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Article ; Online: Some preliminary remarks on the impact of COVID-19 on the exercise of religious freedom in the United States and Italy

Madera, Adelaide

2020

Abstract: The so-called lockdown, imposed to restrain (or at least limit) the spread of COVID-19, has, in the over four seemingly endless months since it started, had an overwhelming impact not only on our personal lives, but also on domestic regulatory frameworks. ...

Abstract	The so-called lockdown, imposed to restrain (or at least limit) the spread of COVID-19, has, in the over four seemingly endless months since it started, had an overwhelming impact not only on our personal lives, but also on domestic regulatory frameworks. Legal systems responded individually, and with differences to the pandemic emergency, ranging from a complete interruption of the collective exercise of religious worship (Italy), to a more cautious recognition of forms of religious accommodation (United States). The present paper compares the impact of COVID-19 restrictions on the exercise of religious freedom in the United States and the Italian legal contexts, and investigates how the pandemic crisis emphasized underlying judicial, political, sociocultural, and economic challenges, giving rise to a tension between competing rights and exacerbating concerns about the “special” role of religion. As the COVID situation is changing so rapidly in the United States, in Italy, and around the world, I clarify that the information in the present paper relates at the situation as at the end of June 2020.
Keywords	Religious worship - Pandemic emergency - Special role of religion ; covid19
Subject code	290
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Some preliminary remarks on the impact of COVID-19 on the exercise of religious freedom in the United States and Italy

Madera , Adelaide

Stato, Chiese e pluralismo confessionale; 2020: 21 settembre ; 1971-8543

2020

Abstract: Summary: 1. Introduction - 2. Italian legal responses to COVID-19: the Italian constitutional and legal framework on religious freedom - 3. The suspension of religious assemblies during phase one of the pandemic - 4. A “cautious resumption” of religious ... ...

Abstract	Summary: 1. Introduction - 2. Italian legal responses to COVID-19: the Italian constitutional and legal framework on religious freedom - 3. The suspension of religious assemblies during phase one of the pandemic - 4. A “cautious resumption” of religious gatherings during the phase two in Italy - 5. U.S. legal responses to COVID-19: U.S. constitutional and legal framework about religious freedom - 6. The legal patchwork because of the pandemic - 7. Judicial balance between individual liberties and the preservation of health - 8. Litigation in lower courts about the exercise of religious freedom during Covid-19 - 9 New creative ways of worshipping in Covid-19 times: drive-in religious services - 10. Third-party burdens and the successful nondiscrimination approach - 11. Department of Justice statements - 12 Supreme Court intervention in temporary state restrictions on religious assemblies - 13. “Religious America” and “secular” Italy during Covid-19 phase one - 14. Management of religious freedom during the pandemic and the lack or presence of a statute governing religious freedom - 15. Effect of the pandemic on the question of whose religious freedom should be protected - 16. Guaranteeing a fair level of religious accommodation during a pandemic - 17. Enhanced need to balance the exercise of religious freedom with third-party harm during a pandemic - 18. Impact of the pandemic on the exercise of religious freedom in the long term. ABSTRACT: The so-called lockdown, imposed to restrain (or at least limit) the spread of COVID-19, has, in the over four seemingly endless months since it started, had an overwhelming impact not only on our personal lives, but also on domestic regulatory frameworks. Legal systems responded individually, and with differences to the pandemic emergency, ranging from a complete interruption of the collective exercise of religious worship (Italy), to a more cautious recognition of forms of religious accommodation (United States). The present paper compares the impact of COVID-19 restrictions on the exercise of religious freedom in the United States and the Italian legal contexts, and investigates how the pandemic crisis emphasized underlying judicial, political, sociocultural, and economic challenges, giving rise to a tension between competing rights and exacerbating concerns about the “special” role of religion. As the COVID situation is changing so rapidly in the United States, in Italy, and around the world, I clarify that the information in the present paper relates at the situation as at the end of June 2020.
Keywords	covid19
Language	Italian
Publishing date	2020-09-21
Publisher	Università degli Studi di Milano
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic review shows that suction-based airway clearance devices for foreign body airway obstruction are promising.

