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  1. Article: Correlation between epicardial fat thickness with intima-media thickness and ankle-brachial index in patients with metabolic syndrome.

    Arana-Pazos, Karla C / Narvaezrivera, Jorge L / Maceda-Serrano, Alberto / Benitez-Maldonado, Daniel R / Rubio-Guerra, Alberto Francisco

    The National medical journal of India

    2021  Volume 34, Issue 3, Page(s) 151–153

    Abstract: Background An increase in epicardial fat thickness (EFT) has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echo-cardiography provides a reliable measurement of EFT. We evaluated the relationship ... ...

    Abstract Background An increase in epicardial fat thickness (EFT) has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echo-cardiography provides a reliable measurement of EFT. We evaluated the relationship of EFT with carotid intima-media thickness (CIMT) and ankle-brachial index (ABI), in patients with metabolic syndrome. Methods We assessed 80 patients with metabolic syndrome who underwent echocardiography; EFT was measured by two cardiologists. The CIMT (B-mode colour imaging of extracranial carotid arteries using high-resolution ultrasound) was also measured by a certified ultrasonographer, and ABI was measured by the main researcher. Results We did not find any correlation between ABI with EFT (r=0.0103, p=0.93) or with CIMT (r=-0.1625, p=0.15). However, we found a significant correlation between EFT and CIMT (r=0.2718, r2=0.074, p=0.015). When we evaluated the risk for a CIMT >0.9 mm in patients with an EFT >3 mm, we found a statistically significant association (p=0.039). Interestingly, only 1 patient with an EFT <3 mm had a CIMT >0.9 mm. Conclusion We found that the EFT correlates with CIMT in patients with metabolic syndrome, which explains, at least in part, the higher risk of atherosclerosis in them. Measurement of EFT should be part of the cardiovascular risk evaluation in patients with metabolic syndrome.
    MeSH term(s) Ankle Brachial Index ; Carotid Intima-Media Thickness ; Humans ; Metabolic Syndrome/diagnostic imaging ; Metabolic Syndrome/epidemiology ; Pericardium/diagnostic imaging ; Risk Factors
    Language English
    Publishing date 2021-11-25
    Publishing country India
    Document type Case Reports
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.25259/NMJI_182_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Epicardial fat thickness, but not intraabdominal fat, correlates with intima-media thickness in patients with metabolic syndrome: Epicardial fat and intima-media thickness.

    Rubio-Guerra, Alberto F / Guerrero-García, Carolina / Meneses-Acero, Ivan / Maceda-Serrano, Alberto / Benítez-Maldonado, Daniel R / Vargas-Ayala, German / Narváez-Rivera, Jorge L

    Obesity research & clinical practice

    2019  Volume 13, Issue 6, Page(s) 602–603

    MeSH term(s) Adipose Tissue/diagnostic imaging ; Adipose Tissue/physiopathology ; Carotid Intima-Media Thickness/statistics & numerical data ; Echocardiography/methods ; Electric Impedance ; Female ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/physiopathology ; Male ; Metabolic Syndrome/physiopathology ; Middle Aged ; Pericardium/diagnostic imaging ; Pericardium/physiopathology ; Ultrasonography/methods
    Language English
    Publishing date 2019-11-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2274031-4
    ISSN 1878-0318 ; 1871-403X
    ISSN (online) 1878-0318
    ISSN 1871-403X
    DOI 10.1016/j.orcp.2019.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correlation between levels of circulating adipokines and adiponectin/resistin index with carotid intima-media thickness in hypertensive type 2 diabetic patients.

    Rubio-Guerra, Alberto F / Cabrera-Miranda, Luis J / Vargas-Robles, Hilda / Maceda-Serrano, Alberto / Lozano-Nuevo, José J / Escalante-Acosta, Bruno A

    Cardiology

    2013  Volume 125, Issue 3, Page(s) 150–153

    Abstract: Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial ... ...

    Abstract Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke.
    Objective: To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients.
    Methods: Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test.
    Results: Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01) in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r = -0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated - negatively - with CIMT (r = -0.39, p < 0.02) in controls.
    Conclusion: Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients.
    MeSH term(s) Adiponectin/blood ; Aged ; Biomarkers/blood ; Carotid Intima-Media Thickness ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnostic imaging ; Female ; Humans ; Hypertension/blood ; Hypertension/complications ; Hypertension/diagnostic imaging ; Male ; Middle Aged ; Resistin/blood
    Chemical Substances Adiponectin ; Biomarkers ; Resistin
    Language English
    Publishing date 2013
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000348651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.31: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article: Correlation between biopterin levels and intimal-media thickness in type-2 diabetic hypertensive patients.

    Rubio-Guerra, Alberto Francisco / Vargas-Robles, Hilda / Del Valle-Mondragon, Leonardo / Maceda-Serrano, Alberto / Huerta-Ramirez, Saul / Duran-Salgado, Montserrat Berenice / Escalante-Acosta, Bruno Alfonso

    Journal of diabetes and metabolic disorders

    2014  Volume 13, Issue 1, Page(s) 6

    Abstract: Background: Biopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins ... ...

    Abstract Background: Biopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins with carotid intima-media thickness (CIMT) in hypertensive type-2 diabetic patients.
    Methods: We studied 30 hypertensive type-2 diabetic patients and 30 normotensive non-diabetic age-matched subjects, in whom biopterins levels were measured by reverse phase high performance liquid chromatography with fluorescence detection. Additionally, the CIMT of both the common and internal carotid arteries was measured. The levels of biopterins and CIMT were correlated using the Pearson correlation coefficient test.
    Results: We did not find a significantly correlation between biopterins levels and CIMT. However, we found a significantly inverse correlation between the BH4/BH2 ratio and the CIMT in patients (r = -0.54, p < 0.01). A multiple regression analysis revealed that the CIMT correlated significantly and independently with the BH4/BH2 ratio.
    Conclusion: Our results suggest that the BH4/BH2 ratio seems to be a better marker of vascular disease than biopterin levels.
    Language English
    Publishing date 2014-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1186/2251-6581-13-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

    Rubio-Guerra, Alberto F. / Cabrera-Miranda, Luis J. / Vargas-Robles, Hilda / Maceda-Serrano, Alberto / Lozano-Nuevo, José J. / Escalante-Acosta, Bruno A.

    Cardiology

    2013  Volume 125, Issue 3, Page(s) 150–153

    Abstract: Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial ... ...

    Institution Hospital General de Ticomán Mexican Group for Basic and Clinical Research in Internal Medicine, and CINVESTAV, México DF, and CINVESTAV, Monterrey, Mexico
    Abstract Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke. Objective: To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients. Methods: Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test. Results: Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01)in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r = -0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated - negatively - with CIMT (r = -0.39, p < 0.02) in controls. Conclusion: Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients.
    Keywords Type 2 diabetes ; Adiponectin ; Resistin ; Adiponectin/resistin index ; Carotid intima-media thickness ; Hypertension
    Language English
    Publishing date 2013-05-30
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Short Communication
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000348651
    Database Karger publisher's database

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.31: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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