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  1. Artikel ; Online: Développement de résistances chez les animaux alors que l’antibiotique ne leur a pas été administré.

    Madec, Jean-Yves

    Comptes rendus biologies

    2024  Band 346, Heft S1, Seite(n) 9–12

    Abstract: The fight against antibiotic resistance in the animal sector over the last ten years in France (Ecoantibio plans) has largely focused on reducing the veterinary use of antibiotics. However, antibiotic resistance in an animal is not necessarily due to ... ...

    Titelübersetzung Development of antibiotic resistance in animals not receiving antibiotic therapy.
    Abstract The fight against antibiotic resistance in the animal sector over the last ten years in France (Ecoantibio plans) has largely focused on reducing the veterinary use of antibiotics. However, antibiotic resistance in an animal is not necessarily due to antibiotic therapy, but can also result from the transmission of resistant bacteria or resistance plasmids. Several examples illustrate the importance of this transmission of antibiotic resistance in the animal world, which are detailed in this communication. Like in human medicine, this nosocomial transmission can be observed in veterinary care institutions, as well as in animal husbandry. It also explains the presence of antibiotic resistance on the surface of foodstuffs, which by definition are not treated with antibiotics. At the international level, countries that are very virtuous in their use of veterinary antibiotics can display high levels of antibiotic resistance through the importation of carrier animals. Finally, the presence of antibiotic resistance in wildlife is likewise explained by contamination and not by antibiotic treatment. All these situations demonstrate that, in addition to paying attention to antibiotic prescription, an equally important facet of the fight against antibiotic resistance is to control the transmission routes of resistant bacteria.
    Mesh-Begriff(e) Animals ; Humans ; Drug Resistance, Microbial ; Animal Husbandry ; Bacteria ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; France
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Französisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland France
    Dokumenttyp Review
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.116
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: L’antibiorésistance, un enjeu transversal (One Health).

    Madec, Jean-Yves

    Revue de l'infirmiere

    2023  Band 72, Heft 294, Seite(n) 24–26

    Abstract: Antibiotic resistance is a public health issue that must be tackled within the One Health concept. This means continuing efforts to coordinate the action plans of the various ministries, on the one hand, and gaining a better understanding (from a ... ...

    Titelübersetzung Antibiotic resistance, a cross-functional issue (One Health).
    Abstract Antibiotic resistance is a public health issue that must be tackled within the One Health concept. This means continuing efforts to coordinate the action plans of the various ministries, on the one hand, and gaining a better understanding (from a scientific point of view) of the key points in the passage of antibiotic resistance between two sectors, on the other. This article shows how human medicine, veterinary medicine and the environment are affected by this issue.
    Mesh-Begriff(e) Humans ; One Health ; Drug Resistance, Microbial ; Public Health ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Französisch
    Erscheinungsdatum 2023-09-29
    Erscheinungsland France
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2023.08.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Antibiothérapie en médecine vétérinaire : quelle évaluation ?

    Madec, Jean-Yves

    La Revue du praticien

    2020  Band 70, Heft 4, Seite(n) 355–359

    Titelübersetzung The use of antimicrobials in veterinary medicine: where are we?
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Humans
    Chemische Substanzen Anti-Bacterial Agents ; Anti-Infective Agents
    Sprache Französisch
    Erscheinungsdatum 2020-09-02
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Colistin: from the shadows to a One Health approach for addressing antimicrobial resistance

    Rhouma, Mohamed / Madec, Jean-Yves / Laxminarayan, Ramanan

    International Journal of Antimicrobial Agents. 2023 Feb., v. 61, no. 2 p.106713-

    2023  

    Abstract: Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria. However, colistin resistance has ... ...

