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  1. Article ; Online: Not from Venus, not from Mars - all equally superstars.

    Mackay, Fabienne

    Nature immunology

    2020  Volume 21, Issue 3, Page(s) 238

    MeSH term(s) Allergy and Immunology/history ; Australia ; Career Mobility ; Female ; History, 21st Century ; Humans ; Male ; Sexism/history ; Universities/history ; Women's Rights/history
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-0605-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  2. Article: The BAFF-APRIL System in Cancer.

    Ullah, Md Ashik / Mackay, Fabienne

    Cancers

    2023  Volume 15, Issue 6

    Abstract: B cell-activating factor (BAFF; also known as CD257, TNFSF13B, BLyS) and a proliferation-inducing ligand (APRIL; also known as CD256, TNFSF13) belong to the tumor necrosis factor (TNF) family. BAFF was initially discovered as a B-cell survival factor, ... ...

    Abstract B cell-activating factor (BAFF; also known as CD257, TNFSF13B, BLyS) and a proliferation-inducing ligand (APRIL; also known as CD256, TNFSF13) belong to the tumor necrosis factor (TNF) family. BAFF was initially discovered as a B-cell survival factor, whereas APRIL was first identified as a protein highly expressed in various cancers. These discoveries were followed by over two decades of extensive research effort, which identified overlapping signaling cascades between BAFF and APRIL, controlling immune homeostasis in health and driving pathogenesis in autoimmunity and cancer, the latter being the focus of this review. High levels of BAFF, APRIL, and their receptors have been detected in different cancers and found to be associated with disease severity and treatment response. Here, we have summarized the role of the BAFF-APRIL system in immune cell differentiation and immune tolerance and detailed its pathogenic functions in hematological and solid cancers. We also highlight the emerging therapeutics targeting the BAFF-APRIL system in different cancer types.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The bigger B cell picture.

    Mackay, Fabienne

    Nature reviews. Immunology

    2016  Volume 16, Issue 3, Page(s) 133

    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Humans ; Immunoglobulin G/biosynthesis ; Insulin Resistance/immunology ; Male ; T-Lymphocytes/immunology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2016.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
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    Zs.MG 34: Show issues

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  4. Article ; Online: Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation.

    Zhu, Yan / Hirata, Tatsumi / Mackay, Fabienne / Murakami, Fujio

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 11830

    Abstract: Long distance tangential migration transports neurons from their birth places to distant destinations to be incorporated into neuronal circuits. How neuronal migration is guided during these long journeys is still not fully understood. We address this ... ...

    Abstract Long distance tangential migration transports neurons from their birth places to distant destinations to be incorporated into neuronal circuits. How neuronal migration is guided during these long journeys is still not fully understood. We address this issue by studying the migration of pontine nucleus (PN) neurons in the mouse hindbrain. PN neurons migrate from the lower rhombic lip first anteriorly and then turn ventrally near the trigeminal ganglion root towards the anterior ventral hindbrain. Previously we showed that in mouse depleted of chemokine receptor CXCR4 or its ligand CXCL12, PN neurons make their anterior-to-ventral turn at posteriorized positions. However, the mechanism that spatiotemporally controls the anterior-to-ventral turning is still unclear. Furthermore, the role of CXCR7, the atypical receptor of CXCL12, in pontine migration has yet to be examined. Here, we find that the PN is elongated in Cxcr7 knockout due to a broadened anterior-to-ventral turning positions. Cxcr7 is not expressed in migrating PN neurons en route to their destinations, but is strongly expressed in the pial meninges. Neuroepithelium-specific knockout of Cxcr7 does not recapitulate the PN phenotype in Cxcr7 knockout, suggesting that CXCR7 acts non-cell-autonomously possibly from the pial meninges. We show further that CXCR7 regulates pontine migration by modulating CXCL12 protein levels.
    MeSH term(s) Animals ; Biomarkers ; Brain Stem/metabolism ; Cell Movement ; Cell Nucleus ; Cells, Cultured ; Immunohistochemistry ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptors, CXCR/genetics ; Receptors, CXCR/metabolism ; Rhombencephalon/metabolism
    Chemical Substances Biomarkers ; Cmkor1 protein, mouse ; Receptors, CXCR
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-68852-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gut Microbiota and Atrial Fibrillation: Pathogenesis, Mechanisms and Therapies.

