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Article ; Online: Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta-analysis.

Macedo, Arthur C / Bitencourt, Fernando Valentim / Faria, André Oliveira Vilela de / Bizzi, Isabella Harb / Durço, Daniella de Freitas Pereira Ângelo / Azevedo, Claudia Britto / Morris, Martin / Ferreira, Karen Dos Santos / De Souza, Leonardo Cruz / Velly, Ana Miriam

Gerodontology

2024

Abstract: Background: This systematic review investigated the prevalence of orofacial pain in patients with mild cognitive impairment (MCI) or dementia.: Materials and methods: The search was conducted in five databases (Medline (Ovid), Embase (Ovid), CINAHL, ... ...

Abstract	Background: This systematic review investigated the prevalence of orofacial pain in patients with mild cognitive impairment (MCI) or dementia. Materials and methods: The search was conducted in five databases (Medline (Ovid), Embase (Ovid), CINAHL, Scopus and LILACS), in three grey literature sources and in included articles' reference lists. Three independent reviewers performed study selection, quality appraisal and data extraction. The risk of bias was assessed with the National Institutes of Health tool. Prevalence was calculated using the random-effects model. Subgroup analysis and meta-regression were used to explore the heterogeneity of results. Results: The database and grey literature search led to 12 246 results, from which nine studies were included; a further four were selected through citation searching. The total sample comprised 6115 patients with dementia and 84 with MCI. All studies had high risk of bias. The overall estimated pooled prevalence of orofacial pain among dementia participants was 19.0% (95% CI, 11.0%-27.0%; I Conclusions: The pooled data from the primary studies revealed that 2 out of 10 patients with dementia have orofacial pain. Further research is needed to clarify the magnitude in individuals with MCI.
Language	English
Publishing date	2024-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604810-9
ISSN	1741-2358 ; 0734-0664
ISSN (online)	1741-2358
ISSN	0734-0664
DOI	10.1111/ger.12740
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Article ; Online: The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework.

Macedo, Arthur C / Tissot, Cécile / Therriault, Joseph / Servaes, Stijn / Wang, Yi-Ting / Fernandez-Arias, Jaime / Rahmouni, Nesrine / Lussier, Firoza Z / Vermeiren, Marie / Bezgin, Gleb / Vitali, Paolo / Ng, Kok Pin / Zimmer, Eduardo R / Guiot, Marie-Christine / Pascoal, Tharick A / Gauthier, Serge / Rosa-Neto, Pedro

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 8, Page(s) 1171–1178

Abstract: Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak and Braak proposed a histopathologic staging system for AD. Braak ... ...

Abstract	Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak and Braak proposed a histopathologic staging system for AD. Braak staging provides a compelling framework for staging and monitoring of NFT progression in vivo using PET imaging. Because AD staging remains based on clinical features, there is an unmet need to translate neuropathologic staging to a biologic clinical staging system. Such a biomarker staging system might play a role in staging preclinical AD or in improving recruitment strategies for clinical trials. Here, we review the literature regarding AD staging with the Braak framework using tau PET imaging, here called PET-based Braak staging. Our aim is to summarize the efforts of implementing Braak staging using PET and assess correspondence with the Braak histopathologic descriptions and with AD biomarkers.
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Reproducibility of Results ; tau Proteins ; Neurofibrillary Tangles ; Amyloid beta-Peptides ; Positron-Emission Tomography ; Plaque, Amyloid
Chemical Substances	tau Proteins ; Amyloid beta-Peptides
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.265200
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Article ; Online: Predicting functional decline in aging and Alzheimer's disease with PET-based Braak staging.

Macedo, Arthur C / Therriault, Joseph / Tissot, Cécile / Fernandez-Arias, Jaime / Ferreira, Pamela C L / Vitali, Paolo / Servaes, Stijn / Rahmouni, Nesrine / Vermeiren, Marie / Bezgin, Gleb / Lussier, Firoza Z / Stevenson, Jenna / Wang, Yi-Ting / Socualaya, Kely Quispialaya / Kunach, Peter / Nazneen, Tahnia / Hosseini, Seyyed Ali / Pallen, Vanessa / Stevenson, Alyssa /

Ferrari-Souza, João Pedro / Bellaver, Bruna / Leffa, Douglas Teixeira / Ng, Kok Pin / Zimmer, Eduardo R / Pascoal, Tharick A / Gauthier, Serge / Rosa-Neto, Pedro

Brain communications

2024 Volume 6, Issue 2, Page(s) fcae043

Abstract: The progression of PET-based Braak stages correlates with cognitive deterioration in aging and Alzheimer's disease. Here, we investigate the association between PET-based Braak stages and functional impairment and assess whether PET-based Braak staging ... ...