    Abstract Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria. However, colistin resistance has been reported in various Enterobacteriaceae species isolated from several sources. The 2015 discovery of the plasmid-mediated mcr-1 (mobile colistin resistance) gene conferring resistance to colistin was a major concern within the scientific community worldwide. The global spread of this plasmid – as well as the subsequent identification of 10 MCR-family genes and their variants that catalyse the addition of phosphoethanolamine to the phosphate group of lipid A – underscores the urgent need to regulate the use of colistin, particularly in animal production. This review traces the history of colistin resistance and mcr-like gene identification, and examines the impact of policy changes regarding the use of colistin on the prevalence of mcr-1-positive Escherichia coli and colistin-resistant E. coli from a One Health perspective. The withdrawal of colistin as a livestock growth promoter in several countries reduced the prevalence of colistin-resistant bacteria and its resistance determinants (e.g. mcr-1 gene) in farm animals, humans and the environment. This reduction was certainly favoured by the significant fitness cost associated with acquisition and expression of the mcr-1 gene in enterobacterial species. The success of this One Health intervention could be used to accelerate regulation of other important antimicrobials, especially those associated with bacterial resistance mechanisms linked to high fitness cost. The development of global collaborations and the implementation of sustainable solutions like the One Health approach are essential to manage AMR.
    Schlagwörter Escherichia coli ; One Health initiative ; animal production ; antibiotic resistance ; colistin ; environmental health ; farms ; genes ; growth promotion ; humans ; issues and policy ; lipid A ; livestock ; multiple drug resistance ; phosphates ; plasmids ; Antimicrobial resistance ; mcr-1 ; One Health ; Policy interventions
    Sprache Englisch
    Erscheinungsverlauf 2023-02
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106713
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Colistin: from the shadows to a One Health approach for addressing antimicrobial resistance.

    Rhouma, Mohamed / Madec, Jean-Yves / Laxminarayan, Ramanan

    International journal of antimicrobial agents

    2023  Band 61, Heft 2, Seite(n) 106713

    Abstract: Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria. However, colistin resistance has ... ...

    Abstract Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria. However, colistin resistance has been reported in various Enterobacteriaceae species isolated from several sources. The 2015 discovery of the plasmid-mediated mcr-1 (mobile colistin resistance) gene conferring resistance to colistin was a major concern within the scientific community worldwide. The global spread of this plasmid - as well as the subsequent identification of 10 MCR-family genes and their variants that catalyse the addition of phosphoethanolamine to the phosphate group of lipid A - underscores the urgent need to regulate the use of colistin, particularly in animal production. This review traces the history of colistin resistance and mcr-like gene identification, and examines the impact of policy changes regarding the use of colistin on the prevalence of mcr-1-positive Escherichia coli and colistin-resistant E. coli from a One Health perspective. The withdrawal of colistin as a livestock growth promoter in several countries reduced the prevalence of colistin-resistant bacteria and its resistance determinants (e.g. mcr-1 gene) in farm animals, humans and the environment. This reduction was certainly favoured by the significant fitness cost associated with acquisition and expression of the mcr-1 gene in enterobacterial species. The success of this One Health intervention could be used to accelerate regulation of other important antimicrobials, especially those associated with bacterial resistance mechanisms linked to high fitness cost. The development of global collaborations and the implementation of sustainable solutions like the One Health approach are essential to manage AMR.
    Mesh-Begriff(e) Animals ; Humans ; Colistin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; One Health ; Drug Resistance, Bacterial/genetics ; Enterobacteriaceae/genetics ; Escherichia coli Proteins/genetics ; Plasmids/genetics
    Chemische Substanzen Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Escherichia coli Proteins ; MCR-1 protein, E coli
    Sprache Englisch
    Erscheinungsdatum 2023-01-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106713
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Is methicillin-susceptible Staphylococcus aureus (MSSA) CC398 a true animal-independent pathogen?

    Tegegne, Henok Ayalew / Madec, Jean-Yves / Haenni, Marisa

    Journal of global antimicrobial resistance

    2022  Band 29, Seite(n) 120–123

    Abstract: Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) belonging to ST398 has been widely described in animals. In parallel, methicillin-susceptible (MSSA) ST398 isolates causing severe infections in humans have recently emerged as animal- ... ...

