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  1. Article ; Online: Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients.

    Zhang, Cathy L / Maccarone, Jennifer R / Grady, Stephanie T / Collins, Christina M / Moy, Marilyn L / Hart, Jaime E / Kang, Choong-Min / Coull, Brent A / Schwartz, Joel D / Koutrakis, Petros / Garshick, Eric

    The Science of the total environment

    2024  Volume 927, Page(s) 171897

    Abstract: Background: Systemic inflammation contributes to cardiovascular risk and chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between systemic inflammation and exposure to ambient fine particulate matter (PM ≤ 2.5 μm diameter; PM!## ...

    Abstract Background: Systemic inflammation contributes to cardiovascular risk and chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between systemic inflammation and exposure to ambient fine particulate matter (PM ≤ 2.5 μm diameter; PM
    Methods: Between 2012 and 2017, COPD patients completed in-home air sampling over one-week intervals, up to four times (seasonally), followed by measurement of plasma biomarkers of systemic inflammation, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activation, soluble vascular adhesion molecule-1 (sVCAM-1). Ambient PM
    Results: 144 participants resulting in 482 observations were included in the analysis. There were significant positive associations between indoor BC and indoor BC of ambient origin with CRP [%-increase per interquartile range (IQR);95 % CI (13.2 %;5.2-21.8 and 11.4 %;1.7-22.1, respectively)]. Associations with indoor PM
    Conclusions: In homes of patients with COPD without major sources of combustion, indoor BC is mainly attributable to the infiltration of ambient sources of combustion indoors. Indoor BC of ambient origin is associated with increases in systemic inflammation in patients with COPD, even when staying indoors.
    MeSH term(s) Pulmonary Disease, Chronic Obstructive/blood ; Humans ; Particulate Matter/analysis ; Biomarkers/blood ; Soot/analysis ; Soot/adverse effects ; Air Pollution, Indoor/analysis ; Air Pollution, Indoor/statistics & numerical data ; Air Pollution, Indoor/adverse effects ; Male ; Female ; Air Pollutants/analysis ; Air Pollutants/adverse effects ; Aged ; Middle Aged ; Environmental Exposure/statistics & numerical data ; Interleukin-6/blood ; C-Reactive Protein/analysis ; Inflammation/blood
    Chemical Substances Particulate Matter ; Biomarkers ; Soot ; Air Pollutants ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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  2. Article ; Online: Deployment-related Cigarette Smoking Behaviors and Pulmonary Function Among U.S. Veterans.

    Maccarone, Jennifer R / Sterns, Olivia R / Timmons, Andrew / Korpak, Anna M / Smith, Nicholas L / Nakayama, Karen S / Baird, Coleen P / Ciminera, Paul / Kheradmand, Farrah / Fan, Vincent S / Hart, Jaime E / Koutrakis, Petros / Jerrett, Michael / Kuschner, Ware G / Ioachimescu, Octavian C / Montgrain, Philippe R / Proctor, Susan P / Redlich, Carrie A / Wendt, Christine H /
    Blanc, Paul D / Garshick, Eric / Wan, Emily S

    Military medicine

    2024  

    Abstract: Introduction: The effects of smoking on lung function among post-9/11 Veterans deployed to environments with high levels of ambient particulate matter are incompletely understood.: Materials and methods: We analyzed interim data (04/2018-03/2020) ... ...

    Abstract Introduction: The effects of smoking on lung function among post-9/11 Veterans deployed to environments with high levels of ambient particulate matter are incompletely understood.
    Materials and methods: We analyzed interim data (04/2018-03/2020) from the Veterans Affairs (VA) Cooperative Studies Program #595, "Service and Health Among Deployed Veterans". Veterans with ≥1 land-based deployments enrolled at 1 of 6 regional Veterans Affairs sites completed questionnaires and spirometry. Multivariable linear regression models assessed associations between cigarette smoking (cumulative, deployment-related and non-deployment-related) with pulmonary function.
    Results: Among 1,836 participants (mean age 40.7 ± 9.6, 88.6% male), 44.8% (n = 822) were ever-smokers (mean age 39.5 ± 9.5; 91.2% male). Among ever-smokers, 86% (n = 710) initiated smoking before deployment, while 11% (n = 90) initiated smoking during deployment(s). Smoking intensity was 50% greater during deployment than other periods (0.75 versus 0.50 packs-per-day; P < .05), and those with multiple deployments (40.4%) were more likely to smoke during deployment relative to those with single deployments (82% versus 74%). Total cumulative pack-years (median [IQR] = 3.8 [1, 10]) was inversely associated with post-bronchodilator FEV1%-predicted (-0.82; [95% CI] = [-1.25, -0.50] %-predicted per 4 pack-years) and FEV1/FVC%-predicted (-0.54; [95% CI] = [-0.78, -0.43] %-predicted per 4 pack-years). Deployment-related pack-years demonstrated similar point estimates of associations with FEV1%-predicted (-0.61; [95% CI] = [-2.28, 1.09]) and FEV1/FVC%-predicted (-1.09; [95% CI] = [-2.52, 0.50]) as non-deployment-related pack-years (-0.83; [95% CI] = [-1.26, -0.50] for FEV1%-predicted; -0.52; [95% CI] = [-0.73, -0.36] for FEV1/FVC%-predicted).
    Conclusions: Although cumulative pack-years smoking was modest in this cohort, an inverse association with pulmonary function was detectable. Deployment-related pack-years had a similar association with pulmonary function compared to non-deployment-related pack-years.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usae049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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