Article ; Online: T cell migration requires ion and water influx to regulate actin polymerization.
2023 Volume 14, Issue 1, Page(s) 7844
Abstract: Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. ... ...
| Abstract | Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4 |
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| MeSH term(s) | Actins/metabolism ; Polymerization ; Cell Movement/physiology ; Actin Cytoskeleton/metabolism ; Signal Transduction/physiology |
| Chemical Substances | Actins |
| Language | English |
| Publishing date | 2023-12-06 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-023-43423-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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