    Abstract Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) belonging to ST398 has been widely described in animals. In parallel, methicillin-susceptible (MSSA) ST398 isolates causing severe infections in humans have recently emerged as animal-independent pathogens. This study aimed at characterising MSSA CC398 from different animal species in France in comparison with MSSA CC398 genomes, mostly of human origin.
    Methods: CC398 were detected by clone-specific PCR. Antimicrobial susceptibility testing was performed using the disk diffusion method. Whole genome sequencing (WGS) was performed on 47 MRSA and MSSA isolates, of which spa-types as well as resistance and virulence genes were extracted. A maximum likelihood phylogenetic tree based on SNPs was performed on all sequenced isolates and 51 additional MRSA and MSSA data found on publicly available databases.
    Results: From 275 MSSA isolates studied, 28 (10.18%) belonged to the CC398 lineage (26 ST398 and two single-locus variants) and mainly originated from cats (n=12/44, 27.3%) and dogs (n=8/55, 14.6%). Five different spa-types were identified, t571 (n=18, 64.3%) and t1451 (n=5, 17.9%) being the most frequent ones. Out of the 28 MSSA isolates, 26 carried the scn gene, whereas 24 carried the erm(T) gene, and all were genetically similar to human isolates.
    Conclusion: This study challenges the current scientific opinion that human infections due to MSSA CC398 should only be considered an animal-independent issue.
    Mesh-Begriff(e) Animals ; Cats ; Dogs ; France ; Humans ; Methicillin ; Phylogeny ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/classification ; Staphylococcus aureus/isolation & purification
    Chemische Substanzen Methicillin (Q91FH1328A)
    Sprache Englisch
    Erscheinungsdatum 2022-03-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.02.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Unexpected role of pig nostrils in the clonal and plasmidic dissemination of extended-spectrum beta-lactamase-producing Escherichia coli at farm level.

    Martínez-Álvarez, Sandra / Châtre, Pierre / François, Pauline / Abdullahi, Idris Nasir / Simón, Carmen / Zarazaga, Myriam / Madec, Jean-Yves / Haenni, Marisa / Torres, Carmen

    Ecotoxicology and environmental safety

    2024  Band 273, Seite(n) 116145

    Abstract: The presence of methicillin-resistant or -susceptible S. aureus in pig nostrils has been known for a long time, but the occurrence of extended-spectrum beta-lactamase (ESBL)-producing E. coli has hardly been investigated. Here, we collected 25 E. coli ... ...

    Abstract The presence of methicillin-resistant or -susceptible S. aureus in pig nostrils has been known for a long time, but the occurrence of extended-spectrum beta-lactamase (ESBL)-producing E. coli has hardly been investigated. Here, we collected 25 E. coli recovered from nasal samples of 40 pigs/10 farmers of four farms. Nine ESBL-producing isolates belonging to ST48, ST117, ST847, ST5440, ST14914 and ST10 were retrieved from seven pigs. All bla
    Mesh-Begriff(e) Animals ; Swine ; Escherichia coli/genetics ; Farms ; Staphylococcus aureus/genetics ; beta-Lactamases/genetics ; Plasmids/genetics ; Anti-Bacterial Agents/pharmacology ; Escherichia coli Infections/veterinary
    Chemische Substanzen beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2024-03-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116145
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Spread of the

    Treilles, Michaël / Châtre, Pierre / Drapeau, Antoine / Madec, Jean-Yves / Haenni, Marisa

    Frontiers in microbiology

    2023  Band 13, Seite(n) 1023403

    Abstract: Introduction: Colistin-resistance widely disseminated in food-producing animals due to decades of colistin use to treat diarrhea. The plasmid-borne : Methods: We looked for colistin-resistant isolates presenting plasmid-borne genes of the mcr family ... ...

    Abstract Introduction: Colistin-resistance widely disseminated in food-producing animals due to decades of colistin use to treat diarrhea. The plasmid-borne
    Methods: We looked for colistin-resistant isolates presenting plasmid-borne genes of the mcr family in both breeding (
    Results: Only the
    Discussion: Our results show that the
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1023403
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: High throughput qPCR analyses suggest that Enterobacterales of French sheep and cow cheese rarely carry genes conferring resistances to critically important antibiotics for human medicine

    Delannoy, Sabine / Hoffer, Corine / Nguyễn, Quang Ân / Madec, Jean-Yves / Brisabois, Anne / Fach, Patrick / Haenni, Marisa

    International Journal of Food Microbiology. 2023 Oct., v. 403 p.110303-

    2023  

    Abstract: Bacteria present in raw milk can carry acquired or intrinsic antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs). However, only a few studies have evaluated raw milk cheese as a potential reservoir of ARGs. This study thus aimed at ... ...

