Article ; Online: ImmunoCAP ISAC in food allergy diagnosis: a systematic review of diagnostic test accuracy.
2021 Volume 51, Issue 6, Page(s) 778–789
Abstract: Objective: To assess the diagnostic test accuracy of the component-resolved diagnosis device ImmunoCAP ISAC, compared with oral food challenge.: Design: Systematic review reported according to the PRISMA-DTA recommendations.: Data sources: Medline, ...
| Abstract | Objective: To assess the diagnostic test accuracy of the component-resolved diagnosis device ImmunoCAP ISAC, compared with oral food challenge. Design: Systematic review reported according to the PRISMA-DTA recommendations. Data sources: Medline, Embase and Cochrane Library databases were searched from inception to May 2019 and updated in March 2021. Eligibility criteria for selecting studies: We included diagnostic test accuracy studies comparing ISAC component results as the index test with oral food challenge as the reference test, in people of any age suspected of IgE mediated food allergy to milk, egg, peanut, shrimp, hake, apple, peach, kiwi, melon, walnut, hazelnut, wheat or pineapple. Risk of bias was evaluated using the QUADAS-2 tool. Results: We screened 799 titles and included 11 studies - seven prospective and two retrospective cohort studies, two case-control studies. Included studies evaluated IgE to Gald1 (three studies, 300 participants, 140 with egg allergy), Bosd5 (three studies, 242 participants, 146 with milk allergy) and Arah1 or 2 (seven studies, 546 participants, 346 with peanut allergy). No studies were identified for other ISAC components. Risk of bias was high or unclear mainly due to inadequate blinding. Applicability was of high or unclear concern due to unclear thresholds, inappropriate exclusions and variable populations. Gald1 sensitivity ranged from 58 to 84%, specificity 87%-97%. Bosd5 sensitivity 24%-40%, specificity 94%-95%. Arah1 sensitivity 45%-91%, specificity 41%-93%. Arah2 sensitivity 70%-94%, specificity 75%-95%. Conclusions: Diagnostic test accuracy information for ISAC components was only available for milk, egg and peanut. Specificity is generally higher than sensitivity, which contrasts with the performance of skin prick and standard specific IgE tests for diagnosing food allergy. Higher quality information is needed to determine the clinical utility of ISAC for food allergy diagnosis. Systematic review registration: Not registered. |
|---|---|
| MeSH term(s) | Allergens/immunology ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin E/immunology ; Immunologic Tests ; Lab-On-A-Chip Devices ; Pathology, Molecular ; Sensitivity and Specificity |
| Chemical Substances | Allergens ; Immunoglobulin E (37341-29-0) |
| Language | English |
| Publishing date | 2021-04-12 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review |
| ZDB-ID | 645204-8 |
| ISSN | 1365-2222 ; 0954-7894 ; 0960-2178 |
| ISSN (online) | 1365-2222 |
| ISSN | 0954-7894 ; 0960-2178 |
| DOI | 10.1111/cea.13871 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 767: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.