LIVIVO - Search results -

Search results

Result 1 - 10 of total 30

Search options

Article ; Online: [Clinical features of 8 patients with multifocal motor neuropathy in the long-term follow-up].

Nemoto, Joe / Shimizu, Fumitaka / Maeda, Toshihiko / Nishihara, Hideaki / Koga, Michiaki / Kanda, Takashi

2023 Volume 63, Issue 4, Page(s) 209–213

Abstract: Objective: To clarify the clinical and long-term characteristics of multifocal motor neuropathy (MMN).: Methods: We retrospectively evaluated data from 8 consecutive MMN patients in Yamaguchi University Hospital from 2005 to 2020. Clinical ... ...

Abstract	Objective: To clarify the clinical and long-term characteristics of multifocal motor neuropathy (MMN). Methods: We retrospectively evaluated data from 8 consecutive MMN patients in Yamaguchi University Hospital from 2005 to 2020. Clinical information including dominant hand, occupations, hobbies, nerve conduction data, protein level in cerebrospinal fluid (CSF), responsiveness to intravenous immunoglobulin (IVIg) therapy as initial therapy as well as maintenance therapy were collected. Results: Unilateral upper limb was initially affected in all patients and a dominant upper extremity was affected in six of them. Seven patients had occupations or hobbies which were associated with overuse of their dominant upper extremity. CSF protein level was normal or slightly elevated. Nerve conduction studies showed conduction blocks in 4 cases. Effectiveness of IVIg treatment as initial therapy was observed in all patients. Maintenance therapy was not needed in 2 patients because of mild symptoms with stable clinical course. Long-term maintenance therapy with immunoglobulin was effective in 5 patients during the follow-up period. Conclusion: Dominant upper extremity was frequently affected and most patients had job or habit associated with its overuse, suggesting that physical overload induces inflammation or demyelination in MMN. IVIg was commonly effective as both introduction and long-term maintenance therapies. Complete remission was achieved after several IVIg treatments in some patients.
MeSH term(s)	Humans ; Follow-Up Studies ; Immunoglobulins, Intravenous ; Treatment Outcome ; Retrospective Studies ; Motor Neuron Disease/drug therapy ; Motor Neuron Disease/diagnosis ; Polyneuropathies/diagnosis ; Polyneuropathies/drug therapy ; Polyneuropathies/etiology ; Neural Conduction/physiology
Chemical Substances	Immunoglobulins, Intravenous
Language	Japanese
Publishing date	2023-03-29
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001810
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: [Clinical and long-term characteristics of the subtypes of chronic inflammatory demyelinating polyneuropathy].

Shimizu, Fumitaka / Nemoto, Jo / Takeshita, Yukio / Maeda, Toshihiko / Koga, Michiaki / Kanda, Takashi

Rinsho shinkeigaku = Clinical neurology

2022 Volume 62, Issue 3, Page(s) 173–177

Abstract: Objective: To clarify the clinical and long-term characteristic of each subtype of chronic inflammatory demyelinating polyneuropathy (CIDP).: Methods: We evaluated data from 30 consecutive CIDP patients who met the criteria proposed by the European ... ...

Abstract	Objective: To clarify the clinical and long-term characteristic of each subtype of chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: We evaluated data from 30 consecutive CIDP patients who met the criteria proposed by the European Federation of Neurological Societies and the Peripheral Nerve Society. Results: Patients were classified as having typical CIDP (t-‍CIDP) (10/30, 33%), multifocal acquired demyelinating sensory and motor (MADSAM) (12/30, 40%), DADS (4/30, 13%), sensory CIDP (3/30, 10%) or motor CIDP (1/30, 3%). Nerve conduction studies showed more prolonged distal motor latencies/F-wave latencies and slower motor nerve conduction in the typical CIDP group than in the MADSAM group. Intravenous immunoglobulin (IVIg) was effective in 80% (8/10) of t-‍CIDP, 100% (12/12) of MADSAM, 100% (4/4) of DADS, and 100% (3/3) of sensory CIDP cases. Maintenance therapy with immunoglobulin was administered in patients with t-‍CIDP (5/10, 50%), MADSAM (9/12, 75%), DADS (1/4, 25%), and sensory CIDP (2/3, 67%). There were no patients with CIDP, in whom CIDP subtype was transformed from the initial diagnosis during five years of follow-up. Discussion: Percentage of MADSAM was the most common phenotype in our cohort of CIDP patients, and IVIg/immunoglobulin maintenance was effective for MADSAM as well as t-‍CIDP in contrast to findings from the previous reports.
MeSH term(s)	Humans ; Immunoglobulins, Intravenous ; Neural Conduction ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/drug therapy
Chemical Substances	Immunoglobulins, Intravenous
Language	Japanese
Publishing date	2022-03-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001667
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: [Acute sarcoid myopathy and neuropathy aggravated by ustekinumab administration in an elderly woman with psoriasis and systemic sarcoidosis].

