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  1. Article ; Online: Multidrug-resistant Acinetobacter baumannii infections in COVID-19 patients hospitalized in intensive care unit.

    Russo, Alessandro / Gavaruzzi, Francesca / Ceccarelli, Giancarlo / Borrazzo, Cristian / Oliva, Alessandra / Alessandri, Francesco / Magnanimi, Eugenia / Pugliese, Francesco / Venditti, Mario

    Infection

    2021  Volume 50, Issue 1, Page(s) 83–92

    Abstract: Objectives: Superinfections in patients hospitalized in intensive care unit (ICU) are an important and challenging complication, also in COVID-19. However, no definitive data are available about the role of multidrug-resistant Acinetobacter baumannii ( ... ...

    Abstract Objectives: Superinfections in patients hospitalized in intensive care unit (ICU) are an important and challenging complication, also in COVID-19. However, no definitive data are available about the role of multidrug-resistant Acinetobacter baumannii (MDR-AB) in COVID-19.
    Methods: This was a single-center, cross-sectional study including patients with MDR-AB infections admitted to ICU with or without COVID-19, between January 2019 and January 2021. The primary objective of the study was to evaluate risk factor for MDR-AB infections in ICU patients hospitalized for COVID-19 or other etiology. The secondary endpoints were 30-days mortality in all study population and risk factors associated with development of bloodstream infection (BSI).
    Results: During the study period 32 adults with COVID-19 were enrolled and compared with 115 patients admitted in the same ICU for other reasons. We observed a total of 114 deaths, with a survival rate of 29.3%: 18.8% in COVID-19 and 32.2% in control group. Relative risk for MDR-AB infection in COVID-19 showed that serum lactate levels mmol/l > 2, Acinetobacter baumannii colonization, BSI and steroid therapy were observed more frequently in COVID-19 patients. Cox regression analysis showed that serum lactate levels > 2 mmol/l, Acinetobacter baumannii colonization, BSI, and steroid therapy were associated with 30-days mortality. Finally, patients with COVID-19, white blood cells count > 11,000 mm
    Conclusions: Our data highlight the impact of BSI on outcome, the role of Acinetobacter baumannii colonization and the use of steroids on the risk to develop MDR-AB infections also during COVID-19.
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter baumannii ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross-Sectional Studies ; Drug Resistance, Multiple, Bacterial ; Humans ; Intensive Care Units ; Risk Factors ; SARS-CoV-2
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01643-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  2. Article ; Online: Identifying ethical values for guiding triage decisions during the COVID-19 pandemic: an Italian ethical committee perspective using Delphi methodology.

    Zeneli, Anita / Brandi, Giovanni / Di Pasquale, Giuseppe / Orlandini, Danilo / De Carolis, Piero / Bravi, Francesca / Pugliese, Francesco / Poluzzi, Elisabetta / Catena, Fausto / Giovanardi, Filippo / Valpiani, Giorgia / Mantovani, Renato / Magnanimi, Eugenia / Iannone, Primiano

    BMJ open

    2021  Volume 11, Issue 5, Page(s) e043239

    Abstract: Objectives: This study aimed to identify the guiding ethical principles that should be considered for critical resource allocation during pandemic emergency situations, and especially for the COVID-19 outbreak. The secondary objective was to define the ... ...

    Abstract Objectives: This study aimed to identify the guiding ethical principles that should be considered for critical resource allocation during pandemic emergency situations, and especially for the COVID-19 outbreak. The secondary objective was to define the priority to be assigned to each principle.
    Setting: The study was conducted from March to June 2020 within the context of an ethical committee (EC) in Northern Italy.
    Participants: Eleven EC members and five additional external healthcare and bioethical professionals, forming a multidisciplinary panel, took part in the study.
    Primary and secondary outcome measures: The compilation of a list of ethical principles (maximum of 10 items) and their priority ranking and application within an emergency pandemic context was established as the expected outcome of this work.
    Results: A consensus on 10 guiding ethical principles was reached by the multidisciplinary panel. Transparency ranked first on the priority list as the most frequently voted principle, followed by the number of lives saved, life-years saved, respect for individuals' autonomy and equity. Other principles including life cycle, 'sickest first', reciprocity, instrumental value and lottery were also considered appropriate as potential tiebreakers. These principles were discussed and made consistent with the current Italian pandemic context by producing an explanatory document.
    Conclusions: The identified principles could be used in preparedness plans to guide resource allocation during pandemic events. By combining their rank and relevance in relation to disease, health system organisations, social and economic settings, and critical resources at risk of scarcity, these principles could help to maximise the benefit of resource use for the community, thus reducing inequalities for individuals.
    MeSH term(s) COVID-19 ; Humans ; Italy/epidemiology ; Pandemics ; SARS-CoV-2 ; Triage
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-043239
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  3. Article ; Online: Fatal Takotsubo syndrome in critical COVID-19 related pneumonia.

