Article ; Online: Supply and demand: Cellular nutrient uptake and exchange in cancer.
2021 Volume 81, Issue 18, Page(s) 3731–3748
Abstract: Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells have developed multiple strategies to secure the necessary nutrients that fuel their metabolic needs. This is more evident upon disruption of homeostasis in ... ...
Abstract | Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells have developed multiple strategies to secure the necessary nutrients that fuel their metabolic needs. This is more evident upon disruption of homeostasis in conditions such as cancer, when cells display high proliferation rates in energetically challenging conditions where nutritional sources may be scarce. Here, we summarize the main routes of nutrient acquisition that fuel mammalian cells and their implications in tumorigenesis. We argue that the molecular mechanisms of nutrient acquisition not only tip the balance between nutrient supply and demand but also determine cell behavior upon nutrient limitation and energetic stress and contribute to nutrient partitioning and metabolic coordination between different cell types in inflamed or tumorigenic environments. |
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MeSH term(s) | ATP-Binding Cassette Transporters/metabolism ; Animals ; Biological Transport/physiology ; Carcinogenesis/metabolism ; Cell Membrane/metabolism ; Homeostasis/physiology ; Humans ; Membrane Transport Proteins/metabolism ; Neoplasms/metabolism ; Nutrients/metabolism ; Solute Carrier Proteins/metabolism |
Chemical Substances | ATP-Binding Cassette Transporters ; Membrane Transport Proteins ; Solute Carrier Proteins |
Language | English |
Publishing date | 2021-09-20 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 1415236-8 |
ISSN | 1097-4164 ; 1097-2765 |
ISSN (online) | 1097-4164 |
ISSN | 1097-2765 |
DOI | 10.1016/j.molcel.2021.08.026 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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