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Article ; Online: A systematic review of randomised controlled trials on topical nasal steroids.

Zeroli, Chiara / Gorica, Armela / Monti, Giulia / Castelnuovo, Paolo Giocondo Maria / Bignami, Maurizio / Macchi, Alberto

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2024 Volume 44, Issue 2, Page(s) 71–75

Abstract: Introduction: Intranasal corticosteroids (INCs) are the first line of therapy for chronic sinonasal conditions such as rhinitis and rhinosinusitis. Among these, one of the most frequently used is beclomethasone dipropionate (BDP). Over the years many ... ...

Abstract	Introduction: Intranasal corticosteroids (INCs) are the first line of therapy for chronic sinonasal conditions such as rhinitis and rhinosinusitis. Among these, one of the most frequently used is beclomethasone dipropionate (BDP). Over the years many studies have evaluated the efficacy of BDP as part of therapy for chronic rhinosinusitis (CRS) and allergic rhinitis (AR) along with nasal washes, which seems to be very well tolerated. Objective: To analyse the data in the literature regarding the various therapeutic regimens of BDP in different sinonasal disease and their efficacy and tolerability. Materials and methods: Using different search engines, the posology, efficacy, and tolerability of BDP were reviewed and a total of 64 full-length articles were examined for eligibility. After applying inclusion and exclusion criteria, 4 articles were reviewed. Results: BDP is among the group of INCs with significant improvement of nasal symptoms and has good efficacy and safety. Conclusions: BDP nasal spray is one of the most frequently prescribed INC for rhinitis and rhinosinusitis. Treatment with BDP resulted in significant and clinically meaningful improvements in nasal symptoms associated with AR and CRS. BDP is well tolerated, and the safety profile is similar to that of placebo in most patients. These results, in conjunction with the significant benefit reported in subjects with CRS and AR, provide convincing evidence of the overall effectiveness of BDP for the treatment of the full spectrum of sinonasal disease.
MeSH term(s)	Humans ; Randomized Controlled Trials as Topic ; Administration, Intranasal ; Rhinitis/drug therapy ; Sinusitis/drug therapy ; Beclomethasone/administration & dosage ; Beclomethasone/therapeutic use ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Chronic Disease
Chemical Substances	Beclomethasone (KGZ1SLC28Z) ; Adrenal Cortex Hormones ; Glucocorticoids
Language	English
Publishing date	2024-04-23
Publishing country	Italy
Document type	Journal Article ; Systematic Review ; Review
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2745
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Article ; Online: Nasal Cytology: A Easy Diagnostic Tool in Precision Medicine for Inflammation in Epithelial Barrier Damage in the Nose. A Perspective Mini Review.

Caruso, Cristiano / Giancaspro, Rossana / Guida, Giuseppe / Macchi, Alberto / Landi, Massimo / Heffler, Enrico / Gelardi, Matteo

Frontiers in allergy

2022 Volume 3, Page(s) 768408

Abstract: Nasal cytology is a diagnostic tool that can be used in precision rhinology medicine. Particularly in non-allergic rhinitis and chronic rhinosinusitis forms it can be useful to evaluate biomarkers of both surgical or biological therapy and especially in ... ...

Abstract	Nasal cytology is a diagnostic tool that can be used in precision rhinology medicine. Particularly in non-allergic rhinitis and chronic rhinosinusitis forms it can be useful to evaluate biomarkers of both surgical or biological therapy and especially in the follow-up it must be used to predict the prognostic index of recurrence of nasal polyposis. All inflammatory cytokines are also linked to the presence of cells such as eosinophils and mastcells and nasal cytology is a non-invasive and repeatable method to assess the situation in real life.
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2022.768408
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Article ; Online: Middle meatus nasal cytology compared to inferior turbinate cytology in non allergic rhinitis.

Bocciolini, Corso / Nappi, Emanuele / Giunta, Gianmarco / Paoletti, Giovanni / Malvezzi, Luca / Monti, Giulia / Macchi, Alberto / Amorosa, Luca / Heffler, Enrico

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2022 Volume 280, Issue 2, Page(s) 913–918

Abstract: Purpose: Non allergic rhinitis (NAR) comprises different clinical definitions and phenotypes, including non inflammatory non allergic (NINAR) and cellular inflammatory forms. Nasal cytology, usually performed by scraping the inferior turbinate, is a non ...

