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Article ; Online: Reply to the comment on "Does valerian work for insomnia? An umbrella review of the evidence".

Valente, Valéria / Machado, Daniela / Jorge, Susana / Drake, Christopher L / Marques, Daniel Ruivo

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2024 Volume 83, Page(s) 55

Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2024.04.003
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Article ; Online: Does valerian work for insomnia? An umbrella review of the evidence.

Valente, Valéria / Machado, Daniela / Jorge, Susana / Drake, Christopher L / Marques, Daniel Ruivo

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2024 Volume 82, Page(s) 6–28

Abstract: Valerian is one of the most used herbal agents (phytotherapeutics) to manage sleep disturbances, in particular, sleep-onset difficulties in young adults. However, the evidence based on primary studies and systematic reviews that supports its use in this ... ...

Abstract	Valerian is one of the most used herbal agents (phytotherapeutics) to manage sleep disturbances, in particular, sleep-onset difficulties in young adults. However, the evidence based on primary studies and systematic reviews that supports its use in this domain is weak or inconclusive. In the current study, an umbrella review was performed on the efficacy of valerian for sleep disturbances with a focus on insomnia. As such, only systematic reviews (with or without meta-analysis) were considered for this study. Systematic searches in PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews, PROSPERO and CNKI databases retrieved 70 records. Only 8 articles were considered eligible for qualitative analysis. Overall, data suggested that valerian has a good safety profile, however, the results showed no evidence of efficacy for the treatment of insomnia. Moreover, valerian appears to be effective concerning subjective improvement of sleep quality, although its effectiveness has not been demonstrated with quantitative or objective measurements. Despite its widespread use and prescription by general practitioners, psychiatrists and other professionals, valerian does not have empirical support for insomnia. Further studies, in particular high quality randomized controlled trials, are highly recommended since there are scarce studies and the existing ones are quite heterogeneous and with low methodological quality. The implications of our findings for clinical practice are critically discussed.
MeSH term(s)	Humans ; Sleep Initiation and Maintenance Disorders/drug therapy ; Valerian ; Phytotherapy/methods
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2024.01.008
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Article: Design and Characterization of a Cheese Spread Incorporating

Faustino, Margarida / Machado, Daniela / Rodrigues, Dina / Andrade, José Carlos / Freitas, Ana Cristina / Gomes, Ana Maria

Foods (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Marine algae have been emerging as natural sources of bioactive compounds, such as soluble dietary fibers and peptides, presenting special interest as ingredients for functional foods. This study developed a cheese spread incorporating red ... ...

Abstract	Marine algae have been emerging as natural sources of bioactive compounds, such as soluble dietary fibers and peptides, presenting special interest as ingredients for functional foods. This study developed a cheese spread incorporating red seaweed
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12030611
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Article ; Online: Akkermansia muciniphila

Machado, Daniela / Fonseca, Mariana / Vedor, Rita / Sousa, Sérgio / Barbosa, Joana Cristina / Gomes, Ana Maria

Gels (Basel, Switzerland)

2023 Volume 9, Issue 11

Abstract: Akkermansia ... ...

Abstract	Akkermansia muciniphila
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9110869
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Article ; Online: Design and Characterization of a Cheese Spread Incorporating Osmundea pinnatifida Extract

Faustino, Margarida / Machado, Daniela / Rodrigues, Dina / Andrade, José Carlos / Freitas, Ana Cristina / Gomes, Ana Maria

Foods. 2023 Feb. 01, v. 12, no. 3

2023

Abstract	Marine algae have been emerging as natural sources of bioactive compounds, such as soluble dietary fibers and peptides, presenting special interest as ingredients for functional foods. This study developed a cheese spread incorporating red seaweed Osmundea pinnatifida extract and subsequently characterized it in terms of nutritional, pH, and microbiological parameters and bioactivities including prebiotic, antidiabetic, antihypertensive, and antioxidant activities. This food was produced through incorporation of O. pinnatifida extract (3%), obtained via enzymatic extraction Viscozyme L in a matrix containing whey cheese (75%) and Greek-type yoghurt (22%). The product was then subjected to thermal processing and subsequently stored for 21 days at 4 °C. During storage, this food showed a high pH stability (variations lower than 0.2 units), the absence of microbial contamination and all tested bioactivities at the sampling timepoints 0 and 21 days. Indeed, it exerted prebiotic effects under Lactobacillus acidophilus LA-5® and Bifidobacterium animalis subsp. lactis BB-12®, increasing their viability to around 4 and 0.5 log CFU/g, respectively. In addition, it displayed antidiabetic (α-glucosidase inhibition: 5–9%), antihypertensive (ACE inhibition: 50–57%), and antioxidant (ABTS: 13–15%; DPPH: 3–5%; hydroxyl radical: 60–76%) activities. In summary, the cheese spread produced may be considered an innovative food with high potential to contribute toward healthier status and well-being of populations.
Keywords	Bifidobacterium animalis subsp. lactis ; Lactobacillus acidophilus ; Rhodophyta ; cheese spreads ; hydroxyl radicals ; microbial contamination ; pH stability ; peptides ; prebiotics ; viability ; whey cheeses ; yogurt
Language	English
Dates of publication	2023-0201
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12030611
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Article ; Online: Carbon fluxes in a carbonate rock dominated microbasin of the Quadrilátero Ferrífero, Brazil

Machado, Daniela V. / Almeida, Gabriel S. / Marques, Eduardo D. / Silva-Filho, Emmanoel V.

