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Article ; Online: A phase transition for chromosome transmission when cells divide.

Maeshima, Kazuhiro

2022 Volume 609, Issue 7925, Page(s) 35–36

MeSH term(s)	Biophysical Phenomena ; Biophysics ; Chromosomes ; Phase Transition
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	News ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-022-01925-3
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Zs.MO 244: Show issues

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Article ; Online: Editorial: Emerging concepts and tools in genome organization and chromatin function in eukaryotes.

Maeshima, Kazuhiro / Meshorer, Eran

Current opinion in cell biology

2022 Volume 78, Page(s) 102120

MeSH term(s)	Chromatin/genetics ; Chromosomes ; Eukaryota/genetics ; Genome
Chemical Substances	Chromatin
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Editorial
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2022.102120
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Zs.A 2963: Show issues

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Article ; Online: The loopy world of cohesin.

Maeshima, Kazuhiro / Iida, Shiori

eLife

2021 Volume 10

Abstract: DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion. ...

Abstract	DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
MeSH term(s)	Cell Cycle Proteins/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomes ; DNA ; Cohesins
Chemical Substances	Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; DNA (9007-49-2)
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.71585
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Article: Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation.

Iida, Shiori / Ide, Satoru / Tamura, Sachiko / Tani, Tomomi / Goto, Tatsuhiko / Shribak, Michael / Maeshima, Kazuhiro

bioRxiv : the preprint server for biology

2024

Abstract: Genomic information must be faithfully transmitted into two daughter cells during mitosis. To ensure the transmission process, interphase chromatin is further condensed into mitotic chromosomes. Although protein factors like condensins and topoisomerase ... ...

Abstract	Genomic information must be faithfully transmitted into two daughter cells during mitosis. To ensure the transmission process, interphase chromatin is further condensed into mitotic chromosomes. Although protein factors like condensins and topoisomerase IIα are involved in the assembly of mitotic chromosomes, the physical bases of the condensation process remain unclear. Depletion force/macromolecular crowding, an effective attractive force that arises between large structures in crowded environments around chromosomes, may contribute to the condensation process. To approach this issue, we investigated the "chromosome milieu" during mitosis of living human cells using orientation-independent-differential interference contrast (OI-DIC) module combined with a confocal laser scanning microscope, which is capable of precisely mapping optical path differences and estimating molecular densities. We found that the molecular density surrounding chromosomes increased with the progression from prometaphase to anaphase, concurring with chromosome condensation. However, the molecular density went down in telophase, when chromosome decondensation began. Changes in the molecular density around chromosomes by hypotonic or hypertonic treatment consistently altered the condensation levels of chromosomes.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.11.566679
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Article ; Online: Immediate Angiography and Decreased In-Hospital Mortality of Adult Trauma Patients: A Nationwide Study.

Yamamoto, Ryo / Maeshima, Katsuya / Funabiki, Tomohiro / Eastridge, Brian J / Cestero, Ramon F / Sasaki, Junichi

Cardiovascular and interventional radiology

2024 Volume 47, Issue 4, Page(s) 472–480

Abstract: Purpose: This study aimed to elucidate whether immediate angiography within 30 min is associated with lower in-hospital mortality compared with non-immediate angiography.: Materials and methods: We conducted a retrospective cohort study using a ... ...

Abstract	Purpose: This study aimed to elucidate whether immediate angiography within 30 min is associated with lower in-hospital mortality compared with non-immediate angiography. Materials and methods: We conducted a retrospective cohort study using a nationwide trauma databank (2019-2020). Adult trauma patients who underwent emergency angiography within 12 h after hospital arrival were included. Patients who underwent surgery before angiography were excluded. Immediate angiography was defined as one performed within 30 min after arrival (door-to-angio time ≤ 30 min). In-hospital mortality and non-operative management (NOM) failure were compared between patients with immediate and non-immediate angiography. Inverse probability weighting with propensity scores was conducted to adjust patient demographics, injury mechanism and severity, vital signs on hospital arrival, and resuscitative procedures. A restricted cubic spline curve was drawn to reveal survival benefits by door-to-angio time. Results: Among 1,455 patients eligible for this study, 92 underwent immediate angiography. Angiography ≤ 30 min was associated with decreased in-hospital mortality (5.0% vs 11.1%; adjusted odds ratio [OR], 0.42 [95% CI, 0.31-0.56]; p < 0.001), as well as lower frequency of NOM failure: thoracotomy and laparotomy after angiography (0.8% vs. 1.8%; OR, 0.44 [0.22-0.89] and 2.6% vs. 6.5%; OR, 0.38 [0.26-0.56], respectively). The spline curve showed a linear association between increasing mortality and prolonged door-to-angio time in the initial 100 min after arrival. Conclusion: In trauma patients, immediate angiography ≤ 30 min was associated with lower in-hospital mortality and fewer NOM failures. Level of evidence: Level 3b, non randomized controlled cohort/follow up study.
MeSH term(s)	Adult ; Humans ; Hospital Mortality ; Retrospective Studies ; Follow-Up Studies ; Cohort Studies ; Angiography
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-024-03664-6
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Article ; Online: Clinical results of 30 consecutive patients of carotid artery stenosis treated with CASPER stent placement: 1-year follow-up and in-stent findings on intravascular ultrasound examination immediately and 6 months after treatment.