Sano, Hironori / Maeda, Toshihiko / Sato, Ryota / Shimizu, Fumitaka / Koga, Michiaki / Kanda, Takashi

Rinsho shinkeigaku = Clinical neurology

2022 Volume 62, Issue 6, Page(s) 475–480

Abstract: A 72-year old woman, who had a history of psoriasis and psoriatic arthritis from age of 69, was admitted because of acute progression of dyspnea and generalized muscle weakness after initiation of ustekinumab. She had been diagnosed as having lung and ... ...

Abstract	A 72-year old woman, who had a history of psoriasis and psoriatic arthritis from age of 69, was admitted because of acute progression of dyspnea and generalized muscle weakness after initiation of ustekinumab. She had been diagnosed as having lung and eye sarcoidosis ten months before admission. Nerve conduction studies revealed multiple mononeuropathy and needle electromyography showed myogenic changes with spontaneous activities. Muscle pathology showed non-caseating epithelioid granuloma and high expression of HLA-class I in myofibers. Diagnosis of sarcoid myopathy and neuropathy aggravated by ustekinumab was made, and ustekinumab administration was discontinued, resulting in slight improvement of her respiratory and neuro-muscular symptoms, but her symptoms remained severely disabled. Treatment with oral steroids further improved her clinical symptoms and she became able to walk independently. We considered that ustekinumab inhibited IL-12 and IL-23 signaling, which caused an imbalance in Th1/Th17 differentiation and activation of Th1 cell differentiation, thereby promoting the development of sarcoid myopathy and neuropathy.
MeSH term(s)	Aged ; Female ; Granuloma/pathology ; Humans ; Myositis/drug therapy ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Psoriasis/drug therapy ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sarcoidosis/drug therapy ; Ustekinumab/adverse effects
Chemical Substances	Ustekinumab (FU77B4U5Z0)
Language	Japanese
Publishing date	2022-05-28
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001714
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells.

Honda, Masaya / Shimizu, Fumitaka / Sato, Ryota / Mizukami, Yoichi / Watanabe, Kenji / Takeshita, Yukio / Maeda, Toshihiko / Koga, Michiaki / Kanda, Takashi

Neurology(R) neuroimmunology & neuroinflammation

2023 Volume 10, Issue 4

Abstract: Background and objectives: Muscle microangiopathy due to dysfunction of endothelial cells because of inflammation is a critical hallmark of dermatomyositis (DM); however, its pathomechanism remains unclear. The aim of this study was to evaluate the ... ...

Abstract	Background and objectives: Muscle microangiopathy due to dysfunction of endothelial cells because of inflammation is a critical hallmark of dermatomyositis (DM); however, its pathomechanism remains unclear. The aim of this study was to evaluate the effect of immunogloblin G (IgG) from patients with idiopathic inflammatory myopathies (IIM) on muscle endothelial cells in vitro. Methods: Using a high-content imaging system, we analyzed whether IgG purified from sera from patients with IIM (n = 15), disease controls (DCs: n = 7), and healthy controls (HCs: n = 7) can bind to muscle endothelial cells and induce complement-dependent cellular cytotoxicity. Results: IgGs from Jo-1 antibody myositis could bind to muscle endothelial cells and caused complement-dependent cell cytotoxicity. RNA-seq demonstrated the upregulation of genes associated with tumor necrosis factor (TNF)-α, triggering receptor expressed on myeloid cells-1 (TREM-1), CD25, and mitochondria pathways after exposure to IgG from the Jo-1, signal recognition particle (SRP), and polymyositis (PM) groups. The high-content imaging system showed that TREM-1 expression in the Jo-1, SRP, and PM groups was increased in comparison with DCs and HCs and that the TNF-α expression in the Jo-1 group was higher in comparison with the SRP, PM, DC, and HC groups. The expression of TREM-1 was observed in biopsied capillaries and the muscle membrane from patients with Jo-1 and in biopsied muscle fiber and capillaries from patients with DM and SRP. The depletion of Jo-1 antibodies by IgG of patients with Jo-1 antibody myositis reduced the Jo-1 antibody-induced complement-dependent cellular cytotoxicity in muscle endothelial cells. Discussion: Jo-1 antibodies from Jo-1 antibody myositis show complement-dependent cellular cytotoxicity in muscle endothelial cells. IgGs from patients with Jo-1, SRP, and DM increase the TREM-1 expression in endothelial cells and muscles.
MeSH term(s)	Humans ; Triggering Receptor Expressed on Myeloid Cells-1 ; Endothelial Cells ; Up-Regulation ; Myositis ; Polymyositis ; Muscles/pathology ; Immunoglobulin G
Chemical Substances	Jo-1 antibody ; Triggering Receptor Expressed on Myeloid Cells-1 ; Immunoglobulin G
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000200116
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A case of otitis externa caused by Schizophyllum commune: An approach to antimicrobial stewardship using Gram staining of otorrhea in a medical clinic.

