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  1. Article ; Online: Hypertension-A Social Disease in Need of Social Solutions.

    Magnani, Jared W

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 7, Page(s) 1414–1416

    MeSH term(s) Humans ; Hypertension/epidemiology
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Health Literacy is Essential to ASCVD Prevention in Youth.

    Mann, Harnoor K / Magnani, Jared W / Johnson, Amber E

    Current atherosclerosis reports

    2023  Volume 25, Issue 4, Page(s) 113–118

    Abstract: Purpose of review: Health literacy is fundamental to primary and primordial prevention of atherosclerotic vascular disease (ASCVD) in children and adolescents. Here we summarize essential components of interventions which address health literacy ... ...

    Abstract Purpose of review: Health literacy is fundamental to primary and primordial prevention of atherosclerotic vascular disease (ASCVD) in children and adolescents. Here we summarize essential components of interventions which address health literacy challenges to reduce ASCVD risk in youth.
    Recent findings: There is a global pandemic of suboptimal health behaviors among youth that may contribute to the increasing rates of ASCVD worldwide. Deficiencies in youth cardiovascular health have promoted increased attention to health education that incorporates health literacy. Studies conducted in both the child (0 to 9 years) and adolescent (10 to 17 years) population have shown improvement in health knowledge, health behaviors such as physical activity and eating habits, and objective measures such as body mass index (BMI), blood pressure, and serum lipid levels. The available literature affirms that the involvement of family and community members in young people's surroundings-including parents, teachers, and peers-can influence educational interventions' protective effects. Educational interventions which incorporate health literacy have demonstrated potential to address ASCVD risk factors in youth and may be augmented by caregiver and community involvement.
    MeSH term(s) Child ; Humans ; Adolescent ; Health Literacy ; Risk Factors ; Atherosclerosis/prevention & control ; Cardiovascular System ; Health Behavior
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-023-01086-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association of Depression and Adherence to Oral Anticoagulation in Patients With Atrial Fibrillation.

    Lapa, Matthew E / Swabe, Gretchen M / Magnani, Jared W

    Journal of the American Heart Association

    2023  , Page(s) e031281

    Abstract: Background: Adherence to oral anticoagulation is essential for stroke prevention in atrial fibrillation (AF). Depression has been associated with decreased adherence to medications in multiple disease states and in AF is further associated with ... ...

    Abstract Background: Adherence to oral anticoagulation is essential for stroke prevention in atrial fibrillation (AF). Depression has been associated with decreased adherence to medications in multiple disease states and in AF is further associated with increased risk of stroke. We hypothesized that individuals with depression and AF have decreased adherence to anticoagulation than those without depression.
    Methods and results: We used administrative claims data to identify individuals with AF initiating anticoagulation with direct-acting oral anticoagulants (DOACs) or warfarin between 2013 and 2019. We quantified adherence using proportion of days covered, categorized as limited (proportion of days covered, <80%), adequate (proportion of days covered, ≥80% to <90%), or optimal (proportion of days covered, ≥90%). We related depression to 12-month adherence to anticoagulation in logistic regression models, adjusting for demographics, medical and psychiatric comorbidities, household income, educational attainment, and insurance type. As a secondary analysis, we determined the association of depression to adherence for each DOAC agent. We identified 101 041 individuals (aged 74.5±8.9 years; 50.6% women; 29.5% race or ethnicity other than White, including Asian or Black race and Hispanic ethnicity) who initiated either DOACs or warfarin. The odds of adequate adherence to DOACs was 11% (95% CI, 0.85-0.93), and the odds of optimal adherence was 12% (95% CI, 0.83-0.91) less in individuals with depression than those without. Depression was not associated with adherence to warfarin.
    Conclusions: We identified an association between depression and decreased adherence to DOACs but not warfarin in individuals with AF. Recognizing depression in AF may guide interventions to improve anticoagulation adherence and reduce stroke risk.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Neighborhood on Cardiovascular Health: A Contemporary Narrative Review.

    Fullin, Kerianne / Keen, Susan / Harris, Kathryn / Magnani, Jared W

    Current cardiology reports

    2023  Volume 25, Issue 9, Page(s) 1015–1027

    Abstract: Purpose of review: This review summarizes approaches towards neighborhood characterization in relation to cardiovascular health; contemporary investigations relating neighborhood factors to cardiovascular risk and disease; and initiatives to support ... ...

