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  1. Article: Efficacy and risk of osteonecrosis of the jaw for pamidronate, zoledronic acid, and denosumab in comparison to alendronate in multiple myeloma patients.

    Browne, Micah / Miles, Brittany / Mackey, James

    Proceedings (Baylor University. Medical Center)

    2024  Volume 37, Issue 2, Page(s) 227–229

    Abstract: Background: Approximately 70% of multiple myeloma patients develop pathologic fractures. Osteoclast inhibitors can provide reduction in vertebral fractures with an increased risk of osteonecrosis of the jaw (ONJ). ONJ associated with currently used ... ...

    Abstract Background: Approximately 70% of multiple myeloma patients develop pathologic fractures. Osteoclast inhibitors can provide reduction in vertebral fractures with an increased risk of osteonecrosis of the jaw (ONJ). ONJ associated with currently used osteoclast inhibitors causes significant morbidity, often from delayed diagnosis and ineffective treatment.
    Methods: The TriNetX Diamond Network was used to create patient cohorts for each medication: alendronate, pamidronate, zoledronic acid, and denosumab. All patients had a diagnosis of multiple myeloma as identified by International Classification of Disease-10 (ICD-10) code C90.0. Pamidronate, zoledronic acid, and denosumab were each compared to alendronate for 5-year incidence of pathologic vertebral fracture (ICD-10 M48.50XA) and development of ONJ.
    Results: The 5-year risk of pathologic vertebral fracture was not statistically different between alendronate versus pamidronate, zoledronic acid, and denosumab. However, the 5-year risk of ONJ was significantly higher for both zoledronic acid and denosumab (relative risk 4.85 and 2.9, respectively).
    Conclusion: This study shows that fracture reduction risk is comparable for all four treatments in multiple myeloma patients, but ONJ risk is lowest for alendronate and pamidronate. Overall, these data support the continued use of pamidronate and alendronate in multiple myeloma patients.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2023.2298667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Point-of-care ultrasound at Role 1: is it time for a rethink?

    Duncan, Patrick G A / Mackey, J

    BMJ military health

    2020  Volume 166, Issue 6, Page(s) 406–410

    Abstract: Introduction: The past 20 years have seen a rapid increase in point-of-care ultrasound (POCUS) use in the prehospital sphere. However, in the British Army there is no POCUS capability in the Defence Primary Healthcare (DPHC) or deployed Role 1 setting. ... ...

    Abstract Introduction: The past 20 years have seen a rapid increase in point-of-care ultrasound (POCUS) use in the prehospital sphere. However, in the British Army there is no POCUS capability in the Defence Primary Healthcare (DPHC) or deployed Role 1 setting. POCUS can improve diagnostic capability, influence management decisions and transfer destination, and is a useful triage tool in mass casualty management.
    Method: A survey on POCUS use was sent to 279 clinicians working in the Role 1, civilian prehospital and Defence Primary Healthcare environments. Questions explored current levels of experience and training, indications for use and attitudes towards roll out. Results were analysed using a mixed methods approach.
    Results: There were 124 respondents (279 recipients; 44.4% response rate). 74.2% (92 respondents) had no experience of using POCUS while 9.7% (12 respondents) were classed as frequent users. The four most common indications for prehospital POCUS were abdominal, cardiac and lung imaging and vascular access. The majority of respondents felt that POCUS would add value in the deployed Role 1 environment; this was even more evident in the frequent user group. Common concerns were difficulty maintaining currency, governance burden and uncertainty over impact on management.
    Conclusion: The majority of doctors surveyed feel that POCUS would add value at Role 1 and is a capability that should be developed. The authors will watch with interest the progress of Project MORPHO.
    MeSH term(s) Humans ; Point-of-Care Systems/standards ; Point-of-Care Systems/trends ; Surveys and Questionnaires ; Ultrasonography/instrumentation ; Ultrasonography/trends ; United Kingdom
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2020-001466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Statin Therapy and Pancreatitis: A Multi-Institutional Retrospective Analysis.

    O'Connor, Caroline E / Dang, Brittany Q / Miles, Brittany / Mackey, James

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51723

    Abstract: Introduction:  Acute pancreatitis is a serious condition that has numerous etiologies and often requires hospital admission due to its high mortality rates. Statins are used worldwide to reduce the risk of cardiovascular disease. Some studies have shown ...