Abstract	The progression of PET-based Braak stages correlates with cognitive deterioration in aging and Alzheimer's disease. Here, we investigate the association between PET-based Braak stages and functional impairment and assess whether PET-based Braak staging predicts a longitudinal decline in the performance of activities of daily living. In this cohort study, we evaluated cognitively unimpaired individuals and individuals with mild cognitive impairment or Alzheimer's disease dementia. Participants underwent [
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcae043
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Article ; Online: Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer's disease pathology.

Therriault, Joseph / Woo, Marcel S / Salvadó, Gemma / Gobom, Johan / Karikari, Thomas K / Janelidze, Shorena / Servaes, Stijn / Rahmouni, Nesrine / Tissot, Cécile / Ashton, Nicholas J / Benedet, Andréa Lessa / Montoliu-Gaya, Laia / Macedo, Arthur C / Lussier, Firoza Z / Stevenson, Jenna / Vitali, Paolo / Friese, Manuel A / Massarweh, Gassan / Soucy, Jean-Paul /

Pascoal, Tharick A / Stomrud, Erik / Palmqvist, Sebastian / Mattsson-Carlgren, Niklas / Gauthier, Serge / Zetterberg, Henrik / Hansson, Oskar / Blennow, Kaj / Rosa-Neto, Pedro

Molecular neurodegeneration

2024 Volume 19, Issue 1, Page(s) 2

Abstract: Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of ... ...

Abstract	Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau Methods: We measured p-tau Results: Mass spectrometry and immunoassays of p-tau Conclusions: Our results suggest that while similar overall, immunoassay-based p-tau biomarkers are slightly superior to antibody-free mass spectrometry-based p-tau biomarkers. Future work is needed to determine whether the potential to evaluate multiple biomarkers within a single run offsets the slightly lower performance of antibody-free mass spectrometry-based p-tau quantification.
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Amyloidogenic Proteins ; Immunoassay ; Mass Spectrometry ; Biomarkers
Chemical Substances	Amyloidogenic Proteins ; Biomarkers
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2244557-2
ISSN	1750-1326 ; 1750-1326
ISSN (online)	1750-1326
ISSN	1750-1326
DOI	10.1186/s13024-023-00689-2
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Article ; Online: Plasma and CSF concentrations of N-terminal tau fragments associate with in vivo neurofibrillary tangle burden.

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 12, Page(s) 5343–5354

Abstract: Introduction: Fluid biomarkers capable of specifically tracking tau tangle pathology in vivo are greatly needed.: Methods: We measured cerebrospinal fluid (CSF) and plasma concentrations of N-terminal tau fragments (NTA-tau), using a novel ... ...

Abstract	Introduction: Fluid biomarkers capable of specifically tracking tau tangle pathology in vivo are greatly needed. Methods: We measured cerebrospinal fluid (CSF) and plasma concentrations of N-terminal tau fragments (NTA-tau), using a novel immunoassay (NTA) in the TRIAD cohort, consisting of 272 individuals assessed with amyloid beta (Aβ) positron emission tomography (PET), tau PET, magnetic resonance imaging (MRI) and cognitive assessments. Results: CSF and plasma NTA-tau concentrations were specifically increased in cognitively impaired Aβ-positive groups. CSF and plasma NTA-tau concentrations displayed stronger correlations with tau PET than with Aβ PET and MRI, both in global uptake and at the voxel level. Regression models demonstrated that both CSF and plasma NTA-tau are preferentially associated with tau pathology. Moreover, plasma NTA-tau was associated with longitudinal tau PET accumulation across the aging and Alzheimer's disease (AD) spectrum. Discussion: NTA-tau is a biomarker closely associated with in vivo tau deposition in the AD continuum and has potential as a tau tangle biomarker in clinical settings and trials. Highlights: An assay for detecting N-terminal tau fragments (NTA-tau) in plasma and CSF was evaluated. NTA-tau is more closely associated with tau PET than amyloid PET or neurodegeneration. NTA-tau can successfully track in vivo tau deposition across the AD continuum. Plasma NTA-tau increased over time only in cognitively impaired amyloid-β positive individuals.
MeSH term(s)	Humans ; Neurofibrillary Tangles/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Positron-Emission Tomography/methods ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/diagnosis
Chemical Substances	Amyloid beta-Peptides ; tau Proteins ; Biomarkers
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13119
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Article ; Online: 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2.

Woo, Marcel S / Nilsson, Johanna / Therriault, Joseph / Rahmouni, Nesrine / Brinkmalm, Ann / Benedet, Andrea L / Ashton, Nicholas J / Macedo, Arthur C / Servaes, Stijn / Wang, Yi-Ting / Tissot, Cécile / Arias, Jaime Fernandez / Hosseini, Seyyed Ali / Chamoun, Mira / Lussier, Firoza Z / Karikari, Thomas K / Stevenson, Jenna / Mayer, Christina / Ferrari-Souza, João Pedro /

Kobayashi, Eliane / Massarweh, Gassan / Friese, Manuel A / Pascoal, Tharick A / Gauthier, Serge / Zetterberg, Henrik / Blennow, Kaj / Rosa-Neto, Pedro

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 278

Abstract: Introduction: Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accumulation. It remains unclear ... ...

