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Article: Immunological comparison of the in vitro and in vivo labeled victorin binding protein from susceptible oats.

Wolpert, T J / Macko, V

2006 Volume 95, Issue 3, Page(s) 917–920

Abstract: The fungus Cochliobolus victoriae causes victoria blight of oats and produces the host-specific toxin victorin. The reaction of oats to the fungus and its toxin is controlled by a single dominant gene whose product has been hypothesized to function as ... ...

Abstract	The fungus Cochliobolus victoriae causes victoria blight of oats and produces the host-specific toxin victorin. The reaction of oats to the fungus and its toxin is controlled by a single dominant gene whose product has been hypothesized to function as the site of action (receptor) of the toxin in susceptible oat genotypes. Previously, using a biologically active (125)I derivative of the toxin, we identified a 100 kilodalton victorin-binding protein (VBP) which binds victorin in a ligand-specific manner and binds in vivo only in susceptible oat genotypes. However, a VBP in both the susceptible and resistant oat genotypes was identified by in vitro binding experiments. One interpretation of the lack of genotype-specific binding in vitro is that the 100 kilodalton protein detected in vitro is not the same 100 kilodalton protein detected in vivo. To clarify the relationship between the 100 kilodalton protein(s) labeled in vivo and in vitro, we developed antisera to the in vitro-labeled VBP from the susceptible genotype and demonstrated that these preparations react with the in vivo-labeled VBP from the susceptible genotype. This finding coupled with previous observations strongly suggest that the VBP observed in vivo is the same protein detected in vitro. Furthermore, the results support our previous observations which suggest that the VBPs labeled in vitro in susceptible and resistant genotypes are closely related or identical.
Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.95.3.917
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Article ; Online: C-13 explosion victims--peculiarities of autopsy findings.

Macko, V / Straka, L / Krajcovic, J

Legal medicine (Tokyo, Japan)

2009 Volume 11 Suppl 1, Page(s) S508–9

Abstract: Mass disasters such as e.g., plane or train crash, shipping accidents or huge explosions in the region of Slovak Republic are not very often, but in spite of this fact sometimes they occur. Such a terrible event--a destructive detonation of non-specified ...

Abstract	Mass disasters such as e.g., plane or train crash, shipping accidents or huge explosions in the region of Slovak Republic are not very often, but in spite of this fact sometimes they occur. Such a terrible event--a destructive detonation of non-specified amount of explosives, happened on 2nd March 2007 in the Military Repairing Enterprise in Novaky, Slovak Republic, by which the whole enterprise was almost totally destroyed, many employees were injured and eight persons died due to consequences of the explosion. Investigation of this disaster took several months, and parts of dead bodies were found in following weeks during the ruins removal; authors describe the autopsy findings on the explosion victim's bodies and the possibilities of unknown human remains identification found in the area of the detonation often provided only by DNA analysis.
MeSH term(s)	Accidents, Aviation ; Adult ; Blast Injuries/pathology ; Explosions ; Female ; Forensic Pathology ; Humans ; Male ; Middle Aged ; Military Personnel ; Slovakia
Language	English
Publishing date	2009-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2009.02.066
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Article ; Online: Ritual suicide of a Japanese girl in the Slovak Republic.

Straka, L / Novomesky, F / Krajcovic, J / Macko, V

Legal medicine (Tokyo, Japan)

2009 Volume 11 Suppl 1, Page(s) S506–7

Abstract: The body of a young Japanese woman was found buried in the mass of snow in February 2006 near the town of Liptovsky Mikulas in the Slovak Republic. Hypothermia was declared as the cause of her death, the body of the deceased was deeply frozen. The ... ...

