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  1. Article ; Online: Vaccine Distrust: A Predictable Response to Structural Racism and an Inadequate Public Health Infrastructure.

    Madorsky, Toni Z / Adebayo, Nihmotallahi A / Post, Sharon L / O'Brian, Catherine A / Simon, Melissa A

    American journal of public health

    2021  Volume 111, Issue S3, Page(s) S185–S188

    MeSH term(s) Humans ; Public Health Administration ; Racism ; Trust ; United States ; Vaccination Refusal/psychology ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-10-02
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2021.306411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Underrepresented Minority (URM) physician exploitation exacerbated by the COVID-19 pandemic: Implications to URM physician-faculty burnout and worsening health disparities.

    Adebayo, Nihmotallahi A / Madorsky, Toni Z / Alhalel, Jonathan / Post, Sharon L / O'Brian, Catherine A / Simon, Melissa A

    Harvard public health review (Cambridge, Mass.)

    2021  Volume 30

    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article
    ISSN 2643-6450
    ISSN (online) 2643-6450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach.

    Meyer, Anne R / Engevik, Amy C / Madorsky, Toni / Belmont, Erika / Stier, Matthew T / Norlander, Allison E / Pilkinton, Mark A / McDonnell, Wyatt J / Weis, Jared A / Jang, Bogun / Mallal, Simon A / Peebles, R Stokes / Goldenring, James R

    Gastroenterology

    2020  Volume 159, Issue 6, Page(s) 2077–2091.e8

    Abstract: Background & aims: Severe injury to the lining of the stomach leads to changes in the epithelium (reprogramming) that protect and promote repair of the tissue, including development of spasmolytic polypeptide-expressing metaplasia (SPEM) and tuft and ... ...

    Abstract Background & aims: Severe injury to the lining of the stomach leads to changes in the epithelium (reprogramming) that protect and promote repair of the tissue, including development of spasmolytic polypeptide-expressing metaplasia (SPEM) and tuft and foveolar cell hyperplasia. Acute gastric damage elicits a type-2 inflammatory response that includes production of type-2 cytokines and infiltration by eosinophils and alternatively activated macrophages. Stomachs of mice that lack interleukin 33 (IL33) or interleukin 13 (IL13) did not undergo epithelial reprogramming after drug-induced injury. We investigated the role of group 2 innate lymphoid cells (ILC2s) in gastric epithelial repair.
    Methods: Acute gastric injury was induced in C57BL/6J mice (wild-type and RAG1 knockout) by administration of L635. We isolated ILC2s by flow cytometry from stomachs of mice that were and were not given L635 and performed single-cell RNA sequencing. ILC2s were depleted from wild-type and RAG1-knockout mice by administration of anti-CD90.2. We assessed gastric cell lineages, markers of metaplasia, inflammation, and proliferation. Gastric tissue microarrays from patients with gastric adenocarcinoma were analyzed by immunostaining.
    Results: There was a significant increase in the number of GATA3-positive ILC2s in stomach tissues from wild-type mice after L635-induced damage, but not in stomach tissues from IL33-knockout mice. We characterized a marker signature of gastric mucosal ILC2s and identified a transcription profile of metaplasia-associated ILC2s, which included changes in expression of Il5, Il13, Csf2, Pd1, and Ramp3; these changes were validated by quantitative polymerase chain reaction and immunocytochemistry. Depletion of ILC2s from mice blocked development of metaplasia after L635-induced injury in wild-type and RAG1-knockout mice and prevented foveolar and tuft cell hyperplasia and infiltration or activation of macrophages after injury. Numbers of ILC2s were increased in stomach tissues from patients with SPEM compared with patients with normal corpus mucosa.
    Conclusions: In analyses of stomach tissues from mice with gastric tissue damage and patients with SPEM, we found evidence of type 2 inflammation and increased numbers of ILC2s. Our results suggest that ILC2s coordinate the metaplastic response to severe gastric injury.
    MeSH term(s) Animals ; Disease Models, Animal ; Gastric Mucosa/drug effects ; Gastric Mucosa/immunology ; Gastric Mucosa/pathology ; Humans ; Immunity, Innate ; Interleukin-33/genetics ; Lymphocyte Subsets/immunology ; Metaplasia/chemically induced ; Metaplasia/genetics ; Metaplasia/immunology ; Mice ; Mice, Knockout
    Chemical Substances Il33 protein, mouse ; Interleukin-33
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.08.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 572: Show issues

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