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  1. AU="Maddi, Abhiram"
  2. AU="Rodríguez, Johanna G"
  3. AU="Frans, J"
  4. AU="Elisa Palazzari"

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  1. Artikel ; Online: Editorial: Fungal cell wall proteins with functions in cell wall biogenesis, cell wall signaling and interactions with host.

    Karkowska-Kuleta, Justyna / Maddi, Abhiram

    Frontiers in cellular and infection microbiology

    2022  Band 12, Seite(n) 1064386

    Mesh-Begriff(e) Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Cell Wall/metabolism ; Signal Transduction ; Biological Phenomena
    Chemische Substanzen Fungal Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1064386
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The relationship between periodontal and kidney disease: a critical review.

    Priyamvara, Aditi / Dey, Amit K / Maddi, Abhiram / Teich, Sorin

    Quintessence international (Berlin, Germany : 1985)

    2022  Band 53, Heft 9, Seite(n) 744–751

    Abstract: Periodontal disease has been associated with various systemic diseases including kidney disease. However, a causal relationship is yet to be established. One possible association is that periodontitis may cause an increased inflammatory response in ... ...

    Abstract Periodontal disease has been associated with various systemic diseases including kidney disease. However, a causal relationship is yet to be established. One possible association is that periodontitis may cause an increased inflammatory response in kidney disease patients which in turn destroys endothelial vasculature. This may contribute to development of risk factors of kidney disease such as diabetic neuropathy and cardiovascular events leading the progression and mortality in kidney disease patients. The role of periodontal inflammation driving kidney disease is still under investigation. This review article highlights the role of periodontal inflammation in the development and progression of kidney disease. It is crucial that dental practitioners and nephrologists understand the association between periodontal and kidney disease. Early periodontal screening and educating patients about the importance of good oral hygiene may play an important role in prevention of progression of kidney disease.
    Mesh-Begriff(e) Dentists ; Humans ; Inflammation ; Kidney Diseases/complications ; Periodontal Diseases/complications ; Periodontitis/complications ; Professional Role
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 7436-6
    ISSN 1936-7163 ; 0033-6572
    ISSN (online) 1936-7163
    ISSN 0033-6572
    DOI 10.3290/j.qi.b3320225
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  3. Artikel: Calcium Sulfate as Bone Replacement Graft in Management of Localized Aggressive Periodontitis: A One-year Follow-up Report.

    Maddi, Abhiram / Sabharwal, Amarpreet / Alqahtani, Nabeeh

    The New York state dental journal

    2018  Band 82, Heft 5, Seite(n) 37–41

    Abstract: We report a case of localized aggressive periodontitis (LAP), which occurred during fixed orthodontic treatment in a 16-year-old African-American female patient. Oral hygiene instruction, removal of orthodontic bands and nonsurgical periodontal therapy ... ...

    Abstract We report a case of localized aggressive periodontitis (LAP), which occurred during fixed orthodontic treatment in a 16-year-old African-American female patient. Oral hygiene instruction, removal of orthodontic bands and nonsurgical periodontal therapy were followed by surgical treatment of multiple sites using calcium sulfate as a synthetic bone graft material and collagen membrane as a barrier to achieve guided tissue regeneration. One-year follow-up of the case demonstrated that use of calcium sulfate as a synthetic bone substitute may provide favorable outcome in LAP patients. Furthermore, LAP patients undergoing orthodontic treatment can be managed successfully without tooth morbidity.
    Mesh-Begriff(e) Adolescent ; Aggressive Periodontitis/surgery ; Bone Substitutes ; Calcium Sulfate ; Female ; Follow-Up Studies ; Humans ; Time Factors
    Chemische Substanzen Bone Substitutes ; Calcium Sulfate (WAT0DDB505)
    Sprache Englisch
    Erscheinungsdatum 2018-12-04
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 415686-9
    ISSN 0028-7571
    ISSN 0028-7571
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  4. Artikel: Candidal carriage in saliva and subgingival plaque among smokers and non-smokers with chronic periodontitis-a cross-sectional study.