Abstract	The body of a young Japanese woman was found buried in the mass of snow in February 2006 near the town of Liptovsky Mikulas in the Slovak Republic. Hypothermia was declared as the cause of her death, the body of the deceased was deeply frozen. The autopsy and police investigation classified her death as a suicide, having some features of an Eastern Asian suicidal ritual. The case shows that the era of world globalization and migration of people bring together also the curious cases of human tragedies. Thus the forensic expert of nowadays must expect that s/he might be faced with cases of death unseen before.
MeSH term(s)	Anti-Anxiety Agents/blood ; Anti-Anxiety Agents/poisoning ; Central Nervous System Depressants/blood ; Ceremonial Behavior ; Ethanol/blood ; Female ; Forensic Medicine ; Humans ; Hypnotics and Sedatives/blood ; Hypnotics and Sedatives/poisoning ; Hypothermia/pathology ; Japan/ethnology ; Slovakia ; Suicide
Chemical Substances	Anti-Anxiety Agents ; Central Nervous System Depressants ; Hypnotics and Sedatives ; Ethanol (3K9958V90M)
Language	English
Publishing date	2009-04
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2009.02.059
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Article ; Online: Gravidity complicated by abdominal neoplastic process.

Krajcovic, J / Macko, V / Straka, L / Novomeský, F

Legal medicine (Tokyo, Japan)

2009 Volume 11 Suppl 1, Page(s) S494–5

Abstract: The case of 31-year-old pregnant woman in the 28th week of pregnancy is presented. She was brought in a bad condition to a small hospital by her parents. The case history of only 5 h included e.g. nausea, multiple emesis, cephalea, deteriorated ... ...

Abstract	The case of 31-year-old pregnant woman in the 28th week of pregnancy is presented. She was brought in a bad condition to a small hospital by her parents. The case history of only 5 h included e.g. nausea, multiple emesis, cephalea, deteriorated respiration. Shock status was diagnosed in the hospital intensive care unit. After the patient lost her consciousness, resuscitation, intubation and artificial ventilation breath control were realised immediately, the doses of 13 mg of adrenalin were applied.
MeSH term(s)	Adrenal Gland Neoplasms/pathology ; Adrenal Medulla/pathology ; Fatal Outcome ; Female ; Fetal Death ; Forensic Pathology ; Gravidity ; Humans ; Malpractice ; Pheochromocytoma/pathology ; Pregnancy ; Pregnancy Complications, Neoplastic/pathology ; Shock/etiology
Language	English
Publishing date	2009-04
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2009.01.110
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Article: Vrazda, samovrazda alebo náhodný úraz?

Straka, L / Novomeský, F / Stuller, F / Krajovic, J / Macko, V / Malachovský, I / Hamzík, J

Soudni lekarstvi

2011 Volume 56, Issue 2, Page(s) 21–23

Abstract: A forensic explanation of womandrinker's death is presented in the article. Exsanguination from multiple cut wounds was cause of death. Origin of wounds was unable to explain due to its atypical character and localisation on body surface. Only a ... ...

Title translation	Homicide, suicide or fatal accident?.
Abstract	A forensic explanation of womandrinker's death is presented in the article. Exsanguination from multiple cut wounds was cause of death. Origin of wounds was unable to explain due to its atypical character and localisation on body surface. Only a subsequent exact allocation of wounding object made clear biomechanical aspects of wounds. A hard ethanol alteration of psychical, senzorical et motorical functions with strong posttraumatic et toxometabolic changes of the body took share on mechanism of death.
MeSH term(s)	Accidents ; Female ; Forensic Pathology ; Homicide ; Humans ; Middle Aged ; Suicide ; Wounds and Injuries/pathology
Language	Slovak
Publishing date	2011-04
Publishing country	Czech Republic
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	138272-x
ISSN	0371-1854
ISSN	0371-1854
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Article: Molecular Features Affecting the Biological Activity of the Host-Selective Toxins from Cochliobolus victoriae.

Wolpert, T J / Macko, V / Acklin, W / Arigoni, D

Plant physiology

2006 Volume 88, Issue 1, Page(s) 37–41

Abstract: The structures of the toxins produced by Cochliobolus victoriae, victorin B, C, D, E, and victoricine, have recently been established. These toxins and modified forms of victorin C were tested for their effect on dark CO(2) fixation in susceptible oat ( ... ...

