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  1. AU="Machuca, Víctor"
  2. AU=Liu Nanyang AU=Liu Nanyang
  3. AU="Boudina, Sihem"
  4. AU="Ma, DongXue"
  5. AU="Bellucci, Margherita"
  6. AU="Prima, Musharrat Jahan"
  7. AU="Saiegh, Fadi Al"
  8. AU="Yang, Deok-Chun"
  9. AU="Arima, Hisatomi"
  10. AU=Czubak Jacek
  11. AU="de Melo, Bruna Oliveira"
  12. AU="Sokhadze, Guela"
  13. AU="Meuleman, Philip"
  14. AU=Mishra Arnab Kumar AU=Mishra Arnab Kumar
  15. AU="Linda A. Gleaves"
  16. AU="Vandelli, Maria Angela"
  17. AU="Guerrera, Luigi Pio"
  18. AU="Sabitri Lamichhane"
  19. AU="Echevarria, Marco"
  20. AU="Yanmin Li"

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  1. Artikel ; Online: Senescent cardiac fibroblasts: A key role in cardiac fibrosis.

    Osorio, José Miguel / Espinoza-Pérez, Claudio / Rimassa-Taré, Constanza / Machuca, Víctor / Bustos, Juan Ortega / Vallejos, Matías / Vargas, Héctor / Díaz-Araya, Guillermo

    Biochimica et biophysica acta. Molecular basis of disease

    2023  Band 1869, Heft 4, Seite(n) 166642

    Abstract: Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular matrix and orchestrates a damage response to maintain cardiac architecture and performance. Due to these functions, fibroblasts play a central role in cardiac ... ...

    Abstract Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular matrix and orchestrates a damage response to maintain cardiac architecture and performance. Due to these functions, fibroblasts play a central role in cardiac fibrosis development, and there are large differences in matrix protein secretion profiles between fibroblasts from aged versus young animals. Senescence is a multifactorial and complex process that has been associated with inflammatory and fibrotic responses. After damage, transient cellular senescence is usually beneficial, as these cells promote tissue repair. However, the persistent presence of senescent cells within a tissue is linked with fibrosis development and organ dysfunction, leading to aging-related diseases such as cardiovascular pathologies. In the heart, early cardiac fibroblast senescence after myocardial infarction seems to be protective to avoid excessive fibrosis; however, in non-infarcted models of cardiac fibrosis, cardiac fibroblast senescence has been shown to be deleterious. Today, two new classes of drugs, termed senolytics and senostatics, which eliminate senescent cells or modify senescence-associated secretory phenotype, respectively, arise as novel therapeutical strategies to treat aging-related pathologies. However, further studies will be needed to evaluate the extent of the utility of senotherapeutic drugs in cardiac diseases, in which pathological context and temporality of the intervention must be considered.
    Mesh-Begriff(e) Animals ; Heart ; Cellular Senescence/physiology ; Aging/pathology ; Fibrosis ; Fibroblasts/metabolism
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.166642
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: COVID-19 pandemic and its impact on medical interns' mental health of public and private hospitals in Guadalajara.

    Barbosa-Camacho, Francisco José / Rodríguez-Machuca, Víctor Ulises / Ibarrola-Peña, Juan Carlos / Chejfec-Ciociano, Jonathan Matías / Guzmán-Ruvalcaba, Mario Jesús / Tavares-Ortega, Jaime Alberto / Delgado-Hernandez, Gonzalo / Cervantes-Guevara, Gabino / Cervantes-Pérez, Enrique / Ramírez-Ochoa, Sol / Fuentes-Orozco, Clotilde / Gonzalez-Ojeda, Alejandro

    Medical education online

    2024  Band 29, Heft 1, Seite(n) 2308360

    Abstract: Introduction: Burnout syndrome is a global burden characterized by exhaustion, work detachment, and a sense of ineffectiveness. It affects millions of individuals worldwide, with a particularly high prevalence among medical students. Factors such as ... ...

