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  1. AU="Maeda, Hiroki"
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  1. Artikel ; Online: Post-embolization syndrome-like symptoms due to shedding of necrotic material of hepatocellular carcinoma into the bile duct following transcatheter arterial chemoembolization: an instructive case.

    Kobori, Ikuhiro / Masaoka, Rion / Maeda, Hiroki / Hayakawa, Fuki / Kusano, Yumi / Kino, Hitoshi / Fujii, Akiko / Soga, Koichi / Katayama, Yasumi / Tamano, Masaya

    Clinical journal of gastroenterology

    2024  

    Abstract: Fever, abdominal pain, and liver dysfunction are almost inevitable complications of transcatheter arterial chemo embolization (TACE) for hepatocellular carcinoma, but these symptoms may also be due to bile duct obstruction caused by shedding of necrotic ... ...

    Abstract Fever, abdominal pain, and liver dysfunction are almost inevitable complications of transcatheter arterial chemo embolization (TACE) for hepatocellular carcinoma, but these symptoms may also be due to bile duct obstruction caused by shedding of necrotic tumor material into the bile duct. A 68-year-old man presented with persistent fever, liver dysfunction, and abdominal pain after TACE. Computed tomography revealed stone-like hyperdensities in the bile duct. Endoscopic retrograde cholangiopancreatography revealed these structures to be necrotic material from hepatocellular carcinoma. We believe this is an instructive case of an often overlooked situation.
    Sprache Englisch
    Erscheinungsdatum 2024-03-02
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-024-01932-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition

    Tamaoki, Junya / Maeda, Hiroki / Kobayashi, Isao / Takeuchi, Miki / Ohashi, Ken / Gore, Aniket / Bonkhofer, Florian / Patient, Roger / Weinstein, Brant M. / Kobayashi, M.

    Elsevier Inc. Developmental Biology. 2023 Sept., v. 501 p.92-103

    2023  

    Abstract: During embryonic development, primitive and definitive waves of hematopoiesis take place to provide proper blood cells for each developmental stage, with the possible involvement of epigenetic factors. We previously found that lysine-specific demethylase ...

    Abstract During embryonic development, primitive and definitive waves of hematopoiesis take place to provide proper blood cells for each developmental stage, with the possible involvement of epigenetic factors. We previously found that lysine-specific demethylase 1 (LSD1/KDM1A) promotes primitive hematopoietic differentiation by shutting down the gene expression program of hemangioblasts in an Etv2/Etsrp-dependent manner. In the present study, we demonstrated that zebrafish LSD1 also plays important roles in definitive hematopoiesis in the development of hematopoietic stem and progenitor cells. A combination of genetic approaches and imaging analyses allowed us to show that LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Analysis of compound mutant lines with Etv2/Etsrp mutant zebrafish revealed that, unlike in primitive hematopoiesis, this function of LSD1 was independent of Etv2/Etsrp. The phenotype of LSD1 mutant zebrafish during the endothelial-to-hematopoietic transition was similar to that of previously reported compound knockout mice of Gfi1/Gfi1b, which forms a complex with LSD1 and represses endothelial genes. Moreover, co-knockdown of zebrafish Gfi1/Gfi1b genes inhibited the development of hematopoietic stem and progenitor cells. We therefore hypothesize that the shutdown of the Gfi1/Gfi1b-target genes during the endothelial-to-hematopoietic transition is one of the key evolutionarily conserved functions of LSD1 in definitive hematopoiesis.
    Schlagwörter Danio rerio ; blood ; blood flow ; embryogenesis ; epigenetics ; gene expression ; hematopoiesis ; mutants ; phenotype ; Definitive hematopoiesis ; Endothelial-to-hematopoietic transition ; Etv2/etsrp ; Gfi1/Gfi1b ; Hematopoietic stem and progenitor cells ; LSD1/KDM1A ; Zebrafish ; CHT ; DA ; ESCs ; Etv2 ; Gfi1 ; HSPCs ; LSD1 ; PCV
    Sprache Englisch
    Erscheinungsverlauf 2023-09
    Umfang p. 92-103.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel ; Online
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2023.06.012
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition.

    Tamaoki, Junya / Maeda, Hiroki / Kobayashi, Isao / Takeuchi, Miki / Ohashi, Ken / Gore, Aniket / Bonkhofer, Florian / Patient, Roger / Weinstein, Brant M / Kobayashi, Makoto

    Developmental biology

    2023  Band 501, Seite(n) 92–103

    Abstract: During embryonic development, primitive and definitive waves of hematopoiesis take place to provide proper blood cells for each developmental stage, with the possible involvement of epigenetic factors. We previously found that lysine-specific demethylase ...