Abstract	Purpose: Non allergic rhinitis (NAR) comprises different clinical definitions and phenotypes, including non inflammatory non allergic (NINAR) and cellular inflammatory forms. Nasal cytology, usually performed by scraping the inferior turbinate, is a non invasive, cheap and point-of-care tool to distinguish among the different NAR phenotypes, but still a relevant proportion of patients evaluated by nasal cytology receive a non precise definition of NAR phenotype. We hypothesize that collecting nasal cytology samples from middle meatus could increase the diagnostic accuracy. Methods: Consecutive patients with chronic rhinitis without evidence of allergic sensitization were assessed for nasal cytology by means of scraping both the inferior turbinate and the middle meatus (lateral-inferior wall of the middle turbinate). Results: 107 consecutive patients with NAR were enrolled in the study. According to inferior turbinate cytology, 42.1% were defined as affected by NINAR, 2.8% by bacterial rhinitis, 10.3% by non allergic rhinitis with eosinophils (NARES), 15.0% non allergic rhinitis with neutrophils (NARNE), 19.6% non allergic rhinitis with mast-cells (NARMA) and 10.3% non allergic rhinitis with eosinophils and mast-cells (NARESMA). Middle meatus cytology was in accordance with inferior turbinate cytology in only 37.6% of cases. Eosinophils and mast-cells were detectable more frequently in middle meatus samples (49.5% vs 19.6%, p < 0.01, 59.8% vs 29.9%, p < 0.01, respectively). 93.3% of NINAR patients received an inflammatory NAR phenotype at middle meatus cytology: 26.7% NARES, 24.4% NARNE, 31.1% NARMA and 11.1% NARESMA. Conclusion: Middle meatus cytology is more reliable than inferior turbinate cytology in phenotyping patients with NAR. Our study strengthen that nasal cytology should be implemented in clinical practice collecting samples at the middle meatus level.
MeSH term(s)	Humans ; Rhinitis/diagnosis ; Turbinates ; Eosinophils ; Nasal Cavity ; Neutrophils ; Hypersensitivity ; Rhinitis, Allergic/diagnosis ; Nasal Mucosa
Language	English
Publishing date	2022-08-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-022-07629-8
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Article ; Online: Surveillance or Dynamic Sentinel Lymph-Node Biopsy in Low-Risk Clinically N0 Penile Squamous Cell Carcinoma: Single-Institution Real World Data.

Nazzani, Sebastiano / Catanzaro, Mario / Bruniera, Martina / Torelli, Tullio / Macchi, Alberto / Stagni, Silvia / Tesone, Antonio / Silvani, Carlo / Ceccato, Tommaso / Bernasconi, Valentina / Lanocita, Rodolfo / Cascella, Tommaso / Claps, Melanie / Giannatempo, Patrizia / Zimatore, Matteo / Cattaneo, Laura / Biasoni, Davide / Montanari, Emanuele / Nicolai, Nicola

Clinical genitourinary cancer

2024 Volume 22, Issue 2, Page(s) 544–548

Abstract: Introduction: Surveillance is the standard management in low-risk cN0 penile squamous cell carcinoma (peSCC) patients. However, no previous analysis focused on early and long-term outcomes of these patients. We report on main oncological outcomes of a ... ...

Abstract	Introduction: Surveillance is the standard management in low-risk cN0 penile squamous cell carcinoma (peSCC) patients. However, no previous analysis focused on early and long-term outcomes of these patients. We report on main oncological outcomes of a large series of low-risk cN0 peSCC patients. Patients and methods: Between 1980 and 2017 included, 93 evaluable consecutive low-risk (ie, pT1a G1 cN0M0) peSCC patients underwent primary tumor surgery and either observation (74) or dynamic sentinel node biopsy (DSNB) (19) following a clinical diagnosis of T1 in 66 (71%), T2 in 15 (16.1%) and Tx in 12 (12.9%) patients, respectively. The statistical significance of differences in medians and proportions was tested with the Kruskal-Wallis and chi-square tests. Kaplan-Meier plots illustrated 5-year inguinal relapse (IR)-free survival rates. Results: Median age was 60 years (IQR: 50-69 years). Median follow-up was 92 months (IQR 54-133 months). Surveillance was more frequently adopted in clinical (c)T1 than in cT2 tumors (79.7% vs. 36.8%). None of 19 patients who had DSNB had nodal metastasis. Overall, 7 (7.5%) out of 93 pT1aG1cN0 peSCC patients had IR after a median interval of 9 months. Of note, 1 patient only relapsed after 12 months of surveillance. After stratification according to IR, relapses occurred more frequently in younger patients (59 vs. 64 years, P < .001). The 5-year IR-free survival rates for the entire cohort was 92% (95% Confidence interval [CI] 87-98%). Conclusions: Observation is a safe and effective management for low-risk peSCC patients. Younger patients may be offered a mini-invasive staging as an alternative.
MeSH term(s)	Male ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Sentinel Lymph Node Biopsy ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Neoplasm Staging
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2225121-2
ISSN	1938-0682 ; 1558-7673
ISSN (online)	1938-0682
ISSN	1558-7673
DOI	10.1016/j.clgc.2024.01.009
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Article: Management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP): Results from a survey among allergists and clinical immunologists of the North-west and Center Italy Inter-Regional Sections of SIAAIC and otorhinolaryngologists of National IAR.