Maeda, Masako / Maeda, Toshihiko / Nakamura, Akihiro / Komatsu, Masaru

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2019 Volume 25, Issue 9, Page(s) 731–734

Abstract: Recently, basidiomycete Schizophyllum commune has been reported as a cause of allergic bronchopulmonary mycosis. However, it is rare as a cause of otitis externa. We experienced a very rare case of otitis externa caused by S. commune in a 68-year-old man ...

Abstract	Recently, basidiomycete Schizophyllum commune has been reported as a cause of allergic bronchopulmonary mycosis. However, it is rare as a cause of otitis externa. We experienced a very rare case of otitis externa caused by S. commune in a 68-year-old man with a history of chronic otitis media. We performed Gram staining at the first consultation and follow-up treatment and found fungal cells on the smear and treated him with an appropriate antifungal drug. The results of identification and antifungal susceptibility testing obtained in cooperation with clinical microbiologists at other facilities was very important for future treatment planning decisions. Medical practitioners worldwide should introduce a Gram staining tool into their workflow and cooperate closely with clinical microbiologists to achieve antimicrobial stewardship.
MeSH term(s)	Aged ; Antifungal Agents/therapeutic use ; Antimicrobial Stewardship ; Gentian Violet ; Humans ; Invasive Pulmonary Aspergillosis/drug therapy ; Invasive Pulmonary Aspergillosis/etiology ; Invasive Pulmonary Aspergillosis/microbiology ; Male ; Otitis Externa/microbiology ; Otitis Media/complications ; Phenazines ; Schizophyllum/isolation & purification
Chemical Substances	Antifungal Agents ; Gram's stain ; Phenazines ; Gentian Violet (J4Z741D6O5)
Language	English
Publishing date	2019-03-21
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2019.03.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5236: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy.

Sato, Ryota / Shimizu, Fumitaka / Kuwahara, Motoi / Mizukami, Yoichi / Watanabe, Kenji / Maeda, Toshihiko / Sano, Yasuteru / Takeshita, Yukio / Koga, Michiaki / Kusunoki, Susumu / Kanda, Takashi

Neurology(R) neuroimmunology & neuroinflammation

2023 Volume 10, Issue 3

Abstract: Background and objectives: Deposition of myelin-associated glycoprotein (MAG) immunoglobulin M (IgM) antibodies in the sural nerve is a key feature in anti-MAG neuropathy. Whether the blood-nerve barrier (BNB) is disrupted in anti-MAG neuropathy remains ...

Abstract	Background and objectives: Deposition of myelin-associated glycoprotein (MAG) immunoglobulin M (IgM) antibodies in the sural nerve is a key feature in anti-MAG neuropathy. Whether the blood-nerve barrier (BNB) is disrupted in anti-MAG neuropathy remains elusive.We aimed to evaluate the effect of sera from anti-MAG neuropathy at the molecular level using our in vitro human BNB model and observe the change of BNB endothelial cells in the sural nerve of anti-MAG neuropathy. Methods: Diluted sera from patients with anti-MAG neuropathy (n = 16), monoclonal gammopathies of undetermined significance (MGUS) neuropathy (n = 7), amyotrophic lateral sclerosis (ALS, n = 10), and healthy controls (HCs, n = 10) incubated with human BNB endothelial cells to identify the key molecule of BNB activation using RNA-seq and a high-content imaging system, and exposed with a BNB coculture model to evaluate small molecule/IgG/IgM/anti-MAG antibody permeability. Results: RNA-seq and the high-content imaging system showed the significant upregulation of tumor necrosis factor (TNF-α) and nuclear factor-kappa B (NF-κB) in BNB endothelial cells after exposure to sera from patients with anti-MAG neuropathy, whereas the serum TNF-α concentration was not changed among the MAG/MGUS/ALS/HC groups. Sera from patients with anti-MAG neuropathy did not increase 10-kDa dextran or IgG permeability but enhanced IgM and anti-MAG antibody permeability. Sural nerve biopsy specimens from patients with anti-MAG neuropathy showed higher TNF-α expression levels in BNB endothelial cells and preservation of the structural integrity of the tight junctions and the presence of more vesicles in BNB endothelial cells. Neutralization of TNF-α reduces IgM/anti-MAG antibody permeability. Discussion: Sera from individuals with anti-MAG neuropathy increased transcellular IgM/anti-MAG antibody permeability via autocrine TNF-α secretion and NF-κB signaling in the BNB.
MeSH term(s)	Humans ; Myelin-Associated Glycoprotein ; Tumor Necrosis Factor-alpha ; Blood-Nerve Barrier ; Endothelial Cells ; Amyotrophic Lateral Sclerosis ; NF-kappa B ; Peripheral Nervous System Diseases ; Autoantibodies ; Immunoglobulin M ; Monoclonal Gammopathy of Undetermined Significance ; Immunoglobulin G
Chemical Substances	Myelin-Associated Glycoprotein ; Tumor Necrosis Factor-alpha ; NF-kappa B ; Autoantibodies ; Immunoglobulin M ; Immunoglobulin G
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000200086
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: [Chronic inflammatory demyelinating polyradiculoneuropathy with myelopathy due to massively enlarged nerve roots].