    Al-Kaisey, Ahmed M / Figgett, William / Hawson, Joshua / Mackay, Fabienne / Joseph, Stephen A / Kalman, Jonathan M

    Arrhythmia & electrophysiology review

    2023  Volume 12, Page(s) e14

    Abstract: Over the past decade there has been an interest in understanding the role of gut microbiota in the pathogenesis of AF. A number of studies have linked the gut microbiota to the occurrence of traditional AF risk factors such as hypertension and obesity. ... ...

    Abstract Over the past decade there has been an interest in understanding the role of gut microbiota in the pathogenesis of AF. A number of studies have linked the gut microbiota to the occurrence of traditional AF risk factors such as hypertension and obesity. However, it remains unclear whether gut dysbiosis has a direct effect on arrhythmogenesis in AF. This article describes the current understanding of the effect of gut dysbiosis and associated metabolites on AF. In addition, current therapeutic strategies and future directions are discussed.
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2813970-7
    ISSN 2050-3377 ; 2050-3369
    ISSN (online) 2050-3377
    ISSN 2050-3369
    DOI 10.15420/aer.2022.33
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CD8

    Deliyanti, Devy / Figgett, William A / Gebhardt, Thomas / Trapani, Joseph A / Mackay, Fabienne / Wilkinson-Berka, Jennifer L

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 4, Page(s) 522–536

    Abstract: Background: CD4: Methods: We describe how CD8: Results: In oxygen-induced retinopathy, flow cytometry revealed the numbers of CD4: Conclusions: We discovered that CXCR3 is central to the migration of ... ...

    Abstract Background: CD4
    Methods: We describe how CD8
    Results: In oxygen-induced retinopathy, flow cytometry revealed the numbers of CD4
    Conclusions: We discovered that CXCR3 is central to the migration of CD8
    MeSH term(s) Animals ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; Neovascularization, Pathologic ; Retina/metabolism ; Retinal Diseases/metabolism ; Interferon-gamma/metabolism ; Vascular Diseases/pathology ; Mice, Inbred C57BL
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.

    Ullah, Md Ashik / Garcillán, Beatriz / Whitlock, Eden / Figgett, William A / Infantino, Simona / Eslami, Mahya / Yang, SiLing / Rahman, M Arifur / Sheng, Yong H / Weber, Nicholas / Schneider, Pascal / Tam, Constantine S / Mackay, Fabienne

    Frontiers in immunology

    2024  Volume 15, Page(s) 1345515

    Abstract: Background: Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19: Methods: We generated novel CLL models lacking BAFF or APRIL. : Results: Our findings demonstrate a crucial role for BAFF, but not APRIL, in the initiation ... ...

    Abstract Background: Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19
    Methods: We generated novel CLL models lacking BAFF or APRIL.
    Results: Our findings demonstrate a crucial role for BAFF, but not APRIL, in the initiation and dissemination of CLL cells. In the absence of BAFF or its receptor BAFF-R, the TCL1 transgene only increases CLL cell numbers in the peritoneal cavity, without dissemination into the periphery. While BAFF binding to BAFF-R is dispensable for peritoneal CLL cell survival, it is necessary to activate a tumor-promoting gene program, potentially linked to CLL initiation and progression. This direct role of BAFF in controlling the expression of tumor-promoting genes was confirmed in patient-derived primary CLL cells ex-vivo.
    Conclusions: Our study, involving both mouse and human CLL cells, suggests that BAFF might initiate CLL through mechanisms independent of cell survival. Combining current CLL therapies with BAFF inhibition could offer a dual benefit by reducing peripheral tumor burden and suppressing transformed CLL cell output.
    MeSH term(s) Animals ; Humans ; Mice ; B-Lymphocytes/metabolism ; Cell Survival/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology
    Chemical Substances TNFSF13B protein, human ; Tnfsf13b protein, mouse
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1345515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells.

    Quah, Pin Shie / Sutton, Vivien / Whitlock, Eden / Figgett, William A / Andrews, Daniel M / Fairfax, Kirsten A / Mackay, Fabienne

    Immunology and cell biology

    2022  Volume 100, Issue 10, Page(s) 761–776

    Abstract: The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to innate immunity remain unclear. Natural killer (NK) cells form the first line of defense against viruses and tumors, and have ... ...