    Santhana Krishnan, Gayathri / Naik, Dilip / Uppoor, Ashita / Nayak, Sangeeta / Baliga, Shrikala / Maddi, Abhiram

    PeerJ

    2020  Band 8, Seite(n) e8441

    Abstract: Background and objectives: Studies of gum or periodontal disease have focused mainly on bacterial pathogens. However, information related to fungal species in the saliva and subgingival mileu is particularly lacking in smokers with periodontitis. This ... ...

    Abstract Background and objectives: Studies of gum or periodontal disease have focused mainly on bacterial pathogens. However, information related to fungal species in the saliva and subgingival mileu is particularly lacking in smokers with periodontitis. This cross-sectional study compared the prevalence of various
    Methodology: Study subjects were recruited into three group-Group 1: Smokers with chronic periodontitis (
    Results: Prevalence of
    Conclusion: Based on the results we can conclude that oral candidal carriage is significantly increased in smokers with periodontal disease. Mechanistic studies are needed to understand the importance of
    Sprache Englisch
    Erscheinungsdatum 2020-01-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.8441
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  5. Artikel ; Online: Knowledge, attitude and oral care practices for preventing ventilator-associated pneumonia among critical care nurses - A questionnaire study.

    Mannava, Yamini / Nayak, Sangeeta Umesh / Uppoor, Ashita / Naik, Dilip / Maddi, Abhiram

    Indian journal of dental research : official publication of Indian Society for Dental Research

    2020  Band 31, Heft 3, Seite(n) 426–432

    Abstract: Background: A cross-sectional study was conducted among intensive care unit (ICU) nurses in private hospitals in India to identify knowledge and practice of ICU nurses in the prevention of ventilator-associated pneumonia (VAP).: Methods: Knowledge of ...

    Abstract Background: A cross-sectional study was conducted among intensive care unit (ICU) nurses in private hospitals in India to identify knowledge and practice of ICU nurses in the prevention of ventilator-associated pneumonia (VAP).
    Methods: Knowledge of 135 nurses working in ICU was tested using a questionnaire consisting of 18 questions. Fourteen forms were excluded from the statistical analysis due to incomplete data entry by the participants. The data of 121 filled questionnaires were analyzed. The information letters, consent forms, and questionnaires were handed to ICU nurses by Research assistant. Data were coded and entered into SPSS version for descriptive and inferential statistics.
    Results: A majority of the participants perceived oral care as a necessity in all critically ill patients. Nurses were generally aware of the most likely mechanism of acquiring pneumonia. The type and frequency of oral care varied widely. Many of them stated that they had adequate supplies to provide oral care. Although a majority of nurses had some formal training in oral care, they would appreciate an opportunity to enhance and improve their knowledge and skills.
    Conclusion: The methods of oral care provided vary widely. In summary, randomized controlled trial to date has demonstrated that tooth brushing is associated with a trend toward lower rates of VAP in intubated mechanically ventilated critically ill patients. But it is also to be noted that there was no clear difference between electric and manual tooth brushing. In-house training and workshop can provide required skills needed for the betterment of the treatment provided.
    Mesh-Begriff(e) Critical Care ; Cross-Sectional Studies ; Humans ; India ; Pneumonia, Ventilator-Associated ; Respiration, Artificial ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2020-08-08
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 1354886-4
    ISSN 1998-3603 ; 0970-9290
    ISSN (online) 1998-3603
    ISSN 0970-9290
    DOI 10.4103/ijdr.IJDR_611_16
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Treponema denticola stimulates Oncostatin M cytokine release and de novo synthesis in neutrophils and macrophages.

    Jones, Megan M / Vanyo, Stephen T / Ibraheem, Wael / Maddi, Abhiram / Visser, Michelle B

    Journal of leukocyte biology

    2020  Band 108, Heft 5, Seite(n) 1527–1541

    Abstract: Oncostatin M (OSM) is a pleiotropic cytokine elevated in a number of inflammatory conditions including periodontal disease. OSM is produced by a variety of immune cells and has diverse functionality such as regulation of metabolic processes, cell ... ...

