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  1. Article ; Online: The Photodynamic Anticancer and Antibacterial Activity Properties of a Series of

    Soy, Rodah / Babu, Balaji / Mack, John / Nyokong, Tebello

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: A series of tetraarylchlorins with 3-methoxy-, 4-hydroxy- and 3-methoxy-4- ... ...

    Abstract A series of tetraarylchlorins with 3-methoxy-, 4-hydroxy- and 3-methoxy-4-hydroxyphenyl
    MeSH term(s) Photochemotherapy/methods ; Staphylococcus aureus ; Coloring Agents/pharmacology ; Escherichia coli ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/pharmacology
    Chemical Substances Coloring Agents ; Photosensitizing Agents ; Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104030
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    Zs.MO 81: Show issues

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  2. Article ; Online: Sn(IV)-porphyrinoids for photodynamic anticancer and antimicrobial chemotherapy.

    Babu, Balaji / Mack, John / Nyokong, Tebello

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 16, Page(s) 5000–5018

    Abstract: Photodynamic therapy (PDT) is a mode of treatment for different types of cancers, which involves a nontoxic photosensitizer (PS), a light source to activate the PS, and ground-state molecular oxygen ( ...

    Abstract Photodynamic therapy (PDT) is a mode of treatment for different types of cancers, which involves a nontoxic photosensitizer (PS), a light source to activate the PS, and ground-state molecular oxygen (
    MeSH term(s) Photosensitizing Agents/chemistry ; Photochemotherapy ; Reactive Oxygen Species ; Singlet Oxygen/chemistry ; Anti-Infective Agents/chemistry ; Porphyrins/chemistry ; Bacteria ; Water
    Chemical Substances Photosensitizing Agents ; Reactive Oxygen Species ; Singlet Oxygen (17778-80-2) ; Anti-Infective Agents ; Porphyrins ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt00603d
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  3. Article ; Online: The photodynamic activity properties of a series of structurally analogous tetraarylporphyrin, chlorin and N-confused porphyrin dyes and their Sn(IV) complexes.

    Soy, Rodah / Babu, Balaji / Mack, John / Nyokong, Tebello

    Photodiagnosis and photodynamic therapy

    2023  Volume 44, Page(s) 103815

    Abstract: A series of tetraarylporphyrin, -chlorin and N-confused porphyrin dyes with 4‑methoxy‑meso-aryl rings (1-Por, 1-Chl and 1-NCP) and their Sn(IV) complexes (1-SnPor, 1-SnChl and 1-SnNCP) have been synthesized and characterized. The heavy atom effect of the ...

    Abstract A series of tetraarylporphyrin, -chlorin and N-confused porphyrin dyes with 4‑methoxy‑meso-aryl rings (1-Por, 1-Chl and 1-NCP) and their Sn(IV) complexes (1-SnPor, 1-SnChl and 1-SnNCP) have been synthesized and characterized. The heavy atom effect of the Sn(IV) ion results in relatively high singlet oxygen quantum yield values of 0.67, 0.71 and 0.85 for 1-SnPor, 1-SnChl and 1-SnNCP, respectively. The photodynamic activities of 1-Por, 1-Chl, 1-NCP, 1-SnPor, 1-SnChl and 1-SnNCP were determined against MCF-7 breast cancer cells through illumination with Thorlabs 625 or 660 nm (240 or 280 mW.cm
    MeSH term(s) Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Coloring Agents/pharmacology ; Porphyrins/pharmacology ; Escherichia coli
    Chemical Substances Photosensitizing Agents ; chlorin (2683-84-3) ; Coloring Agents ; Porphyrins
    Language English
    Publishing date 2023-09-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103815
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  4. Article ; Online: Expanded, Contracted, and Isomeric Porphyrins: Theoretical Aspects.

    Mack, John

    Chemical reviews

    2017  Volume 117, Issue 4, Page(s) 3444–3478

    Abstract: The use of cyclic polyene perimeter-model approaches, such as Gouterman's four-orbital model and Michl's perimeter model, to analyze trends in the electronic structures and optical properties of expanded, contracted, and isomeric porphyrins is described ... ...

    Abstract The use of cyclic polyene perimeter-model approaches, such as Gouterman's four-orbital model and Michl's perimeter model, to analyze trends in the electronic structures and optical properties of expanded, contracted, and isomeric porphyrins is described with an emphasis on the use of magnetic circular dichroism (MCD) spectroscopy to validate the results of TD-DFT calculations. Trends in the electronic structures and optical properties of isomeric porphyrins are examined by comparing the properties of porphycenes, corrphycenes, hemiporphycenes, isoporphycenes, N-confused and neoconfused porphyrins, and norroles, whereas those of ring-contracted porphyrins are examined by comparing the properties of subporphyrins, triphyrins, and vacataporphyrins. The ring-expanded compounds that are examined include cyclo[n]pyrroles, [22]pentaphyrins(1.1.1.1.1), sapphyrins, smaragdyrins, isosmaragdyrins, orangarins, ozaphyrins, [26]hexaphyrins(1.1.1.1.1.1), rubyrins, rosarins, amethyrins, isoamethyrins, bronzaphyrins, and doubly N-confused hexaphyrins.
    Language English
    Publishing date 2017-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.6b00568
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  5. Article ; Online: A Rapid Food-Preference Assay in Drosophila.

