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Article ; Online: A solider and a victim: Masculinity, violence, and incels celebration of December 6th.

Halpin, Michael / Preston, Kayla / Lockyer, Demeter / Maguire, Finlay

Canadian review of sociology = Revue canadienne de sociologie

2024 Volume 61, Issue 1, Page(s) 7–24

Abstract: In 1989, Marc Lépine murdered 14 women at L'École Polytechnique de Montréal. We demonstrate how involuntarily celibate ("incel") men celebrate Lépine and claim him as a member of their community. Our analysis draws on 637 comments made on incels.is, the ... ...

Abstract	In 1989, Marc Lépine murdered 14 women at L'École Polytechnique de Montréal. We demonstrate how involuntarily celibate ("incel") men celebrate Lépine and claim him as a member of their community. Our analysis draws on 637 comments made on incels.is, the main English-language incel forum, that explicitly mentions Marc Lépine. We argue that incels use Lépine to situate themselves in relation to masculinity and to justify violence against women. First, incels orient to both hegemonic and subordinate masculinity by arguing that feminists are waging a gender war against men. Second, incels celebrate Lépine as a methodical and efficient murderer, connecting both themselves and Lépine to hegemonic masculinity. Third, incels describe both themselves and Lépine as victims of feminists and use this perceived subordination to justify violence against women. We discuss findings in relation to theories of masculinity and policies regulating online communities.
MeSH term(s)	Humans ; Male ; Female ; Masculinity ; Violence ; Feminism ; Marital Status
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2441049-4
ISSN	1755-618X ; 1755-6171
ISSN (online)	1755-618X
ISSN	1755-6171
DOI	10.1111/cars.12460
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Article ; Online: Prevalence and Risk Factors for Urinary Incontinence in Nulliparous Women: A Contemporary, Population-Based Cohort Study.

Kupfer, Nathalie / Clancy, Aisling / Maguire, Finlay / Stairs, Jocelyn

Urogynecology (Philadelphia, Pa.)

2022 Volume 29, Issue 5, Page(s) 520–527

Abstract: Importance and objectives: Epidemiologic studies of incontinence largely focus on parous women, and there are limited data regarding nulliparous women. Our objectives were to evaluate risk factors for urinary incontinence among a nationally ... ...

Abstract	Importance and objectives: Epidemiologic studies of incontinence largely focus on parous women, and there are limited data regarding nulliparous women. Our objectives were to evaluate risk factors for urinary incontinence among a nationally representative, contemporary sample of nulliparous women of all ages in the United States and to describe the prevalence and subtypes of urinary incontinence and nocturia in this population. Study design: This cross-sectional, population-based study used the National Health and Nutrition Examination Survey cycles 2011-2018 to assemble a sample of nulliparous women 20-80 years old. Crude and adjusted odds ratios were estimated using multivariable logistic regression for the exposures of interest: body mass index (BMI), age, physical activity, prior hysterectomy, and current smoking. Prevalence of urinary incontinence and nocturia were estimated. Results: Among 1,603 nulliparous women, prevalence of any urinary incontinence was 29.38%. Prevalence of stress, urgency, and mixed urinary incontinence and nocturia, respectively, were 27.68%, 19.64%, 10.57%, and 58.95%. Women with a BMI ≥25 (calculated as weight in kilograms divided by height in meters squared; adjusted odds ratio [aOR], 1.57; 95% confidence interval [CI], 1.11-2.23), at least 45 years (aOR, 3.75; 95% CI, 2.31-5.83), and current smoking (aOR, 1.63; 95% CI, 1.07-2.49) had increased the odds of incontinence compared with women without these risk factors. When stress urinary incontinence (SUI) was considered alone, only women with a BMI ≥25 (aOR, 1.66; 95% CI, 1.20-2.31) and age at least 45 years (aOR, 3.17; 95% CI, 2.01-5.00) had increased odds of SUI compared with women without these risk factors. Conclusions: Urinary incontinence and nocturia are prevalent in nulliparous women, and age, elevated BMI, and current smoking may represent risk factors for incontinence in this population.
MeSH term(s)	Female ; Humans ; United States/epidemiology ; Middle Aged ; Young Adult ; Adult ; Aged ; Aged, 80 and over ; Nocturia/epidemiology ; Cohort Studies ; Prevalence ; Cross-Sectional Studies ; Nutrition Surveys ; Urinary Incontinence/epidemiology ; Risk Factors ; Urinary Incontinence, Stress/epidemiology
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article
ISSN	2771-1897
ISSN (online)	2771-1897
DOI	10.1097/SPV.0000000000001296
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Article: Lachnoanaerobaculum orale