    Abstract Introduction:  Acute pancreatitis is a serious condition that has numerous etiologies and often requires hospital admission due to its high mortality rates. Statins are used worldwide to reduce the risk of cardiovascular disease. Some studies have shown an association between long-term statin use and acute pancreatitis. However, other studies have shown no effect or even postulated a mild protective effect. Due to conflicting information in the medical literature, the relationship between statins and acute pancreatitis remains unclear. The current study uses the TriNetX global research database to further investigate the impact of statin use on the development of acute pancreatitis over a five-year period.
    Methods:  Two cohorts were created using the TriNetX global research database. One group consisted of patients not taking statins, while the other group included patients taking any statins. Patients in both groups were required to be between the ages of 40 and 75 and had normal low-density lipoprotein cholesterol (LDL) (≤200 mg/dl) and triglyceride (≤150 mg/dl) levels. Patients were matched for age, gender, race, and comorbidities. The statin group was then compared to the no-statin group and measured for the outcome of the incidence of acute pancreatitis and the frequency of episodes within the first five years of statin use. Patients who experienced any acute pancreatitis episode before starting statin therapy or before meeting inclusion criteria were excluded from the study.
    Results:  Patients on statin therapy were significantly more likely to develop acute pancreatitis compared to patients not taking statin therapy (risk ratio 1.332, 95% CI: 1.242-1.429, P<0.0001). However, the statin group had a lower mean number of pancreatitis episodes than the no-statin group (4.6 vs. 5.3, P=0.043).
    Conclusion:  The results from this large global dataset support the previously established idea that prolonged use of statins is associated with an increased risk of pancreatitis. Clinicians should strongly consider statin-induced pancreatitis when other common etiologies have been ruled out.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pitfalls of “slippery indicators”: the importance of reading between the lines

    Fischer-Mackey, Julia / Fox, Jonathan

    Development in Practice. 2023 Aug. 18, v. 33, no. 6 p.665-674

    2023  

    Abstract: Within the field of social accountability, studies about “community monitoring” have made broad claims about “what works” – or not – in practice, with significant implications for practitioners and policymakers. Interpretation of these findings is ... ...

    Abstract Within the field of social accountability, studies about “community monitoring” have made broad claims about “what works” – or not – in practice, with significant implications for practitioners and policymakers. Interpretation of these findings is complicated when studies rely on “slippery indicators” that do not measure the real-world processes they claim to address. This article illustrates the problem of slippery indicators, which has two main elements. First, some studies rely on indicators that do not actually measure community monitoring. Second, studies that claim to show a failure of community monitoring to deliver improvements may actually show a failure to deliver community monitoring in the first place. While complex research methods may obscure these two related problems, readers can still assess whether studies’ claims are supported by their empirical data by checking whether the findings are grounded in indicators that actually measure what they claim to study.
    Keywords accountability ; fields ; monitoring ; reading ; research methods ; participation ; civil society ; governance and public policy
    Language English
    Dates of publication 2023-0818
    Size p. 665-674.
    Publishing place Routledge
    Document type Article ; Online
    ZDB-ID 1484991-4
    ISSN 1364-9213 ; 0961-4524
    ISSN (online) 1364-9213
    ISSN 0961-4524
    DOI 10.1080/09614524.2022.2104220
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: What is known about the FTP

    Mackey, Jon / Horner, Katy

    Journal of sports sciences

    2021  Volume 39, Issue 23, Page(s) 2735–2745

    Abstract: Functional Threshold Power (FTP) in cycling is increasingly used in exercise prescription, particularly with the rise in use of home trainers and virtual exercise platforms. FTP testing does not require biological sampling and is considered a more ... ...

    Abstract Functional Threshold Power (FTP) in cycling is increasingly used in exercise prescription, particularly with the rise in use of home trainers and virtual exercise platforms. FTP testing does not require biological sampling and is considered a more practical test than others. This scoping review investigated what is known about the 20-minute FTP (FTP
    MeSH term(s) Bicycling ; Exercise ; Exercise Test ; Humans ; Male ; Oxygen Consumption ; Reproducibility of Results
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2021.1955515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2388: Show issues Location:
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  6. Article ; Online: Estimates of lithium mass yields from produced water sourced from the Devonian-aged Marcellus Shale.

    Mackey, Justin / Bain, Daniel J / Lackey, Greg / Gardiner, James / Gulliver, Djuna / Kutchko, Barbara

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8813

    Abstract: Decarbonatization initiatives have rapidly increased the demand for lithium. This study uses public waste compliance reports and Monte Carlo approaches to estimate total lithium mass yields from produced water (PW) sourced from the Marcellus Shale in ... ...

