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  1. Book ; Thesis: Technische Machbarkeit und Offenheitsraten der stentgestützten Angioplastie der Arteria iliaca interna im Rahmen komplexer endovaskulärer Aorteneingriffe zur Prophylaxe von spinalen Ischämien

    Gronert, Catharina / Magnus, Tim / Kölbel, Tilo

    2022  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Catherina Gronert ; Prüfungsausschuss, der/die Vorsitzende: Prof. Dr. Tim Magnus, Prüfungsausschuss, zweite/r Gutachter/in: Prof. Dr. Tilo Kölbel
    Language German ; English
    Size 9, 21 Blätter, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2023
    Note Text in deutsch, Zeitschriftenartikel in englisch ; Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg ; Enthält 1 Zeitschriftenartikel
    HBZ-ID HT030346325
    Database Catalogue ZB MED Medicine, Health

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    2023 E 1234 order for loan Magazin

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  2. Book ; Thesis: The effects of intravenous immunoglobulins on the cytokine release from primary murine microglia

    Jank, Larissa / Mittrücker, Hans-Willi / Magnus, Tim

    2021  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Larissa Jank ; Prüfungsausschuss, der/die Vorsitzende: Prof. Dr. Hans-Willi Mittrücker, Prüfungsausschuss, zweite/r Gutachter/in: Prof. Dr. Tim Magnus
    Language English
    Size 75 Blätter, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2021
    Note Literaturverzeichnis: Blatt 61-72. - Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg
    HBZ-ID HT021374250
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Therapie und Verlauf neurologischer Erkrankungen

    Schoser, Benedikt / Schulz, Jörg B. / Dietz, Volker / Ghilescu, Voica / Münchau, Alexander / Wick, Wolfgang / Bingel, Ulrike / Hermann, Wieland / Wiendl, Heinz / Krauss, Joachim K. / Timmann-Braun, Dagmar / Katsarava, Zaza / Forsting, Michael / Kastrup, Oliver / Magnus, Tim / Thomalla, Götz / Fetter, Michael / Schankin, Christoph / Schipper, Jörg H. /
    Diener, Hans-Christoph / Gerloff, Christian / Dieterich, Marianne / Endres, Matthias

    2023  

    Author's details Hans-Cristoph Diener, Christian Gerloff, Marianne Dieterich, Matthias Endres (Hrsg.)
    MeSH term(s) Nervous System Diseases/therapy
    Keywords Hirnstamm ; Kognitive Störungen ; Nervenheilkunde ; Neurologie ; Neurowissenschaften ; Zerebrovaskuläre Erkrankungen ; Neurologie, Klinische Neurowissenschaft ; Single-item retail product ; Psychiatrie, Sozialpsychiatrie, Suchttherapie ; Allgemeinmedizin, Familienmedizin ; Nervensystem ; Krankheit ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS
    Language German
    Size Inklusive kostenfreiem Zugang zur Online-Ausgabe ; 1704 Seiten
    Edition 8., erweiterte und überarbeitete Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT021872044
    ISBN 978-3-17-039966-2 ; 9783170399679 ; 9783170399686 ; 3-17-039966-7 ; 3170399675 ; 3170399683
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Unveiling the immunopathology of stroke: a comprehensive view on brain-immune interaction.

    Magnus, Tim / Liesz, Arthur

    Seminars in immunopathology

    2023  Volume 45, Issue 3, Page(s) 279–280

    MeSH term(s) Humans ; Cytokines/metabolism ; Stroke/therapy ; Brain/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-06-15
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00995-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1425: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Book ; Thesis: Klonierung der Transposoninsertionsstellen Biofilm-nagativer Staphylococcus-epidermidis-Transposonmutanten

    Magnus, Tim

    1999  

    Author's details vorgelegt von Tim Ulrich Magnus
    Language German
    Size 81 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2000
    HBZ-ID HT013171588
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2001 E 2786 order for loan Magazin

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  6. Article ; Online: Blood neurofilament light chain in Parkinson's disease.