Bagnasco, Diego / Brussino, Luisa / Biagini, Cesare / Cosmi, Lorenzo / De Corso, Eugenio / La Mantia, Ignazio / Macchi, Alberto / Maggiore, Giandomenico / Matucci, Andrea / Nicola, Stefania / Passalacqua, Giovanni / Presutti, Livio / Seccia, Veronica / Vultaggio, Alessandra / Riparbelli, Michele / Sartor, Chiara / Parronchi, Paola / Canevari, Frank Rikki Mauritz

The World Allergy Organization journal

2024 Volume 17, Issue 4, Page(s) 100895

Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2024.100895
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Article ; Online: Surgical Approaches for Possible Positions of an Olfactory Implant to Stimulate the Olfactory Bulb.

Menzel, Susanne / Konstantinidis, Iordanis / Valentini, Marco / Battaglia, Paolo / Turri-Zanoni, Mario / Sileo, Giorgio / Monti, Giulia / Castelnuovo, Paolo Giocondo Maria / Hummel, Thomas / Macchi, Alberto

ORL; journal for oto-rhino-laryngology and its related specialties

2023 Volume 85, Issue 5, Page(s) 253–263

Abstract: Introduction: Current scientific developments seem to allow for an "olfactory implant" in analogy to cochlear implants. However, the position and surgical approaches for electrical stimulation of the olfactory system are unclear.: Methods: In a human ...

Abstract	Introduction: Current scientific developments seem to allow for an "olfactory implant" in analogy to cochlear implants. However, the position and surgical approaches for electrical stimulation of the olfactory system are unclear. Methods: In a human anatomic cadaver study, we investigated different endoscopic approaches to electrically stimulate the olfactory bulb (OB) based on the following considerations: (1) the stimulating electrode should be close to the OB. (2) The surgical procedure should be as non-invasive and safe as possible and (3) as easy as possible for an experienced ENT surgeon. Results: In summary, the endoscopic intracranial positioning of the electrode via a widened ostium of the fila olfactoria or a frontal sinus surgery like a Draf IIb procedure is a good option in terms of patients' risk, degree of difficulty for ENT surgeons, and position to the OB. Endoscopic intranasal positioning appeared to be the best option in terms of patient risk and the degree of difficulty for ENT surgeons. Although a bigger approach to the OB using a drill and the combined intranasal endoscopic and external approach enabled a close placement of the electrode to the OB, they do not seem relevant in practice due to their higher invasiveness. Conclusion: The study suggested that an intranasal positioning of a stimulating electrode is possible, with placements beneath the cribriform plate, extra- or intracranially, applying elegant surgical techniques with low or medium risk to the patient and a close placement to OB.
MeSH term(s)	Humans ; Cadaver ; Cochlear Implants ; Endoscopy ; Olfactory Bulb/surgery ; Olfactory Bulb/physiology ; Smell/physiology ; Olfaction Disorders/etiology ; Olfaction Disorders/surgery ; Cranial Sinuses/surgery
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121482-2
ISSN	1423-0275 ; 0301-1569
ISSN (online)	1423-0275
ISSN	0301-1569
DOI	10.1159/000529563
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Article ; Online: Diagnostic therapeutic assistance pathway (PDTA) of type 2 chronic rhinosinusitis.