    Abstract Introduction: Burnout syndrome is a global burden characterized by exhaustion, work detachment, and a sense of ineffectiveness. It affects millions of individuals worldwide, with a particularly high prevalence among medical students. Factors such as demanding education, exposure to suffering, and the COVID-19 pandemic have contributed to elevated stress levels. Addressing this issue is crucial due to its impact on well-being and health-care quality.
    Materials and methods: This cross-sectional survey study assessed fear of COVID-19 and burnout levels among medical student interns in hospitals in Guadalajara, Jalisco. The study used validated scales and collected data from September 2021 to September 2022. A snowball sampling method was employed and a minimum sample size of 198 participants was calculated.
    Results: This study included 311 medical students (62.1% female and 37.9% male with a mean age of 23.51 ± 2.21 years). The majority were in their second semester of internship (60.5%) and from public hospitals (89.1%). Most students believed that the COVID-19 pandemic affected the quality of their internship (82.6%). Female students had higher personal burnout scores, while male students had higher work-related burnout scores. The mean score for fear of COVID-19 was 13.71 ± 6.28, with higher scores among women (
    Conclusion: Our study emphasizes the significant impact of various factors on burnout levels among medical students and health-care professionals during the COVID-19 pandemic. Prolonged exposure to COVID-19 patients, reduced staffing, and increased workload contributed to burnout, affecting well-being and quality of care. Targeted interventions and resilience-building strategies are needed to mitigate burnout and promote well-being in health-care settings.
    Mesh-Begriff(e) Humans ; Male ; Female ; Young Adult ; Adult ; COVID-19/epidemiology ; Mental Health ; Cross-Sectional Studies ; Pandemics ; Hospitals, Private ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2024-01-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2052877-2
    ISSN 1087-2981 ; 1087-2981
    ISSN (online) 1087-2981
    ISSN 1087-2981
    DOI 10.1080/10872981.2024.2308360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Angiotensin II Triggers NLRP3 Inflammasome Activation by a Ca

    Espitia-Corredor, Jenaro Antonio / Boza, Pía / Espinoza-Pérez, Claudio / Lillo, José Miguel / Rimassa-Taré, Constanza / Machuca, Víctor / Osorio-Sandoval, José Miguel / Vivar, Raúl / Bolivar, Samir / Pardo-Jiménez, Viviana / Sánchez-Ferrer, Carlos Félix / Peiró, Concepción / Díaz-Araya, Guillermo

    Inflammation

    2022  Band 45, Heft 6, Seite(n) 2498–2512

    Abstract: Angiotensin II (Ang-II) is a widely studied hypertensive, profibrotic, and pro-inflammatory peptide. In the heart, cardiac fibroblasts (CF) express type 1 angiotensin II receptors (AT1R), Toll-like receptor-4 (TLR4), and the NLRP3 inflammasome complex, ... ...

    Abstract Angiotensin II (Ang-II) is a widely studied hypertensive, profibrotic, and pro-inflammatory peptide. In the heart, cardiac fibroblasts (CF) express type 1 angiotensin II receptors (AT1R), Toll-like receptor-4 (TLR4), and the NLRP3 inflammasome complex, which play important roles in pro-inflammatory processes. When activated, the NLRP3 inflammasome triggers proteolytic cleavage of pro-IL-1, resulting in its activation. However, in CF the mechanism by which Ang-II assembles and activates the NLRP3 inflammasome remains not fully known. To elucidate this important point, we stimulated TLR4 receptors in CF and evaluated the signaling pathways by which Ang-II triggers the assembly and activity. In cultured rat CF, pro-IL-1β levels, NLRP3, ASC, and caspase-1 expression levels were determined by Western blot. NLRP3 inflammasome complex assembly was analyzed by immunocytochemistry, whereas by ELISA, we analyzed NLRP3 inflammasome activity and [Formula: see text] release. In CF, Ang-II triggered NLRP3 inflammasome assembly and caspase-1 activity; and in LPS-pretreated CF, Ang-II also triggered [Formula: see text] secretion. These effects were blocked by losartan (AT1R antagonist), U73221 (PLC inhibitor), 2-APB (IP3R antagonist), and BAPTA-AM (Ca
    Mesh-Begriff(e) Rats ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Angiotensin II/pharmacology ; Toll-Like Receptor 4 ; Interleukin-1beta/metabolism ; Caspase 1/metabolism ; Fibroblasts/metabolism
    Chemische Substanzen Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Angiotensin II (11128-99-7) ; Toll-Like Receptor 4 ; Interleukin-1beta ; Caspase 1 (EC 3.4.22.36) ; Nlrp3 protein, rat
    Sprache Englisch
    Erscheinungsdatum 2022-07-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-022-01707-z
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  4. Artikel: Avoiding and managing vascular injury during robotic-assisted radical prostatectomy.

