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  1. Article ; Online: Pain assessment in autism: updating the ethical and methodological challenges through a state-of-the-art review.

    Nicolardi, Valentina / Fanizza, Isabella / Accogli, Giuseppe / Macchitella, Luigi / Scoditti, Sara / Trabacca, Antonio

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 11, Page(s) 3853–3861

    Abstract: Sensory features of autism include hypo- or hyper-reactivity to pain; however, previous studies on pain in autism lead to conflicting results. Here, we present the state of the art and the methodological challenges concerning pain perception in autism, ... ...

    Abstract Sensory features of autism include hypo- or hyper-reactivity to pain; however, previous studies on pain in autism lead to conflicting results. Here, we present the state of the art and the methodological challenges concerning pain perception in autism, focusing on studies that used standardized protocol as Quantitative Sensory Testing (QST) to measure perception. Despite there are still scant evidences found with the use of QST, they have challenged the presumed hyposensitivity to pain in autisms, which emerged from parents' reports. Both, peripheral and central mechanisms, have been found involved in typical features of perception in autism. Nonetheless, evidences with controlled protocols are still scarce, and even scarcer are studies focused on children. Overall, complex ethical challenges have to be overcome in order to collect subjective and objective measures from autistic children. With heterogeneous neurodevelopmental features, or intellectual disability, novel or modified protocols are needed.
    MeSH term(s) Child ; Humans ; Pain Measurement/methods ; Autistic Disorder/complications ; Autistic Disorder/diagnosis ; Pain/diagnosis ; Pain Perception ; Parents
    Language English
    Publishing date 2023-07-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06942-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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  2. Article: Visuo-Spatial Working Memory and Mathematical Skills in Children: A Network Analysis Study.

    Macchitella, Luigi / Tosi, Giorgia / Romano, Daniele Luigi / Iaia, Marika / Vizzi, Francesca / Mammarella, Irene C / Angelelli, Paola

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Visuo-spatial working memory is one of the main domain-general cognitive mechanisms underlying mathematical abilities and their development in children. However, if visuo-spatial working memory involves different processes and components, then the term ' ... ...

    Abstract Visuo-spatial working memory is one of the main domain-general cognitive mechanisms underlying mathematical abilities and their development in children. However, if visuo-spatial working memory involves different processes and components, then the term 'mathematics' refers to a broad concept that includes multiple domains and skills. The aim of this present study was to investigate the relationship between different visuo-spatial working memory components and several mathematical abilities in a sample of third- to fifth-grade Italian children. To assess the relationships between different visuo-spatial working memory components and different mathematical abilities, we relied on Network Analysis (NA). Results indicate that some but not all visuo-spatial working memory components are associated with some mathematical abilities.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13040294
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  3. Article: Grey-matter correlates of empathy in 4-Repeat Tauopathies.

    Tafuri, Benedetta / Urso, Daniele / Nigro, Salvatore / Macchitella, Luigi / De Blasi, Roberto / Ray Chaudhuri, K / Logroscino, Giancarlo

    NPJ Parkinson's disease

    2023  Volume 9, Issue 1, Page(s) 138

    Abstract: Loss of empathy is an early and central symptom of frontotemporal lobar degeneration spectrum diseases. We aimed to investigate the topographical distribution of morphometric brain changes associated with empathy in Progressive Supranuclear Palsy (PSP) ... ...

    Abstract Loss of empathy is an early and central symptom of frontotemporal lobar degeneration spectrum diseases. We aimed to investigate the topographical distribution of morphometric brain changes associated with empathy in Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS) patients. Twenty-seven participants with CBS and 31 with PSP were evaluated using Interpersonal Reactivity Index scales in correlation with gray matter atrophy using a voxel-based morphometry approach. Lower levels of empathy were associated with an increased atrophy in fronto-temporal cortical structures. At subcortical level, empathy scores were positively correlated with gray matter volume in the amygdala, hippocampus and the cerebellum. These findings allow to extend the traditional cortico-centric view of cognitive empathy to the cerebellar regions in patients with neurodegenerative disorders and suggest that the cerebellum may play a more prominent role in social cognition than previously appreciated.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-023-00576-z
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  4. Article ; Online: A narrative review of the use of a cutting-edge virtual reality rehabilitation technology in neurological and neuropsychological rehabilitation.

