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  1. Article: Regards croisés sur le rôle d'un service de stomatologie et de médecine dentaire à Lausanne et ...ailleurs.

    Madrid, C

    Revue medicale suisse

    2012  Volume 8, Issue 364, Page(s) 2292–2293

    Title translation Perspectives on the role of a stomatology and dentistry service in Lausanne and... elsewhere.
    MeSH term(s) Dental Health Services/organization & administration ; Dentistry/organization & administration ; Humans ; Oral Medicine/organization & administration ; Switzerland
    Language French
    Publishing date 2012-11-28
    Publishing country Switzerland
    Document type Interview
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans.

    Dhusia, Kalyani / Madrid, Carlos / Su, Zhaoqian / Wu, Yinghao

    Journal of proteome research

    2022  Volume 21, Issue 2, Page(s) 349–359

    Abstract: The interactions between ectodomains of cell surface proteins are vital players in many important cellular processes, such as regulating immune responses, coordinating cell differentiation, and shaping neural plasticity. However, while the construction ... ...

    Abstract The interactions between ectodomains of cell surface proteins are vital players in many important cellular processes, such as regulating immune responses, coordinating cell differentiation, and shaping neural plasticity. However, while the construction of a large-scale protein interactome has been greatly facilitated by the development of high-throughput experimental techniques, little progress has been made to support the discovery of extracellular interactome for cell surface proteins. Harnessed by the recent advances in computational modeling of protein-protein interactions, here we present a structure-based online database for the extracellular interactome of cell surface proteins in humans, called EXCESP. The database contains both experimentally determined and computationally predicted interactions among all type-I transmembrane proteins in humans. All structural models for these interactions and their binding affinities were further computationally modeled. Moreover, information such as expression levels of each protein in different cell types and its relation to various signaling pathways from other online resources has also been integrated into the database. In summary, the database serves as a valuable addition to the existing online resources for the study of cell surface proteins. It can contribute to the understanding of the functions of cell surface proteins in the era of systems biology.
    MeSH term(s) Computational Biology/methods ; Humans ; Membrane Proteins/genetics ; Protein Interaction Mapping/methods ; Signal Transduction ; Systems Biology
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.1c00612
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  3. Article ; Online: Change in triggered EMG thresholds for thoracic pedicle screws caused by pneumothorax during surgery for adolescent idiopathic scoliosis. Report of two cases.

    Madrid, C / Gómez-Rice, A / Cordón, S / Sanz-Barbero, E / Zúñiga, L

    Revista espanola de cirugia ortopedica y traumatologia (English ed.)

    2021  

    Abstract: Posterior spinal instrumentation and fusion with pedicle screws inserted by free-hand technique and controlled by multimodal intraoperative monitoring is the most common technique in adolescent idiopathic scoliosis surgery. Pneumothorax is a described ... ...

    Title translation Alteración en los umbrales de estimulación de tornillos pediculares torácicos secundaria a neumotórax en cirugía por escoliosis idiopática del adolescente. A propósito de dos casos.
    Abstract Posterior spinal instrumentation and fusion with pedicle screws inserted by free-hand technique and controlled by multimodal intraoperative monitoring is the most common technique in adolescent idiopathic scoliosis surgery. Pneumothorax is a described complication of this kind of procedure. Triggered electromyography is used to identify pedicle wall breakthrough and prevent neurological injuries. We report 2 clinical cases in which unilateral decrease in triggered electromyography values associate with ipsilateral pneumothorax. Postoperative chest radiographs need to be done in order to diagnose a pneumothorax. However, routinely performing a chest radiograph has been questioned because of the low incidence of this surgical complication. As a result of the association described in this article, we consider that when a unilateral decrease in triggered electromyography values is detected, a hidden pneumothorax should be suspected and ruled out.
    Language Spanish
    Publishing date 2021-05-31
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-576X
    ISSN (online) 2173-576X
    DOI 10.1016/j.recot.2020.09.007
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  4. Article: Corrigendum: Temperature Dependent Control of the R27 Conjugative Plasmid Genes.

    Gibert, Marta / Paytubi, Sonia / Madrid, Cristina / Balsalobre, Carlos

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 723430

    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.723430
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  5. Article: Temperature Dependent Control of the R27 Conjugative Plasmid Genes.