Parri, Niccolò / Madera, Anna / D'Aiuto, Francesca / Zampogna, Stefania / Milani, Gregorio Paolo

Acta paediatrica (Oslo, Norway : 1992)

2024

Language	English
Publishing date	2024-04-02
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17229
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Article: Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus.

Morgens, David W / Gulyas, Leah / Rivera-Madera, Alejandro / Souza, Annabelle S / Glaunsinger, Britt A

bioRxiv : the preprint server for biology

2023

Abstract: Gene regulation in eukaryotes relies on many mechanisms for optimal expression, including both protein transcription factors and DNA regulatory elements. CRISPR-based screens of both protein coding genes and non-coding regions have allowed identification ...

Abstract	Gene regulation in eukaryotes relies on many mechanisms for optimal expression, including both protein transcription factors and DNA regulatory elements. CRISPR-based screens of both protein coding genes and non-coding regions have allowed identification of these transcriptional networks in human cells. Double-stranded DNA viruses also invoke human-like regulation to control transcription of viral genes that are required at different stages of the viral lifecycle. Here, we applied CRISPR-based tools to dissect regulation of a viral gene at high resolution in the oncogenic human herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV), whose compact, densely encoded genome provides unique challenges and opportunities for studying transcriptional networks. Through a combination of CRISPR-interference (CRISPRi) and Cas9 nuclease screening, we mapped a novel regulatory network comprised of coding and noncoding elements that influence expression of the essential KSHV protein ORF68 at early and late stages of the viral lifecycle. ORF68 encodes an essential protein involved in packaging the replicated viral DNA into nascent capsids. Although ORF68 expression initiates early in the viral lifecycle, we found that it is primarily required at later times. This work demonstrates the ability to exhaustively identify features controlling a given locus, capturing a complete viral regulatory circuit that functions within the human nucleus to control transcription.
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.08.548212
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Article ; Online: Association of juvenile idiopathic arthritis and morphea: a case series.

Giani, Teresa / Madera, Anna / Cimaz, Rolando

Clinical rheumatology

2019 Volume 39, Issue 4, Page(s) 1341–1345

Abstract: The association of different autoimmune diseases in the same subject is not uncommon, also in the pediatric age. The coexistence of morphea and juvenile idiopathic arthritis (JIA) is however exceptional. We report four such cases. Unlike the few other ... ...

Abstract	The association of different autoimmune diseases in the same subject is not uncommon, also in the pediatric age. The coexistence of morphea and juvenile idiopathic arthritis (JIA) is however exceptional. We report four such cases. Unlike the few other reported cases, in 3/4 of our patients, morphea appeared well after the onset of JIA, when the articular disease was in full clinical remission. Based on the epidemiology of pediatric morphea in the general population, this association is unlikely to be fortuitous. Pediatric rheumatologists should be aware of this possible association, and follow clinically patients who achieve long-term clinical remission. Key Points ⦁ Morphea is an unusual occurrence in the context of JIA. These conditions have a common autoimmune background, but are very rarely reported together. ⦁ It is important to follow JIA patients even during long-term remission since other autoimmune phenomena can occur.
MeSH term(s)	Arthritis, Juvenile/complications ; Arthritis, Juvenile/diagnosis ; Child ; Child, Preschool ; Female ; Humans ; Male ; Remission Induction ; Scleroderma, Localized/complications ; Scleroderma, Localized/diagnosis
Language	English
Publishing date	2019-12-14
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-019-04850-5
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Article ; Online: Diversity, equity, and inclusion (DEI) in medical education: DEI at the bedside.