Matsumoto, Hiroyuki / Izawa, Daisuke / Nishiyama, Hirokazu / Nakayama, Yukie / Maeshima, Kazuhide

Journal of neurointerventional surgery

2023

Abstract: Background: The CASPER stent is expected to reduce periprocedural ischemic complications, but there is concern about restenosis in the early period. One-year follow-up results of CASPER stenting and findings on intravascular ultrasound (IVUS) ... ...

Abstract	Background: The CASPER stent is expected to reduce periprocedural ischemic complications, but there is concern about restenosis in the early period. One-year follow-up results of CASPER stenting and findings on intravascular ultrasound (IVUS) immediately and 6 months after treatment are evaluated. Methods: Thirty consecutive patients were treated with CASPER stents for carotid artery stenosis. IVUS was performed immediately after stenting, and MRI and carotid ultrasonography were performed the next day, at 1 week, at 2 weeks, and then every 3 months. One-year follow-up results were evaluated. Twenty-five patients underwent follow-up angiography and IVUS after 6 months and their findings were investigated. Results: All patients were treated without complications during the intraoperative and periprocedural periods. After 6 months, all 25 patients with follow-up angiography and IVUS showed various degrees of intimal formation on IVUS and 8 of them had ≥50% stenosis on angiography. Three of the 30 patients required retreatment within 6 months because of severe restenosis. In these patients, the inner layer of the stent was deformed toward the inside due to intimal hyperplasia on follow-up IVUS, and there was dissociation between the inner and outer layers. All but the 3 of 30 patients with 1-year follow-up did not lead to symptomatic cerebrovascular events or retreatment. Conclusions: The CASPER stent appears to be effective for preventing periprocedural ischemic complications. IVUS showed various degrees of intimal formation within 6 months after treatment, and it is possible that the CASPER stent is structurally prone to intimal formation or hyperplasia.
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-020186
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Zs.A 6845: Show issues

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Article ; Online: Anifrolumab for refractory lupus erythematosus panniculitis in systemic lupus erythematosus.

Maeshima, Keisuke / Abe, Tasuku / Imada, Chiharu / Ozaki, Takashi / Shibata, Hirotaka

Rheumatology (Oxford, England)

2023 Volume 63, Issue 3, Page(s) e115–e117

MeSH term(s)	Humans ; Panniculitis, Lupus Erythematosus/drug therapy ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	anifrolumab (38RL9AE51Q) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead553
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Zs.MO 497: Show issues

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Article: Chromatin organization and DNA damage.

Minami, Katsuhiko / Iida, Shiori / Maeshima, Kazuhiro

The Enzymes

2022 Volume 51, Page(s) 29–51

Abstract: Genomic DNA is organized three-dimensionally in the nucleus as chromatin. Recent accumulating evidence has demonstrated that chromatin organizes into numerous dynamic domains in higher eukaryotic cells, which act as functional units of the genome. These ... ...

Abstract	Genomic DNA is organized three-dimensionally in the nucleus as chromatin. Recent accumulating evidence has demonstrated that chromatin organizes into numerous dynamic domains in higher eukaryotic cells, which act as functional units of the genome. These compacted domains facilitate DNA replication and gene regulation. Undamaged chromatin is critical for healthy cells to function and divide. However, the cellular genome is constantly threatened by many sources of DNA damage (e.g., radiation). How do cells maintain their genome integrity when subjected to DNA damage? This chapter describes how the compact state of chromatin safeguards the genome from radiation damage and chemical attacks. Together with recent genomics data, our finding suggests that DNA compaction, such as chromatin domain formation, plays a critical role in maintaining genome integrity. But does the formation of such domains limit DNA accessibility inside the domain and hinder the recruitment of repair machinery to the damaged site(s) during DNA repair? To approach this issue, we first describe a sensitive imaging method to detect changes in chromatin states in living cells (single-nucleosome imaging/tracking). We then use this method to explain how cells can overcome potential recruiting difficulties; cells can decompact chromatin domains following DNA damage and temporarily increase chromatin motion (∼DNA accessibility) to perform efficient DNA repair. We also speculate on how chromatin compaction affects DNA damage-resistance in the clinical setting.
MeSH term(s)	DNA Damage ; Chromatin/genetics ; Nucleosomes ; DNA Repair ; DNA
Chemical Substances	Chromatin ; Nucleosomes ; DNA (9007-49-2)
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article
ISSN	0423-2607
ISSN	0423-2607
DOI	10.1016/bs.enz.2022.08.003
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Article ; Online: Trauma-Angio score as a predictor of urgent angioembolization for blunt trauma: development and validation using independent cohorts.