Abstract	The structures of the toxins produced by Cochliobolus victoriae, victorin B, C, D, E, and victoricine, have recently been established. These toxins and modified forms of victorin C were tested for their effect on dark CO(2) fixation in susceptible oat (Avena sativa) leaf slices. Half-maximal inhibition of dark CO(2) fixation occurred with the native toxins in the range of 0.004 to 0.546 micromolar. An essential component for the inhibitory activity of victorin is the glyoxylic acid residue, particularly its hydrated aldehyde group. Removal of glyoxylic acid completely abolished the inhibitory activity of victorin, and the reduction of the aldehydo group transformed the toxin into a protectant. Conversion of victorin to its methyl ester resulted in diminution of inhibitory activity to 10% of the original activity of the toxin, whereas derivatization of the epsilon-amino group of the beta-hydroxylysine moiety resulted in a decrease of inhibitory activity to 1% of that of victorin C. However, the derivatized toxin retained its host selectivity. In addition, the opening of the macrocyclic ring of the toxin drastically reduced the inhibitory activity.
Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.88.1.37
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Article: Tafonomické aspekty kadaveróznych zmien u mŕtvol ulozených do zeme v plastových obaloch.

Stuller, F / Straka, L / Macko, V / Krivos, D / Krajcovic, J / Novomeský, F

Soudni lekarstvi

2008 Volume 53, Issue 4, Page(s) 46–50

Abstract: The forensic expertise of the 6 human bodies, being murdered in organised crime activities, had been realised by the authors. All the cadavers were packed in plastic bags or plastic foils, then buried to the illegal graves, being prepared in advance. The ...

Title translation	The taphonomic aspects of cadaverous changes in corpses, buried in the plastic foils.
Abstract	The forensic expertise of the 6 human bodies, being murdered in organised crime activities, had been realised by the authors. All the cadavers were packed in plastic bags or plastic foils, then buried to the illegal graves, being prepared in advance. The detail overlook and autopsy of the bodies had disclosed, that due of almost airtight sealing of the cadavers in plastic materials, the postmortal cadaverous changes went on much slower and were manifested under a different picture, as seen in the human cadavers being buried in the standard wooden coffins. The authors point out the peculiarities of such a postmortal changes, with particular focusing on the estimation of postmortal period.
MeSH term(s)	Adult ; Burial ; Forensic Pathology ; Homicide ; Humans ; Male ; Middle Aged ; Plastics ; Postmortem Changes
Chemical Substances	Plastics
Language	Slovak
Publishing date	2008-10
Publishing country	Czech Republic
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	138272-x
ISSN	0371-1854
ISSN	0371-1854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 897: Show issues

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Article: Biological Activity of the Isomeric Forms of Helminthosporium sacchari Toxin and of Homologs Produced in Culture.

Duvick, J P / Daly, J M / Kratky, Z / Macko, V / Acklin, W / Arigoni, D

Plant physiology

2006 Volume 74, Issue 1, Page(s) 117–122

Abstract: The effect of Helminthosporium sacchari (HS) toxin isomers and related, pathogen-produced compounds on dark CO(2) fixation in HS-susceptible sugar cane leaf slices was investigated. HS toxin consists of a mixture of three isomeric bis-5-O-(beta- ... ...