Jellins, Tennyson S / Borko, Tyler L / Otero-Bell, RayLee / Arnett, Kelly / Saunders, Scott / Poisson, Sharon N / Orjuela, Karen D / Salehi Omran, Setareh / Jones, William J / Leppert, Michelle / Madera, Ashley / Carlson, Aaron / Pastula, Daniel M / Sauer, Brian M / Piquet, Amanda L / Gonzales, Nicole R

Journal of the neurological sciences

2024 Volume 459, Page(s) 122946

Abstract: Background: The ability to recognize and address bias is an important communication skill not typically addressed during training. We describe the design of an educational curriculum that aims to identify and change behavior related to diversity, equity, ...

Abstract	Background: The ability to recognize and address bias is an important communication skill not typically addressed during training. We describe the design of an educational curriculum that aims to identify and change behavior related to diversity, equity, and inclusion (DEI). "DEI at the Bedside" uses the existing infrastructure of bedside teaching and provides a tool to normalize DEI discussions and develop skills to address bias during a neurology inpatient rotation. Methods: As part of traditional clinical rounds, team members on an inpatient service shared experiences with DEI topics, including bias. The team developed potential responses should they encounter a similar situation in the future. We report the results of our needs assessment and curriculum development to evaluate the feasibility of incorporating a DEI educational curriculum in the neurology inpatient setting. Results: Forty-two DEI experiences were recorded. Medical students were the most frequent discussants (44%). Direction of bias occurred between healthcare team members (33%), against patients (31%), and patients against healthcare team members (28%). Experiences ranged from microaggressions to explicit comments of racism, sexism, and homophobia. Conclusions: Based on needs assessment data, we developed a DEI educational curriculum for the inpatient neurology setting aimed to improve knowledge and skills related to DEI topics as well as to normalize conversation of DEI in the clinical setting. Additional study will demonstrate whether this initiative translates into measurable and sustained improvement in knowledge of how bias and disparity show up in the clinical setting and behavioral intent to discuss and address them.
MeSH term(s)	Humans ; Diversity, Equity, Inclusion ; Education, Medical ; Inpatients ; Communication ; Neurology
Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2024.122946
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Article: Prioritizing Cardiovascular Disease-Associated Variants Altering NKX2-5 Binding through an Integrative Computational Approach.

Peña-Martínez, Edwin G / Pomales-Matos, Diego A / Rivera-Madera, Alejandro / Messon-Bird, Jean L / Medina-Feliciano, Joshua G / Sanabria-Alberto, Leandro / Barreiro-Rosario, Adriana C / Rodriguez-Rios, Jessica M / Rodríguez-Martínez, José A

medRxiv : the preprint server for health sciences

2023

Abstract: Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are heavily influenced by genetic factors. Genome-wide association studies (GWAS) have mapped > 90% of CVD-associated variants within the non-coding genome, which can alter the ... ...

Abstract	Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are heavily influenced by genetic factors. Genome-wide association studies (GWAS) have mapped > 90% of CVD-associated variants within the non-coding genome, which can alter the function of regulatory proteins, like transcription factors (TFs). However, due to the overwhelming number of GWAS single nucleotide polymorphisms (SNPs) (>500,000), prioritizing variants for in vitro analysis remains challenging. In this work, we implemented a computational approach that considers support vector machine (SVM)-based TF binding site classification and cardiac expression quantitative trait loci (eQTL) analysis to identify and prioritize potential CVD-causing SNPs. We identified 1,535 CVD-associated SNPs that occur within human heart footprints/enhancers and 9,309 variants in linkage disequilibrium (LD) with differential gene expression profiles in cardiac tissue. Using hiPSC-CM ChIP-seq data from NKX2-5 and TBX5, two cardiac TFs essential for proper heart development, we trained a large-scale gapped k-mer SVM (LS-GKM-SVM) predictive model that can identify binding sites altered by CVD-associated SNPs. The computational predictive model was tested by scoring human heart footprints and enhancers in vitro through electrophoretic mobility shift assay (EMSA). Three variants (rs59310144, rs6715570, and rs61872084) were prioritized for in vitro validation based on their eQTL in cardiac tissue and LS-GKM-SVM prediction to alter NKX2-5 DNA binding. All three variants altered NKX2-5 DNA binding. In summary, we present a bioinformatic approach that considers tissue-specific eQTL analysis and SVM-based TF binding site classification to prioritize CVD-associated variants for in vitro experimental analysis.
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.01.23294951
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Article ; Online: Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity.

