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  1. Book ; Online ; E-Book: Controversies in Testosterone Deficiency

    Mulhall, John P. / Maggi, M. / Trost, Landon

    2021  

    Abstract: This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone ... ...

    Author's details edited by John P. Mulhall, Mario Maggi, Landon Trost
    Abstract This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.
    Keywords Urology ; Endocrinology ; Reproductive health ; Reproductive Medicine
    Subject code 612.61
    Language English
    Size 1 online resource (143 pages)
    Edition 1st ed. 2021.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-77111-3 ; 3-030-77110-5 ; 978-3-030-77111-9 ; 978-3-030-77110-2
    DOI 10.1007/978-3-030-77111-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: La comunicazione del rischio chimico. Sperimentazione e valutazione nelle scuole di Roma

    Maggi, Manlio / Fasanella, Antonio / De Cataldo, Alessandra

    2016  

    Abstract: The book contains the results of a research on the outcomes of a communication campaign of the risks related to exposure to chemicals. The initiative, aimed at students of 3rd, 4th and 5th high school classes of the City of Rome, explored the initial ... ...

    Abstract The book contains the results of a research on the outcomes of a communication campaign of the risks related to exposure to chemicals. The initiative, aimed at students of 3rd, 4th and 5th high school classes of the City of Rome, explored the initial level of skills and knowledge on the chemical hazard, and then assessed the increase as a result of an information campaign conducted by experts of Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), in order to spread knowledge on the subject and form a group of aware young citizens
    Keywords Sociology (General) ; Social sciences (General)
    Size 1 electronic resource ( p.)
    Publisher FrancoAngeli
    Document type Book ; Online
    Note Italian ; Open Access
    HBZ-ID HT020092282
    ISBN 9788891739612 ; 8891739618
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Response to Letter to the Editor from Lui et al.: 'Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease': prognostic significance of non-thyroidal illness syndrome in the whole spectrum of COVID-19 severity.

    Sparano, C / Maggi, M / Petrone, L

    Journal of endocrinological investigation

    2022  Volume 45, Issue 4, Page(s) 903–904

    MeSH term(s) Biomarkers ; COVID-19 ; Euthyroid Sick Syndromes/diagnosis ; Humans ; Prognosis ; SARS-CoV-2
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-01-28
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-021-01733-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1480: Show issues Location:
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  4. Article: Update on known and emergent viruses affecting human male genital tract and fertility.

    Dabizzi, Sara / Maggi, Mario / Torcia, Maria Gabriella

    Basic and clinical andrology

    2024  Volume 34, Issue 1, Page(s) 6

    Abstract: Many viruses infect the male genital tract with harmful consequences at individual and population levels. In fact, viral infections may induce damage to different organs of the male genital tract (MGT), therefore compromising male fertility. The ... ...

    Abstract Many viruses infect the male genital tract with harmful consequences at individual and population levels. In fact, viral infections may induce damage to different organs of the male genital tract (MGT), therefore compromising male fertility. The oxidative stress, induced during viral-mediated local and systemic inflammation, is responsible for testicular damage, compromising germinal and endocrine cell functions. A reduction in sperm count, motility, number of normal sperm and an increase in DNA fragmentation are all common findings in the course of viral infections that, however, generally regress after infection clearance. In some cases, however, viral shedding persists for a long time leading to unexpected sexual transmission, even after the disappearance of the viral load from the blood.The recent outbreak of Zika and Ebola Virus evidenced how the MGT could represent a reservoir of dangerous emergent viruses and how new modalities of surveillance of survivors are strongly needed to limit viral transmission among the general population.Here we reviewed the evidence concerning the presence of relevant viruses, including emergent and re-emergent, on the male genital tract, their route of entry, their adverse effects on male fertility and the pattern of viral shedding in the semen.We also described laboratory strategies to reduce the risk of horizontal or vertical cross-infection in serodiscordant couples undergoing assisted reproductive technologies.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2732675-5
    ISSN 2051-4190
    ISSN 2051-4190
    DOI 10.1186/s12610-024-00222-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Essbare Stadt

    Maggi, Maurice / Périsset, Boris / Chrétien, Juliette

    2014  

    Author's details Maurice Maggi
    Keywords Wildpflanzen ; Essbare Pflanzen ; Wildkräuter
    Subject Wildpflanze
    Language German
    Size 319 S. : zahlr. Ill., 265 mm x 195 mm
    Publisher AT Verl
    Publishing place Aarau u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018165125
    ISBN 978-3-03800-777-7 ; 3-03800-777-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    144/107 available for loan (reading room) Freihandmagazin (U1)

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  6. Article ; Online: Testosterone Therapy is Associated With Depression, Suicidality, and Intentional Self-harm: Analysis of a National Federated Database Testosterone Therapy with a Man with Equivocal Testosterone Levels.

    Corona, Giovanni / Maggi, Mario

    The journal of sexual medicine

    2022  Volume 19, Issue 7, Page(s) 1201–1203

    MeSH term(s) Depression/drug therapy ; Humans ; Male ; Self-Injurious Behavior ; Suicidal Ideation ; Suicide ; Testosterone/adverse effects
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-04-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2022.03.613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6417: Show issues Location:
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    Zs.MO 505: Show issues

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  7. Article ; Online: The role of testosterone in male sexual function.

    Corona, Giovanni / Maggi, Mario

    Reviews in endocrine & metabolic disorders

    2022  Volume 23, Issue 6, Page(s) 1159–1172

    Abstract: Sexual function, and testosterone (T) levels, progressively decline in aging men. Associated morbidities and metabolic disorders can accelerate the phenomenon. The specific contribution of low T to sexual function impairment in aging men has still not ... ...

