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  1. Article ; Online: Tackling inflammation in atherosclerosis.

    Shoaran, Mohsen / Maffia, Pasquale

    Nature reviews. Cardiology

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-024-01007-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Canonical and non-canonical roles of complement in atherosclerosis.

    Maffia, Pasquale / Mauro, Claudio / Case, Ayden / Kemper, Claudia

    Nature reviews. Cardiology

    2024  

    Abstract: Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of cardiovascular diseases. Immune responses have a central role in the pathogenesis of atherosclerosis, with ...

    Abstract Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the major contributor to the development and progression of cardiovascular diseases. Immune responses have a central role in the pathogenesis of atherosclerosis, with the complement system being an acknowledged contributor. Chronic activation of liver-derived and serum-circulating canonical complement sustains endothelial inflammation and innate immune cell activation, and deposition of complement activation fragments on inflamed endothelial cells is a hallmark of atherosclerotic plaques. However, increasing evidence indicates that liver-independent, cell-autonomous and non-canonical complement activities are underappreciated contributors to atherosclerosis. Furthermore, complement activation can also have atheroprotective properties. These specific detrimental or beneficial contributions of the complement system to the pathogenesis of atherosclerosis are dictated by the location of complement activation and engagement of its canonical versus non-canonical functions in a temporal fashion during atherosclerosis progression. In this Review, we summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential strategies for therapeutic modulation of complement for the prevention and treatment of atherosclerotic cardiovascular disease.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-024-01016-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

    Mohanta, Sarajo / Habenicht, Andreas J.R. / Yin, Changjun / Maffia, Pasquale

    2017  

    Abstract: The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places ...

    Abstract The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases
    Keywords Immunologic diseases. Allergy ; Medicine (General)
    Size 1 electronic resource (235 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095398
    ISBN 9782889451807 ; 2889451801
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Why we should reward peer reviewers.

    Maffia, Pasquale

    Cardiovascular research

    2018  Volume 114, Issue 5, Page(s) e30–e31

    MeSH term(s) Biomedical Research/ethics ; Biomedical Research/standards ; Databases, Factual ; Guidelines as Topic/standards ; Humans ; Journal Impact Factor ; Peer Review, Research/ethics ; Peer Review, Research/standards ; Periodicals as Topic/ethics ; Periodicals as Topic/standards ; Research Personnel/ethics ; Research Personnel/standards ; Reward ; Scientific Misconduct
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvy050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Understanding and controlling the increasing burden of cardiovascular diseases in Africa.

    Olowoyo, Paul / Maffia, Pasquale / Guzik, Tomasz J / Owolabi, Mayowa

    Cardiovascular research

    2024  Volume 120, Issue 4, Page(s) e9–e13

    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Africa/epidemiology ; Cause of Death ; Risk Factors
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immune and inflammatory mechanisms in hypertension.

    Guzik, Tomasz J / Nosalski, Ryszard / Maffia, Pasquale / Drummond, Grant R

    Nature reviews. Cardiology

    2024  

    Abstract: Hypertension is a global health problem, with >1.3 billion individuals with high blood pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension, emphasizing the crucial roles of immune cells, cytokines and chemokines in ... ...

    Abstract Hypertension is a global health problem, with >1.3 billion individuals with high blood pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension, emphasizing the crucial roles of immune cells, cytokines and chemokines in disease initiation and progression. T cells, monocytes, macrophages, dendritic cells, B cells and natural killer cells are all implicated in hypertension. Neoantigens, the NLRP3 inflammasome and increased sympathetic outflow, as well as cytokines (including IL-6, IL-7, IL-15, IL-18 and IL-21) and a high-salt environment, can contribute to immune activation in hypertension. The activated immune cells migrate to target organs such as arteries (especially the perivascular fat and adventitia), kidneys, the heart and the brain, where they release effector cytokines that elevate blood pressure and cause vascular remodelling, renal damage, cardiac hypertrophy, cognitive impairment and dementia. IL-17 secreted by CD4
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00964-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunopharmacology sessions at the 19th World Congress of Basic & Clinical Pharmacology 2023.

    Peh, Hong Yong / Gurgone, Danila / Maffia, Pasquale

    Pharmacological research

    2023  Volume 196, Page(s) 106911

    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106911
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  8. Article ; Online: Cellular metabolism and diseases.

    Maiuri, Maria Chiara / Maffia, Pasquale

    British journal of pharmacology

    2021  Volume 178, Issue 10, Page(s) 2031–2033

    Abstract: Linked articles: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc. ...

    Abstract Linked articles: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation.

    Wiejak, Jolanta / Murphy, Fiona A / Maffia, Pasquale / Yarwood, Stephen J

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15889

    Abstract: Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamentally attributed ... ...

    Abstract Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamentally attributed to a complex cellular crosstalk between vascular smooth muscle cells (VSMCs), vascular endothelial cells (VECs) and central immune cells, such as macrophages (Mɸs), which promote vascular inflammation. The presence of VSMCs exerts both positive and negative effects during atheroma development, which can be attributed to their phenotypic plasticity. Understanding the interactions between these key cell types during the development of vascular inflammation and atheroma will enhance the scope for new therapeutic interventions. This study aims to determine the importance of VSMCs for shaping the extracellular cytokine/chemokine profile and transcriptional responses of VECs (human coronary artery endothelial cells; HCAECs) to activated lipopolysaccharide (LPS)-stimulated THP1 Mɸs, in a 3-cell model of human vascular inflammation. It is evident that within the presence of VSMCs, enhanced cytokine production was associated with up-regulation of genes associated with vascular inflammation t. Results demonstrate that the presence of VSMCs in co-culture experiments enhanced cytokine production (including CXCL1/GROα, IL-6, IL-8 and CCL2/MCP1) and inflammatory gene expression (including genes involved in JAK/STAT, Jun and NFκB signalling) in HCAECs co-cultured with LPS-stimulated THP1 Mɸs. Our results highlight the importance of VSMCs in immune/endothelial cell interplay and indicate that 3-cell, rather than 2-cell co-culture, may be more appropriate for the study of cellular crosstalk between immune and vascular compartments in response to inflammatory and atherogenic stimuli.
    MeSH term(s) Humans ; Muscle, Smooth, Vascular/metabolism ; Plaque, Atherosclerotic/pathology ; Cells, Cultured ; Endothelial Cells/metabolism ; Lipopolysaccharides/metabolism ; Cytokines/metabolism ; Atherosclerosis/pathology ; Inflammation/metabolism ; Myocytes, Smooth Muscle/metabolism
    Chemical Substances Lipopolysaccharides ; Cytokines
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43221-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Light sheet fluorescence microscopy for quantitative three-dimensional imaging of vascular remodelling.

    MacRitchie, Neil / Maffia, Pasquale

    Cardiovascular research

    2020  Volume 117, Issue 2, Page(s) 348–350

    MeSH term(s) Humans ; Imaging, Three-Dimensional ; Microscopy, Fluorescence ; Vascular Remodeling ; Vascular System Injuries
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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