    Buhmann, Carsten / Magnus, Tim / Choe, Chi-Un

    Journal of neural transmission (Vienna, Austria : 1996)

    2023  Volume 130, Issue 6, Page(s) 755–762

    Abstract: Blood neurofilament light chain (NfL) is an easily accessible, highly sensitive and reliable biomarker for neuroaxonal damage. Currently, its role in Parkinson's disease (PD) remains unclear. Here, we demonstrate that blood NfL can distinguish idiopathic ...

    Abstract Blood neurofilament light chain (NfL) is an easily accessible, highly sensitive and reliable biomarker for neuroaxonal damage. Currently, its role in Parkinson's disease (PD) remains unclear. Here, we demonstrate that blood NfL can distinguish idiopathic PD from atypical parkinsonian syndromes (APS) with high sensitivity and specificity. In cross-sectional studies, some found significant correlations between blood NfL with motor and cognitive function, whereas others did not. In contrast, prospective studies reported very consistent associations between baseline blood NfL with motor progression and cognitive worsening. Amongst PD subtypes, especially postural instability and gait disorder (PIGD) subtype, symptoms and scores are reliably linked with blood NfL. Different non-motor PD comorbidities have also been associated with high blood NfL levels suggesting that the neuroaxonal damage of the autonomic nervous system as well as serotonergic, cholinergic and noradrenergic neurons is quantifiable. Numerous absolute NfL cutoff levels have been suggested in different cohort studies; however, validation across cohorts remains weak. However, age-adjusted percentiles and intra-individual blood NfL changes might represent more valid and consistent parameters compared with absolute NfL concentrations. In summary, blood NfL has the potential as biomarker in PD patients to be used in clinical practice for prediction of disease severity and especially progression.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Prospective Studies ; Cross-Sectional Studies ; Intermediate Filaments ; Neurofilament Proteins ; Biomarkers
    Chemical Substances Neurofilament Proteins ; Biomarkers
    Language English
    Publishing date 2023-04-17
    Publishing country Austria
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-023-02632-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.150: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Real-Time Flow Cytometry as a Tool to Monitor Cellular Consequences of P2X7 Activation in Multiple Cell Populations Mixed in a Single FACS Tube.

    Veltkamp, Alexander W / Magnus, Tim / Rissiek, Björn

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2510, Page(s) 291–302

    Abstract: The P2X7 receptor is an ATP-gated ion channel expressed by cells of the immune system. In murine T cells, P2X7 activation by high concentrations of ATP or by covalent ADP-ribosylation are potent triggers of cell death. In innate immune cells, such as ... ...

    Abstract The P2X7 receptor is an ATP-gated ion channel expressed by cells of the immune system. In murine T cells, P2X7 activation by high concentrations of ATP or by covalent ADP-ribosylation are potent triggers of cell death. In innate immune cells, such as macrophages or brain microglia, P2X7 is a key regulator of inflammasome activation and the release of mature interleukin 1 beta. ATP-mediated P2X7 activation is accompanied by several direct downstream events, including the influx of calcium, pore formation at the plasma membrane, ectodomain shedding, and cell shrinkage. With this chapter we provide a protocol to monitor all these immediate consequences of P2X7 activation in a time dependent fashion using real-time flow cytometry. We illustrate, for example, how to simultaneously monitor calcium influx and shedding of CD27 in four T cell subpopulations and how to simultaneously analyze calcium influx, pore formation and cell shrinkage in mouse primary microglia. We further provide an extended protocol to compare consequences of P2X7 activation among identical cell populations from two or more different donor mice mixed in a single FACS tube. Taken together, the here presented real-time flow cytometry protocol for measuring P2X7 activation is flexible, scalable and can easily be transferred to other experimental settings.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Cell Death ; Flow Cytometry ; Inflammasomes ; Mice
    Chemical Substances Inflammasomes ; Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2384-8_16
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  8. Article ; Online: Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.