Maeda, Toshihiko / Kawai, Motoharu / Ishiguchi, Eri / Omoto, Masatoshi / Ogasawara, Jun-Ichi / Kanda, Takashi

Rinsho shinkeigaku = Clinical neurology

2020 Volume 60, Issue 9, Page(s) 603–608

Abstract: We report a 77-year-old man who presented with numbness and weakness of the feet bilaterally, that had progressed over 13 years. He was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) on the basis of nerve conduction ... ...

Abstract	We report a 77-year-old man who presented with numbness and weakness of the feet bilaterally, that had progressed over 13 years. He was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) on the basis of nerve conduction studies and a sural nerve biopsy; however, he was inadequately treated and his weakness had progressed. At 76 years of age, he developed spasticity in the legs as well as bladder and rectal incontinences. Gd-enhanced MRI revealed severe compression of the cervical cord by massively enlarged nerve roots. A cervical laminectomy was performed to decompress the cervical cord. A fascicular biopsy of the C5 dorsal root showed a prominent lymphocyte infiltration and edema. Repeated methylprednisolone pulse therapy and IVIg ameliorated the weakness. We concluded that the main cause of nerve root hypertrophy in this patient was active inflammation.
MeSH term(s)	Aged ; Cervical Vertebrae ; Edema ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Laminectomy ; Lymphocytes/pathology ; Male ; Methylprednisolone/administration & dosage ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/etiology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/therapy ; Pulse Therapy, Drug ; Spinal Cord Compression/etiology ; Spinal Cord Compression/therapy ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/therapy ; Spinal Nerve Roots/pathology ; Treatment Outcome
Chemical Substances	Immunoglobulins, Intravenous ; Methylprednisolone (X4W7ZR7023)
Language	Japanese
Publishing date	2020-08-08
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001416
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases].

Maeda, Toshihiko / Kanda, Takashi

Nihon rinsho. Japanese journal of clinical medicine

2013 Volume 71, Issue 5, Page(s) 789–794

Abstract: The blood-brain barrier (BBB) and blood-nerve barrier (BNB) restrict exchanges of soluble factors and cells between the blood and neural tissue, thus playing a crucial role in the maintenance of central (CNS) and peripheral nervous system (PNS) ... ...

Abstract	The blood-brain barrier (BBB) and blood-nerve barrier (BNB) restrict exchanges of soluble factors and cells between the blood and neural tissue, thus playing a crucial role in the maintenance of central (CNS) and peripheral nervous system (PNS) homeostasis. In neuroinflammatory diseases, disruption of the BBB/BNB is the initial key step in the development of inflammatory lesions. BBB/BNB breakdown during inflammation is related to two main processes: (1) leakage between opposing endothelial cells and alteration of junctional components, and (2) leukocyte extravasation into the CNS or PNS. The control of inflammatory cells and humoral factors such as cytokines at the level of BBB/BNB can develop a novel therapeutic strategy toward the inflammatory/autoimmune nervous system disorders.
MeSH term(s)	Blood-Brain Barrier ; Blood-Nerve Barrier ; Central Nervous System Diseases/immunology ; Homeostasis ; Humans ; Inflammation/immunology ; Leukocytes
Language	Japanese
Publishing date	2013-05
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 429: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: [A women with aplastic anemia developed chronic inflammatory demyelinating polyneuropathy].