Abstract	The effect of Helminthosporium sacchari (HS) toxin isomers and related, pathogen-produced compounds on dark CO(2) fixation in HS-susceptible sugar cane leaf slices was investigated. HS toxin consists of a mixture of three isomeric bis-5-O-(beta-galactofuranosyl)-beta-galactofuranosides (A, B, and C) differing in the position of one double bond in the sesquiterpene aglycone. Maximum inhibition of dark CO(2) fixation in susceptible sugar cane (CP52-68) occurred within 30 to 40 minutes, and amounts necessary to reach 50% inhibition values typically were approximately 1.7 micromolar for natural toxin mixture ( approximately 2:3:5 mixture of isomers A:B:C) and 4, 6, and 0.7 micromolar for isomers A, B, and C, respectively. Other fractions from cultures of the pathogen consist of comparable mixtures of sesquiterpene isomers but have only 1, 2, or 3 galactofuranose units (HS(1), HS(2), HS(3)) or two alpha-glucopyranose units as well as four beta-galactofuranose units (HS(6)). The lower toxin homologs were not toxic to clone CP52-68, but protected sugar cane from the effects of toxin. Minimum ratios of protectant: toxin giving 95% protection were approximately 50:1, 6:1, and 12:1 for HS(1), HS(2), and HS(3), respectively. HS(2) and HS(3) protected when added up to 12 minutes after toxin as well as when added with or before toxin. Some common plant galactopyranosides were not toxic and did not protect at 500:1 molar excess. The sample of HS(6) was toxic at 500 micromolar, and did not protect against HS toxin. With the availability of purified, homogeneous preparations of HS toxin, homologs, and chemically modified or synthetic analogs, the dark CO(2) fixation assay should prove to be a useful tool for understanding the mode of action of HS toxin.
Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.74.1.117
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Article: Specific binding of victorin to a 100-kDa protein from oats.

Wolpert, T J / Macko, V

Proceedings of the National Academy of Sciences of the United States of America

1989 Volume 86, Issue 11, Page(s) 4092–4096

Abstract: Susceptibility of oats to victoria blight, caused by the fungus Cochliobolus victoriae, and sensitivity to the host-specific toxin victorin, produced by the fungus, are controlled by the dominant allele at the Vb locus. It has been postulated that the Vb ...

Abstract	Susceptibility of oats to victoria blight, caused by the fungus Cochliobolus victoriae, and sensitivity to the host-specific toxin victorin, produced by the fungus, are controlled by the dominant allele at the Vb locus. It has been postulated that the Vb locus encodes a toxin receptor, although direct evidence for such a receptor is not available. Our recent studies on structure-activity relationships of the toxin established a methodology for producing (125)I-labeled victorin. Electrophoretic analysis of proteins from isogenic susceptible and resistant oat genotypes following treatment of leaves with radiolabeled victorin showed that victorin binds in a covalent and a genotype-specific manner to a 100-kDa protein only in susceptible oat leaf slices. This in vivo binding was competitively displaced by reduced victorin, a nontoxic protective compound, and appeared to be correlated with biological activity. In vitro binding to the 100-kDa protein in leaf extracts showed several differences from in vivo binding. Binding was not genotype specific and required a reducing agent that was not required for in vivo binding. Differential centrifugation showed that the 100-kDa victorin binding protein was not a cytosolic protein but was enriched in a high-speed particulate fraction. The data support the hypothesis that the 100-kDa protein is the victorin receptor.
Language	English
Publishing date	1989-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.86.11.4092
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Zs.A 1148: Show issues

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Book ; Online: AdaNet

Weill, Charles / Gonzalvo, Javier / Kuznetsov, Vitaly / Yang, Scott / Yak, Scott / Mazzawi, Hanna / Hotaj, Eugen / Jerfel, Ghassen / Macko, Vladimir / Adlam, Ben / Mohri, Mehryar / Cortes, Corinna

A Scalable and Flexible Framework for Automatically Learning Ensembles

2019

Abstract: AdaNet is a lightweight TensorFlow-based (Abadi et al., 2015) framework for automatically learning high-quality ensembles with minimal expert intervention. Our framework is inspired by the AdaNet algorithm (Cortes et al., 2017) which learns the structure ...

Abstract	AdaNet is a lightweight TensorFlow-based (Abadi et al., 2015) framework for automatically learning high-quality ensembles with minimal expert intervention. Our framework is inspired by the AdaNet algorithm (Cortes et al., 2017) which learns the structure of a neural network as an ensemble of subnetworks. We designed it to: (1) integrate with the existing TensorFlow ecosystem, (2) offer sensible default search spaces to perform well on novel datasets, (3) present a flexible API to utilize expert information when available, and (4) efficiently accelerate training with distributed CPU, GPU, and TPU hardware. The code is open-source and available at: https://github.com/tensorflow/adanet.
Keywords	Computer Science - Machine Learning ; Statistics - Machine Learning
Publishing date	2019-04-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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