Canevari, Frank Rikki / Giorli, Alessia / Monti, Giulia / Biagini, Cesare / Bagnasco, Diego / Cavaliere, Carlo / Pipolo, Carlotta / De Corso, Eugenio / Gelardi, Matteo / Gramellini, Giulia / Ioppi, Alessandro / La Mantia, Ignazio / Malvezzi, Luca / Bignami, Maurizio / Dehgani-Mobaraki, Puya / Seccia, Veronica / Maggiore, Giandomenico / Macchi, Alberto

Frontiers in allergy

2023 Volume 4, Page(s) 1237131

Abstract: Chronic rhinosinusitis (CRS) is a complex and heterogeneous disorder whose etiopathogenetic picture is not yet completely known and is classically divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). But today the distinction is made with ... ...

Abstract	Chronic rhinosinusitis (CRS) is a complex and heterogeneous disorder whose etiopathogenetic picture is not yet completely known and is classically divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). But today the distinction is made with type 2 and nontype 2 variants. A rational and defined pathway for the diagnosis of chronic rhinosinusitis is an indispensable means to be able to arrive at a correct identification of the patient. This typing is essential to be able to arrive at the correct course of treatment, which turns out to be different for different types of patients. For this reason, the realization of a diagnostic therapeutic pathway represents a fundamental way for the otolaryngologist specialist but not only, since today diagnostics has a multidisciplinary framework. In the present work, precise indications have been developed to arrive at a correct diagnosis. The various diagnostic pathways and processes to arrive at a correct therapeutic framing have been highlighted. Therapy ranging from medical therapy to surgical therapy without neglecting the new biological therapies. It does not represent a guideline but a diagnostic method that can be adapted to all the various territorial realities.
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2023.1237131
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Article ; Online: Solar ultraviolet light collector for germicidal irradiation on the moon.

Lombini, Matteo / Schreiber, Laura / Albertini, Roberto / Alessi, Elisa Maria / Attinà, Primo / Bianco, Andrea / Cascone, Enrico / Colucci, Maria Eugenia / Cortecchia, Fausto / De Caprio, Vincenzo / Diolaiti, Emiliano / Fiorini, Mauro / Lessio, Luigi / Macchi, Alberto / Malaguti, Giuseppe / Mongelluzzo, Giuseppe / Pareschi, Giovanni / Pelizzo, Maria G / Pasquarella, Cesira

Scientific reports

2023 Volume 13, Issue 1, Page(s) 8326

Abstract: Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonisation in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne biological ... ...

Abstract	Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonisation in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne biological contaminants represent a relevant problem in space missions. A possible way to perform pathogens' inactivation is by employing the shortest wavelength range of Solar ultraviolet radiation, the so-called germicidal range. On Earth, it is totally absorbed by the atmosphere and does not reach the surface. In space, such Ultraviolet solar component is present and effective germicidal irradiation for airborne pathogens' inactivation can be achieved inside habitable outposts through a combination of highly reflective internal coating and optimised geometry of the air ducts. The Solar Ultraviolet Light Collector for Germicidal Irradiation on the Moon is a project whose aim is to collect Ultraviolet solar radiation and use it as a source to disinfect the re-circulating air of the human outposts. The most favourable positions where to place these collectors are over the peaks at the Moon's poles, which have the peculiarity of being exposed to solar radiation most of the time. On August 2022, NASA communicated to have identified 13 candidate landing regions near the lunar South Pole for Artemis missions. Another advantage of the Moon is its low inclination to the ecliptic, which maintains the Sun's apparent altitude inside a reduced angular range. For this reason, Ultraviolet solar radiation can be collected through a simplified Sun's tracking collector or even a static collector and used to disinfect the recycled air. Fluid-dynamic and optical simulations have been performed to support the proposed idea. The expected inactivation rates for some airborne pathogens, either common or found on the International Space Station, are reported and compared with the proposed device efficiency. The results show that it is possible to use Ultraviolet solar radiation directly for air disinfection inside the lunar outposts and deliver a healthy living environment to the astronauts.
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35438-4
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Article ; Online: Bilateral inguinal lymph-node dissection vs. unilateral inguinal lymph-node dissection and dynamic sentinel node biopsy in clinical N1 squamous cell carcinoma of the penis.