    Abstract Purpose of review: This review summarizes approaches towards neighborhood characterization in relation to cardiovascular health; contemporary investigations relating neighborhood factors to cardiovascular risk and disease; and initiatives to support community-based interventions to address neighborhood-based social determinants related to cardiovascular health.
    Recent findings: Neighborhoods may be characterized by Census-derived measures, geospatial data, historical databases, and metrics that incorporate data from electronic medical records and health information exchange databases. Current research has examined neighborhood determinants spanning racial segregation, access to healthcare and food, educational opportunities, physical and built environment, and social environment, and their relations to cardiovascular health and associated outcomes. Community-based interventions have potential to alleviate health disparities but remain limited by implementation challenges. Consideration of neighborhood context is essential in the design of interventions to prevent cardiovascular disease (CVD) and promote health equity. Partnership with community stakeholders may enhance implementation of programs addressing neighborhood-based health determinants.
    MeSH term(s) Humans ; Health Promotion ; Cardiovascular Diseases/prevention & control
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01919-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Four "E"s to speed adoption of mHealth and promote cardiovascular behavioral medicine.

    Rollman, Bruce L / Muldoon, Matthew F / Magnani, Jared W

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association

    2022  Volume 41, Issue 10, Page(s) 765–769

    Abstract: Mobile health, also referred to as mHealth, is defined by the World Health Organization as the delivery of medical practice supported by mobile devices including smartphones, tablets, virtual assistants, and other wireless devices. Systematic reviews and ...

    Abstract Mobile health, also referred to as mHealth, is defined by the World Health Organization as the delivery of medical practice supported by mobile devices including smartphones, tablets, virtual assistants, and other wireless devices. Systematic reviews and meta-analyses confirm the effectiveness of mHealth tools at improving patient adherence to various self-care activities with downstream beneficial effects on blood pressure control and reduced health services utilization. Yet the clinical application of mHealth to cardiovascular behavioral medicine has been limited. Given high rates of smartphone ownership in the U.S., it is now possible, at least theoretically, to utilize mHealth on both a population-wide and highly personalized basis to prevent, diagnose, treat, and monitor response to therapy for a broad variety of cardiovascular behavioral medicine conditions. In keeping with the theme of this special issue of
    MeSH term(s) Behavioral Medicine ; Cardiovascular Diseases/therapy ; Humans ; Patient Acceptance of Health Care ; Self Care ; Smartphone ; Telemedicine
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 226369-5
    ISSN 1930-7810 ; 0278-6133
    ISSN (online) 1930-7810
    ISSN 0278-6133
    DOI 10.1037/hea0001171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Leaving the Social Vacuum: Expanding Cardiovascular Guidelines to Embrace Equity.

    Magnani, Jared W / Brewer, LaPrincess C

    Circulation

    2022  Volume 146, Issue 3, Page(s) 156–158

    MeSH term(s) Cardiovascular System ; Health Equity ; Humans
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.060881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cardiovascular Health in Black Americans: How Important Is Resilience?

    Johnson, Amber E / Magnani, Jared W

    Circulation. Cardiovascular quality and outcomes

    2020  Volume 13, Issue 10, Page(s) e007357

    MeSH term(s) Adult ; African Americans ; European Continental Ancestry Group ; Health Equity ; Hispanic Americans ; Humans
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.120.007357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Association of patient copayment and medication adherence in systemic lupus erythematosus.

    Lomanto Silva, Raisa / Swabe, Gretchen M / Sattui, Sebastian Eduardo / Magnani, Jared W

    Lupus science & medicine

    2023  Volume 10, Issue 2

    Abstract: Objective: To investigate the association of medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for SLE.: Methods: We conducted a retrospective analysis of health claims data using Optum's de-identified ... ...