    Abstract During embryonic development, primitive and definitive waves of hematopoiesis take place to provide proper blood cells for each developmental stage, with the possible involvement of epigenetic factors. We previously found that lysine-specific demethylase 1 (LSD1/KDM1A) promotes primitive hematopoietic differentiation by shutting down the gene expression program of hemangioblasts in an Etv2/Etsrp-dependent manner. In the present study, we demonstrated that zebrafish LSD1 also plays important roles in definitive hematopoiesis in the development of hematopoietic stem and progenitor cells. A combination of genetic approaches and imaging analyses allowed us to show that LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Analysis of compound mutant lines with Etv2/Etsrp mutant zebrafish revealed that, unlike in primitive hematopoiesis, this function of LSD1 was independent of Etv2/Etsrp. The phenotype of LSD1 mutant zebrafish during the endothelial-to-hematopoietic transition was similar to that of previously reported compound knockout mice of Gfi1/Gfi1b, which forms a complex with LSD1 and represses endothelial genes. Moreover, co-knockdown of zebrafish Gfi1/Gfi1b genes inhibited the development of hematopoietic stem and progenitor cells. We therefore hypothesize that the shutdown of the Gfi1/Gfi1b-target genes during the endothelial-to-hematopoietic transition is one of the key evolutionarily conserved functions of LSD1 in definitive hematopoiesis.
    Mesh-Begriff(e) Animals ; Mice ; Cell Differentiation ; Hematopoiesis/genetics ; Histone Demethylases/genetics ; Stem Cells/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zebrafish
    Chemische Substanzen Histone Demethylases (EC 1.14.11.-) ; Transcription Factors ; KDM1A protein, zebrafish (EC 1.14.11.-)
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2023.06.012
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  4. Artikel ; Online: Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.

    Homma, Tomoyuki / Nagata, Noriyo / Hashimoto, Masayuki / Iwata-Yoshikawa, Naoko / Seki, Naomi M / Shiwa-Sudo, Nozomi / Ainai, Akira / Dohi, Keiji / Nikaido, Eiji / Mukai, Akiko / Ukai, Yuuta / Nakagawa, Takayuki / Shimo, Yusuke / Maeda, Hiroki / Shirai, Seiki / Aoki, Miwa / Sonoyama, Takuhiro / Sato, Mamoru / Fumoto, Masataka /
    Nagira, Morio / Nakata, Fumihisa / Hashiguchi, Takao / Suzuki, Tadaki / Omoto, Shinya / Hasegawa, Hideki

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 2599

    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52772-3
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  5. Artikel ; Online: Congenital anaemia associated with loss-of-function variants in DNA polymerase epsilon 1.

    Takeuchi, Ichiro / Tanase-Nakao, Kanako / Ogawa, Ayame / Sugawara, Tohru / Migita, Osuke / Kashima, Makoto / Yamazaki, Touko / Iguchi, Akihiro / Naiki, Yasuhiro / Uchiyama, Toru / Tamaoki, Junya / Maeda, Hiroki / Shimizu, Hirotaka / Kawai, Toshinao / Taniguchi, Kosuke / Hirata, Hiromi / Kobayashi, Makoto / Matsumoto, Kimikazu / Naruse, Kiyoshi /
    Hata, Kenichiro / Akutsu, Hidenori / Kato, Takashi / Narumi, Satoshi / Arai, Katsuhiro / Ishiguro, Akira

    Journal of medical genetics

    2024  Band 61, Heft 3, Seite(n) 239–243

    Abstract: DNA polymerase epsilon (Pol ε), a component of the core replisome, is involved in DNA replication. Although genetic defects of Pol ε have been reported to cause immunodeficiency syndromes, its role in haematopoiesis remains unknown. Here, we identified ... ...

    Abstract DNA polymerase epsilon (Pol ε), a component of the core replisome, is involved in DNA replication. Although genetic defects of Pol ε have been reported to cause immunodeficiency syndromes, its role in haematopoiesis remains unknown. Here, we identified compound heterozygous variants (p.[Asp1131fs];[Thr1891del]) in
    Mesh-Begriff(e) Animals ; Humans ; DNA Polymerase II/genetics ; DNA Polymerase II/metabolism ; HEK293 Cells ; DNA Replication/genetics ; Tumor Suppressor Protein p53/genetics ; RNA, Messenger
    Chemische Substanzen DNA Polymerase II (EC 2.7.7.7) ; Tumor Suppressor Protein p53 ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmg-2023-109444
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 177: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Artikel: BODIPY-based probes for the fluorescence imaging of biomolecules in living cells

    Kowada, Toshiyuki / Maeda, Hiroki / Kikuchi, Kazuya

    Chemical Society reviews. 2015 July 7, v. 44, no. 14

    2015  

    Abstract: Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can ...