    Titi, Luca / Magnanimi, Eugenia / Mancone, Massimo / Infusino, Fabio / Coppola, Giulia / Del Nonno, Franca / Colombo, Daniele / Nardacci, Roberta / Falasca, Laura / d'Amati, Giulia / Tarsitano, Maria Grazia / Merlino, Lucia / Fedele, Francesco / Pugliese, Francesco

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2020  Volume 51, Page(s) 107314

    Abstract: COVID-19 can involve several organs and systems, often with indirect and poorly clarified mechanisms. Different presentations of myocardial injury have been reported, with variable degrees of severity, often impacting on the prognosis of COVID-19 ... ...

    Abstract COVID-19 can involve several organs and systems, often with indirect and poorly clarified mechanisms. Different presentations of myocardial injury have been reported, with variable degrees of severity, often impacting on the prognosis of COVID-19 patients. The pathogenic mechanisms underlying cardiac damage in SARS-CoV-2 infection are under active investigation. We report the clinical and autopsy findings of a fatal case of Takotsubo Syndrome occurring in an 83-year-old patient with COVID-19 pneumonia. The patient was admitted to Emergency Department with dyspnea, fever and diarrhea. A naso-pharyngeal swab test for SARS-CoV-2 was positive. In the following week his conditions worsened, requiring intubation and deep sedation. While in the ICU, the patient suddenly showed ST segment elevation. Left ventricular angiography showed decreased with hypercontractile ventricular bases and mid-apical ballooning, consistent with diagnosis of Takotsubo syndrome. Shortly after the patient was pulseless. After extensive resuscitation maneuvers, the patient was declared dead. Autopsy revealed a subepicardial hematoma, in absence of myocardial rupture. On histology, the myocardium showed diffuse edema, multiple foci of contraction band necrosis in both ventricles and occasional coagulative necrosis of single cardiac myocytes. Abundant macrophages CD68+ were detected in the myocardial interstitium. The finding of diffuse contraction band necrosis supports the pathogenic role of increased catecholamine levels; the presence of a significant interstitial inflammatory infiltrate, made up by macrophages, remains of uncertain significance.
    MeSH term(s) Aged, 80 and over ; Autopsy ; Biopsy ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; COVID-19 Nucleic Acid Testing ; Fatal Outcome ; Humans ; Male ; Myocardium/pathology ; Takotsubo Cardiomyopathy/etiology ; Takotsubo Cardiomyopathy/pathology ; Takotsubo Cardiomyopathy/therapy
    Language English
    Publishing date 2020-11-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2020.107314
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3572: Show issues Location:
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  4. Article ; Online: Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19

    Chistolini, Antonio / Ruberto, Franco / Alessandri, Francesco / Santoro, Cristina / Barone, Francesco / Cristina Puzzolo, Maria / Ceccarelli, Giancarlo / De Luca, Maria L. / Mancone, Massimo / Alvaro, Domenico / Pulcinelli, Fabio M. / Martelli, Maurizio / Foà, Robin / Pugliese, Francesco / Albante, Alida / Antonelli, Guido / Araimo‐Morselli, Fabio / Auricchio, Daniela / Baldacci, Erminia /
    Bilotta, Federico / Brisciani, Matteo / Bruno, Katia / Cappannoli, Alessandro / Cardinale, Vincenzo / Celli, Paola / Consolo, Stella / Croce, Claudia / Crocitti, Beatrice / Curreli, Mariaignazia / D'Ettorre, Gabriella / De Lauri, Daniela / De Lazzaro, Francesco / De Luca, Maria Lucia / Fedele, Francesco / Ferretti, Antonietta / Galardo, Gioacchino / Giannetti, Lorena / Ianni, Stefano / Imperiale, Carmela / Maestrini, Viviana / Magnanimi, Eugenia / Maldarelli, Federica / Martelli, Sabina / Mastroianni, Claudio / Messina, Teresa / Olivieri, Sandra / Pallotta, Agnese / Pattelli, Elisa / Pecorari, Filippo / Perrella, Serena / Piazzolla, Mario / Portieri, Monica / Pulcinelli, Fabio / Ratini, Fabiola / Ricci, Claudia / Santopietro, Pietro / Serrao, Alessandra / Tellan, Guglielmo / Titi, Luca / Tordiglione, Paolo / Tosi, Antonella / Trigilia, Fausto

    2020  

    Abstract: The clinical picture of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)/coronavirus disease 2019 (COVID‐19)‐related acute respiratory syndrome is often associated with a coagulopathy.1 An elevated D‐dimer has been linked with an ... ...