    Mack, John O / Zhang, Yali V

    Journal of visualized experiments : JoVE

    2021  , Issue 168

    Abstract: To select food with nutritional value while avoiding the consumption of harmful agents, animals need a sophisticated and robust taste system to evaluate their food environment. The fruit fly, Drosophila melanogaster, is a genetically tractable model ... ...

    Abstract To select food with nutritional value while avoiding the consumption of harmful agents, animals need a sophisticated and robust taste system to evaluate their food environment. The fruit fly, Drosophila melanogaster, is a genetically tractable model organism that is widely used to decipher the molecular, cellular, and neural underpinnings of food preference. To analyze fly food preference, a robust feeding method is needed. Described here is a two-choice feeding assay, which is rigorous, cost-saving, and fast. The assay is Petri-dish-based and involves the addition of two different foods supplemented with blue or red dye to the two halves of the dish. Then, ~70 prestarved, 2-4-day-old flies are placed in the dish and allowed to choose between blue and red foods in the dark for about 90 min. Examination of the abdomen of each fly is followed by the calculation of the preference index. In contrast to multiwell plates, each Petri dish takes only ~20 s to fill and saves time and effort. This feeding assay can be employed to quickly determine whether flies like or dislike a particular food.
    MeSH term(s) Animals ; Biological Assay/methods ; Coloring Agents ; Drosophila melanogaster/physiology ; Feeding Behavior ; Food Preferences ; Indicators and Reagents ; Starvation
    Chemical Substances Coloring Agents ; Indicators and Reagents
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62051
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  6. Article ; Online: Blue-Light-Activated Water-Soluble Sn(IV)-Porphyrins for Antibacterial Photodynamic Therapy (aPDT) against Drug-Resistant Bacterial Pathogens.

    Nagarajan, T / Gayathri, M P / Mack, John / Nyokong, Tebello / Govindarajan, Sutharsan / Babu, Balaji

    Molecular pharmaceutics

    2024  Volume 21, Issue 5, Page(s) 2365–2374

    Abstract: Antimicrobial resistance has emerged as a global threat to the treatment of infectious diseases. Antibacterial photodynamic therapy (aPDT) is a promising alternative approach and is highly suitable for the treatment of cutaneous bacterial infections ... ...

    Abstract Antimicrobial resistance has emerged as a global threat to the treatment of infectious diseases. Antibacterial photodynamic therapy (aPDT) is a promising alternative approach and is highly suitable for the treatment of cutaneous bacterial infections through topical applications. aPDT relies on light-responsive compounds called photosensitizer (PS) dyes, which generate reactive oxygen species (ROS) when induced by light, thereby killing bacterial cells. Despite several previous studies in this area, the molecular details of targeting and cell death mediated by PS dyes are poorly understood. In this study, we further investigate the antibacterial properties of two water-soluble Sn(IV) tetrapyridylporphyrins that were quaternized with methyl and hexyl groups (
    MeSH term(s) Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Porphyrins/pharmacology ; Porphyrins/chemistry ; Light ; Reactive Oxygen Species/metabolism ; Microbial Sensitivity Tests ; Humans ; Water/chemistry ; Drug Resistance, Bacterial/drug effects ; Tin/chemistry
    Chemical Substances Photosensitizing Agents ; Anti-Bacterial Agents ; Porphyrins ; Reactive Oxygen Species ; Water (059QF0KO0R) ; Tin (7440-31-5)
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c01162
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Expanded, Contracted, and Isomeric Porphyrins: Theoretical Aspects

    Mack, John

    Chemical Reviews. 2017 Feb. 22, v. 117, no. 4

    2017  

    Abstract: The use of cyclic polyene perimeter-model approaches, such as Gouterman’s four-orbital model and Michl’s perimeter model, to analyze trends in the electronic structures and optical properties of expanded, contracted, and isomeric porphyrins is ... ...