    Abstract Decarbonatization initiatives have rapidly increased the demand for lithium. This study uses public waste compliance reports and Monte Carlo approaches to estimate total lithium mass yields from produced water (PW) sourced from the Marcellus Shale in Pennsylvania (PA). Statewide, Marcellus Shale PW has substantial extractable lithium, however, concentrations, production volumes and extraction efficiencies vary between the northeast and southwest operating zones. Annual estimates suggest statewide lithium mass yields of approximately 1160 (95% CI 1140-1180) metric tons (mt) per year. Production decline curve analysis on PW volumes reveal cumulative volumetric disparities between the northeast (median = 2.89 X 10
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58887-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Use of Neodymium-Doped Yttrium Aluminum Garnet Laser for Treatment of Hypertrophic Port-Wine Stain.

    Miles, Brittany / Armenta, Andrew / Mackey, James

    Case reports in dermatological medicine

    2022  Volume 2022, Page(s) 8788417

    Abstract: Port-wine stains (also called nevus flammeus) are congenital malformations of the capillaries and postcapillary venules. They occur in 0.1-2% of newborns without sex predilection. Although PWS lesions are flat early in life, with age, they become ... ...

    Abstract Port-wine stains (also called nevus flammeus) are congenital malformations of the capillaries and postcapillary venules. They occur in 0.1-2% of newborns without sex predilection. Although PWS lesions are flat early in life, with age, they become hypertrophic and darker. Pulsed dye laser therapy is the standard of care for treating these lesions, although other laser wavelengths have been utilized with varying degrees of success. We present the case of a gentleman with a hypertrophic PWS who had an excellent response to Nd:YAG laser treatment. The increased tissue penetration of longer laser wavelengths may be of benefit to patients with hypertrophic PWS, and further research into this concept is warranted.
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2022/8788417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation and management of stroke in young adults.

    Mackey, Jason

    Continuum (Minneapolis, Minn.)

    2014  Volume 20, Issue 2 Cerebrovascular Disease, Page(s) 352–369

    Abstract: Purpose of review: This article provides an overview of the evaluation and management of ischemic stroke in young adults, with an emphasis on cervical artery dissection, patent foramen ovale, and hypercoagulable states.: Recent findings: The ... ...

    Abstract Purpose of review: This article provides an overview of the evaluation and management of ischemic stroke in young adults, with an emphasis on cervical artery dissection, patent foramen ovale, and hypercoagulable states.
    Recent findings: The incidence of ischemic stroke in young patients is increasing, although the reasons remain unclear. Patients with ischemic stroke at a young age are more likely to die at an early age than their peers. Well-established vascular risk factors are prevalent in young stroke patients. Recent studies have informed the treatment of dissection and patent foramen ovale among others. The utility of testing for hypercoagulable states in ischemic stroke is unclear.
    Summary: Ischemic stroke in young adults is a major public health problem. A wide range of etiologies of ischemic stroke is found in this age group. A careful history, thorough examination, and methodical workup are essential. Specific management is predicated on identification of the underlying etiology.
    MeSH term(s) Adult ; Brain Ischemia/diagnosis ; Brain Ischemia/therapy ; Humans ; Middle Aged ; Risk Factors ; Stroke/diagnosis ; Stroke/therapy ; Young Adult
    Language English
    Publishing date 2014-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/01.CON.0000446106.74796.e9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advanced cerebrovascular disease management. Preface.

    Mackey, Jason

    Seminars in neurology

    2014  Volume 33, Issue 5, Page(s) 425–426

    MeSH term(s) Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/therapy ; Disease Management ; Humans
    Language English
    Publishing date 2014-02-06
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0033-1364209
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    Zs.A 1737: Show issues Location:
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  10. Article: Lessons learned while undertaking high altitude medical research in the Himalayas.

    Mackey, J / Mellor, A

    Journal of the Royal Naval Medical Service

    2015  Volume 101, Issue 2, Page(s) 143–146

    Abstract: Undertaking medical research during military adventurous training expeditions presents a unique set of challenges to medical personnel, and for those considering doing so in the future the task may seem daunting. This article details some of the ... ...

    Abstract Undertaking medical research during military adventurous training expeditions presents a unique set of challenges to medical personnel, and for those considering doing so in the future the task may seem daunting. This article details some of the challenges faced whilst undertaking high altitude research on a recent Defence Medical Services (DMS) adventurous training expedition to the Dhaulagiri circuit in Nepal. By discussing what led to some of the problems encountered, how they were overcome, and in some instances how they could have been avoided in the first place, it is hoped that the article will act as a guide for others who plan on undertaking future research in a similar environment.
    MeSH term(s) Humans ; Military Medicine/education ; Nepal ; United Kingdom ; Wilderness Medicine/education
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764213-1
    ISSN 0035-9033
    ISSN 0035-9033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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