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  1. Article ; Online: First report of

    Rodrigues, Bruna M / Diniz, Carlos C / da Rocha, Vinicius N / Köhler, Mateus H / Brandão, Guilherme P / Machado, Luana A / da Silva Júnior, Eufranio N / Iglesias, Bernardo A

    RSC advances

    2023  Volume 13, Issue 16, Page(s) 11121–11129

    Abstract: In this work, the synthesis, characterization and photophysical assays of a ... ...

    Abstract In this work, the synthesis, characterization and photophysical assays of a new
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra00823a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Decoding Directing Groups and Their Pivotal Role in C-H Activation.

    Murali, Karunanidhi / Machado, Luana A / Carvalho, Renato L / Pedrosa, Leandro F / Mukherjee, Rishav / Da Silva Júnior, Eufrânio N / Maiti, Debabrata

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 49, Page(s) 12453–12508

    Abstract: Synthetic organic chemistry has witnessed a plethora of functionalization and defunctionalization strategies. In this regard, C-H functionalization has been at the forefront due to the multifarious applications in the development of simple to complex ... ...

    Abstract Synthetic organic chemistry has witnessed a plethora of functionalization and defunctionalization strategies. In this regard, C-H functionalization has been at the forefront due to the multifarious applications in the development of simple to complex molecular architectures and holds a brilliant prospect in drug development and discovery. Despite been explored tremendously by chemists, this functionalization strategy still enjoys the employment of novel metal catalysts as well metal-free organic ligands. Moreover, the switch to photo- and electrochemistry has widened our understanding of the alternative pathways via which a reaction can proceed and these strategies have garnered prominence when applied to C-H activation. Synthetic chemists have been foraging for new directing groups and templates for the selective activation of C-H bonds from a myriad of carbon-hydrogen bonds in aromatic as well as aliphatic systems. As a matter of fact, by varying the templates and directing groups, scientists found the answer to the challenge of distal C-H bond activation which remained an obstacle for a very long time. These templates have been frequently harnessed for selectively activating C-H bonds of natural products, drugs, and macromolecules decorated with multiple C-H bonds. This itself was a challenge before the commencement of this field as functionalization of a site other than the targeted site could modify and hamper the biological activity of the pharmacophore. Total synthesis and pharmacophore development often faces the difficulty of superfluous reaction steps towards selective functionalization. This obstacle has been solved by late-stage functionalization simply by harnessing C-H bond activation. Moreover, green chemistry and metal-free reaction conditions have seen light in the past few decades due to the rising concern about environmental issues. Therefore, metal-free catalysts or the usage of non-toxic metals have been recently showcased in a number of elegant works. Also, research groups across the world are developing rational strategies for directing group free or non-directed protocols that are just guided by ligands. This review encapsulates the research works pertinent to C-H bond activation and discusses the science devoted to it at the fundamental level. This review gives the readers a broad understanding of how these strategies work, the execution of various metal catalysts, and directing groups. This not only helps a budding scientist towards the commencement of his/her research but also helps a matured mind searching out for selective functionalization. A detailed picture of this field and its progress with time has been portrayed in lucid scientific language with a motive to inculcate and educate scientific minds about this beautiful strategy with an overview of the most relevant and significant works of this era. The unique trait of this review is the detailed description and classification of various directing groups and their utility over a wide substrate scope. This allows an experimental chemist to understand the applicability of this domain and employ it over any targeted substrate.
    MeSH term(s) Carbon ; Catalysis ; Female ; Humans ; Hydrogen Bonding ; Ligands ; Male ; Metals
    Chemical Substances Ligands ; Metals ; Carbon (7440-44-0)
    Language English
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202101004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Looking deep into C–H functionalization: the synthesis and application of cyclopentadienyl and related metal catalysts

    Jardim, Guilherme A. M. / de Carvalho, Renato L. / Nunes, Mateus P. / Machado, Luana A. / Almeida, Leandro D. / Bahou, Karim A. / Bower, John F. / da Silva Júnior, Eufrânio N.

    Chemical communications. 2022 Mar. 3, v. 58, no. 19

    2022  

    Abstract: Metal catalyzed C–H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of ... ...

    Abstract Metal catalyzed C–H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of transition metals and their correlative analogues have found widespread application in this area, and herein we highlight several key applications of commonly used transition-metal Cp-type catalysts. In addition, an understanding of transition metal Cp-type catalyst synthesis is important, particularly where modifications to the catalyst structure are required for different applications, and a summary of this aspect is given.
    Keywords carbon-hydrogen bond activation ; catalysts ; catalytic activity ; chemical communication ; organic compounds ; transition elements
    Language English
    Dates of publication 2022-0303
    Size p. 3101-3121.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc07040a
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Looking deep into C-H functionalization: the synthesis and application of cyclopentadienyl and related metal catalysts.

    Jardim, Guilherme A M / de Carvalho, Renato L / Nunes, Mateus P / Machado, Luana A / Almeida, Leandro D / Bahou, Karim A / Bower, John F / da Silva Júnior, Eufrânio N

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 19, Page(s) 3101–3121

    Abstract: Metal catalyzed C-H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of ... ...