    Abstract The use of cyclic polyene perimeter-model approaches, such as Gouterman’s four-orbital model and Michl’s perimeter model, to analyze trends in the electronic structures and optical properties of expanded, contracted, and isomeric porphyrins is described with an emphasis on the use of magnetic circular dichroism (MCD) spectroscopy to validate the results of TD-DFT calculations. Trends in the electronic structures and optical properties of isomeric porphyrins are examined by comparing the properties of porphycenes, corrphycenes, hemiporphycenes, isoporphycenes, N-confused and neoconfused porphyrins, and norroles, whereas those of ring-contracted porphyrins are examined by comparing the properties of subporphyrins, triphyrins, and vacataporphyrins. The ring-expanded compounds that are examined include cyclo[n]pyrroles, [22]pentaphyrins(1.1.1.1.1), sapphyrins, smaragdyrins, isosmaragdyrins, orangarins, ozaphyrins, [26]hexaphyrins(1.1.1.1.1.1), rubyrins, rosarins, amethyrins, isoamethyrins, bronzaphyrins, and doubly N-confused hexaphyrins.
    Keywords circular dichroism spectroscopy ; magnetism ; models ; optical properties ; porphyrins ; pyrroles
    Language English
    Dates of publication 2017-0222
    Size p. 3444-3478.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021%2Facs.chemrev.6b00568
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    In stock of ZB MED Bonn / Germany

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  8. Article: A rapid food-preference assay in Drosophila

    Mack, John O. / Zhang, Yali V.

    Journal of visualized experiments. 2021 Feb. 11, , no. 168

    2021  

    Abstract: To select food with nutritional value while avoiding the consumption of harmful agents, animals need a sophisticated and robust taste system to evaluate their food environment. The fruit fly, Drosophila melanogaster, is a genetically tractable model ... ...

    Abstract To select food with nutritional value while avoiding the consumption of harmful agents, animals need a sophisticated and robust taste system to evaluate their food environment. The fruit fly, Drosophila melanogaster, is a genetically tractable model organism that is widely used to decipher the molecular, cellular, and neural underpinnings of food preference. To analyze fly food preference, a robust feeding method is needed. Described here is a two-choice feeding assay, which is rigorous, cost-saving, and fast. The assay is Petri-dish-based and involves the addition of two different foods supplemented with blue or red dye to the two halves of the dish. Then, ~70 prestarved, 2-4-day-old flies are placed in the dish and allowed to choose between blue and red foods in the dark for about 90 min. Examination of the abdomen of each fly is followed by the calculation of the preference index. In contrast to multiwell plates, each Petri dish takes only ~20 s to fill and saves time and effort. This feeding assay can be employed to quickly determine whether flies like or dislike a particular food.
    Keywords Drosophila melanogaster ; abdomen ; cost effectiveness ; dyes ; food choices ; fruit flies ; nutritive value ; taste
    Language English
    Dates of publication 2021-0211
    Size p. e62051.
    Publishing place Journal of Visualized Experiments
    Document type Article
    Note NAL-light
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62051
    Database NAL-Catalogue (AGRICOLA)

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  9. Book: Borderline states in psychiatry

    Mack, John E.

    (Seminars in psychiatry)

    1975  

    Author's details ed. by John E. Mack
    Series title Seminars in psychiatry
    Language English
    Size 146 S.
    Publisher Grune and Stratton
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT005001456
    ISBN 0-8089-0878-2 ; 978-0-8089-0878-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1977 A 257 order for loan Magazin

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  10. Article ; Online: Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.

    Liu, Jiangqu / Liu, Weiwei / Thakur, Dhananjay / Mack, John / Spina, Aidin / Montell, Craig

    Current biology : CB

    2023  Volume 33, Issue 12, Page(s) 2397–2406.e6

    Abstract: Acute avoidance of dangerous temperatures is critical for animals to prevent or minimize injury. Therefore, surface receptors have evolved to endow neurons with the capacity to detect noxious heat so that animals can initiate escape behaviors. Animals ... ...

    Abstract Acute avoidance of dangerous temperatures is critical for animals to prevent or minimize injury. Therefore, surface receptors have evolved to endow neurons with the capacity to detect noxious heat so that animals can initiate escape behaviors. Animals including humans have evolved intrinsic pain-suppressing systems to attenuate nociception under some circumstances. Here, using Drosophila melanogaster, we uncovered a new mechanism through which thermal nociception is suppressed. We identified a single descending neuron in each brain hemisphere, which is the center for suppression of thermal nociception. These Epi neurons, for Epione-the goddess of soothing of pain-express a nociception-suppressing neuropeptide Allatostatin C (AstC), which is related to a mammalian anti-nociceptive peptide, somatostatin. Epi neurons are direct sensors for noxious heat, and when activated they release AstC, which diminishes nociception. We found that Epi neurons also express the heat-activated TRP channel, Painless (Pain), and thermal activation of Epi neurons and the subsequent suppression of thermal nociception depend on Pain. Thus, while TRP channels are well known to sense noxious temperatures to promote avoidance behavior, this work reveals the first role for a TRP channel for detecting noxious temperatures for the purpose of suppressing rather than enhancing nociception behavior in response to hot thermal stimuli.
    MeSH term(s) Animals ; Humans ; Drosophila melanogaster/physiology ; Hot Temperature ; Drosophila Proteins/metabolism ; Nociception/physiology ; Pain ; Neurons/metabolism ; Brain/metabolism ; Mammals
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.04.055
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    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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