    Abstract Sexual function, and testosterone (T) levels, progressively decline in aging men. Associated morbidities and metabolic disorders can accelerate the phenomenon. The specific contribution of low T to sexual function impairment in aging men has still not been completely clarified. Similarly, the role of T replacement therapy (TRT), as well as the combination of TRT with phosphodiesterase type 5 inhibitors (PDE5i) for patients with erectile dysfunction (ED), is still conflicting. Here we aim to summarize and critically discuss all available data supporting the contribution of low T to sexual impairment observed with aging as well as the possible role of TRT. Available data on men with sexual dysfunction show that reduced sexual desire is the most important correlate of male hypogonadism. Conversely, aging and associated morbidities substantially attenuate the relationship between ED and T. TRT is effective in improving sexual function in middle-aged and older subjects but its role is small and extremely variable. Lifestyle interventions can result in similar outcomes to those of TRT. In conclusion, it is our opinion that PDE5i along with lifestyle measures should be considered the first approach for treating ED even in subjects with milder T deficiency. When these interventions fail or are difficult to apply, TRT should be considered.
    Language English
    Publishing date 2022-08-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-022-09748-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6069: Show issues Location:
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  8. Article ; Online: Testosterone Therapy With a Man With Equivocal Testosterone Levels.

    Corona, Giovanni / Maggi, Mario

    The journal of sexual medicine

    2022  Volume 19, Issue 11, Page(s) 1587–1590

    MeSH term(s) Male ; Humans ; Testosterone/therapeutic use ; Hypogonadism/drug therapy ; Hormone Replacement Therapy
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2022.03.601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6417: Show issues Location:
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  9. Article ; Online: Structural Aspects of

    Maggi, Maristella / Scotti, Claudia

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: Bacterial L-asparaginases are amidohydrolases (EC 3.5.1.1) capable of deaminating L-asparagine and, with reduced efficiency, L-glutamine. Interest in the study of L-asparaginases is driven by their use as biodrugs for the treatment of acute lymphoblastic ...

    Abstract Bacterial L-asparaginases are amidohydrolases (EC 3.5.1.1) capable of deaminating L-asparagine and, with reduced efficiency, L-glutamine. Interest in the study of L-asparaginases is driven by their use as biodrugs for the treatment of acute lymphoblastic leukemia. Here, we report for the first time the description of the molecular structure of type II asparaginase from
    MeSH term(s) Asparaginase/chemistry ; Asparaginase/genetics ; Aspartic Acid/metabolism ; Dickeya chrysanthemi ; Escherichia coli/metabolism ; Glutamic Acid/metabolism ; Glutamine/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; Aspartic Acid (30KYC7MIAI) ; Glutamic Acid (3KX376GY7L) ; Asparaginase (EC 3.5.1.1)
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23115942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of diabetes mellitus on sperm quality and fertility outcomes: Clinical evidence.

    Lotti, Francesco / Maggi, Mario

    Andrology

    2022  Volume 11, Issue 2, Page(s) 399–416

    Abstract: Background: Diabetes mellitus is a global epidemic characterized by high morbidity and mortality. Diabetes mellitus can lead to acute and chronic systemic complications. Among them, a negative effect of diabetes mellitus on sperm quality and male/couple ...

    Abstract Background: Diabetes mellitus is a global epidemic characterized by high morbidity and mortality. Diabetes mellitus can lead to acute and chronic systemic complications. Among them, a negative effect of diabetes mellitus on sperm quality and male/couple fertility has been suggested. However, available studies in diabetes mellitus men evaluated relatively small cohorts with discordant results.
    Objectives: To evaluate the clinical evidences of the effects of diabetes mellitus on sperm quality and fertility outcomes.
    Methods: An extensive Medline search was performed identifying studies in the English language.
    Results: The prevalence of diabetes mellitus in infertile men ranges from 0.7% to 1.4%, while the prevalence of infertility in diabetes mellitus men, evaluated in a few studies, ranges from 35% to 51%. Male diabetes mellitus seems to play a negative effect on couple fecundity, while being childless or subfertile men might increase the risk of diabetes mellitus. Available cross-sectional studies investigating semen parameters and male sexual hormones in men with diabetes mellitus are heterogeneous, assessed relatively small cohorts, show often discordant results and frequently are not directly comparable to derive robust conclusions. Two meta-analyses support a negative effect of diabetes mellitus on sperm normal morphology and no effect on sperm total count, with contradictory results regarding other semen parameters. Considering only studies on type 1 diabetes mellitus men, meta-analyses support a negative effect of diabetes mellitus on sperm motility and no effect on sperm total count, with contradictory results regarding other semen parameters. The rate of children observed among type 1 diabetes mellitus men was lower than controls, especially in subjects with a longer diabetes mellitus duration. Couples with a diabetes mellitus male partner undergoing assisted reproduction techniques showed lower pregnancy rates than controls. No study evaluated the impact of diabetes mellitus treatment on semen quality and male fertility.
    Conclusions: Overall, available data show that diabetes mellitus might impair male reproductive health and couple fertility. However, further larger and full of details studies are needed.
    MeSH term(s) Female ; Humans ; Male ; Pregnancy ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Fertility ; Infertility, Male/etiology ; Meta-Analysis as Topic ; Semen ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa
    Language English
    Publishing date 2022-12-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13342
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6983: Show issues Location:
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