Abstract	Introduction: Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accumulation. It remains unclear whether microglia activation independently causes synaptic cleavage before tau aggregation appears. Methods: We investigated 104 participants across the AD continuum by measuring 14-3-3 zeta/delta ([Formula: see text]) as a cerebrospinal fluid biomarker for synaptic degradation, and fluid and imaging biomarkers of tau, amyloidosis, astrogliosis, neurodegeneration, and inflammation. We performed correlation analyses in cognitively unimpaired and impaired participants and used structural equation models to estimate the impact of microglia activation on synaptic injury in different disease stages. Results: 14-3-3 [Formula: see text] was increased in participants with amyloid pathology at the early stages of tau aggregation before hippocampal volume loss was detectable. 14-3-3 [Formula: see text] correlated with amyloidosis and tau load in all participants but only with biomarkers of neurodegeneration and memory deficits in cognitively unimpaired participants. This early synaptic damage was independently mediated by sTREM2. At later disease stages, tau and astrogliosis additionally mediated synaptic loss. Conclusions: Our results advertise that sTREM2 is mediating synaptic injury at the early stages of tau accumulation, underlining the importance of microglia activation for AD disease propagation.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloidosis ; Biomarkers/cerebrospinal fluid ; Gliosis ; tau Proteins/metabolism ; 14-3-3 Proteins
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins ; 14-3-3 Proteins ; TREM2 protein, human
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02962-z
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Article ; Online: Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease.

Therriault, Joseph / Servaes, Stijn / Tissot, Cécile / Rahmouni, Nesrine / Ashton, Nicholas J / Benedet, Andréa Lessa / Karikari, Thomas K / Macedo, Arthur C / Lussier, Firoza Z / Stevenson, Jenna / Wang, Yi-Ting / Fernandez-Arias, Jaime / Stevenson, Alyssa / Socualaya, Kely Quispialaya / Haeger, Arlette / Nazneen, Tahnia / Aumont, Étienne / Hosseini, Ali / Rej, Soham /

Vitali, Paolo / Triana-Baltzer, Gallen / Kolb, Hartmuth C / Soucy, Jean-Paul / Pascoal, Tharick A / Gauthier, Serge / Zetterberg, Henrik / Blennow, Kaj / Rosa-Neto, Pedro

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 11, Page(s) 4967–4977

Abstract: Introduction: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed.: Methods: We assessed the diagnostic performance of p-tau: Results: Plasma p-tau biomarkers ... ...

Abstract	Introduction: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed. Methods: We assessed the diagnostic performance of p-tau Results: Plasma p-tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p-tau. Plasma p-tau Discussion: Plasma and CSF p-tau Highlights: p-tau
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Spinal Puncture ; Amyloidogenic Proteins ; Plasma ; Biomarkers ; tau Proteins ; Amyloid beta-Peptides
Chemical Substances	Amyloidogenic Proteins ; Biomarkers ; tau Proteins ; Amyloid beta-Peptides
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13026
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Article ; Online: Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals.

Woo, Marcel S / Tissot, Cécile / Lantero-Rodriguez, Juan / Snellman, Anniina / Therriault, Joseph / Rahmouni, Nesrine / Macedo, Arthur C / Servaes, Stijn / Wang, Yi-Ting / Arias, Jaime Fernandez / Hosseini, Seyyed Ali / Chamoun, Mira / Lussier, Firoza Z / Benedet, Andrea L / Ashton, Nicholas J / Karikari, Thomas K / Triana-Baltzer, Gallen / Kolb, Hartmuth C / Stevenson, Jenna /

Mayer, Christina / Kobayashi, Eliane / Massarweh, Gassan / Friese, Manuel A / Pascoal, Tharick A / Gauthier, Serge / Zetterberg, Henrik / Blennow, Kaj / Rosa-Neto, Pedro

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 20, Issue 2, Page(s) 1166–1174

Abstract: Introduction: We set out to identify tau PET-positive (A+T+) individuals among amyloid-beta (Aβ) positive participants using plasma biomarkers.: Methods: In this cross-sectional study we assessed 234 participants across the AD continuum who were ... ...

