Article ; Online: Cervical intraepithelial neoplasia in women who had vaccination against HPV.
2019 Volume 147, Issue 2, Page(s) 233–237
Abstract: Objective: To investigate the characteristics of women developing cervical intraepithelial neoplasia who had had a vaccination against human papillomavirus (HPV).: Methods: A retrospective cohort study was carried out of women diagnosed with moderate ...
| Abstract | Objective: To investigate the characteristics of women developing cervical intraepithelial neoplasia who had had a vaccination against human papillomavirus (HPV). Methods: A retrospective cohort study was carried out of women diagnosed with moderate or severe cervical dysplasia (CIN2+) in four Italian centers between 2015 and 2017. All women included had had previous bivalent or quadrivalent vaccination against HPV. Results: The present study included 43 patients affected by CIN2+. The median age was 28 (range, 21-41) years. Ten (23.3%) patients did not have a diagnosis of specific HPV type(s) involved: high-risk HPV was detected in 7 (16.3%) women while HPV testing was negative in 3 (6.9%) women. Lesions related to HPV16 were found in two patients. HPV types covered by nonavalent vaccination were diagnosed in 27/33 (81.8%) women. HPV types not covered by nonavalent vaccination were diagnosed in 6 (18.2%) women. Co-infections are most commonly detected in women with HPVs other than those included in the nonavalent vaccination (P=0.024). Conclusion: Cervical dysplasia occurring after HPV vaccination is a rare condition. Theoretically, nonavalent vaccination should improve protection against more than 80% of HPV-related lesions compared to other vaccines. |
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| MeSH term(s) | Adult ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/virology ; Female ; Humans ; Middle Aged ; Papillomaviridae/immunology ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/administration & dosage ; Papillomavirus Vaccines/immunology ; Retrospective Studies ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Dysplasia/virology ; Uterine Cervical Neoplasms/diagnosis ; Young Adult | ||||||||||
| Chemical Substances | Papillomavirus Vaccines | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2019-08-08 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Multicenter Study | ||||||||||
| ZDB-ID | 80149-5 | ||||||||||
| ISSN | 1879-3479 ; 0020-7292 | ||||||||||
| ISSN (online) | 1879-3479 | ||||||||||
| ISSN | 0020-7292 | ||||||||||
| DOI | 10.1002/ijgo.12934 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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