-Cheng / Foronjy, Robert F / Geraghty, Patrick

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 15394

    Abstract: Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine ... ...

    Abstract Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave PLTP in diseased airways. We propose to identify if airway PLTP activity can be restored by AAT augmentation therapy and how PLTP subdues degranulation of neutrophils in AAT deficient subjects. Airway PLTP activity was lower in AAT deficient patients but elevated in the airways of patients on augmentation therapy. Functional AAT protein (from PiMM homozygotes) prevented PLTP cleavage unlike its mutated ZZ variant (PiZZ). PLTP lowered leukotriene B4 induced degranulation of primary, secondary and tertiary granules from neutrophils from both groups (n = 14/group). Neutrophils isolated from Pltp knockout mice have enhance neutrophil degranulation. Both AAT and PLTP reduced neutrophil degranulation and superoxide production, possibly though their inhibition of the Src tyrosine kinase, Hck. Src kinase inhibitors saracatinib and dasatinib reduced neutrophil degranulation and superoxide production. Therefore, AAT protects PLTP from proteolytic cleavage and both AAT and PLTP mediate degranulation, possibly via Hck tyrosine kinase inhibition. Deficiency of AAT could contribute to reduced lung PLTP activity and elevated neutrophil signaling associated with lung disease.
    MeSH term(s) Aged ; Animals ; Cell Degranulation/genetics ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Neutrophil Activation/genetics ; Neutrophils/physiology ; Phospholipid Transfer Proteins/genetics ; Phospholipid Transfer Proteins/physiology ; Proto-Oncogene Proteins c-hck/metabolism ; Signal Transduction/genetics ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin/physiology ; alpha 1-Antitrypsin Deficiency/genetics ; alpha 1-Antitrypsin Deficiency/metabolism ; alpha 1-Antitrypsin Deficiency/pathology
    Chemical Substances PLTP protein, human ; Phospholipid Transfer Proteins ; alpha 1-Antitrypsin ; phospholipid transfer protein, mouse ; HCK protein, human (EC 2.7.10.2) ; Hck protein, mouse (EC 2.7.10.2) ; Proto-Oncogene Proteins c-hck (EC 2.7.10.2)
    Language English
    Publishing date 2018-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-33851-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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