Abstract	Introduction: We set out to identify tau PET-positive (A+T+) individuals among amyloid-beta (Aβ) positive participants using plasma biomarkers. Methods: In this cross-sectional study we assessed 234 participants across the AD continuum who were evaluated by amyloid PET with [ Results: Highest associations with tau positivity in Aβ+ individuals were found for plasma pTau-217 (AUC [CI Discussion: The potential for identifying tau accumulation in later Braak stages will be useful for patient stratification and prognostication in treatment trials and in clinical practice. Highlights: We found that in a cohort without pre-selection pTau-181, pTau-217, and NTA-tau showed the highest association with tau PET positivity. We found that in Aβ+ individuals pTau-217 and NTA-tau showed the highest association with tau PET positivity. Combining pTau-217 and NTA-tau resulted in the strongest agreement with the tau PET-based classification.
MeSH term(s)	Humans ; Alzheimer Disease ; tau Proteins ; Cross-Sectional Studies ; Amyloid beta-Peptides ; Biomarkers ; Positron-Emission Tomography
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Biomarkers
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13528
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Article ; Online: Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.

Ferreira, Pamela C L / Therriault, Joseph / Tissot, Cécile / Ferrari-Souza, João Pedro / Benedet, Andréa L / Povala, Guilherme / Bellaver, Bruna / Leffa, Douglas T / Brum, Wagner S / Lussier, Firoza Z / Bezgin, Gleb / Servaes, Stijn / Vermeiren, Marie / Macedo, Arthur C / Cabrera, Arlec / Stevenson, Jenna / Triana-Baltzer, Gallen / Kolb, Hartmuth / Rahmouni, Nesrine /

Klunk, William E / Lopez, Oscar L / Villemagne, Victor L / Cohen, Ann / Tudorascu, Dana L / Zimmer, Eduardo R / Karikari, Thomas K / Ashton, Nicholas J / Zetterberg, Henrik / Blennow, Kaj / Gauthier, Serge / Rosa-Neto, Pedro / Pascoal, Tharick A

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 10, Page(s) 4463–4474

Abstract: Introduction: Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify ...

Abstract	Introduction: Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify Aβ and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI). Methods: We assessed 138 CU and 87 CI with available plasma p-tau231, 217 Results: In CU, only plasma p-tau231 and p-tau217 Discussion: Our results support plasma p-tau231 and p-tau217 Highlights: It is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex). Plasma p-tau231 and p-tau217
MeSH term(s)	Humans ; Amyloid beta-Peptides ; Plasma ; Biomarkers ; Alzheimer Disease ; tau Proteins ; Positron-Emission Tomography
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13393
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Article ; Online: Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology.

Bellaver, Bruna / Puig-Pijoan, Albert / Ferrari-Souza, João Pedro / Leffa, Douglas T / Lussier, Firoza Z / Ferreira, Pamela C L / Tissot, Cécile / Povala, Guilherme / Therriault, Joseph / Benedet, Andréa L / Ashton, Nicholas J / Servaes, Stijn / Chamoun, Mira / Stevenson, Jenna / Rahmouni, Nesrine / Vermeiren, Marie / Macedo, Arthur C / Fernández-Lebrero, Aida / García-Escobar, Greta /

Navalpotro-Gómez, Irene / Lopez, Oscar / Tudorascu, Dana L / Cohen, Ann / Villemagne, Victor L / Klunk, William E / Gauthier, Serge / Zimmer, Eduardo R / Karikari, Thomas K / Blennow, Kaj / Zetterberg, Henrik / Suárez-Calvet, Marc / Rosa-Neto, Pedro / Pascoal, Tharick A

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 9, Page(s) 3815–3825

Abstract: Introduction: Amyloid-β (Aβ) and tau can be quantified in blood. However, biological factors can influence the levels of brain-derived proteins in the blood. The blood-brain barrier (BBB) regulates protein transport between cerebrospinal fluid (CSF) and ...

Abstract	Introduction: Amyloid-β (Aβ) and tau can be quantified in blood. However, biological factors can influence the levels of brain-derived proteins in the blood. The blood-brain barrier (BBB) regulates protein transport between cerebrospinal fluid (CSF) and blood. BBB altered permeability might affect the relationship between brain and blood biomarkers. Methods: We assessed 224 participants in research (TRIAD, n = 96) and clinical (BIODEGMAR, n = 128) cohorts with plasma and CSF/positron emission tomography Aβ, p-tau, and albumin measures. Results: Plasma Aβ Discussion: These findings suggest that BBB integrity may influence the performance of plasma Aβ, but not p-tau, biomarkers in research and clinical settings. Highlights: BBB permeability affects the association between brain and plasma Aβ levels. BBB integrity does not affect the association between brain and plasma p-tau levels. Plasma Aβ was most affected by BBB permeability in AD-related brain regions. BBB permeability increases with age but not according to cognitive status.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Blood-Brain Barrier/metabolism ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/metabolism ; Brain/pathology ; Positron-Emission Tomography ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13014
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