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  1. Article: Therapy and Prevention for Human Toxocariasis

    Magnaval, Jean-François / Bouhsira, Emilie / Fillaux, Judith

    Microorganisms. 2022 Jan. 22, v. 10, no. 2

    2022  

    Abstract: For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has ... ...

    Abstract For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has lagged behind. To date, only four drugs are registered for human use, and their efficacy has rarely been assessed in prospective controlled trials. It is likely that the repurposing of potent anthelmintics from veterinary medicine will improve this situation. Due to its wide availability and a lack of major side effects during short regimens, albendazole has become the drug of choice. However, its efficacy should be more precisely assessed. The role of anthelmintics in the treatment of neurological or ocular toxocariasis remains to be clarified. Prophylactic measures in humans or companion animals are efficient and represent first-line treatments for the control of this zoonosis. Unfortunately, their implementation in areas or countries where toxocariasis epidemiology is driven by poverty is quite difficult or unrealistic.
    Keywords albendazole ; epidemiology ; humans ; laboratory diagnosis ; pathophysiology ; poverty ; therapeutics ; toxocariasis ; veterinary medicine ; zoonoses
    Language English
    Dates of publication 2022-0122
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020241
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis

    Magnaval, Jean-François / Fillaux, Judith / Berry, Antoine

    Pathogens. 2022 July 20, v. 11, no. 7

    2022  

    Abstract: In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 ... ...

    Abstract In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 mg/kg b/w daily for 14 days, and diethylcarbamazine (DEC) was given at 4 mg/kg b/w daily for 21 days. In both groups, follow-up consultations occurred approximately 48 days after the end of the anthelmintic therapy. ABZ and DEC displayed a similar efficacy on the kinetics of the clinical picture (−64.5% of reduction vs. −72.7%, respectively) and on the levels of blood eosinophilia, serum eosinophil cationic protein and serum total IgE. However, the effect of the medication on the laboratory parameters was moderate. The rate of adverse reactions was similar in both groups (38% for ABZ vs. 31% for DEC), but DEC-treated patients complained of more intense and long-lasting side effects. The DEC group had more major adverse reactions, resulting in the termination of the anthelmintic treatment. The results from this retrospective study bring further arguments for considering ABZ, given at 10 mg/kg daily for 2 weeks, as the drug of choice in the treatment of human toxocariasis.
    Keywords albendazole ; blood serum ; diethylcarbamazine ; drug therapy ; eosinophilia ; humans ; mycology ; parasitology ; retrospective studies ; toxocariasis
    Language English
    Dates of publication 2022-0720
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11070813
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Therapy and Prevention for Human Toxocariasis.

    Magnaval, Jean-François / Bouhsira, Emilie / Fillaux, Judith

    Microorganisms

    2022  Volume 10, Issue 2

    Abstract: For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has ... ...

    Abstract For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has lagged behind. To date, only four drugs are registered for human use, and their efficacy has rarely been assessed in prospective controlled trials. It is likely that the repurposing of potent anthelmintics from veterinary medicine will improve this situation. Due to its wide availability and a lack of major side effects during short regimens, albendazole has become the drug of choice. However, its efficacy should be more precisely assessed. The role of anthelmintics in the treatment of neurological or ocular toxocariasis remains to be clarified. Prophylactic measures in humans or companion animals are efficient and represent first-line treatments for the control of this zoonosis. Unfortunately, their implementation in areas or countries where toxocariasis epidemiology is driven by poverty is quite difficult or unrealistic.
    Language English
    Publishing date 2022-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis.

    Magnaval, Jean-François / Fillaux, Judith / Berry, Antoine

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 7

    Abstract: In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 ... ...

    Abstract In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 mg/kg b/w daily for 14 days, and diethylcarbamazine (DEC) was given at 4 mg/kg b/w daily for 21 days. In both groups, follow-up consultations occurred approximately 48 days after the end of the anthelmintic therapy. ABZ and DEC displayed a similar efficacy on the kinetics of the clinical picture (-64.5% of reduction vs. -72.7%, respectively) and on the levels of blood eosinophilia, serum eosinophil cationic protein and serum total IgE. However, the effect of the medication on the laboratory parameters was moderate. The rate of adverse reactions was similar in both groups (38% for ABZ vs. 31% for DEC), but DEC-treated patients complained of more intense and long-lasting side effects. The DEC group had more major adverse reactions, resulting in the termination of the anthelmintic treatment. The results from this retrospective study bring further arguments for considering ABZ, given at 10 mg/kg daily for 2 weeks, as the drug of choice in the treatment of human toxocariasis.
    Language English
    Publishing date 2022-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11070813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach.