Sabrie, Nasruddin Ali Salad / Halani, Sheliza / Maguire, Finlay / Aftanas, Patryk / Kozak, Robert / Andany, Nisha

IDCases

2023 Volume 33, Page(s) e01837

Abstract: Background: Lachnoanaerobaculum orale: Methods: We present a case of a 46-year-old woman with a recent diagnosis of AML who presented to Sunnybrook Health Sciences Center with febrile neutropenia following induction chemotherapy with daunorubicin- ... ...

Abstract	Background: Lachnoanaerobaculum orale Methods: We present a case of a 46-year-old woman with a recent diagnosis of AML who presented to Sunnybrook Health Sciences Center with febrile neutropenia following induction chemotherapy with daunorubicin-cytarabine (3 +7 regimen) with Gemtuzumab and Ozogamycin. Despite being on intravenous pipercillin-tazobactam she remained febrile. Following our clinical assessment and investigations, potential sources of infection included a swollen digit and severe mucositis. Results: One blood culture from admission grew Conclusion: With the increasing use of intensive immunosuppressive regimens and hematopoietic stem cell transplantation for patients with hematologic malignancies, there has been an increase in the incidence and detection of bloodstream infections due to anaerobic organisms. This is only the second case report of
Language	English
Publishing date	2023-07-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01837
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Article: The Black Pill: New Technology and the Male Supremacy of Involuntarily Celibate Men.

Preston, Kayla / Halpin, Michael / Maguire, Finlay

Men and masculinities

2021 Volume 24, Issue 5, Page(s) 823–841

Abstract: Involuntary celibates, or "incels," are people who identify themselves by their inability to establish sexual partnerships. In this article, we use analytic abduction to qualitatively analyze 9,062 comments on a popular incel forum for heterosexual men ... ...

Abstract	Involuntary celibates, or "incels," are people who identify themselves by their inability to establish sexual partnerships. In this article, we use analytic abduction to qualitatively analyze 9,062 comments on a popular incel forum for heterosexual men that is characterized by extensive misogyny. Incels argue that emerging technologies reveal and compound the gender practices that produce involuntarily celibate men. First, incels argue that women's use of dating apps accelerates hypergamy. Second, incels suggest that highly desirable men use dating apps to partner with multiple women. Third, incels assert that subordinate men inflate women's egos and their "sexual marketplace value" through social media platforms. We argue that incels' focus on technology reinforces essentialist views on gender, buttresses male domination, dehumanizes women, and minimizes incels' own misogyny. We discuss findings in relation to theories of masculinity and social scientific research on the impacts of emerging technology.
Language	English
Publishing date	2021-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2057721-7
ISSN	1552-6828 ; 1097-184X
ISSN (online)	1552-6828
ISSN	1097-184X
DOI	10.1177/1097184X211017954
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Article: A resident-led clinic that promotes the health of refugee women through advocacy and partnership.

Stairs, Jocelyn / Bal, Navpreet / Maguire, Finlay / Scott, Heather

Canadian medical education journal

2019 Volume 10, Issue 4, Page(s) e102–e104

Language	English
Publishing date	2019-11-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2689512-2
ISSN	1923-1202
ISSN	1923-1202
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Article ; Online: Motivation to access laparoscopic skills training: Results of a Canadian survey of obstetrics and gynecology residents.

