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  1. AU="Machneva, Elena"
  2. AU="Smith, Morgan A"
  3. AU="Liang, Margaret I"
  4. AU="Taura, Pilar"
  5. AU="Magee, Alex"
  6. AU="J. Walden"
  7. AU="Fowden, Abigail L"
  8. AU="Clemens, Roger A."
  9. AU="Lee, Jacky Kwan Ho"
  10. AU="Margaret Greenwood-Ericksen"
  11. AU=Chang Yuan
  12. AU="Cervantes, Paige E"
  13. AU="Tankova, T"
  14. AU="Callegari, Rachel A"
  15. AU=Wang Yan AU=Wang Yan
  16. AU=Hassan Md Imtaiyaz
  17. AU="Galgani, Alessandro"
  18. AU="Yoshimura, Katsuhiro"
  19. AU=Periyasamy Petrick AU=Periyasamy Petrick
  20. AU="Lockey, David"
  21. AU="Gibson, G G"
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  1. Artikel ; Online: Allogeneic Hematopoietic Stem Cell Transplantation Activity in Inborn Errors of Immunity in Russian Federation.

    Laberko, Alexandra / Mukhinа, Anna / Machneva, Elena / Pashchenko, Olga / Bykova, Tatiana / Vahonina, Larisa / Bronin, Gleb / Skvortsova, Yulia / Skorobogatova, Elena / Kondratenko, Irina / Fechina, Larisa / Shcherbina, Anna / Zubarovskaya, Ludmila / Balashov, Dmitry / Rumiantsev, Alexander

    Journal of clinical immunology

    2023  Band 43, Heft 6, Seite(n) 1241–1249

    Abstract: Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy for many inborn errors of immunity (IEI). The indications for HSCT have expanded over the last decade. The study aimed to collect and analyze the data on HSCT ... ...

    Abstract Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy for many inborn errors of immunity (IEI). The indications for HSCT have expanded over the last decade. The study aimed to collect and analyze the data on HSCT activity in IEI in Russia.
    Methods: The data were collected from the Russian Primary Immunodeficiency Registry and complemented with information from five Russian pediatric transplant centers. Patients diagnosed with IEI by the age of 18 years and who received allogeneic HSCT by the end of 2020 were included.
    Results: From 1997 to 2020, 454 patients with IEI received 514 allogeneic HSCT. The median number of HSCTs per year has risen from 3 in 1997-2009 to 60 in 2015-2020. The most common groups of IEI were immunodeficiency affecting cellular and humoral immunity (26%), combined immunodeficiency with associated/syndromic features (28%), phagocyte defects (21%), and diseases of immune dysregulation (17%). The distribution of IEI diagnosis has changed: before 2012, the majority (65%) had severe combined immunodeficiency (SCID) and hemophagocytic lymphohistiocytosis (HLH), and after 2012, only 24% had SCID and HLH. Of 513 HSCTs, 48.5% were performed from matched-unrelated, 36.5% from mismatched-related (MMRD), and 15% from matched-related donors. In 349 transplants T-cell depletion was used: 325 TCRαβ/CD19+ depletion, 39 post-transplant cyclophosphamide, and 27 other. The proportion of MMRD has risen over the recent years.
    Conclusion: The practice of HSCT in IEI has been changing in Russia. Expanding indications to HSCT and SCID newborn screening implementation may necessitate additional transplant beds for IEI in Russia.
    Mesh-Begriff(e) Child ; Infant, Newborn ; Humans ; Adolescent ; Hematopoietic Stem Cell Transplantation ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/epidemiology ; Immunologic Deficiency Syndromes/therapy ; Receptors, Antigen, T-Cell, alpha-beta ; Severe Combined Immunodeficiency/therapy ; Lymphohistiocytosis, Hemophagocytic/diagnosis
    Chemische Substanzen Receptors, Antigen, T-Cell, alpha-beta
    Sprache Englisch
    Erscheinungsdatum 2023-04-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01476-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD.