    Abstract Oncostatin M (OSM) is a pleiotropic cytokine elevated in a number of inflammatory conditions including periodontal disease. OSM is produced by a variety of immune cells and has diverse functionality such as regulation of metabolic processes, cell differentiation, and the inflammatory response to bacterial pathogens. The oral cavity is under constant immune surveillance including complementary neutrophil and macrophage populations, due to a persistent symbiotic bacterial presence. Periodontal disease is characterized by a dysbiotic bacterial community, with an abundance of Treponema denticola. Despite strong associations with severe periodontal disease, the source and mechanism of the release of OSM have not been defined in the oral cavity. We show that OSM protein is elevated in the gingival epithelium and immune cell infiltrate during periodontal disease. Furthermore, salivary and oral neutrophil OSM is elevated in correlation with the presence of T. denticola. In an air pouch infection model, T. denticola stimulated higher levels of OSM than the oral pathogen Porphorymonas gingivalis, despite differential recruitment of innate immune cells suggesting T. denticola has distinct properties to elevate OSM levels. OSM release and transcription were increased in isolated human blood, oral neutrophils, or macrophages exposed to T. denticola in vitro as measured by ELISA, qPCR, and microscopy. Using transcription, translation, and actin polymerization inhibition, we found that T. denticola stimulates both OSM release through degranulation and de novo synthesis in neutrophils and also OSM release and synthesis in macrophages. Differential induction of OSM by T. denticola may promote clinical periodontal disease.
    Mesh-Begriff(e) Adult ; Aged ; Female ; Humans ; Macrophages/immunology ; Male ; Middle Aged ; Neutrophils/immunology ; Oncostatin M/immunology ; Treponema denticola/immunology ; Treponemal Infections/immunology
    Chemische Substanzen OSM protein, human ; Oncostatin M (106956-32-5)
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4MA0620-072RR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Oral biofilms, oral and periodontal infections, and systemic disease.

    Maddi, Abhiram / Scannapieco, Frank A

    American journal of dentistry

    2013  Band 26, Heft 5, Seite(n) 249–254

    Abstract: Purpose: Oral biofilms harbor several hundreds of species of bacteria as well as spirochetes, protozoa, fungi and viruses. The composition of the oral biofilm varies from health to disease. It is the source of microorganisms that cause dental and ... ...

    Abstract Purpose: Oral biofilms harbor several hundreds of species of bacteria as well as spirochetes, protozoa, fungi and viruses. The composition of the oral biofilm varies from health to disease. It is the source of microorganisms that cause dental and periodontal infections. Oral infections and periodontal disease have been implicated in the etiopathogenesis of several important chronic systemic diseases.
    Mesh-Begriff(e) Bacteria/classification ; Bacteria/pathogenicity ; Bacterial Infections/physiopathology ; Biofilms ; Chronic Disease ; Disease ; Humans ; Microbial Consortia/physiology ; Mouth/microbiology ; Periodontal Diseases/microbiology
    Sprache Englisch
    Erscheinungsdatum 2013-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 645142-1
    ISSN 0894-8275
    ISSN 0894-8275
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  8. Artikel: The microbiome and lung cancer.

    Maddi, Abhiram / Sabharwal, Amarpreet / Violante, Timothy / Manuballa, Sunita / Genco, Robert / Patnaik, Santosh / Yendamuri, Sai

    Journal of thoracic disease

    2019  Band 11, Heft 1, Seite(n) 280–291

    Abstract: It has become increasingly clear that we live in a symbiotic relationship with microbes within us. We are just beginning to unravel the nature and strength of this relationship and its impact on both physiology and by extension, pathology. While ... ...