    Gibert, Marta / Paytubi, Sonia / Madrid, Cristina / Balsalobre, Carlos

    Frontiers in molecular biosciences

    2020  Volume 7, Page(s) 124

    Abstract: Conjugation of R27 plasmid is thermoregulated, being promoted at 25°C and repressed at 37°C. Previous studies identified plasmid-encoded regulators, HtdA, TrhR and TrhY, that control expression of conjugation-related genes ( ...

    Abstract Conjugation of R27 plasmid is thermoregulated, being promoted at 25°C and repressed at 37°C. Previous studies identified plasmid-encoded regulators, HtdA, TrhR and TrhY, that control expression of conjugation-related genes (
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2020.00124
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  6. Article ; Online: Unusual cause at an unusual time-Powassan virus rhombencephalitis.

    Dumic, Igor / Madrid, Cristian / Vitorovic, Danilo

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 103, Page(s) 88–90

    Abstract: Powassan virus lineage II (POWV) is an emerging tick-borne neurotropic pathogen, transmitted to humans by the bite of infected Ixodes scapularis ticks. In the United States, the disease is most prevalent in the Northeast and the upper Midwest and occurs ... ...

    Abstract Powassan virus lineage II (POWV) is an emerging tick-borne neurotropic pathogen, transmitted to humans by the bite of infected Ixodes scapularis ticks. In the United States, the disease is most prevalent in the Northeast and the upper Midwest and occurs mostly during the spring and summer months when tick activity is the highest. Some patients infected with POWV develop severe encephalitis, with high mortality. We report the case of a 42-year-old healthy man who developed progressive diplopia and dysarthria in December following a deer hunting trip. Routine blood work was unrevealing and MRI was normal. Extensive work-up for infectious, autoimmune, and paraneoplastic causes was positive only for POWV. The patient was treated with supportive care and intravenous corticosteroids, with an excellent outcome. We present a rare clinical presentation of a potentially fatal emerging disease that responded favorably to corticosteroids.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Encephalitis Viruses, Tick-Borne/isolation & purification ; Encephalitis, Tick-Borne/diagnosis ; Encephalitis, Tick-Borne/diagnostic imaging ; Encephalitis, Tick-Borne/drug therapy ; Encephalitis, Tick-Borne/virology ; Humans ; Magnetic Resonance Imaging ; Male ; Rhombencephalon ; United States
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2020-11-20
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.11.159
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    Zs.A 4516: Show issues Location:
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  7. Article: Clinical Manifestations of Leukocytoclastic Vasculitis, Treatment, and Outcome in Patients with Ulcerative Colitis: A Systematic Review of the Literature.

    Pantic, Ivana / Jevtic, Djordje / Nordstrom, Charles W / Madrid, Cristian / Milovanovic, Tamara / Dumic, Igor

    Journal of clinical medicine

    2022  Volume 11, Issue 3

    Abstract: Leukocytoclastic vasculitis (LCV) is a rare extraintestinal manifestation (EIM) of ulcerative colitis (UC). Observations about its association with UC stem from case reports and small case series. Due to its rarity, more rigorous cross-sectional studies ... ...

    Abstract Leukocytoclastic vasculitis (LCV) is a rare extraintestinal manifestation (EIM) of ulcerative colitis (UC). Observations about its association with UC stem from case reports and small case series. Due to its rarity, more rigorous cross-sectional studies are scarce and difficult to conduct. The aim of this systematic review was to synthetize the knowledge on this association by reviewing published literature in the form of both case reports and case series; and report the findings according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In contrast to LCV in Chron disease (CD), which occurs secondary to biologic therapies used for its treatment, LCV in UC is a true reactive skin manifestation. Both genders are equally affected. Palpable purpura (41%) and erythematous plaques (27%) are the most common clinical manifestations. In 41% of patients, the rash is painful, and the lower extremities are most commonly involved (73%). Systemic symptoms such as fever, arthralgias, fatigue, and malaise are seen in 60% of patients. Unlike previous reports, we found that LCV more commonly occurs after the UC diagnosis (59%), and 68% of patients have active intestinal disease at the time of LCV diagnosis. Antineutrophil cytoplasmic antibody (ANCA) is positive in 41% of patients, and 36% of patients have other EIMs present concomitantly with LCV. The majority of patients were treated with corticosteroids (77%), and two (10%) required colectomy to control UC and LCV symptoms. Aside from one patient who died from unrelated causes, all others survived with their rash typically resolving without scarring (82%).
    Language English
    Publishing date 2022-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11030739
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  8. Article: In Situ Monitoring and Quantitative Determination of R27 Plasmid Conjugation.