    Macchitella, Luigi / Amendola, Simone / Barraco, Giulia / Scoditti, Sara / Gallo, Ivana / Oliva, Maria Carmela / Trabacca, Antonio

    NeuroRehabilitation

    2023  Volume 53, Issue 4, Page(s) 439–457

    Abstract: Background: Virtual reality (VR) interventions have been increasingly used in the rehabilitation of a wide range of neurological and neuropsychological dysfunctions. Findings of previous reviews showed positive and promising effects of VR-based ... ...

    Abstract Background: Virtual reality (VR) interventions have been increasingly used in the rehabilitation of a wide range of neurological and neuropsychological dysfunctions. Findings of previous reviews showed positive and promising effects of VR-based interventions. However, they summarized findings on VR-based intervention carried out through different VR systems and tasks.
    Objective: We carried out a narrative review with the aim of qualitatively synthesising the results of previous studies that used specific VR systems, i.e. the Khymeia -Virtual Reality Rehabilitation System, for treatment purposes.
    Methods: We searched the literature in various databases (i.e. EMBASE, Web of Science, SCOPUS, PubMed and PubMed Central) for studies published until November 23, 2023.
    Results: 30 studies were selected. The VRRS was used for neuromotor rehabilitation only in 13 studies, for cognitive rehabilitation in 11 studies, and for both neuromotor and cognitive rehabilitation in six studies. The study design was heterogeneous including 15 randomised controlled trials.
    Conclusion: After discussing each study according to the type of rehabilitation we concluded that the use and efficacy of VRRS rehabilitative intervention for increasing the neurological and neuropsychological functioning of patients are promising but more evidence is needed to make a comparison with conventional treatment. Future studies should also include long-term follow-up as well as cost-effectiveness analysis.
    MeSH term(s) Humans ; Telerehabilitation ; Virtual Reality ; Virtual Reality Exposure Therapy/methods
    Language English
    Publishing date 2023-12-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1087912-2
    ISSN 1878-6448 ; 1053-8135
    ISSN (online) 1878-6448
    ISSN 1053-8135
    DOI 10.3233/NRE-230066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Genuine Memory Deficits as Assessed by the Free and Cued Selective Reminding Test (FCSRT) in the Behavioural Variant of Frontotemporal Dementia. A Systematic Review and Meta-analysis Study.

    Macchitella, Luigi / Tosi, Giorgia / Giaquinto, Francesco / Iaia, Marika / Rizzi, Ezia / Chiarello, Ylenia / Bertoux, Maxime / Angelelli, Paola / Romano, Daniele Luigi

    Neuropsychology review

    2023  

    Abstract: The current diagnostic criteria for the behavioural variant of frontotemporal dementia (bvFTD) foresee a relative sparing of long-term memory. Although bvFTD patients were thought to report secondary memory deficits associated with prefrontal ... ...