    Abstract The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to innate immunity remain unclear. Natural killer (NK) cells form the first line of defense against viruses and tumors, and have been shown to be defective in patients with systemic lupus erythematosus (SLE). The link between BAFF and NK cells in the development and progression of SLE remains unstudied. By assessing NK cell numbers in wild-type (WT), BAFF<sup>-/-</sup> (BAFF deficient), BAFF-R<sup>-/-</sup> (BAFF receptor deficient), TACI<sup>-/-</sup> (transmembrane activator and calcium modulator and cyclophilin ligand interactor deficient), BCMA<sup>-/-</sup> (B-cell maturation antigen deficient) and BAFF transgenic (Tg) mice, we observed that BAFF signaling through BAFF-R was essential for sustaining NK cell numbers in the spleen. However, according to the cell surface expression of CD27 and CD11b on NK cells, we found that BAFF was dispensable for NK cell maturation. Ex vivo and in vivo models showed that NK cells from BAFF<sup>-/-</sup> and BAFF Tg mice produced interferon-γ and killed tumor cells at a level similar to that in WT mice. Finally, we established that NK cells do not express receptors that interact with BAFF in the steady state or in the BAFF Tg mouse model of SLE. Our findings demonstrate that BAFF has an indirect effect on NK cell homeostasis and no effect on NK cell function.
    MeSH term(s) Mice ; Animals ; Transmembrane Activator and CAML Interactor Protein/genetics ; Population Density ; Lupus Erythematosus, Systemic ; Interleukin-4 ; Mice, Transgenic ; Killer Cells, Natural/metabolism
    Chemical Substances Transmembrane Activator and CAML Interactor Protein ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.175: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Editorial overview: Autoimmunity.

    Anderson, Mark S / Mackay, Fabienne

    Current opinion in immunology

    2015  Volume 37, Page(s) v–vii

    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/microbiology ; Autoimmune Diseases/therapy ; Autoimmunity ; Humans ; Immune Tolerance ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/microbiology ; Immunologic Deficiency Syndromes/therapy ; Lymphocyte Activation ; Microbiota/immunology ; Probiotics/therapeutic use ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2015.10.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  10. Article: Distinguishing naive- from memory-derived human B cells during acute responses.

    Auladell, Maria / Nguyen, Thi Ho / Garcillán, Beatriz / Mackay, Fabienne / Kedzierska, Katherine / Fox, Annette

    Clinical & translational immunology

    2019  Volume 8, Issue 11, Page(s) e01090

    Abstract: Objectives: A fundamental question in influenza research is whether antibody titre decline upon successive exposure to variant strains is consequent to recall of cross-reactive memory B cells that competitively inhibit naive B-cell responses. In ... ...

    Abstract Objectives: A fundamental question in influenza research is whether antibody titre decline upon successive exposure to variant strains is consequent to recall of cross-reactive memory B cells that competitively inhibit naive B-cell responses. In connection, it is not clear whether naive and memory B cells remain phenotypically distinct acutely after activation such that they may be distinguished
    Methods: Here, we first compared the capacity of anti-Ig and Toll-like-receptor (TLR) 7/8 and TLR9 agonists (R848 and CpG) to augment human B-cell differentiation induced by IL-21 and sCD40L. The conditions that induced optimal differentiation were then used to compare the post-activation phenotype of sort-purified naive and memory B-cell subsets by FACS and antibody-secreting cell (ASC) ELISPOT.
    Results: Sort-purified naive and memory B cells underwent robust plasmablast and ASC formation when stimulated with R848, but not CpG, and co-cultured with monocytes. This coincided with increased IL-1β and IL-6 production when B cells were co-cultured with monocytes and stimulated with R848, but not CpG. Naive B cells underwent equivalent ASC generation, but exhibited less class-switch and modulation of CD27, CD38 and CD20 expression than memory B cells after stimulation with R848 and monocytes for 6 days.
    Conclusion: Stimulation with R848, IL-21 and sCD40L in the presence of monocytes induces robust differentiation and ASC generation from both naive and memory B-cells. However, naive and memory B cells retain key phenotypic differences after activation that may facilitate
    Language English
    Publishing date 2019-11-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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