    Abstract Metal catalyzed C-H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of transition metals and their correlative analogues have found widespread application in this area, and herein we highlight several key applications of commonly used transition-metal Cp-type catalysts. In addition, an understanding of transition metal Cp-type catalyst synthesis is important, particularly where modifications to the catalyst structure are required for different applications, and a summary of this aspect is given.
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc07040a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Removal and modification of directing groups used in metal-catalyzed C-H functionalization: the magical step of conversion into 'conventional' functional groups.

    Carvalho, Renato L / Almeida, Renata G / Murali, Karunanidhi / Machado, Luana A / Pedrosa, Leandro F / Dolui, Pravas / Maiti, Debabrata / da Silva Júnior, Eufrânio N

    Organic & biomolecular chemistry

    2021  Volume 19, Issue 3, Page(s) 525–547

    Abstract: Over the past few decades, regioselective catalytic C-H functionalization has provided an attractive tool for unique retrosynthetic disconnections. The advancement of the directing group strategy in metal catalyzed synthetic transformation has ... ...

    Abstract Over the past few decades, regioselective catalytic C-H functionalization has provided an attractive tool for unique retrosynthetic disconnections. The advancement of the directing group strategy in metal catalyzed synthetic transformation has contributed significantly to the incorporation of a wide range of functionalization reactions in both aromatic systems and aliphatic backbones. However, the extensive utilization of these methodologies depends on the ease of removal of the directing group to restore the free functional group. In this review, we have summarised the reported approaches for removing/modifying versatile directing groups.
    Language English
    Publishing date 2021-01-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d0ob02232b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Electrochemical Diselenation of BODIPY Fluorophores for Bioimaging Applications and Sensitization of

    Bozzi, Ícaro A O / Machado, Luana A / Diogo, Emilay B T / Delolo, Fábio G / Barros, Luiza O F / Graça, Gabriela A P / Araujo, Maria H / Martins, Felipe T / Pedrosa, Leandro F / da Luz, Lilian C / Moraes, Emmanuel S / Rodembusch, Fabiano S / Guimarães, João S F / Oliveira, André G / Röttger, Sebastian H / Werz, Daniel B / Souza, Cauê P / Fantuzzi, Felipe / Han, Jianhua /
    Marder, Todd B / Braunschweig, Holger / da Silva Júnior, Eufrânio N

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 11, Page(s) e202303883

    Abstract: We report a rapid, efficient, and scope-extensive approach for the late-stage electrochemical diselenation of BODIPYs. Photophysical analyses reveal red-shifted absorption - corroborated by TD-DFT and DLPNO-STEOM-CCSD computations - and color-tunable ... ...

    Abstract We report a rapid, efficient, and scope-extensive approach for the late-stage electrochemical diselenation of BODIPYs. Photophysical analyses reveal red-shifted absorption - corroborated by TD-DFT and DLPNO-STEOM-CCSD computations - and color-tunable emission with large Stokes shifts in the selenium-containing derivatives compared to their precursors. In addition, due to the presence of the heavy Se atoms, competitive ISC generates triplet states which sensitize
    MeSH term(s) Molecular Structure ; Selenium ; Boron Compounds ; Fluorescence ; Fluorescent Dyes
    Chemical Substances 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Selenium (H6241UJ22B) ; Boron Compounds ; Fluorescent Dyes
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Electrochemical Diselenation of BODIPY Fluorophores for Bioimaging Applications and Sensitization of

    Bozzi, Ícaro A O / Machado, Luana A / Diogo, Emilay B T / Delolo, Fábio G / Barros, Luiza O F / Graça, Gabriela A P / Araujo, Maria H / Martins, Felipe T / Pedrosa, Leandro F / da Luz, Lilian C / Moraes, Emmanuel S / Rodembusch, Fabiano S / Guimarães, João S F / Oliveira, André G / Röttger, Sebastian H / Werz, Daniel B / Souza, Cauê P / Fantuzzi, Felipe / Han, Jianhua /
    Marder, Todd B / Braunschweig, Holger / da Silva Júnior, Eufrânio N

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 11, Page(s) e202400244

    Abstract: Invited for the cover of this issue are the groups of Holger Braunschweig at the Julius-Maximilians-Universität Würzburg, Germany and Eufrânio N. da Silva Júnior at the Universidade Federal de Minas Gerais, UFMG, Brazil. The image depicts the ... ...

    Abstract Invited for the cover of this issue are the groups of Holger Braunschweig at the Julius-Maximilians-Universität Würzburg, Germany and Eufrânio N. da Silva Júnior at the Universidade Federal de Minas Gerais, UFMG, Brazil. The image depicts the electrochemical synthesis of selenium-containing BODIPY molecules with lightning symbolizing the electrifying synthetic process, while the surrounding elemental chaos hints at the red-shifted absorption and emission and the transformative photophysical properties of these new compounds. Read the full text of the article at 10.1002/chem.202303883.
    Language English
    Publishing date 2024-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400244
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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