Environ Sci Pollut Res. 2022 Oct., v. 29, no. 50 p.76177-76191

2022

Abstract: This study evaluated carbon dynamics in a carbonate microbasin (Bule stream), located in an important metallogenetic area (QF) in Brazil. River water collections were performed on a base and high flow. The microbasin showed high DIC, with HCO₃⁻ being the ...

Abstract	This study evaluated carbon dynamics in a carbonate microbasin (Bule stream), located in an important metallogenetic area (QF) in Brazil. River water collections were performed on a base and high flow. The microbasin showed high DIC, with HCO₃⁻ being the main component, followed by CO₂. The pCO₂ showed high values, indicating fluxes in the water → air direction. The degassing was 683.4 mmol m⁻² day⁻¹ (average at low flow) and 43.4 mmol m⁻² day⁻¹ (average at high flow). The fluvial flow was 9 to 31 kg km⁻² day⁻¹ of HCO₃⁻ and 1.4 to 0.7 kg km⁻² day⁻¹ of CO₂, respectively, at the base and high flow. Considering the importance of the lithological unit of the Minas Supergroup for the QF, the total flow of CO₂ released by all the basins that compose such units was estimated. The estimated values were 1.3 × 10¹² mmol day⁻¹ in low flow and 8.4 × 10¹⁰ mmol day⁻¹ in high flow. The data obtained in this study were the first in the QF region. The Bule stream is an environmental protection area, free from contamination, considered a background for other drainage basins inserted in the QF. The results obtained reinforce the importance of hydrographic microbasins influence on the river carbon fluxes in a regional and global context.
Keywords	air ; carbon ; carbon dioxide ; carbonate rocks ; carbonates ; drainage ; environmental protection ; river water ; rivers ; streams ; Brazil
Language	English
Dates of publication	2022-10
Size	p. 76177-76191.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21155-4
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Article ; Online: Insights into the Antimicrobial Resistance Profile of a Next Generation Probiotic

Machado, Daniela / Barbosa, Joana Cristina / Almeida, Diana / Andrade, José Carlos / Freitas, Ana Cristina / Gomes, Ana Maria

International journal of environmental research and public health

2022 Volume 19, Issue 15

Abstract: Akkermansia ... ...

Abstract	Akkermansia muciniphila
MeSH term(s)	Akkermansia ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Base Composition ; Drug Resistance, Bacterial/genetics ; Phylogeny ; Probiotics ; RNA, Ribosomal, 16S ; Sequence Analysis, DNA ; Verrucomicrobia/genetics ; Virulence Factors
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; RNA, Ribosomal, 16S ; Virulence Factors
Language	English
Publishing date	2022-07-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19159152
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Article ; Online: Carbon fluxes in a carbonate rock dominated microbasin of the Quadrilátero Ferrífero, Brazil.

Machado, Daniela V / Almeida, Gabriel S / Marques, Eduardo D / Silva-Filho, Emmanoel V

Environmental science and pollution research international

2022 Volume 29, Issue 50, Page(s) 76177–76191

Abstract	This study evaluated carbon dynamics in a carbonate microbasin (Bule stream), located in an important metallogenetic area (QF) in Brazil. River water collections were performed on a base and high flow. The microbasin showed high DIC, with HCO
MeSH term(s)	Brazil ; Carbon/analysis ; Carbon Dioxide/analysis ; Carbonates ; Rivers ; Water
Chemical Substances	Carbonates ; Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21155-4
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Article: Conventional Phacoemulsification Surgery Versus Femtosecond Laser Phacoemulsification Surgery: A Comparative Analysis of Cumulative Dissipated Energy and Corneal Endothelial Loss in Cataract Patients.

Léda, Rayssa Medeiros / Machado, Daniela Cristina Schroff / Hida, Wilson Takashi / Motta, Antônio Francisco Pimenta / Pacini, Thiago de Faria / Amorim, Rivadavio Fernandes

Clinical ophthalmology (Auckland, N.Z.)

2023 Volume 17, Page(s) 1709–1716

Abstract: Purpose: To analyze whether femtosecond laser-assisted surgery leads to less cumulative dissipated energy (CDE) and decreased endothelial cell loss compared to conventional surgery.: Patients and methods: This non-blinded, non-randomized, quasi- ... ...