    Abstract Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can be easily tuned by synthetic chemical modification. For this reason, various fluorescent probes have been developed for targeting biological components, such as proteins, peptides, amino acids, and ions, to the interior and exterior of cells. In this review, we cover advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade.
    Schlagwörter amino acids ; biological properties and phenomena ; fluorescence ; fluorescent dyes ; image analysis ; ions ; peptides ; proteins
    Sprache Englisch
    Erscheinungsverlauf 2015-0707
    Umfang p. 4953-4972.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c5cs00030k
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  7. Artikel ; Online: BODIPY-based probes for the fluorescence imaging of biomolecules in living cells.

    Kowada, Toshiyuki / Maeda, Hiroki / Kikuchi, Kazuya

    Chemical Society reviews

    2015  Band 44, Heft 14, Seite(n) 4953–4972

    Abstract: Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can ...

    Abstract Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can be easily tuned by synthetic chemical modification. For this reason, various fluorescent probes have been developed for targeting biological components, such as proteins, peptides, amino acids, and ions, to the interior and exterior of cells. In this review, we cover advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade.
    Mesh-Begriff(e) Animals ; Boron Compounds ; Cell Line ; Cytological Techniques ; Fluorescent Dyes ; Humans ; Mice ; Optical Imaging/methods
    Chemische Substanzen 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Boron Compounds ; Fluorescent Dyes
    Sprache Englisch
    Erscheinungsdatum 2015-07-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c5cs00030k
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  8. Artikel: [Frontiers in Live Bone Imaging Researches. Development of fluorescent pH probe for imaging osteoclast activation].

    Kikuchi, Kazuya / Kowada, Toshiyuki / Maeda, Hiroki

    Clinical calcium

    2015  Band 25, Heft 6, Seite(n) 877–882

    Abstract: For the clinical diagnosis of osteoporosis, X-ray CT and biochemical bone metabolism markers, however, there is no method to monitor osteoclast activity in the living system. We have developed the fluorescent probe to monitor osteoclast activity, by the ... ...

    Abstract For the clinical diagnosis of osteoporosis, X-ray CT and biochemical bone metabolism markers, however, there is no method to monitor osteoclast activity in the living system. We have developed the fluorescent probe to monitor osteoclast activity, by the combination of pH sensitive fluorescent dye with bisphosphonate which is delivered to the bone surface by its high affinity to hydroxyl apatite, which is named BAp-E. In vivo mouse imaging of activated osteoclast was successfully demonstrated using two photon excitation laser microscope.
    Mesh-Begriff(e) Drug Design ; Fluorescent Dyes ; Humans ; Hydrogen-Ion Concentration ; Microscopy, Confocal/methods ; Microscopy, Fluorescence, Multiphoton/methods ; Molecular Imaging/methods ; Osteoclasts/physiology ; Osteoclasts/ultrastructure
    Chemische Substanzen Fluorescent Dyes
    Sprache Japanisch
    Erscheinungsdatum 2015-06
    Erscheinungsland Japan
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1506877882
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Quantitative evaluation of hepatic integrin α

    Hiroyama, Shuichi / Rokugawa, Takemi / Ito, Miwa / Iimori, Hitoshi / Morita, Ippei / Maeda, Hiroki / Fujisawa, Kae / Matsunaga, Keiko / Shimosegawa, Eku / Abe, Kohji

    EJNMMI research

    2020  Band 10, Heft 1, Seite(n) 118

    Abstract: Background: Integrin α: Methods: 18: Results: Biochemical and histological evaluation confirmed the development of NASH rats. Integrin α: Conclusions: We have demonstrated that the ... ...

    Abstract Background: Integrin α
    Methods: 18
    Results: Biochemical and histological evaluation confirmed the development of NASH rats. Integrin α
    Conclusions: We have demonstrated that the V
    Sprache Englisch
    Erscheinungsdatum 2020-10-07
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-020-00704-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: In Vivo

    Minoshima, Masafumi / Kikuta, Junichi / Omori, Yuta / Seno, Shigeto / Suehara, Riko / Maeda, Hiroki / Matsuda, Hideo / Ishii, Masaru / Kikuchi, Kazuya

    ACS central science

    2019  Band 5, Heft 6, Seite(n) 1059–1066

    Abstract: ... In ... ...

    Abstract In vivo
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.9b00220
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