    Gibert, Marta / Jiménez, Carlos J / Comas, Jaume / Zechner, Ellen L / Madrid, Cristina / Balsalobre, Carlos

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 8

    Abstract: Horizontal gene transfer (HGT) by plasmid conjugation is a major driving force in the spread of antibiotic resistance ... ...

    Abstract Horizontal gene transfer (HGT) by plasmid conjugation is a major driving force in the spread of antibiotic resistance among
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12081212
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  9. Article ; Online: Fístula colopericárdica tras cirugía de reemplazo esofágico: reporte de caso y revisión bibliográfica.

    Rosière, N I / Madrid, C / Mendoza, M / Martínez, A / Bellia Munzón, G

    Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica

    2019  Volume 32, Issue 3, Page(s) 150–153

    Abstract: Introduction: Colopericardial fistula is a rare complication of colonic replacement surgery whose incidence is unknown. Therefore, we present the following case and perform a literature review.: Clinical case: 17-year-old female patient of age ... ...

    Title translation Colopericardial fistula after esophageal replacement surgery: case report and literature review.
    Abstract Introduction: Colopericardial fistula is a rare complication of colonic replacement surgery whose incidence is unknown. Therefore, we present the following case and perform a literature review.
    Clinical case: 17-year-old female patient of age consults for respiratory distress and precordial pain of 5 days of evolution. Background: Long gap esophageal atresia (esophagostoma and feeding gastrostomy, subsequent colonic graft). Bilateral pneumonia is initially diagnosed. It rapidly evolves to a state of sepsis. On chest x-ray, pneumopericardium is observed. Water-soluble contrasted study confirms diagnosis of colopericardial fistula. Surgical treatment is established, despite this the patient dies due to respiratory distress.
    Comment: Colopericardial fistula is a very serious entity with a high mortality rate. The clinical presentation and the complementary methods of diagnostic confirmation must be known in order to carry out the appropriate treatment.
    MeSH term(s) Adolescent ; Colonic Diseases/diagnosis ; Colonic Diseases/etiology ; Colonic Diseases/surgery ; Esophageal Atresia/surgery ; Esophagus/surgery ; Fatal Outcome ; Female ; Fistula/diagnosis ; Fistula/etiology ; Fistula/surgery ; Gastrostomy/methods ; Humans ; Pneumopericardium/diagnostic imaging ; Postoperative Complications/diagnosis
    Language Spanish
    Publishing date 2019-07-29
    Publishing country Spain
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1214833-7
    ISSN 2445-2807 ; 0214-1221
    ISSN (online) 2445-2807
    ISSN 0214-1221
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    Zs.A 4152: Show issues Location:
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  10. Article ; Online: Expression of accessory genes in Salmonella requires the presence of the Gre factors.

    Gaviria-Cantin, Tania / Fernández-Coll, Llorenç / Vargas, Andrés Felipe / Jiménez, Carlos Jonay / Madrid, Cristina / Balsalobre, Carlos

    Genomics

    2023  Volume 116, Issue 1, Page(s) 110777

    Abstract: Genomic studies with Salmonella enterica serovar Typhimurium reveal a crucial role of horizontal gene transfer (HGT) in the acquisition of accessory cellular functions involved in host-interaction. Many virulence genes are located in genomic islands, ... ...

    Abstract Genomic studies with Salmonella enterica serovar Typhimurium reveal a crucial role of horizontal gene transfer (HGT) in the acquisition of accessory cellular functions involved in host-interaction. Many virulence genes are located in genomic islands, plasmids and prophages. GreA and GreB proteins, Gre factors, interact transiently with the RNA polymerase alleviating backtracked complexes during transcription elongation. The overall effect of Gre factors depletion in Salmonella expression profile was studied. Both proteins are functionally redundant since only when both Gre factors were depleted a major effect in gene expression was detected. Remarkably, the accessory gene pool is particularly sensitive to the lack of Gre factors, with 18.6% of accessory genes stimulated by the Gre factors versus 4.4% of core genome genes. Gre factors involvement is particularly relevant for the expression of genes located in genomic islands. Our data reveal that Gre factors are required for the expression of accessory genes.
    MeSH term(s) Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Plasmids ; Virulence/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2023.110777
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