    Candelario-Jalil, Eduardo / Dijkhuizen, Rick M / Magnus, Tim

    Stroke

    2022  Volume 53, Issue 5, Page(s) 1473–1486

    Abstract: Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system. Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular macrophages ... ...

    Abstract Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system. Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular macrophages in the neurovascular unit. Brain ischemia unleashes a profound neuroinflammatory response to remove the damaged tissue and prepare the brain for repair. However, the intense neuroinflammation occurring during the acute phase of stroke is associated with BBB breakdown, neuronal injury, and worse neurological outcomes. Here, we critically discuss the role of neuroinflammation in ischemic stroke pathology, focusing on the BBB and the interactions between central nervous system and peripheral immune responses. We highlight inflammation-driven injury mechanisms in stroke, including oxidative stress, increased MMP (matrix metalloproteinase) production, microglial activation, and infiltration of peripheral immune cells into the ischemic tissue. We provide an updated overview of imaging techniques for in vivo detection of BBB permeability, leukocyte infiltration, microglial activation, and upregulation of cell adhesion molecules following ischemic brain injury. We discuss the possibility of clinical implementation of imaging modalities to assess stroke-associated neuroinflammation with the potential to provide image-guided diagnosis and treatment. We summarize the results from several clinical studies evaluating the efficacy of anti-inflammatory interventions in stroke. Although convincing preclinical evidence suggests that neuroinflammation is a promising target for ischemic stroke, thus far, translating these results into the clinical setting has proved difficult. Due to the dual role of inflammation in the progression of ischemic damage, more research is needed to mechanistically understand when the neuroinflammatory response begins the transition from injury to repair. This could have important implications for ischemic stroke treatment by informing time- and context-specific therapeutic interventions.
    MeSH term(s) Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; Humans ; Inflammation/pathology ; Ischemic Stroke ; Neuroinflammatory Diseases ; Stroke/metabolism
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.122.036946
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    Zs.A 448: Show issues Location:
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  9. Article: Zerebrale Vaskulitis: ein Update zu Symptomen, Diagnostik und Therapie

    Deb-Chatterji, Milani / Magnus, Tim

    Neuroradiologie Scan

    2022  Volume 12, Issue 02, Page(s) 119–129

    Language German
    Publishing date 2022-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1616-9700 ; 1616-9697
    ISSN (online) 1616-9700
    ISSN 1616-9697
    DOI 10.1055/a-1678-3536
    Database Thieme publisher's database

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  10. Article ; Online: Autoimmunity After Ischemic Stroke and Brain Injury.

    Javidi, Ehsan / Magnus, Tim

    Frontiers in immunology

    2019  Volume 10, Page(s) 686

    Abstract: Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential ... ...

    Abstract Ischemic Stroke is a major cause of morbidity and mortality worldwide. Sterile inflammation occurs after both stroke subtypes and contributes to neuronal injury and damage to the blood-brain barrier with release of brain antigens and a potential induction of autoimmune responses that escape central and peripheral tolerance mechanisms. In stroke patients, the detection of T cells and antibodies specific to neuronal antigens suggests a role of humoral adaptive immunity. In experimental models stroke leads to a significant increase of autoreactive T and B cells to CNS antigens. Lesion volume and functional outcome in stroke patients and murine stroke models are connected to antigen-specific responses to brain proteins. In patients with traumatic brain injury (TBI) a range of antibodies against brain proteins can be detected in serum samples. In this review, we will summarize the role of autoimmunity in post-lesional conditions and discuss the role of B and T cells and their potential neuroprotective or detrimental effects.
    MeSH term(s) Animals ; Antibody Formation ; Autoantibodies/metabolism ; Autoantigens/immunology ; Autoimmunity ; B-Lymphocytes/immunology ; Brain Injuries/immunology ; Brain Ischemia/immunology ; Humans ; T-Lymphocytes/immunology
    Chemical Substances Autoantibodies ; Autoantigens
    Language English
    Publishing date 2019-04-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00686
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