    Abstract The current diagnostic criteria for the behavioural variant of frontotemporal dementia (bvFTD) foresee a relative sparing of long-term memory. Although bvFTD patients were thought to report secondary memory deficits associated with prefrontal dysfunctions, some studies indicated the presence of a "genuine memory deficit" related to mesial temporal lobe dysfunctions. Among various neuropsychological tests, the Free and Cue Selective Reminding Test (FCSRT) has been recommended to distinguish genuine from apparent amnesia. We conducted a systematic review and a random effect Bayesian meta-analysis to evaluate the nature and severity of memory deficit in bvFTD. Our objective was to determine whether the existing literature offers evidence of genuine or apparent amnesia in patients with bvFTD, as assessed via the FCSRT. On 06/19/2021, we conducted a search across four databases (PMC, Scopus, Web of Science, and PubMed). We included all studies that evaluated memory performance using the FCSRT in patients with bvFTD, as long as they also included either cognitively unimpaired participants or AD groups. We tested publication bias through the Funnel plot and Egger's test. To assess the quality of studies, we used the Newcastle-Ottawa quality assessment scale adapted for cross-sectional studies. We included 16 studies in the meta-analysis. The results showed that bvFTD patients perform better than AD patients (pooled effects between 0.95 and 1.14), as their memory performance stands between AD and control groups (pooled effects between - 2.19 and - 1.25). Moreover, patients with bvFTD present both genuine and secondary memory disorders. As a major limitation of this study, due to our adoption of a rigorous methodology and stringent inclusion criteria, we ended up with just 16 studies. Nonetheless, our robust findings can contribute to the ongoing discussion on international consensus criteria for bvFTD and the selection of appropriate neuropsychological tools to facilitate the differential diagnosis between AD and bvFTD.
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1062572-0
    ISSN 1573-6660 ; 1040-7308
    ISSN (online) 1573-6660
    ISSN 1040-7308
    DOI 10.1007/s11065-023-09613-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Erratum: Macchitella et al. Sleepiness, Neuropsychological Skills, and Scholastic Learning in Children.

    Macchitella, Luigi / Marinelli, Chiara Valeria / Signore, Fulvio / Ciavolino, Enrico / Angelelli, Paola

    Brain sciences

    2021  Volume 11, Issue 7

    Abstract: The author wishes to make an erratum to the published version of the paper [ ... ]. ...

    Abstract The author wishes to make an erratum to the published version of the paper [...].
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11070892
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  7. Article: The Simple View of Reading in Children Acquiring a Regular Orthography (Italian): A Network Analysis Approach.

    Angelelli, Paola / Romano, Daniele Luigi / Marinelli, Chiara Valeria / Macchitella, Luigi / Zoccolotti, Pierluigi

    Frontiers in psychology

    2021  Volume 12, Page(s) 686914

    Abstract: In the present study, we explored the unique contribution of reading accuracy, reading fluency and linguistic comprehension within the frame of Simple View of Reading (SVR). The experimental sample included 118 3rd to 5th grade children learning Italian, ...

    Abstract In the present study, we explored the unique contribution of reading accuracy, reading fluency and linguistic comprehension within the frame of Simple View of Reading (SVR). The experimental sample included 118 3rd to 5th grade children learning Italian, a language with a highly regular orthography. We adopted a flexible method of analysis, i.e., the Network Analysis (NA), particularly suited for exploring relations among different domains and where the direct relations between a set of intercorrelated variables is the main interest. Results indicated an independent and unique contribution of syntactic comprehension skills as well as reading fluency and reading accuracy in the comprehension of a written text. The decoding measures were not directly associated with non-verbal reasoning and the latter was not directly associated with reading comprehension but was strongly related to oral syntactic comprehension. Overall, the pattern of findings is broadly consistent with the predictions of SVR and underscores how, in an orthographically regular language, reading fluency and reading accuracy as well as oral comprehension skills directly influence reading comprehension. Data are discussed in a cross-linguistic perspective. Implications for education and rehabilitation are also presented.
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.686914
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  8. Article: Sleepiness, Neuropsychological Skills, and Scholastic Learning in Children.

    Macchitella, Luigi / Marinelli, Chiara Valeria / Signore, Fulvio / Ciavolino, Enrico / Angelelli, Paola

    Brain sciences

    2020  Volume 10, Issue 8

    Abstract: Excessive daytime sleepiness is a frequent condition among children and adolescents that may lead to several and significant daytime consequences, including impaired neurocognitive skills and scholastic performance. Here, we evaluated in one hundred and ... ...