    Sotelo, René / Nunez Bragayrac, Luciano A / Machuca, Victor / Garza Cortes, Roberto / Azhar, Raed A

    Therapeutic advances in urology

    2015  Band 7, Heft 1, Seite(n) 41–48

    Abstract: There has been an increase in the number of urologic procedures performed robotically assisted; this is the case for radical prostatectomy. Currently, in the USA, 67% of prostatectomies are performed robotically assisted. With this increase in robotic ... ...

    Abstract There has been an increase in the number of urologic procedures performed robotically assisted; this is the case for radical prostatectomy. Currently, in the USA, 67% of prostatectomies are performed robotically assisted. With this increase in robotic urologic surgery it is clear that there are more surgeons in their learning curve, where most of the complications occur. Among the complications that can occur are vascular injuries. These can occur in the initial stages of surgery, such as in accessing the abdominal cavity, as well as in the intraoperative or postoperative setting. We present the most common vascular injuries in robot-assisted radical prostatectomy, as well as their management and prevention. We believe that it is of vital importance to be able to recognize these injuries so that they can be prevented.
    Sprache Englisch
    Erscheinungsdatum 2015-01-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2492591-3
    ISSN 1756-2880 ; 1756-2872
    ISSN (online) 1756-2880
    ISSN 1756-2872
    DOI 10.1177/1756287214553967
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  5. Artikel ; Online: Robotic repair of vesicovaginal fistulae with the transperitoneal-transvaginal approach: a case series.

    Bragayrac, Luciano A Nunez / Azhar, Raed A / Fernandez, Golena / Cabrera, Marino / Saenz, Eric / Machuca, Victor / Andrade, Robert de / Carmona, Oswaldo / Sotelo, Rene

    International braz j urol : official journal of the Brazilian Society of Urology

    2014  Band 40, Heft 6, Seite(n) 810–815

    Abstract: Objective: To describe a novel technique of repairing the VVF using the transperitoneal-transvaginal approach.: Materials and methods: From June 2011 to October 2013, four patients with symptoms of urine leakage in the vagina underwent robotic repair ...

    Abstract Objective: To describe a novel technique of repairing the VVF using the transperitoneal-transvaginal approach.
    Materials and methods: From June 2011 to October 2013, four patients with symptoms of urine leakage in the vagina underwent robotic repair of VVF with the transperitoneal-transvaginal approach. Cystoscopy revealed the fistula opening on the bladder. A ureteral stent was placed through the fistulous tract. After trocar placement, the omental flap was prepared and mobilized robotically. The vagina was identified and incised. The fistulous tract was excised. Cystorrhaphy was performed in two layers in an interrupted fashion. The vaginal opening was closed with running stitches. The omentum was interposed and anchored between the bladder and vagina. Finally, the ureteral catheters were removed in case they have been placed, and an 18 Fr urethral catheter was removed on the 14th postoperative day.
    Results: The mean age was 46 years (range: 41 to 52 years). The mean fistula diameter was 1.5 cm (range 0.3 to 2 cm). The mean operative time was 117.5 min (range: 100 to 150 min). The estimated blood loss was 100 mL (range: 50 to 150 mL). The mean hospital stay was 1.75 days (range: 1 to 3 days). The mean Foley catheter duration was 15.75 days (range: 10 to 25 days). There was no evidence of recurrence in any of the cases.
    Conclusions: The robot-assisted laparoscopic transperitoneal transvaginal approach for VVF is a feasible procedure when the fistula tract is identified by first intentionally opening the vagina, thereby minimizing the bladder incision and with low morbidity.
    Mesh-Begriff(e) Adult ; Female ; Humans ; Laparoscopy/methods ; Length of Stay ; Middle Aged ; Operative Time ; Reproducibility of Results ; Robotic Surgical Procedures/methods ; Treatment Outcome ; Urinary Bladder/surgery ; Urologic Surgical Procedures/methods ; Vesicovaginal Fistula/surgery
    Sprache Englisch
    Erscheinungsdatum 2014-11
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2014.06.12
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Transvesical Laparoendoscopic Single-Site Management of Distal Ureter During Laparoscopic Radical Nephroureterectomy.