    Abstract Objective: To investigate the association of medication copayment and treatment adherence to hydroxychloroquine and immunosuppressants for SLE.
    Methods: We conducted a retrospective analysis of health claims data using Optum's de-identified Clinformatics Data Mart Database. Individuals with SLE continuously enrolled for 180 days from 1 July 2010 to 31 December 2019 were included. Adherence was defined as the proportion of days covered ≥80%. Copayment for a 30-day supply of medication was dichotomised as high (≥$10) or low (<$10). We examined the association between copayment and odds of adherence in multivariable-adjusted logistic regression models, including age, sex, race or ethnicity, comorbidities, educational attainment and household income.
    Results: We identified 12 510 individuals (age 54.2±15.5 years; 88.2% female sex), of whom 9510 (76%) were prescribed hydroxychloroquine and 1880 (15%) prescribed hydroxychloroquine and an additional immunosuppressant (azathioprine, methotrexate or mycophenolate mofetil). Median (IQR) 30-day copayments were $8 (4-10) for hydroxychloroquine, $7 (2-10) for azathioprine, $8 (3-11) for methotrexate and $10 (5-20) for mycophenolate mofetil. High copayments were associated with OR of adherence of 0.61 (95% CI 0.55 to 0.68) for hydroxychloroquine, OR 0.44 (95% CI 0.30 to 0.66) for azathioprine and OR 0.69 (95% CI 0.49 to 0.96) for mycophenolate mofetil. For methotrexate, the association was not significant.
    Conclusion: In a large, administrative health claims database, we identified that high copayments were associated with reduced adherence to commonly prescribed medications for SLE. Incorporating awareness of the burden of copayments and its consequences into healthcare is essential to promote optimal medication adherence.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Aged ; Male ; Lupus Erythematosus, Systemic/drug therapy ; Hydroxychloroquine/therapeutic use ; Azathioprine/therapeutic use ; Methotrexate/therapeutic use ; Mycophenolic Acid/therapeutic use ; Retrospective Studies ; Immunosuppressive Agents/therapeutic use ; Medication Adherence
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azathioprine (MRK240IY2L) ; Methotrexate (YL5FZ2Y5U1) ; Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2779620-6
    ISSN 2053-8790
    ISSN 2053-8790
    DOI 10.1136/lupus-2023-000966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Income and antiplatelet adherence following percutaneous coronary intervention.

    LaRosa, Anna R / Swabe, Gretchen M / Magnani, Jared W

    International journal of cardiology. Cardiovascular risk and prevention

    2022  Volume 14, Page(s) 200140

    Abstract: Objective: To investigate the relation of annual household income to antiplatelet adherence following PCI.: Background: Treatment with 6-12 months of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) is a Class I ... ...

    Abstract Objective: To investigate the relation of annual household income to antiplatelet adherence following PCI.
    Background: Treatment with 6-12 months of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) is a Class I recommendation. Adherence to these medications is essential to reduce risk of stent thrombosis and recurrent ischemic events. Social risk factors like household income modify how patients access and adhere to essential pharmacologic therapies such as antiplatelet agents.
    Methods: We identified individuals presenting with PCI in an administrative claims database of commercially insured and Medicare Advantage beneficiaries from 2017 to 2019. We collected data on age, sex, race, ethnicity, educational attainment, and covariates (prevalent coronary disease, medications, healthcare visits, insurance type, copay, antiplatelet medications, and Elixhauser Comorbidity Index conditions). We related annual household income, categorized as <$40,000; $40-49,999; $50-59,999; $60-74,999; $75-99,999; and ≥$100 K, to proportion of days covered (PDC) in multivariable-adjusted regression models. We defined non-adherence as PDC <80%.
    Results: Our dataset included 90,163 individuals (age 69.0 ± 10.9 years, 33.1% women, 25.1% non-White race) who underwent PCI. We observed graded, decreased antiplatelet adherence across income categories: rates of PDC≥80% decreased with successively lower income. Individuals with annual income <$40,000 had 1.5-fold higher odds of non-adherence (95% CI, 1.40-1.56) compared to those with income ≥$100,000 after multivariable adjustment.
    Conclusions: In a claims-based analysis, we determined that lower income is associated with decreased likelihood of adherence to antiplatelet agents following PCI. Our results indicate the importance of considering social risk factors in the evaluation of barriers to antiplatelet adherence following PCI.
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-4875
    ISSN (online) 2772-4875
    DOI 10.1016/j.ijcrp.2022.200140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risk assessment for atrial fibrillation: Enter the P-wave.

    Magnani, Jared W

    Heart rhythm

    2015  Volume 12, Issue 9, Page(s) 1896–1897

    MeSH term(s) Atrial Fibrillation/physiopathology ; Electrocardiography/methods ; Female ; Humans ; Male ; Registries
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2015.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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