Abstract	Purpose: To analyze whether femtosecond laser-assisted surgery leads to less cumulative dissipated energy (CDE) and decreased endothelial cell loss compared to conventional surgery. Patients and methods: This non-blinded, non-randomized, quasi-experimental clinical trial was conducted at one center and involved one surgeon. Patients with cataracts and 50-80 years old were included, and the exclusion criteria were radial keratotomy, trabeculectomy, drain tube implant, corneal transplant, posterior vitrectomy, and re-implantation of intraocular lens. In total, 298 patients were recruited between October 2020 and April 2021, and the data collected included sex, laterality, age, ocular comorbidities, systemic comorbidities and CDE. An endothelial cell count was performed before and after surgery. Patients were divided according to femtosecond laser-assisted phacoemulsification or conventional phacoemulsification. The femtolaser patients were submitted to the equipment, and then, immediately after treatment, phacoemulsification surgery was performed. In the conventional method, the "divide and conquer" technique was used. The statistical analysis was made using an analysis of covariance linear model, using SAS version 9.4 (SAS Institute, Inc., 1999). Values with p < 0.05 were considered significant. Results: A total of 132 patients were analyzed. The only statistically relevant predictors of CDE were the severity of the cataract (p < 0.0001) and age of ≥75 years (p = 0.0003). The following factors were not significant: technique with or without laser (p = 0.6862), sex (p = 0.8897), systemic arterial hypertension (p = 0.1658), and diabetes (p = 0.9017). Grade 4 cataracts were associated with higher CDE than grade 3 cataracts, which in turn were associated with higher CDE than grade 2 cataracts. A comparison of pre- and post-operative specular microscopy with and without laser revealed no significant discrepancy (p = 0.5017). Conclusion: Femtosecond laser-assisted cataract surgery did not reduce CDE or endothelial cell loss compared to conventional surgery regardless of severity.
Language	English
Publishing date	2023-06-19
Publishing country	New Zealand
Document type	Case Reports ; Clinical Trial
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S408717
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Article: Revealing antimicrobial resistance profile of the novel probiotic candidate Faecalibacterium prausnitzii DSM 17677

Machado, Daniela / Barbosa, Joana Cristina / Domingos, Melany / Almeida, Diana / Andrade, José Carlos / Freitas, Ana Cristina / Gomes, Ana Maria

International journal of food microbiology. 2022 Feb. 16, v. 363

2022

Abstract: Faecalibacterium prausnitzii, a resident anaerobic bacterium commonly found in healthy gut microbiota, has been proposed as a next generation probiotic with high potential for application in food matrices and pharmaceutical formulations. Despite its ... ...

Abstract	Faecalibacterium prausnitzii, a resident anaerobic bacterium commonly found in healthy gut microbiota, has been proposed as a next generation probiotic with high potential for application in food matrices and pharmaceutical formulations. Despite its recognized health benefits, detailed information regarding its antimicrobial susceptibility profile is still lacking. However, this information is crucial to determine its safety, since the absence of acquired antimicrobial resistance is required to qualify a probiotic candidate as safe for human and animal consumption. Herein, the antimicrobial susceptibility profile of F. prausnitzii DSM 17677 strain was evaluated by integrating both phenotypic and in silico data. Phenotypic antimicrobial susceptibility was evaluated by determining minimum inhibitory concentrations of 9 antimicrobials using broth microdilution and E-test® methods. Also, the whole genome of F. prausnitzii DSM 17677 was analysed, using several databases and bioinformatics tools, to identify possible antibiotic resistance genes (ARG), genomic islands (GI) and mobile genetic elements (MGE). With exception of erythromycin, the same classification (susceptible or resistant) was obtained in both broth microdilution and E-test® methods. Phenotypic resistance to ampicillin, gentamycin, kanamycin and streptomycin were detected, which was supported by the genomic context. Other ARG were also identified but they seem not to be expressed under the tested conditions. F. prausnitzii DSM 17677 genome contains 24 annotated genes putatively involved in resistance against the following classes of antimicrobials: aminoglycosides (such as gentamycin, kanamycin and streptomycin), macrolides (such as erythromycin), tetracyclines and lincosamides. The presence of putative ARG conferring resistance to β-lactams could only be detected using a broader homology search. The majority of these genes are not encoded within GI or MGE and no plasmids were reported for this strain. Despite the fact that most genes are related with general resistance mechanisms, a streptomycin-specific ARG poses the only potential concern identified. This specific ARG is encoded within a GI and a MGE, meaning that it could have been laterally acquired and might be transferred to other bacteria present in the same environment. Thus, our findings provide relevant insights regarding the phenotypic and genotypic antimicrobial resistance profiles of the probiotic candidate F. prausnitzii DSM 17677.
Keywords	ampicillin ; antibiotic resistance ; bacteria ; bioinformatics ; computer simulation ; erythromycin ; food microbiology ; genomics ; gentamicin ; humans ; intestinal microorganisms ; kanamycin ; minimum inhibitory concentration ; phenotype ; plasmids ; probiotics ; streptomycin
Language	English
Dates of publication	2022-0216
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2021.109501
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