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  1. Article ; Online: Screening for coronavirus disease 2019 in pregnant women admitted for delivery: an observational study.

    Cavalcante, Ana Nery Melo / Almeida, Rosa Lívia Freitas de / Oliveira, Denise Nunes / Lima, Danielle Malta / Cavalcante, Candice Torres de Melo Bezerra / Tavares, Lohanna Valeska de Sousa / Almeida, Renata Parente / Machado, Rosângela Pinheiro Gonçalves / Araujo Júnior, Edward / Cavalcante, Marcelo Borges

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 7, Page(s) e20230084

    Abstract: Objective: The aim of this study was to examine the impact of symptom-based screening on the prevalence and outcomes of neonatal coronavirus disease 2019 in pregnant women admitted for delivery.: Methods: A retrospective observational study was ... ...

    Abstract Objective: The aim of this study was to examine the impact of symptom-based screening on the prevalence and outcomes of neonatal coronavirus disease 2019 in pregnant women admitted for delivery.
    Methods: A retrospective observational study was conducted from June to August 2020 at Gonzaga Mota of Messejana Hospital, Fortaleza, CE, Brazil. All pregnant women were screened for coronavirus disease 2019 based on symptoms. Reverse transcription-polymerase chain reaction or immunology assays for severe acute respiratory syndrome coronavirus 2 were performed when a patient reported a symptom. All newborns of symptomatic patients were submitted for Reverse transcription-polymerase chain reaction. Newborns were divided into groups according to the Reverse transcription-polymerase chain reaction results to identify the relationship between maternal symptoms and neonatal coronavirus disease 2019.
    Results: A total of 55 (55/1,026, 5.4%) and 50 (50/1,026, 4.8%) pregnant women reported symptoms and had a positive confirmatory test, respectively. The most common symptom of coronavirus disease 2019 among the pregnant women with positive confirmatory test was cough (n=23, 46%). Seven newborns (7/50, 14%) of symptomatic mothers had positive Reverse transcription-polymerase chain reaction. Upon birth, no newborn had serious complications.
    Conclusion: Universal screening of pregnant women admitted for delivery can reduce the perinatal transmission of coronavirus disease 2019. Symptom-based screening can be an alternative for regions with a low prevalence of the disease where a better allocation of financial resources is necessary.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; Pregnant Women ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Infectious Disease Transmission, Vertical ; SARS-CoV-2 ; Pregnancy Outcome
    Language English
    Publishing date 2023-07-17
    Publishing country Brazil
    Document type Observational Study ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis.

    Barbosa, Joycilene da Silva / Silva Júnior, Geraldo Bezerra da / Meneses, Gdayllon Cavalcante / Martins, Alice Maria Costa / Daher, Elizabeth De Francesco / Machado, Rosângela Pinheiro Gonçalves / Lemes, Romélia Pinheiro Gonçalves

    Jornal brasileiro de nefrologia

    2021  Volume 44, Issue 1, Page(s) 97–108

    Abstract: Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been associated with significant death rates. Early detection of the condition is the first step to ... ...

    Abstract Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been associated with significant death rates. Early detection of the condition is the first step to improving prevention, treatment, and outcomes, while decreasing length of hospitalization, care costs, and morbimortality. AKI may progress to chronic kidney disease (CKD), a condition linked with dialysis and greater risk of cardiovascular disease. This review article aims to discuss cases of AKI in preterm newborns with sepsis, the use of biomarkers in lab workup, and the use of non-conventional biomarkers for the early identification of AKI.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Biomarkers ; Early Diagnosis ; Humans ; Infant, Newborn ; Intensive Care Units ; Renal Dialysis/adverse effects ; Risk Factors ; Sepsis/complications ; Sepsis/diagnosis
    Chemical Substances Biomarkers
    Language Portuguese
    Publishing date 2021-11-29
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2020-0222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hemostasis profile in COVID-19 infection.

    Duarte, Fernando Barroso / Machado, Rosângela Pinheiro Gonçalves / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araújo / Duarte, Beatrice Araújo / Machado, Clarissa Maria Gonçalves / Duarte, João Vitor Araújo / Rocha, Samuel Gonçalves Machado da / Moura, Anna Thawanny Gadelha / Holanda, Rosangela de Albuquerque Ribeiro Rodrigues

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 5, Page(s) 571–572

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Disseminated Intravascular Coagulation/blood ; Fibrin Fibrinogen Degradation Products/metabolism ; Hemostasis/physiology ; Humans ; Interleukins/metabolism ; Pandemics ; Partial Thromboplastin Time ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Prothrombin Time ; Respiratory Distress Syndrome/blood ; Respiratory Distress Syndrome/etiology ; Risk Factors ; SARS-CoV-2 ; Tumor Necrosis Factors/metabolism
    Chemical Substances Fibrin Fibrinogen Degradation Products ; Interleukins ; Tumor Necrosis Factors ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.5.571
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  4. Book ; Online: Hemostasis profile in COVID-19 infection

    Duarte, Fernando Barroso / Machado, Rosângela Pinheiro Gonçalves / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araújo / Duarte, Beatrice Araújo / Machado, Clarissa Maria Gonçalves / Duarte, João Vitor Araújo / Rocha, Samuel Gonçalves Machado da / Moura, Anna Thawanny Gadelha / Holanda, Rosangela de Albuquerque Ribeiro Rodrigues