    Abstract The clinical picture of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)/coronavirus disease 2019 (COVID‐19)‐related acute respiratory syndrome is often associated with a coagulopathy.1 An elevated D‐dimer has been linked with an unfavourable prognosis in patients with COVID‐19. In a recent cohort study, 71% of patients who died matched the International Society of Thrombosis and Hemostasis (ISTH) criteria for disseminated intravascular coagulation (DIC)2, while this percentage was only 0·6% in patients who survived.
    Keywords low‐molecular‐weight heparin ; thrombin ; COVID‐19 ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19

    Chistolini, Antonio / Ruberto, Franco / Alessandri, Francesco / Santoro, Cristina / Barone, Francesco / Cristina Puzzolo, Maria / Ceccarelli, Giancarlo / De Luca, Maria L. / Mancone, Massimo / Alvaro, Domenico / Pulcinelli, Fabio M. / Martelli, Maurizio / Foà, Robin / Pugliese, Francesco / Albante, Alida / Antonelli, Guido / Araimo‐Morselli, Fabio / Auricchio, Daniela / Baldacci, Erminia /
    Bilotta, Federico / Brisciani, Matteo / Bruno, Katia / Cappannoli, Alessandro / Cardinale, Vincenzo / Celli, Paola / Consolo, Stella / Croce, Claudia / Crocitti, Beatrice / Curreli, Mariaignazia / D'Ettorre, Gabriella / Daniela, De Lauri / De Lazzaro, Francesco / De Luca, Maria Lucia / Fedele, Francesco / Ferretti, Antonietta / Galardo, Gioacchino / Giannetti, Lorena / Ianni, Stefano / Imperiale, Carmela / Maestrini, Viviana / Magnanimi, Eugenia / Maldarelli, Federica / Martelli, Sabina / Mastroianni, Claudio / Messina, Teresa / Olivieri, Sandra / Pallotta, Agnese / Pattelli, Elisa / Pecorari, Filippo / Perrella, Serena / Piazzolla, Mario / Portieri, Monica / Pulcinelli, Fabio / Ratini, Fabiola / Ricci, Claudia / Santopietro, Pietro / Serrao, Alessandra / Tellan, Guglielmo / Titi, Luca / Tordiglione, Paolo / Tosi, Antonella / Trigilia, Fausto

    British Journal of Haematology

    2020  Volume 190, Issue 4

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Uh III Zs.182: Show issues Location:
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  6. Article ; Online: Usefulness of bronchoalveolar lavage in suspect COVID-19 repeatedly negative swab test and interstitial lung disease

    Vannucci, Jacopo / Ruberto, Franco / Diso, Daniele / Galardo, Gioacchino / Mastroianni, Claudio M. / Raponi, Giammarco / Bassi, Massimiliano / Ceccarelli, Giancarlo / Mancone, Massimo / Antonelli, Guido / Venuta, Federico / Pugliese, Francesco / Albante, Alida / Alessandri, Francesco / Amore, Davide / Anile, Marco / Antognoli, Maria Gloria / Morselli, Fabio Araimo / Auricchio, Daniela /
    Bianco, Martina / Bilotta, Federico / Birtolo, Lucia Ilaria / Brisciani, Matteo / Bruno, Katia / Bufi, Maurizio / Cagnetti, Sara / Calzecchi, Elena / Cappannoli, Alessandro / Carillo, Carolina / Casaretti, Romina / Catalano, Carlo / Celli, Paola / Consolo, Stella / Croce, Claudia / Crocitti, Beatrice / Cuscianna, Enrica / D’Agostino, Federica Gilda / Giacomo, Tiziano De / Lauri, Daniela De / Lazzaro, Francesco De / Del Monte, Maurizio / D’Ettorre, Gabriella / Di Bella, Valerio / Fedele, Francesco / Gentile, Massimo / Giordano, Giovanni / Ianni, Stefano / Imperiale, Carmela / Infusino, Fabio / Loiacono, Cinzia / Maestrini, Viviana / Magnanimi, Eugenia / Maldarelli, Federica / Mantovani, Sara / Martelli, Sabina / Messercola, Paolo / Messina, Teresa / Mottola, Emilia / Pati, Valeria / Pattelli, Elisa / Pecorari, Filippo / Pecoraro, Ylenia / Perrella, Serena Maria / Piazzolla, Mario / Pietropaolo, Valeria / Poggi, Camilla / Portieri, Monica / Ratini, Fabiola / Ricci, Claudia / Ricci, Paolo / Rumori, Mario / Russo, Gianluca / Santopietro, Pietro / Tellan, Guglielmo / Titi, Luca / Tordiglione, Paolo / Tosi, Antonella / Tosti, Silvia / Trigilia, Fausto / Turriziani, Ombretta / Vaccaro, Paola / Verduci, Noemi / Vivino, Gabriella

    Journal of Global Antimicrobial Resistance

    2020  Volume 23, Page(s) 67–69

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2020.07.030
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