    Abstract Excessive daytime sleepiness is a frequent condition among children and adolescents that may lead to several and significant daytime consequences, including impaired neurocognitive skills and scholastic performance. Here, we evaluated in one hundred and ninety-one unselected primary school children, the relationship between sleepiness and a wide range of cognitive and academic skills through a standardized neuropsychological test battery. In order to assess the statistical relationship, we performed a partial least squares path modelling, a non-parametrical approach which combined a model of paths between latent variables and the coefficients between indicators and dimensions. Results were validated through the bootstrap approach and suggest that sleepiness is not associated with all cognitive and scholastic abilities, but only with those relying on verbal abilities and complex cognitive functions (i.e., reading comprehension, oral/syntactic comprehension, spelling, and mathematic skills). Our data suggest the idea that sleepiness in children is associated mostly with "higher" (mainly verbal) cognitive function(s), while the visuospatial domain was not affected.
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci10080529
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  9. Article ; Online: The indirect effect of cognitive reserve on the relationship between age and cognition in pathological ageing: A cross-sectional retrospective study in an unselected and consecutively enrolled sample.

    Giaquinto, Francesco / Tosi, Giorgia / Abbatantuono, Chiara / Pepe, Ilaria / Iaia, Marika / Macchitella, Luigi / Rizzi, Ezia / De Caro, Maria Fara / Romano, Daniele / Taurisano, Paolo / Angelelli, Paola

    Journal of neuropsychology

    2023  Volume 17, Issue 3, Page(s) 477–490

    Abstract: Cognitive reserve (CR) allows individuals to maintain cognitive functionality even in the presence of pathologies. The compensation hypothesis suggests that CR plays an indirect role between age and cognitive decline, contrasting the negative effect of ... ...

    Abstract Cognitive reserve (CR) allows individuals to maintain cognitive functionality even in the presence of pathologies. The compensation hypothesis suggests that CR plays an indirect role between age and cognitive decline, contrasting the negative effect of ageing on cognition. We test this hypothesis in an unselected and consecutively enrolled sample of memory clinic attendees (n = 134) who completed the CR Index questionnaire and three neuropsychological tests assessing global cognition (MMSE, FAB, CDT). Participants were divided into two groups based on standard diagnostic criteria (DSM-5): those who were cognitively impaired (n = 92) and those who were preserved (n = 42). A principal component analysis was used to extract a composite measure of global cognitive functioning from the three neuropsychological tests, and mediation analysis was used to examine the relationship between CR, age and global cognitive functioning in the two groups. Results revealed that: (i) age had a significant direct negative effect on the global cognitive score in both groups; (ii) the three socio-behavioural proxies of CR together suppress the direct negative relationship between age and global cognitive score in cognitively impaired patients but not in cognitively preserved participants. This study confirms the association between CR, age and cognition and allows us to validate its role in a population with cognitive impairment and extend findings to a low-to-middle educated population. These results hold important implications for public health and wellness promotion, emphasising the beneficial role of maintaining healthy and active physical, cognitive and social lifestyles.
    MeSH term(s) Humans ; Cognitive Reserve ; Retrospective Studies ; Cross-Sectional Studies ; Cognition ; Aging/psychology ; Cognitive Dysfunction/psychology ; Neuropsychological Tests
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2380753-2
    ISSN 1748-6653 ; 1748-6645
    ISSN (online) 1748-6653
    ISSN 1748-6645
    DOI 10.1111/jnp.12323
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  10. Article ; Online: Neuropsychological and socio-cognitive deficits in patients with obstructive sleep apnea.

    Macchitella, Luigi / Romano, Daniele Luigi / Marinelli, Chiara Valeria / Toraldo, Domenico Maurizio / Arigliani, Michele / De Benedetto, Michele / Angelelli, Paola

    Journal of clinical and experimental neuropsychology

    2021  Volume 43, Issue 5, Page(s) 514–533

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Bayes Theorem ; Cognition ; Cognitive Dysfunction/complications ; Humans ; Middle Aged ; Neuropsychological Tests ; Polysomnography ; Sleep Apnea, Obstructive/complications
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 605982-x
    ISSN 1744-411X ; 0168-8634 ; 1380-3395
    ISSN (online) 1744-411X
    ISSN 0168-8634 ; 1380-3395
    DOI 10.1080/13803395.2021.1944609
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