Maeshima, Katsuya / Yamamoto, Ryo / Sasaki, Junichi

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2022 Volume 48, Issue 6, Page(s) 4837–4845

Abstract: Purpose: This research aimed to establish a scoring system for selecting candidates for urgent angioembolization (AE).: Methods: Patients with blunt trauma were retrospectively identified in a nationwide trauma registry. Patients aged ≥ 15 years with ...

Abstract	Purpose: This research aimed to establish a scoring system for selecting candidates for urgent angioembolization (AE). Methods: Patients with blunt trauma were retrospectively identified in a nationwide trauma registry. Patients aged ≥ 15 years with a systolic blood pressure of ≥90 mmHg were included. These individuals were then categorized into development and validation cohorts based on the date of admission. Next, an eight-point scaled system was developed using odds ratios obtained from the multivariate analysis of patients' clinical factors on their arrival at the hospital, with the implementation of urgent AE as a dependent variable. Results: The development cohort and validation cohort included 158,192 and 116,941 patients, respectively, and 3296 (2.1%) patients in the development cohort and 2,550 (2.2%) patients in the validation cohort underwent urgent AE. The frequency of transfusion within 24 h after arrival and the Injury Severity Score were similar between the two cohorts (16,867 [10.7%] vs. 11,222 [9.6%] and 10 [9-18] vs. 10 [9-17], respectively). The number of patients who were discharged and hospital-free days were comparable between the two cohorts (139,436 [94.4%] vs. 106,107 [95.6%] and 72 [53-84] vs. 73 [57-84] days, respectively). The probabilities and the observed rates of urgent AE increased proportionally from 2% at a score of ≤ 3 to almost 15% at a score of ≥ 7. In terms of predictive factors, no significant interaction was noted. Conclusion: The Trauma-Angio scoring system can be used as a trigger to suggest the possibility of urgent AE. Trial registration: 20090087, 31st July 2009.
MeSH term(s)	Humans ; Retrospective Studies ; Embolization, Therapeutic ; Wounds, Nonpenetrating/therapy ; Injury Severity Score ; Blood Transfusion
Language	English
Publishing date	2022-06-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-022-02008-8
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 607: Show issues

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Article ; Online: Chromatin behavior in living cells: Lessons from single-nucleosome imaging and tracking.

Ide, Satoru / Tamura, Sachiko / Maeshima, Kazuhiro

BioEssays : news and reviews in molecular, cellular and developmental biology

2022 Volume 44, Issue 7, Page(s) e2200043

Abstract: Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome structure. Together with associated proteins and RNAs, these nucleosomes are organized three-dimensionally in the cell as chromatin. Emerging evidence demonstrates that ... ...

Abstract	Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome structure. Together with associated proteins and RNAs, these nucleosomes are organized three-dimensionally in the cell as chromatin. Emerging evidence demonstrates that chromatin consists of rather irregular and variable nucleosome arrangements without the regular fiber structure and that its dynamic behavior plays a critical role in regulating various genome functions. Single-nucleosome imaging is a promising method to investigate chromatin behavior in living cells. It reveals local chromatin motion, which reflects chromatin organization not observed in chemically fixed cells. The motion data is like a gold mine. Data analyses from many aspects bring us more and more information that contributes to better understanding of genome functions. In this review article, we describe imaging of single-nucleosomes and their tracked behavior through oblique illumination microscopy. We also discuss applications of this technique, especially in elucidating nucleolar organization in living cells.
MeSH term(s)	Chromatin ; Chromatin Assembly and Disassembly ; DNA/chemistry ; Histones/metabolism ; Nucleosomes
Chemical Substances	Chromatin ; Histones ; Nucleosomes ; DNA (9007-49-2)
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	50140-2
ISSN	1521-1878 ; 0265-9247
ISSN (online)	1521-1878
ISSN	0265-9247
DOI	10.1002/bies.202200043
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