    Revista da Associação Médica Brasileira v.66 n.5 2020

    2020  

    Keywords COVID-19 ; Coronavirus infections ; Hemostasis ; covid19
    Language English
    Publishing date 2020-05-01
    Publisher Associação Médica Brasileira
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Hemostasis profile in COVID-19 infection

    Duarte, Fernando Barroso / Machado, Rosangela Pinheiro Goncalves / Lemes, Romelia Pinheiro Goncalves / Duarte, Isabella Araujo / Duarte, Beatrice Araujo / Machado, Clarissa Maria Goncalves / Duarte, Joao Vitor Araujo / Rocha, Samuel Goncalves Machado da / Moura, Anna Thawanny Gadelha / Holanda, Rosangela de Albuquerque Ribeiro Rodrigues
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #636980
    Database COVID19

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  6. Article: Clinical events and their relation to the tumor necrosis factor-alpha and interleukin-10 genotypes in Sickle-Cell-Anemia patients.

    Cavalcante, Jânio Emanuel Andrade / Machado, Rosângela Pinheiro Gonçalves / Laurentino, Marilia Rocha / dos Santos, Talyta Ellen de Jesus / Bandeira, Izabel Cristina Justino / Maia Filho, Pedro Aurio / Figueiredo, Monalisa Feliciano / Martins, Alice Maria Costa / Lemes, Romélia Pinheiro Gonçalves

    Hematology/oncology and stem cell therapy

    2016  Volume 9, Issue 1, Page(s) 14–19

    Abstract: Objective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the ... ...

    Abstract Objective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF-alpha-308 G→A, IL-10-1082 G→A, IL-10-819 C→T, and IL-10-592 A→C; serum TNF-alpha; and IL-10 levels, and the incidence of clinical events in SCA patients.
    Methods: Polymerase chain reaction-restriction fragment length polymorphism and enzyme-linked immunosorbent assay were performed on 25 adults with SCA at the steady state; their data were compared with those for 26 healthy individuals.
    Results: The most frequent genotype of the TNF-alpha polymorphism was GG (low producer), and the most frequent genotype of the IL-10 polymorphisms was "low producer" (ACC ACC, ACC ATA, ATA ATA). The TNF-alpha levels were significantly higher in SCA in patients with acute chest syndrome (ACS). The IL-10 levels were reduced in polytransfusion and in patients with ACS.
    Conclusion: The patients presented prevalence of TNF-alpha and IL-10 low-profile producer. The cytokine serum levels presented an association with the presence of polytransfusion and ACS in SCA patients.
    MeSH term(s) Adult ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/pathology ; Cross-Sectional Studies ; Female ; Genotype ; Humans ; Interleukin-10/blood ; Interleukin-10/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/genetics ; Young Adult
    Chemical Substances IL10 protein, human ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2651893-4
    ISSN 1658-3876
    ISSN 1658-3876
    DOI 10.1016/j.hemonc.2015.11.002
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  7. Article ; Online: Is there still a role for G-banding in CLL?

    Machado, Rosangela Pinheiro Gonçalves / Queiroz, Jose Ajax / de Sousa, Juliana Cordeiro / Gonçalves, Romelia Pinheiro / Magalhaes, Silvia Maria Meira / Pinheiro, Ronald Feitosa

    Leukemia research

    2010  Volume 34, Issue 10, Page(s) e278–9

    MeSH term(s) Chromosome Aberrations ; Chromosome Banding/methods ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Middle Aged
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2010.05.018
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  8. Article: Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.

    Moreira, Juliane Almeida / Laurentino, Marília Rocha / Machado, Rosângela Pinheiro Gonçalves / Barbosa, Maritza Cavalcante / Gonçalves, Ronaldo Pinheiro / Mota, Amanda de Menezes / Rocha, Lilianne Brito da Silva / Martins, Alice Maria Costa / de Lima Arruda, Alcínia Braga / de Souza, Iêda Pereira / Gonçalves, Romélia Pinheiro

    Revista brasileira de hematologia e hemoterapia

    2015  Volume 37, Issue 3, Page(s) 167–171

    Abstract: Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients.: Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking ... ...

    Abstract Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients.
    Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA individuals. The reticulocyte count was performed by an automated methodology, lactate dehydrogenase and uric acid were measured by spectrophotometry and arginase I by enzyme-linked immunosorbent assay (ELISA). The presence of Hb S was detected by high-performance liquid chromatography. The level of significance was set for a p-value <0.05.
    Results: A significant increase was observed in the reticulocyte count and lactate dehydrogenase, uric acid and arginase I levels in sickle cell anemia patients compared to the control group (p-value <0.05). Patients having Hb F levels greater than 10% showed a significant decrease in the reticulocyte count, arginase I and lactate dehydrogenase. A significant decrease was observed in arginase I levels in patients taking hydroxyurea at a dose greater than 20mg/kg/day.
    Conclusion: The results of this study show that sickle cell anemia patients have increases in the hemolysis biomarkers, lactate dehydrogenase, reticulocyte count, arginase I, uric acid and increases in Hb F can reduce the reticulocyte count and arginase I and lactate dehydrogenase levels.
    Language English
    Publishing date 2015-04-14
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.1016/j.bjhh.2015.01.008
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