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  1. Article ; Online: Intervertebral disc cell chondroptosis elicits neutrophil response in

    Schweizer, Tiziano A / Andreoni, Federica / Acevedo, Claudio / Scheier, Thomas C / Heggli, Irina / Maggio, Ewerton Marques / Eberhard, Nadia / Brugger, Silvio D / Dudli, Stefan / Zinkernagel, Annelies S

    Frontiers in immunology

    2022  Volume 13, Page(s) 908211

    Abstract: To understand the pathophysiology of spondylodiscitis due ... ...

    Abstract To understand the pathophysiology of spondylodiscitis due to
    MeSH term(s) Animals ; Cytokines/metabolism ; Discitis/metabolism ; Discitis/pathology ; Humans ; Intervertebral Disc/metabolism ; Neutrophils/metabolism ; Retrospective Studies ; Staphylococcal Infections/metabolism ; Staphylococcus aureus/metabolism ; Swine
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.908211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of macrophages type 2 and T-regs in immune checkpoint inhibitor related adverse events.

    Mihic-Probst, Daniela / Reinehr, Michael / Dettwiler, Susanne / Kolm, Isabel / Britschgi, Christian / Kudura, Ken / Maggio, Ewerton Marques / Lenggenhager, Daniela / Rushing, Elisabeth J

    Immunobiology

    2020  Volume 225, Issue 5, Page(s) 152009

    Abstract: Immune checkpoint inhibitory (ICI) therapy represents a novel approach in a variety of cancers, with impressive survival benefit. With ICIs, however, a new spectrum of immune related adverse events (irAE) including life threatening hypohysitis has ... ...

    Abstract Immune checkpoint inhibitory (ICI) therapy represents a novel approach in a variety of cancers, with impressive survival benefit. With ICIs, however, a new spectrum of immune related adverse events (irAE) including life threatening hypohysitis has emerged. This autopsy study aimed to investigate inflammatory cells, PD-1 and PD-L1 expression in cases of patients who developed hypophysitis and involvement of other organs. We analysed 6 patients, who were treated with ICIs and developed hypophysitis. Two received an additional MAP-kinase inhibitor, MEK-inhibitor and cytotoxic chemotherapy. Besides the pituitary gland, all investigated adrenal glands (5/5) were affected; three cases had other organs involved (liver (2/6), thyroid (2/6), lung (1/6), myocardium (1/6), colon (1/6). The inflammatory cells of involved organs were further specified and PD1 and PDL-1 expression was analyzed using immunohistochemistry. We observed that patients treated with ICIs alone showed T-cell predominant lymphocytic infiltrates, whereas patients receiving additional therapies demonstrated an increase in B- and T-lymphocytes. Surprisingly, the dominant inflammatory population was not T-cell, but type 2 macrophages. CD25 positive T-regs were sparse or absent. Our study suggests that T cell activation is only partially responsible for irAE. ICI therapy interaction with CTLA-4, PD-1 and PDL-1 in type 2 macrophages appears to result in disturbance of their control. Furthermore, depletion of T-regs seems to contribute significantly. Our findings with simultaneous pituitary and adrenal gland involvement underlines the systemic involvement as well as the importance of monitoring cortisol levels to avoid potentially life threatening hypocortisolism.
    MeSH term(s) Adrenal Glands/drug effects ; Adrenal Glands/immunology ; Adrenal Glands/pathology ; Adult ; Aged, 80 and over ; Antineoplastic Agents/adverse effects ; B7-H1 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/antagonists & inhibitors ; Colon/drug effects ; Colon/immunology ; Colon/pathology ; Fatal Outcome ; Female ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Macrophages/drug effects ; Macrophages/immunology ; Male ; Middle Aged ; Myocardium/immunology ; Myocardium/pathology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Pituitary Gland/drug effects ; Pituitary Gland/immunology ; Pituitary Gland/pathology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Thyroid Gland/drug effects ; Thyroid Gland/immunology ; Thyroid Gland/pathology
    Chemical Substances Antineoplastic Agents ; B7-H1 Antigen ; CD274 protein, human ; CTLA-4 Antigen ; CTLA4 protein, human ; Immune Checkpoint Inhibitors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-08-21
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2020.152009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.32: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Congenital peribronchial myofibroblastic tumor: a case report.

    de Noronha, Lúcia / Cecílio, William Augusto Casteleins / da Silva, Tarcísio Fulgêncio Alves / Maggio, Ewerton Marques / Serapião, Maria José

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2010  Volume 13, Issue 3, Page(s) 243–246

    Abstract: We describe a rare occurrence of congenital peribronchial myofibroblastic tumor of the lung presenting in early fetal life. A female patient in the 24th week of gestation who presented with polyhydramnios was admitted for examination. Ultrasound ... ...

    Abstract We describe a rare occurrence of congenital peribronchial myofibroblastic tumor of the lung presenting in early fetal life. A female patient in the 24th week of gestation who presented with polyhydramnios was admitted for examination. Ultrasound examination revealed a mass compromising the lungs. Because the intrauterine fetal death was revealed by the ultrasound, delivery was induced. Necropsy revealed a pulmonary lesion compromising the left lower pulmonary lobe together with hepatomegaly. Microscopic analysis of the lung showed a lesion with a storiform arrangement of spindle cells with focal peribronchial distribution. Hepatic architecture was diffusely altered by fibrotic tissue. Immunohistochemical analysis on the pulmonary lesion showed high vimentin positivity in the fusocellular components, pointing to the mesenchymal nature of the lesion. Significant differentiation of smooth muscle tissue, as indicated by high HHF35 positivity, was also observed. Electron microscopy on the pulmonary lesion revealed elongated cells with some cytoplasmatic processes, a finding that is also compatible with mesenchymal differentiation.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Female ; Fetal Death ; Gestational Age ; Humans ; Immunohistochemistry ; Liver/metabolism ; Liver/pathology ; Lung Neoplasms/congenital ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Neoplasms, Muscle Tissue/congenital ; Neoplasms, Muscle Tissue/metabolism ; Neoplasms, Muscle Tissue/pathology ; Pregnancy ; Pregnancy Complications, Neoplastic ; Ultrasonography, Prenatal ; Vimentin/metabolism
    Chemical Substances Biomarkers, Tumor ; Vimentin
    Language English
    Publishing date 2010-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.2350/07-05-0282.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5063: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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