    Kostareva, Irina / Kirgizov, Kirill / Machneva, Elena / Ustyuzhanina, Nadezhda / Nifantiev, Nikolay / Skvortsova, Yulia / Shubina, Irina / Reshetnikova, Vera / Valiev, Timur / Varfolomeeva, Svetlana / Kiselevskiy, Mikhail

    Pharmaceuticals (Basel, Switzerland)

    2022  Band 15, Heft 9

    Abstract: Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the ... ...

    Abstract Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD.
    Sprache Englisch
    Erscheinungsdatum 2022-09-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15091100
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Primary Immunodeficiencies in Russia: Data From the National Registry.

    Mukhina, Anna A / Kuzmenko, Natalya B / Rodina, Yulia A / Kondratenko, Irina V / Bologov, Andrei A / Latysheva, Tatiana V / Prodeus, Andrei P / Pampura, Alexander N / Balashov, Dmitrii N / Ilyina, Natalya I / Latysheva, Elena A / Deordieva, Ekaterina A / Shvets, Oksana A / Deripapa, Elena V / Abramova, Irina N / Pashenko, Olga E / Vahlyarskaya, Svetlana S / Zinovyeva, Natalya V / Zimin, Sergei B /
    Skorobogatova, Elena V / Machneva, Elena B / Fomina, Daria S / Ipatova, Maria G / Barycheva, Ludmila Yu / Khachirova, Ludmila S / Tuzankina, Irina A / Bolkov, Michail A / Shakhova, Natalya V / Kamaltynova, Elena M / Sibgatullina, Farida I / Guseva, Marina N / Kuznetsova, Raisa N / Milichkina, Anzhelika M / Totolian, Areg A / Kalinina, Natalia M / Goltsman, Evgenia A / Sulima, Ekatherina I / Kutlyanceva, Anastasia Yu / Moiseeva, Anna A / Khoreva, Anna L / Nesterenko, Zoya / Tymofeeva, Elena V / Ermakova, A / Proligina, Dilyara D / Kalmetieva, Linara R / Davletbaieva, Gulshat A / Mirsayapova, Irina A / Richkova, Olga A / Kuzmicheva, Ksenia P / Grakhova, Maria A / Yudina, Natalya B / Orlova, Ekaterina A / Selezneva, Olga S / Piskunova, Svetlana G / Samofalova, Tatiana V / Bukina, Tatiana V / Pechkurova, Anna D / Migacheva, N / Zhestkov, A / Barmina, Elena V / Parfenova, Natalya A / Isakova, Svetlana N / Averina, Elena V / Sazonova, Irina V / Starikova, Svetlana Yu / Shilova, Tatiana V / Asekretova, Tatiana V / Suprun, Roman N / Kleshchenko, Elena I / Lebedev, Vladimir V / Demikhova, Elena V / Demikhov, Valerii G / Kalinkina, Veronica A / Gorenkova, Alla V / Duryagina, Svetlana N / Pavlova, Tatiana B / Shinkareva, Vera M / Smoleva, Irina V / Aleksandrova, Tatiana P / Bambaeva, Zema V / Philippova, Marina A / Gracheva, Elena M / Tcyvkina, Galina I / Efremenkov, Alexey V / Mashkovskaya, D / Yarovaya, Irina V / Alekseenko, Valentina A / Fisyun, Ivan V / Molokova, Galina V / Troitskya, Ekatherina V / Piatkina, Ludmila I / Vlasova, Elena V / Ukhanova, O / Chernishova, Ekaterina G / Vasilieva, M / Laba, Olga M / Volodina, E / Safonova, Ekaterina V / Voronin, Kirill A / Gurkina, Maria V / Rumyantsev, Alexander G / Novichkova, Galina A / Shcherbina, Anna Yu

    Frontiers in immunology

    2020  Band 11, Seite(n) 1491

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Adult ; Child ; Databases, Factual ; Delayed Diagnosis ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Pathology, Molecular ; Prevalence ; Primary Immunodeficiency Diseases/epidemiology ; Primary Immunodeficiency Diseases/therapy ; Registries ; Russia/epidemiology
    Chemische Substanzen Immunoglobulins, Intravenous
    Sprache Englisch
    Erscheinungsdatum 2020-08-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01491
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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