Article ; Online: 5-Axis CNC Micromilling for Rapid, Cheap, and Background-Free NMR Microcoils.
2020 Volume 92, Issue 23, Page(s) 15454–15462
Abstract: The superior mass sensitivity of microcoil technology in nuclear magnetic resonance (NMR) spectroscopy provides potential for the analysis of extremely small-mass-limited samples such as eggs, cells, and tiny organisms. For optimal performance and ... ...
| Abstract | The superior mass sensitivity of microcoil technology in nuclear magnetic resonance (NMR) spectroscopy provides potential for the analysis of extremely small-mass-limited samples such as eggs, cells, and tiny organisms. For optimal performance and efficiency, the size of the microcoil should be tailored to the size of the mass-limited sample of interest, which can be costly as mass-limited samples come in many shapes and sizes. Therefore, rapid and economic microcoil production methods are needed. One method with great potential is 5-axis computer numerical control (CNC) micromilling, commonly used in the jewelry industry. Most CNC milling machines are designed to process larger objects and commonly have a precision of >25 μm (making the machining of common spiral microcoils, for example, impossible). Here, a 5-axis MiRA6 CNC milling machine, specifically designed for the jewelry industry, with a 0.3 μm precision was used to produce working planar microcoils, microstrips, and novel microsensor designs, with some tested on the NMR in less than 24 h after the start of the design process. Sample wells could be built into the microsensor and could be machined at the same time as the sensors themselves, in some cases leaving a sheet of Teflon as thin as 10 μm between the sample and the sensor. This provides the freedom to produce a wide array of designs and demonstrates 5-axis CNC micromilling as a versatile tool for the rapid prototyping of NMR microsensors. This approach allowed the experimental optimization of a prototype microstrip for the analysis of two intact adult |
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| MeSH term(s) | Animals ; Costs and Cost Analysis ; Daphnia/chemistry ; Equipment Design ; Magnetic Resonance Spectroscopy/economics ; Magnetic Resonance Spectroscopy/instrumentation ; Mechanical Phenomena ; Microtechnology/instrumentation ; Time Factors | |||||
| Language | English | |||||
| Publishing date | 2020-11-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1508-8 | |||||
| ISSN | 1520-6882 ; 0003-2700 | |||||
| ISSN (online) | 1520-6882 | |||||
| ISSN | 0003-2700 | |||||
| DOI | 10.1021/acs.analchem.0c03126 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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