    Foroutan, Masoud / Vafae Eslahi, Aida / Soltani, Shahrzad / Kamyari, Naser / Moradi-Joo, Ehsan / Magnaval, Jean-Francois / Badri, Milad

    Journal of immunology research

    2024  Volume 2024, Page(s) 4246781

    Abstract: Toxocariasis is one of the most common zoonotic diseases distributed worldwide. This study aimed to estimate the seroprevalence of anti- ...

    Abstract Toxocariasis is one of the most common zoonotic diseases distributed worldwide. This study aimed to estimate the seroprevalence of anti-
    MeSH term(s) Male ; Female ; Humans ; Animals ; Dogs ; Middle Aged ; Toxocariasis/epidemiology ; Toxocariasis/etiology ; Seroepidemiologic Studies ; Cross-Sectional Studies ; Iran/epidemiology ; One Health ; Antibodies, Helminth ; Toxocara ; Zoonoses/epidemiology ; Zoonoses/complications ; Enzyme-Linked Immunosorbent Assay ; Risk Factors ; Immunoglobulin G ; Water
    Chemical Substances Antibodies, Helminth ; Immunoglobulin G ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-13
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2024/4246781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Parasitic Infections and Biological Therapies Targeting Type 2 Inflammation: A VigiBase Study.

    Lifar, Philippine / Montastruc, François / Reber, Laurent L / Magnaval, Jean-François / Guilleminault, Laurent

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 9, Page(s) 1253–1255

    MeSH term(s) Humans ; Asthma ; Parasitic Diseases ; Biological Therapy ; Inflammation
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1898LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.80: Show issues Location:
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  7. Article: Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic.

    Magnaval, Jean-François / Fillaux, Judith / Fabre, Richard / Cassaing, Sophie / Valentin, Alexis / Iriart, Xavier / Berry, Antoine

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: The present retrospective study analyzed the characteristics of strongyloidiasis in patients who were diagnosed at the Outpatient Clinic of the Department of Parasitology-Mycology, Toulouse, France. Sixty-nine file records were included in the study on ... ...

    Abstract The present retrospective study analyzed the characteristics of strongyloidiasis in patients who were diagnosed at the Outpatient Clinic of the Department of Parasitology-Mycology, Toulouse, France. Sixty-nine file records were included in the study on the basis of a positive stool examination that used Baermann's method. The prominent epidemiological findings were the presence of former immigrants from Italy or Portugal, veterans from the 1st Indochina war, and autochthonous cases. Almost 1/4 of the patients were asymptomatic. Manifestations of skin allergy were the main clinical feature. Blood eosinophilia was present in 76.8% of the patients, and serum total IgE was ≥150 kIU/L in 79.7%. Immunodiagnosis was achieved from 1990 to 2001 by indirect immunofluorescence (IFAT) that was then replaced with ELISA, both methods using
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12080983
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  8. Article ; Online: Toxocariasis-associated urinary system diseases: a systematic review of reported cases.

    Ardekani, Ali / Roshanshad, Amirhossein / Hosseini, Seyed Ali / Magnaval, Jean-François / Abdollahi, Ali / Rostami, Ali

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2021  Volume 116, Issue 7, Page(s) 668–672

    Abstract: Background: Toxocariasis is a neglected tropical disease caused by Toxocara canis and Toxocara cati. Toxocara species can involve many organs, such as the brain, heart and lungs, however, the urinary system involvement of toxocariasis is largely unknown. ...