Abe, Masaaki / Shimizu, Fumitaka / Suzukawa, Munehisa / Maeda, Toshihiko / Omoto, Masatoshi / Kanda, Takashi

Rinsho shinkeigaku = Clinical neurology

2019 Volume 59, Issue 12, Page(s) 818–822

Abstract: A 66-year-old female developed chronic inflammatory demyelinating polyneuropathy (CIDP) one year after the diagnosis of aplastic anemia. High-dose intravenous immunoglobulin (IVIg) therapy, followed by IVIg maintenance therapy, rapidly improved her ... ...

Abstract	A 66-year-old female developed chronic inflammatory demyelinating polyneuropathy (CIDP) one year after the diagnosis of aplastic anemia. High-dose intravenous immunoglobulin (IVIg) therapy, followed by IVIg maintenance therapy, rapidly improved her weakness and hyperesthesia in four extremities. In addition, pancytopenia caused by aplastic anemia also improved following IVIg treatment in parallel. This is the first report to show the co-existence of CIDP and aplastic anemia, and a common pathomechanism may be present in these two rare autoimmune disorders.
MeSH term(s)	Aged ; Anemia, Aplastic/complications ; Anemia, Aplastic/drug therapy ; Anemia, Aplastic/etiology ; Autoimmunity ; Female ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/drug therapy ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/etiology ; Treatment Outcome
Chemical Substances	Immunoglobulins, Intravenous
Language	Japanese
Publishing date	2019-11-23
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001312
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.

Shimizu, Fumitaka / Ogawa, Ryo / Mizukami, Yoichi / Watanabe, Kenji / Hara, Kanako / Kadono, Chihiro / Takahashi, Toshiyuki / Misu, Tatsuro / Takeshita, Yukio / Sano, Yasuteru / Fujisawa, Miwako / Maeda, Toshihiko / Nakashima, Ichiro / Fujihara, Kazuo / Kanda, Takashi

Neurology(R) neuroimmunology & neuroinflammation

2021 Volume 9, Issue 1

Abstract: Background and objectives: To analyze (1) the effect of immunoglobulin G (IgG) from patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivity of ...

Abstract	Background and objectives: To analyze (1) the effect of immunoglobulin G (IgG) from patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivity of glucose-regulated protein 78 (GRP78) antibodies in MOG-Ab-associated disorders. Methods: IgG was purified from sera with patients with MOG-Ab-associated disorder in the acute phase (acute MOG, n = 15), in the stable stage (stable MOG, n = 14), healthy controls (HCs, n = 9), and disease controls (DCs, n = 27). Human brain microvascular endothelial cells (BMECs) were incubated with IgG, and the number of nuclear NF-κB p65-positive cells in BMECs using high-content imaging system and the quantitative messenger RNA change in gene expression over the whole transcriptome using RNA-seq were analyzed. GRP78 antibodies from patient IgGs were detected by Western blotting. Results: IgG in the acute MOG group significantly induced the nuclear translocation of NF-κB and increased the vascular cell adhesion molecule 1/intercellular adhesion molecule 1 expression/permeability of 10-kDa dextran compared with that from the stable MOG and HC/DC groups. RNA-seq and pathway analysis revealed that NF-κB signaling and oxidative stress (NQO1) play key roles. The NQO1 and Nrf2 protein amounts were significantly decreased after exposure to IgG in the acute MOG group. The rate of GRP78 antibody positivity in the acute MOG group (10/15, 67% [95% confidence interval, 38%-88%]) was significantly higher than that in the stable MOG group (5/14, 36% [13%-65%]), multiple sclerosis group (4/29, 14% [4%-32%]), the DCs (3/27, 11% [2%-29%]), or HCs (0/9, 0%). Removal of GRP78 antibodies from MOG-IgG reduced the effect on NF-κB nuclear translocation and increased permeability. Discussion: GRP78 antibodies may be associated with BBB dysfunction in MOG-Ab-associated disorder.
MeSH term(s)	Adolescent ; Adult ; Aged ; Autoantibodies/blood ; Autoimmune Diseases of the Nervous System/blood ; Autoimmune Diseases of the Nervous System/immunology ; Autoimmune Diseases of the Nervous System/physiopathology ; Blood-Brain Barrier/physiopathology ; Child, Preschool ; Endoplasmic Reticulum Chaperone BiP/immunology ; Endothelial Cells ; Female ; Humans ; Male ; Middle Aged ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Young Adult
Chemical Substances	Autoantibodies ; Endoplasmic Reticulum Chaperone BiP ; HSPA5 protein, human ; MOG protein, human ; Myelin-Oligodendrocyte Glycoprotein
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000001038
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito