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Article ; Online: Anifrolumab for refractory lupus erythematosus panniculitis in systemic lupus erythematosus.

Maeshima, Keisuke / Abe, Tasuku / Imada, Chiharu / Ozaki, Takashi / Shibata, Hirotaka

2023 Volume 63, Issue 3, Page(s) e115–e117

MeSH term(s)	Humans ; Panniculitis, Lupus Erythematosus/drug therapy ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	anifrolumab (38RL9AE51Q) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead553
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Article ; Online: Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus.

Maeshima, Keisuke / Shibata, Hirotaka

Annals of the rheumatic diseases

2020 Volume 79, Issue 5, Page(s) 674–675

MeSH term(s)	Adult ; Alopecia/drug therapy ; Alopecia/etiology ; Alopecia/pathology ; Azetidines/administration & dosage ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Janus Kinase 1/drug effects ; Janus Kinase 2/drug effects ; Janus Kinase Inhibitors/administration & dosage ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Mycophenolic Acid/administration & dosage ; Prednisolone/administration & dosage ; Retreatment ; Risk Assessment ; Sulfonamides/administration & dosage ; Tacrolimus/administration & dosage ; Treatment Outcome
Chemical Substances	Azetidines ; Janus Kinase Inhibitors ; Sulfonamides ; Prednisolone (9PHQ9Y1OLM) ; Janus Kinase 1 (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; Mycophenolic Acid (HU9DX48N0T) ; baricitinib (ISP4442I3Y) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2020-01-03
Publishing country	England
Document type	Case Reports ; Letter ; Review
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2019-216571
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Article ; Online: Preparation and characterization of carbonic anhydrase-conjugated liposomes for catalytic synthesis of calcium carbonate particles.

Maeshima, Keisuke / Yoshimoto, Makoto

Enzyme and microbial technology

2017 Volume 105, Page(s) 9–17

Abstract: The biomimetic approach using immobilized enzymes is useful for the synthesis of structurally defined inorganic materials. In this work, carbonic anhydrase (CA) from bovine erythrocytes was covalently conjugated at 25°C to the liposomes composed of 15mol% ...

Abstract	The biomimetic approach using immobilized enzymes is useful for the synthesis of structurally defined inorganic materials. In this work, carbonic anhydrase (CA) from bovine erythrocytes was covalently conjugated at 25°C to the liposomes composed of 15mol% 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl) (NG-POPE), and the zwitterionic and anionic phospholipids with the same acyl chains as NG-POPE. For the conjugation, the carboxyl groups of liposomal NG-POPE were activated with 11mM 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and 4.6mM N-hydroxysulfosuccinimide (sulfo-NHS). The carbonic anhydrase-conjugated liposomes (CALs) with the mean hydrodynamic diameter of 149nm showed the esterase activity corresponding to on average 5.5×10
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	423729-8
ISSN	1879-0909 ; 0141-0229
ISSN (online)	1879-0909
ISSN	0141-0229
DOI	10.1016/j.enzmictec.2017.06.002
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Article: Preparation and characterization of carbonic anhydrase-conjugated liposomes for catalytic synthesis of calcium carbonate particles

Maeshima, Keisuke / Makoto Yoshimoto

Enzyme and Microbial Technology. 2017,

2017

Abstract	The biomimetic approach using immobilized enzymes is useful for the synthesis of structurally defined inorganic materials. In this work, carbonic anhydrase (CA) from bovine erythrocytes was covalently conjugated at 25Â°C to the liposomes composed of 15 mol% 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine-N-(glutaryl) (NG-POPE), and the zwitterionic and anionic phospholipids with the same acyl chains as NG-POPE. For the conjugation, the carboxyl groups of liposomal NG-POPE were activated with 11mM 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and 4.6mM N-hydroxysulfosuccinimide (sulfo-NHS). The carbonic anhydrase-conjugated liposomes (CALs) with the mean hydrodynamic diameter of 149nm showed the esterase activity corresponding to on average 5.5Ã102 free CA molecules per liposome. On the other hand, the intrinsic fluorescence and absorbance measurements consistently revealed that on average 1.4Ã103 CA molecules were conjugated to a liposome, suggesting that the molecular orientation of enzyme affected its activity. The formation of calcium carbonate particles was significantly accelerated by the CALs ([lipid]=50Î¼ M) in the 0.3M Tris solution at 10â40Â°C with dissolved CO2 (â17mM) and CaCl2 (46mM). The anionic CALs were adsorbed with calcium as revealed with the Î¶-potential measurements. The CAL system offered the calcium-rich colloidal interface where the bicarbonate ions were catalytically produced by the liposome-conjugated CA molecules. The CALs also functioned in the external loop airlift bubble column operated with a model flue gas (10 vol/vo% CO2), yielding partly agglomerated calcium carbonate particles as observed with the scanning electron microscopy (SEM).
Keywords	absorbance ; bicarbonates ; biomimetics ; calcium ; calcium carbonate ; calcium chloride ; carbon dioxide ; carbonate dehydratase ; cattle ; chemical bonding ; dissolved carbon dioxide ; erythrocytes ; esterases ; flue gas ; fluorescence ; hydrodynamics ; immobilized enzymes ; models ; phospholipids ; scanning electron microscopy ; zeta potential ; zwitterions
Language	English
Size	p. .
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	423729-8
ISSN	1879-0909 ; 0141-0229
ISSN (online)	1879-0909
ISSN	0141-0229
DOI	10.1016/j.enzmictec.2017.06.002
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Article: Dr. Maeshima,

Maeshima, Keisuke / Okada, Satoshi / Shibata, Hirotaka

The Journal of rheumatology

2019 Volume 46, Issue 6, Page(s) 655–656

MeSH term(s)	Autoimmune Diseases ; Gain of Function Mutation ; Humans ; Mutation ; STAT1 Transcription Factor
Chemical Substances	STAT1 Transcription Factor ; STAT1 protein, human
Language	English
Publishing date	2019-06-01
Publishing country	Canada
Document type	Journal Article ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.181455
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Article: An Adult Fatal Case with a

Maeshima, Keisuke / Ishii, Koji / Shibata, Hirotaka

The Journal of rheumatology

2018 Volume 46, Issue 3, Page(s) 325–327

MeSH term(s)	Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Fatal Outcome ; Female ; Gain of Function Mutation ; Humans ; Immunosuppressive Agents/therapeutic use ; Japan ; Phenotype ; Prednisolone/administration & dosage ; Prednisolone/therapeutic use ; Primary Immunodeficiency Diseases/diagnosis ; Primary Immunodeficiency Diseases/drug therapy ; STAT1 Transcription Factor/genetics ; Sequence Analysis, DNA ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/drug therapy
Chemical Substances	Anti-Inflammatory Agents ; Immunosuppressive Agents ; STAT1 Transcription Factor ; STAT1 protein, human ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2018-11-15
Publishing country	Canada
Document type	Case Reports ; Letter
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.180210
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Article ; Online: Effectiveness of subcutaneous tocilizumab in refractory adult Still's disease: report of three cases and a review of the literature.

Torigoe, Masataka / Maeshima, Keisuke / Kuriyama, Yuhei / Abe, Itomi / Ozaki, Takashi / Omura, Yuichi / Umeki, Tatsuhito / Imada, Chiharu / Ishii, Koji / Shibata, Hirotaka

Modern rheumatology case reports

2021 Volume 5, Issue 2, Page(s) 365–370

Abstract: Adult Still's disease (ASD) is a systemic inflammatory disorder characterised by spiking fever, skin rash, arthritis, hepatosplenomegaly, and elevated inflammatory markers. Several proinflammatory cytokines, including interleukin (IL)-6, contribute to ... ...

Abstract	Adult Still's disease (ASD) is a systemic inflammatory disorder characterised by spiking fever, skin rash, arthritis, hepatosplenomegaly, and elevated inflammatory markers. Several proinflammatory cytokines, including interleukin (IL)-6, contribute to its pathogenesis. There have been some recent reports on the efficacy of tocilizumab (TCZ), a humanised anti-IL-6 receptor antibody, in the treatment of ASD refractory to conventional therapy. However, most of the evidence is for intravenous administration of TCZ, whereas subcutaneous injection is often preferred in terms of efficiency in cost and labour. We have experienced three patients whose ASD was refractory to corticosteroid and immunosuppressant therapy but showed a marked response to off-label use of subcutaneous TCZ (TCZ-SC). Patient 1 received TCZ-SC 162 mg on days 0 and 14 and every week thereafter. Patients 2 and 3 received TCZ-SC every 2 weeks. At the time of initiation of TCZ-SC, all three patients had elevated inflammatory markers and two had fever despite previous therapy. After the first TCZ-SC injection, the patients became afebrile within one day and inflammatory parameters (i.e. C-reactive protein and erythrocyte sedimentation rate) returned to normal within 2 weeks. None of the patients developed severe infection or other serious side effects during 104 weeks of follow-up. There have been only a limited number of case reports showing that TCZ-SC significantly improves refractory ASD during its active phase. Our experience with these patients suggests that TCZ-SC could, as well as offering cost efficiency in clinical practice, be a potent treatment option for refractory ASD.
MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/administration & dosage ; Humans ; Injections, Subcutaneous ; Still's Disease, Adult-Onset/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
Language	English
Publishing date	2021-04-15
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1080/24725625.2021.1886402
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Article ; Online: Factors Influencing Plasma Coproporphyrin-I Concentration as Biomarker of OATP1B Activity in Patients With Rheumatoid Arthritis.

Ono, Hiroyuki / Tanaka, Ryota / Suzuki, Yosuke / Oda, Ayako / Ozaki, Takashi / Tatsuta, Ryosuke / Maeshima, Keisuke / Ishii, Koji / Ohno, Keiko / Shibata, Hirotaka / Itoh, Hiroki

Clinical pharmacology and therapeutics

2021 Volume 110, Issue 4, Page(s) 1096–1105

Abstract: Organic anion transporting polypeptides (OATPs) 1B are drug transporters mainly expressed in the sinusoidal membrane. In previous reports, genetic factor, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), which is one of the uremic toxins, ... ...

Abstract	Organic anion transporting polypeptides (OATPs) 1B are drug transporters mainly expressed in the sinusoidal membrane. In previous reports, genetic factor, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), which is one of the uremic toxins, inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) decreased OATP1B1 activity in vitro, but in vivo effects of these factors have not been elucidated. Plasma coproporphyrin-I (CP-I) is spotlighted as a highly accurate endogenous substrate of OATP1B. This study focused on patients with rheumatoid arthritis (RA) and evaluated the influence of several factors comprising gene polymorphisms, uremic toxins, and inflammatory cytokines on OATP1B activity using plasma CP-I concentration. Thirty-seven outpatients with RA who satisfied the selection criteria were analyzed at the time of recruitment (baseline) and at the next visit. OATP1B115 carriers tended to have higher CP-I concentration compared with noncarriers. Plasma CP-I correlated positively with CMPF concentration, but did not correlate with IL-6 or TNF-α concentration. Multiple logistic regression analysis by stepwise selection identified plasma CMPF concentration and OATP1B115 allele as significant factors independently affecting plasma CP-I concentration at baseline and at the next visit, respectively. In conclusion, the present results suggest that inflammatory cytokines do not have clinically significant effects on OATP1B activity, whereas the effects of genetic polymorphisms and uremic toxins should be considered.
MeSH term(s)	Aged ; Arthritis, Rheumatoid/metabolism ; Biomarkers/blood ; Coproporphyrins/blood ; Female ; Furans/metabolism ; Humans ; Interleukin-6/metabolism ; Liver-Specific Organic Anion Transporter 1/genetics ; Male ; Middle Aged ; Pharmacogenomic Variants ; Propionates/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid ; Biomarkers ; Coproporphyrins ; Furans ; Interleukin-6 ; Liver-Specific Organic Anion Transporter 1 ; Propionates ; SLCO1B1 protein, human ; Tumor Necrosis Factor-alpha ; coproporphyrin I (531-14-6)
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2375
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Article ; Online: Congenital intrahepatic portosystemic venous shunt presenting with paraparesis as the initial symptom.

Torigoe, Masataka / Maeshima, Keisuke / Takeshita, Yasushi

Internal medicine (Tokyo, Japan)

2013 Volume 52, Issue 21, Page(s) 2439–2442

Abstract: An 85-year-old woman was hospitalized with rapidly progressive paraparesis without altered consciousness, although she was not definitively diagnosed. She developed acute drowsiness and disorientation several days later. An intrahepatic portosystemic ... ...

Abstract	An 85-year-old woman was hospitalized with rapidly progressive paraparesis without altered consciousness, although she was not definitively diagnosed. She developed acute drowsiness and disorientation several days later. An intrahepatic portosystemic venous shunt (IPSVS) was observed on enhanced computed tomography, and hyperammonemia suggested leakage of neurotoxins from the shunt as the etiology of the patient's symptoms. Her neurological symptoms and hyperammonemia improved following transcatheter shunt embolization. We diagnosed her with hepatic myelopathy, which is a rare complication of liver cirrhosis and portosystemic venous shunts. Hepatic myelopathy resulting from a congenital IPSVS has not been previously reported. A diagnosis of hepatic myelopathy should be ruled out in diagnostically difficult cases of paraparesis.
MeSH term(s)	Aged, 80 and over ; Embolization, Therapeutic ; Female ; Hepatic Encephalopathy/etiology ; Hepatic Veins/abnormalities ; Hepatic Veins/diagnostic imaging ; Humans ; Paraparesis/etiology ; Paraparesis/therapy ; Portal Vein/abnormalities ; Portal Vein/diagnostic imaging ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/therapy ; Tomography, X-Ray Computed ; Vascular Malformations/complications ; Vascular Malformations/diagnosis ; Vascular Malformations/diagnostic imaging
Language	English
Publishing date	2013-11-05
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.52.0881
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Article ; Online: Successful leukocytapheresis therapy in a patient with rheumatoid arthritis on maintenance hemodialysis.

Maeshima, Keisuke / Torigoe, Masataka / Iwakura, Mikako / Yamanaka, Kunitoshi / Ishii, Koji

Modern rheumatology

2015 Volume 25, Issue 1, Page(s) 154–157

Abstract: We report the case of a 44-year-old female undergoing maintenance hemodialysis in whom early-phase rheumatoid arthritis (RA) was successfully treated by leukocytapheresis (LCAP). The effects of prednisone, tacrolimus, and etanercept were limited, but ... ...

Abstract	We report the case of a 44-year-old female undergoing maintenance hemodialysis in whom early-phase rheumatoid arthritis (RA) was successfully treated by leukocytapheresis (LCAP). The effects of prednisone, tacrolimus, and etanercept were limited, but LCAP was highly effective and its efficacy continued even after cessation of LCAP. Moreover, remission was maintained for 2 years after discontinuation of medication. LCAP may be an important treatment option for RA patients with end-stage renal failure who are on hemodialysis.
MeSH term(s)	Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/therapy ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/therapy ; Female ; Humans ; Leukapheresis ; Middle Aged ; Remission Induction ; Renal Dialysis ; Treatment Outcome
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.3109/14397595.2013.874752
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