    Bragayrac, Luciano A Nunez / Machuca, Victor / Saenz, Eric / Cabrera, Marino / de Andrade, Robert / Sotelo, Rene J

    Journal of endourology

    2014  Band 35, Heft 5, Seite(n) 745–748

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell/surgery ; Humans ; Laparoscopy ; Middle Aged ; Nephrectomy ; Nephroureterectomy ; Ureter/surgery ; Urinary Bladder/surgery
    Sprache Englisch
    Erscheinungsdatum 2014-09-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 356931-7
    ISSN 1557-900X ; 0892-7790
    ISSN (online) 1557-900X
    ISSN 0892-7790
    DOI 10.1089/end.2014.0071
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  7. Artikel ; Online: Safer Surgery by Learning from Complications: A Focus on Robotic Prostate Surgery.

    Sotelo, René J / Haese, Alexander / Machuca, Victor / Medina, Luis / Nuñez, Luciano / Santinelli, Flavio / Hernandez, Andrés / Kural, Ali Riza / Mottrie, Alexander / Giedelman, Camilo / Mirandolino, Mariano / Palmer, Kenneth / Abaza, Ronney / Ghavamian, Reza / Shalhav, Arieh / Moinzadeh, Alireza / Patel, Vipul / Stifelman, Michael / Tuerk, Ingolf /
    Canes, David

    European urology

    2016  Band 69, Heft 2, Seite(n) 334–344

    Abstract: Background: The uptake of robotic surgery has led to changes in potential operative complications, as many surgeons learn minimally invasive surgery, and has allowed the documentation of such complications through the routine collection of ... ...

    Abstract Background: The uptake of robotic surgery has led to changes in potential operative complications, as many surgeons learn minimally invasive surgery, and has allowed the documentation of such complications through the routine collection of intraoperative video.
    Objective: We documented intraoperative complications from robot-assisted radical prostatectomy (RARP) with the aim of reporting the mechanisms, etiology, and necessary steps to avoid them. Our goal was to facilitate learning from these complications to improve patient care.
    Design, setting, and participants: Contributors delivered videos of complications that occurred during laparoscopic and robotic prostatectomy between 2010 and 2015.
    Surgical procedure: Surgical footage was available for a variety of complications during RARP.
    Outcome measurements and statistical analysis: Based on these videos, a literature search was performed using relevant terms (prostatectomy, robotic, complications), and the intraoperative steps of the procedures and methods of preventing complications were outlined.
    Results and limitations: As a major surgical procedure, RARP has much potential for intra- and postoperative complications related to patient positioning, access, and the procedure itself. However, with a dedicated approach, increasing experience, a low index of suspicion, and strict adherence to safety measures, we suggest that the majority of such complications are preventable.
    Conclusions: Considering the complexity of the procedure, RARP is safe and reproducible for the surgical management of prostate cancer. Insight from experienced surgeons may allow surgeons to avoid complications during the learning curve.
    Patient summary: Robot-assisted radical prostatectomy has potential for intra- and postoperative complications, but with a dedicated approach, increasing experience, a low index of suspicion, and strict adherence to safety measures, most complications are preventable.
    Mesh-Begriff(e) Blood Vessels/injuries ; Equipment Failure ; Humans ; Incisional Hernia/etiology ; Intestinal Perforation/etiology ; Intraoperative Complications/etiology ; Intraoperative Complications/prevention & control ; Intraoperative Complications/therapy ; Learning ; Male ; Patient Positioning ; Peripheral Nerve Injuries/etiology ; Postoperative Hemorrhage/etiology ; Prostatectomy ; Rectal Diseases/etiology ; Robotic Surgical Procedures ; Ureter/injuries
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Video-Audio Media
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2015.08.060
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