Peña-Martínez, Edwin G / Rivera-Madera, Alejandro / Pomales-Matos, Diego A / Sanabria-Alberto, Leandro / Rosario-Cañuelas, Brittany M / Rodríguez-Ríos, Jessica M / Carrasquillo-Dones, Emanuel A / Rodríguez-Martínez, José A

Biochimica et biophysica acta. Gene regulatory mechanisms

2023 Volume 1866, Issue 1, Page(s) 194906

Abstract: Genome-wide association studies (GWAS) have mapped over 90 % of disease- or trait-associated variants within the non-coding genome, like cis-regulatory elements (CREs). Non-coding single nucleotide polymorphisms (SNPs) are genomic variants that can ... ...

Abstract	Genome-wide association studies (GWAS) have mapped over 90 % of disease- or trait-associated variants within the non-coding genome, like cis-regulatory elements (CREs). Non-coding single nucleotide polymorphisms (SNPs) are genomic variants that can change how DNA-binding regulatory proteins, like transcription factors (TFs), interact with the genome and regulate gene expression. NKX2-5 is a TF essential for proper heart development, and mutations affecting its function have been associated with congenital heart diseases (CHDs). However, establishing a causal mechanism between non-coding genomic variants and human disease remains challenging. To address this challenge, we identified 8475 SNPs predicted to alter NKX2-5 DNA-binding using a position weight matrix (PWM)-based predictive model. Five variants were prioritized for in vitro validation; four of them are associated with traits and diseases that impact cardiovascular health. The impact of these variants on NKX2-5 binding was evaluated with electrophoretic mobility shift assay (EMSA) using purified recombinant NKX2-5 homeodomain. Binding curves were constructed to determine changes in binding between variant and reference alleles. Variants rs7350789, rs7719885, rs747334, and rs3892630 increased binding affinity, whereas rs61216514 decreased binding by NKX2-5 when compared to the reference genome. Our findings suggest that differential TF-DNA binding affinity can be key in establishing a causal mechanism of pathogenic variants.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA-Binding Proteins/metabolism ; Regulatory Sequences, Nucleic Acid ; DNA/genetics ; Homeobox Protein Nkx-2.5/genetics
Chemical Substances	Transcription Factors ; DNA-Binding Proteins ; DNA (9007-49-2) ; NKX2-5 protein, human ; Homeobox Protein Nkx-2.5
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2918786-2
ISSN	1876-4320 ; 1874-9399
ISSN (online)	1876-4320
ISSN	1874-9399
DOI	10.1016/j.bbagrm.2023.194906
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Article: System hierarchical modelling

Madera, Alexander

Logistics and supply chain management: modern trends in Germany and Russia , p. 153-159

optimization of logistics systems

2009 , Page(s) 153–159

Author's details	Alexander Madera
Keywords	Logistik ; Operations Research
Language	Russian
Size	graph. Darst.
Publisher	Cuvillier
Publishing place	Göttingen
Document type	Article
Note	Text in kyrill. Schr., russ. ; Zsfassung in engl. Sprache
Database	ECONomics Information System

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Article ; Online: Lessons from the large-scale incident of animal feed contamination with dioxins in Germany in 2011

Zentek, J. / Knorr, F. / Mader, A.

2014

Keywords	Text ; studies ; study ; Food ; food safety ; Safety
Language	English
Publishing date	2014-02-28
Publishing country	de
Document type	Article ; Online
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