Nazzani, Sebastiano / Catanzaro, Mario / Biasoni, Davide / Maccauro, Marco / Stagni, Silvia / Torelli, Tullio / Macchi, Alberto / Bernasconi, Valentina / Taverna, Alessandra / Sessa, Dario / Lorenzoni, Alice / Piva, Luigi / Lanocita, Rodolfo / Cascella, Tommaso / Cattaneo, Laura / Montanari, Emanuele / Salvioni, Roberto / Nicolai, Nicola

Urologic oncology

2023 Volume 41, Issue 4, Page(s) 210.e1–210.e8

Abstract: Introduction: To evaluate the role of unilateral inguinal lymph-node dissection (ILND) plus contralateral dynamic sentinel node biopsy (DSNB) vs. bilateral ILND in clinical N1 (cN1) penile squamous cell carcinoma (peSCC) patients.: Material and ... ...

Abstract	Introduction: To evaluate the role of unilateral inguinal lymph-node dissection (ILND) plus contralateral dynamic sentinel node biopsy (DSNB) vs. bilateral ILND in clinical N1 (cN1) penile squamous cell carcinoma (peSCC) patients. Material and methods: Within our institutional database (1980-2020, included), we identified 61 consecutive cT1-4 cN1 cM0 patients with histological confirmed peSCC who underwent either unilateral ILND plus DSNB (26) or bilateral ILND (35). Results: Median age was 54 years (Interquartile range [IQR]: 48-60 years). Median follow-up was 68 months (IQR 21-105 months). Most patients had pT1 (23 %) or pT2 (54.1%), as well as G2 (47.5%) or G3 (23%) tumors, while lymphovascular invasion (LVI) was present in 67.1% of cases. Considering a cN1 and a cN0 groin, overall 57 out of 61 patients (93.5%) had nodal disease in the cN1 groin. Conversely, only 14 out of 61 patients (22.9%) had nodal disease in the cN0 groin. 5-year IR-free survival was 91% (Confidence interval [CI] 80%-100%) for bilateral ILND group and 88% (CI 73%-100%) for the ipsilateral ILND plus DSNB group (P-value 0.8). Conversely, 5-year CSS was 76% (CI 62%-92%) for bilateral ILND group and 78% (CI 63%-97%) for the ipsilateral ILND plus contralateral DSNB group (P-value 0.9). Conclusions: In patients with cN1 peSCC the risk of occult contralateral nodal disease is comparable to cN0 high risk peSCC and the gold standard, namely bilateral ILND, may be replaced by unilateral ILND and contralateral DSNB without affecting positive node detection, IRRs and CSS.
MeSH term(s)	Male ; Humans ; Middle Aged ; Sentinel Lymph Node Biopsy ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Penis/pathology ; Penile Neoplasms/surgery ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Neoplasm Staging
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2023.02.001
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Article ; Online: An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein.

Strizzi, Sergio / Bernardo, Letizia / D'Ursi, Pasqualina / Urbinati, Chiara / Bianco, Andrea / Limanaqi, Fiona / Manconi, Andrea / Milanesi, Maria / Macchi, Alberto / Di Silvestre, Dario / Cavalleri, Adalberto / Pareschi, Giovanni / Rusnati, Marco / Clerici, Mario / Mauri, PierLuigi / Biasin, Mara

Pharmacological research

2023 Volume 194, Page(s) 106862

Abstract: The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive ... ...

Abstract	The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive results. We developed a multidisciplinary approach by coupling in vitro infection assay, mass spectrometry (MS), protein 3D modelling, and surface plasma resonance (SPR). As a proof of concept, the effect of low UV-C (273 nm) irradiation on SARS-CoV-2 spike (S) protein was investigated. Following UV-C exposure, MS analysis identified, among other modifications, the disruption of a disulphide bond within the conserved S2 subunit of S protein. Computational analyses revealed that this bond breakage associates with an allosteric effect resulting in the generation of a closed conformation with a reduced ability to bind the ACE2 receptor. The UV-C-induced reduced affinity of S protein for ACE2 was further confirmed by SPR analyses and in vitro infection assays. This comprehensive approach pinpoints the S2 domain of S protein as a potential therapeutic target to prevent SARS-CoV-2 infection. Notably, this workflow could be used to screen a wide variety of microbial protein domains, resulting in a precise molecular fingerprint and providing new insights to adequately address future epidemics.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Protein Binding
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2023-07-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106862
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