    Abstract Background: Toxocariasis is a neglected tropical disease caused by Toxocara canis and Toxocara cati. Toxocara species can involve many organs, such as the brain, heart and lungs, however, the urinary system involvement of toxocariasis is largely unknown.
    Methods: We performed a systematic review to identify cases infected with urinary tract toxocariasis.
    Results: We identified seven cases that were eligible to be reviewed. Among the included citations, four studies reported bladder involvement and three reported kidney involvement. Fever, urinary, and abdominal presentations were amongst the most important clinical symptoms. Eosinophilic cystitis and nephrotic syndrome were the most common diagnoses.. The treatment regimen included a combination of anthelmintic drugs and steroids.
    Conclusions: In cases of urinary tract presentations accompanied by eosinophilia or histopathologic findings suggestive of parasitic infection, toxocariasis should be included in the list of differential diagnoses, especially in endemic areas.
    MeSH term(s) Animals ; Anthelmintics/therapeutic use ; Eosinophilia/diagnosis ; Humans ; Neglected Diseases/complications ; Toxocara ; Toxocara canis ; Toxocariasis/diagnosis ; Toxocariasis/drug therapy ; Toxocariasis/epidemiology
    Chemical Substances Anthelmintics
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trab177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Un I Zs.257: Show issues Location:
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  9. Article ; Online: Human toxocariasis and atopy.

    Magnaval, Jean-François / Fillaux, Judith / Cassaing, Sophie / Valentin, Alexis / Iriart, Xavier / Berry, Antoine

    Parasite (Paris, France)

    2020  Volume 27, Page(s) 32

    Abstract: To assess the possible influence of atopy on the clinical picture of human toxocariasis, a retrospective study was carried out using file records for patients who attended the Outpatient Clinic of Parasitology in Toulouse University Hospitals. A total of ...

    Title translation Toxocarose humaine et atopie.
    Abstract To assess the possible influence of atopy on the clinical picture of human toxocariasis, a retrospective study was carried out using file records for patients who attended the Outpatient Clinic of Parasitology in Toulouse University Hospitals. A total of 106 file records for patients who had been diagnosed with common/covert toxocariasis were extracted from the database. Forty-nine patients (20 females and 29 males) were considered atopic since they exhibited a long (≥ 1 year) history of various allergic issues along with a titer ≥ 0.7 kIU/L for specific IgE against at least two out of nine mixes of common inhalant allergens. Fifty-seven patients (42 females and 15 males) were designated nonatopic on the basis of a negative result (<0.35 kIU/L) of the test for specific IgE. Demographic (age and sex), clinical (20 signs or symptoms) and laboratory (blood eosinophil count, eosinophil cationic protein, serum total IgE, and specific anti-Toxocara IgE) variables were investigated by bivariate analysis followed by multivariate regression analysis using "atopy" as the outcome variable. On the basis of our results, the clinical or laboratory picture of toxocaral disease was not affected by the presence of an atopic status.
    MeSH term(s) Adult ; Animals ; Antibodies, Helminth/blood ; Eosinophil Cationic Protein/blood ; Eosinophils/cytology ; Female ; France ; Humans ; Hypersensitivity, Immediate/immunology ; Hypersensitivity, Immediate/parasitology ; Immunoglobulin E/blood ; Leukocyte Count ; Male ; Middle Aged ; Outpatients ; Retrospective Studies ; Toxocara ; Toxocariasis/immunology
    Chemical Substances Antibodies, Helminth ; Immunoglobulin E (37341-29-0) ; Eosinophil Cationic Protein (EC 3.1.27.-)
    Language English
    Publishing date 2020-05-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 1187629-3
    ISSN 1776-1042 ; 1252-607X
    ISSN (online) 1776-1042
    ISSN 1252-607X
    DOI 10.1051/parasite/2020029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3965: Show issues Location:
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  10. Article: Toxocariasis after slug ingestion characterized by severe neurologic, ocular, and pulmonary involvement.

    Fellrath, Jean-Marc / Magnaval, Jean-François

    Open forum infectious diseases

    2014  Volume 1, Issue 2, Page(s) ofu063

    Abstract: Human toxocariasis is generally a benign, self-curing disease, and neurologic involvement is quite exceptional. In this study, we report a case of toxocariasis caused by ingestion of an unusual transport host, namely live slugs. The clinical picture ... ...

    Abstract Human toxocariasis is generally a benign, self-curing disease, and neurologic involvement is quite exceptional. In this study, we report a case of toxocariasis caused by ingestion of an unusual transport host, namely live slugs. The clinical picture comprised eosinophilic lung involvement with severe neurologic disorders in relation to vasculitis as well as retinal detachment.
    Keywords covid19
    Language English
    Publishing date 2014-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofu063
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