    Abstract It has become increasingly clear that we live in a symbiotic relationship with microbes within us. We are just beginning to unravel the nature and strength of this relationship and its impact on both physiology and by extension, pathology. While microorganisms have long been known to have carcinogenic potential, their role may have been underestimated. The knowledge of the role of the microbiome in carcinogenesis is rapidly evolving. This evolution has reached a tipping point with current omics technologies used for cataloguing the microbiome. The lung is an organ constantly exposed to the environment. It is now clear that the lung has a distinct microbiome and that this may influence the development of lung cancer. In addition, evidence suggests that this microbiome originates from the oral microbiome. This review summarizes current knowledge about the role of microbiome, especially the oral and lung microbiome in human lung cancer. The goal of the manuscript is to provide a summary of this rapidly evolving field while providing a context of the general role of the microbiome in carcinogenesis. In addition, a primer of the current technology used in evaluating the microbiome is provided to familiarize the practicing clinician with the experimental methods used to generate the information that will likely impact the field of lung cancer.
    Sprache Englisch
    Erscheinungsdatum 2019-03-07
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.12.88
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Management of Gingival Overgrowth in a Cardiac Transplant Patient Using Laser-Assisted Gingivectomy/Gingivoplasty.

    Maddi, Abhiram / Alluri, Leela Subhashini / Ciancio, Sebastian G

    Journal of the International Academy of Periodontology

    2015  Band 17, Heft 3, Seite(n) 77–81

    Abstract: Drug-induced gingival overgrowth (DIGO) is an oral clinical manifestation associated with certain medications such as immunosuppressants that are administered to organ transplant patients to prevent graft rejection. In patients with cardiac transplants, ... ...

    Abstract Drug-induced gingival overgrowth (DIGO) is an oral clinical manifestation associated with certain medications such as immunosuppressants that are administered to organ transplant patients to prevent graft rejection. In patients with cardiac transplants, management of DIGO is critical. In such patients, plaque biofilm accumulation at the gingival interface might be detrimental as it may lead to transient bacteremia as well as systemic inflammation resulting in thromboembolic events. This case report describes the management of DIGO in a cardiac transplant recipient by change of immunosuppressant medication, non-surgical periodontal therapy and laser-assisted gingivectomy.
    Mesh-Begriff(e) Adult ; Cyclosporine/adverse effects ; Dental Scaling/methods ; Follow-Up Studies ; Gingival Overgrowth/chemically induced ; Gingival Overgrowth/surgery ; Gingivectomy/methods ; Gingivoplasty/methods ; Heart Transplantation ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Laser Therapy/methods ; Lasers, Semiconductor/therapeutic use ; Male ; Oral Hygiene/education ; Root Planing/methods ; Sirolimus/therapeutic use
    Chemische Substanzen Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Sirolimus (W36ZG6FT64)
    Sprache Englisch
    Erscheinungsdatum 2015-07
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2146303-7
    ISSN 2518-3745 ; 1466-2094
    ISSN (online) 2518-3745
    ISSN 1466-2094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Functions of

    Mancuso, Ryan / Chinnici, Jennifer / Tsou, Charlene / Busarajan, Sujay / Munnangi, Raveena / Maddi, Abhiram

    PeerJ

    2018  Band 6, Seite(n) e5685

    Abstract: Background: Candida albicans: Methods: C. albicans : Results: Analysis of the heterologous mutants indicated that Dfg5p is more important for growth while Dcw1p appeared to play a role in cell wall integrity response. The conditional double mutant ...

    Abstract Background: Candida albicans
    Methods: C. albicans
    Results: Analysis of the heterologous mutants indicated that Dfg5p is more important for growth while Dcw1p appeared to play a role in cell wall integrity response. The conditional double mutant was observed to be less resistant to cell wall stress. However, growth of the mutants was similar under control and osmotic stress conditions. The mutants were also able to grow similar to wild type under heat stress. Biofilm formation was reduced in the mutants where
    Conclusions: These data indicate that
    Sprache Englisch
    Erscheinungsdatum 2018-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.5685
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