    Abstract Bacteria present in raw milk can carry acquired or intrinsic antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs). However, only a few studies have evaluated raw milk cheese as a potential reservoir of ARGs. This study thus aimed at providing new data regarding resistance markers present in raw milk cheese. Sheep (n = 360) and cow (n = 360) cheese samples produced in France were incubated in buffered peptone water supplemented with acriflavin or novobiocin; as corroborated by 16S metabarcoding, samples were enriched in Gram-negative bacteria since Escherichia coli and Hafnia alvei respectively accounted for 40 % and 20 % of the samples' microbiota. Screening of the samples for the presence of 30 ARGs and 16 MGEs by high throughput qPCR array showed that nine ARGs conferring resistances to 1st-generation beta-lactams, aminoglycosides, trimethoprim/sulfonamides and tetracyclines occurred in >75 % of both sheep and cow samples. This is neither surprising nor alarming since these resistance genes are widely spread across the One Health human, animal and environmental sectors. Conversely, genes conferring resistances to last-generations cephalosporins were rarely identified, while those conferring resistances to carbapenems or amikacin, which are restricted to human use, were never detected. Multiple MGEs were detected, the most frequent ones being IncF plasmids, confirming the potential transmission of ARGs. Our results are in line with the few studies of the resistome of milk or milk cheese showing that genes conferring resistances to 1st-generation beta-lactams, aminoglycosides and tetracyclines families are widespread, while those conferring resistances to critically important antibiotics are rare or absent.
    Schlagwörter DNA barcoding ; Escherichia coli ; Hafnia alvei ; amikacin ; antibiotic resistance ; antibiotic resistance genes ; carbapenems ; cephalosporins ; cheeses ; cows ; food microbiology ; humans ; medicine ; microorganisms ; milk ; novobiocin ; peptones ; plasmids ; raw milk ; sheep ; trimethoprim ; France ; Resistome ; Raw milk cheese ; Dairy products ; Antimicrobial resistance genes ; Enterobacterales ; High-throughput qPCR ; Metabarcoding
    Sprache Englisch
    Erscheinungsverlauf 2023-10
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2023.110303
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Antimicrobial resistance plasmid reservoir in food and food-producing animals.

    Madec, Jean-Yves / Haenni, Marisa

    Plasmid

    2018  Band 99, Seite(n) 72–81

    Abstract: Antimicrobial resistance (AMR) plasmids have been recognized as important vectors for efficient spread of AMR phenotypes. The food reservoir includes both food-producing animals and food products, and a huge diversity of AMR plasmids have been reported ... ...

    Abstract Antimicrobial resistance (AMR) plasmids have been recognized as important vectors for efficient spread of AMR phenotypes. The food reservoir includes both food-producing animals and food products, and a huge diversity of AMR plasmids have been reported in this sector. Based on molecular typing methods and/or whole genome sequencing approaches, certain AMR genes/plasmids combinations were found more frequently in food compared to other settings. However, the food source of a definite AMR plasmid is highly complex to confirm due to cross-sectorial transfers and international spread of AMR plasmids. For risk assessment purposes related to human health, AMR plasmids found in food and bearing genes conferring resistances to critically important antibiotics in human medicine - such as to extended-spectrum cephalosporins, carbapenems or colistin - have been under specific scrutiny these last years. Those plasmids are often multidrug resistant and their dissemination can be driven by the selective pressure exerted by any of the antibiotics concerned. Also, AMR plasmids carry numerous other genes conferring vital properties to the bacterial cell and are recurrently subjected to evolutionary steps such as hybrid plasmids, making the epidemiology of AMR plasmids in food a moving picture.
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/genetics ; Food Microbiology ; Humans ; Plasmids/genetics
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2018-09-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 282384-6
    ISSN 1095-9890 ; 0147-619X
    ISSN (online) 1095-9890
    ISSN 0147-619X
    DOI 10.1016/j.plasmid.2018.09.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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