Stairs, Jocelyn / Bergey, Bradley W / Maguire, Finlay / Scott, Stephanie

PloS one

2020 Volume 15, Issue 4, Page(s) e0230931

Abstract: Objective: Competency based medical education (CBME) requires novel approaches to surgical education. Significant investment has been made in laparoscopic simulation, which has been shown to foster skill development prior to patient encounters. However, ...

Abstract	Objective: Competency based medical education (CBME) requires novel approaches to surgical education. Significant investment has been made in laparoscopic simulation, which has been shown to foster skill development prior to patient encounters. However, research suggests variable voluntary use of these resources by residents, and little is known about the motivational factors that influence their utilization. The purpose of this study was to characterize factors that motivate residents to seek laparoscopic simulation experience outside of the formal curriculum. Design: We developed a questionnaire grounded in Expectancy Value Theory, an established psychological theory of motivation, by adapting validated measures to fit the study context. We conducted a cross sectional survey of Canadian obstetrics and gynecology residents. Setting: We invited residents enrolled in English-language obstetrics and gynecology training programs in Canada to participate. Participants: All residents engaged in clinical duties during Winter 2018 were invited to complete the questionnaire. Forty-four Obstetrics and Gynecology (Ob/Gyn) residents participated in the study. Results: Residents reported limited use of simulation resources and identified multiple barriers including lack of time, access, and supervision. They expressed concern about development of bad habits during independent practice, and simulation use was positively correlated with perceived utility. Compared to junior residents, senior residents reported greater enjoyment of laparoscopic surgery, less emotional costs, and higher self-efficacy for learning laparoscopy. Conclusions: Residents' perception of utility and barriers impede voluntary simulation use and overall use was limited. As programs undertake curricula redevelopment for CBME, mitigating barriers and improving perceived utility of laparoscopic simulation is vital to increase use and enhance skill development.
MeSH term(s)	Canada ; Clinical Competence/statistics & numerical data ; Cross-Sectional Studies ; Curriculum/statistics & numerical data ; Education, Medical/statistics & numerical data ; Female ; Gynecology/education ; Humans ; Internship and Residency/statistics & numerical data ; Laparoscopy/education ; Male ; Motivation/physiology ; Obstetrics/education ; Surveys and Questionnaires
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0230931
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Article ; Online: Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing.

Raphenya, Amogelang R / Robertson, James / Jamin, Casper / de Oliveira Martins, Leonardo / Maguire, Finlay / McArthur, Andrew G / Hays, John P

Scientific data

2022 Volume 9, Issue 1, Page(s) 341

Abstract: Whole genome sequencing (WGS) is a key tool in identifying and characterising disease-associated bacteria across clinical, agricultural, and environmental contexts. One increasingly common use of genomic and metagenomic sequencing is in identifying the ... ...

Abstract	Whole genome sequencing (WGS) is a key tool in identifying and characterising disease-associated bacteria across clinical, agricultural, and environmental contexts. One increasingly common use of genomic and metagenomic sequencing is in identifying the type and range of antimicrobial resistance (AMR) genes present in bacterial isolates in order to make predictions regarding their AMR phenotype. However, there are a large number of alternative bioinformatics software and pipelines available, which can lead to dissimilar results. It is, therefore, vital that researchers carefully evaluate their genomic and metagenomic AMR analysis methods using a common dataset. To this end, as part of the Microbial Bioinformatics Hackathon and Workshop 2021, a 'gold standard' reference genomic and simulated metagenomic dataset was generated containing raw sequence reads mapped against their corresponding reference genome from a range of 174 potentially pathogenic bacteria. These datasets and their accompanying metadata are freely available for use in benchmarking studies of bacteria and their antimicrobial resistance genes and will help improve tool development for the identification of AMR genes in complex samples.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/genetics ; Benchmarking ; Drug Resistance, Bacterial/genetics ; Genome, Bacterial ; Microbial Sensitivity Tests ; Whole Genome Sequencing
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-06-15
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01463-7
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Article ; Online: Persistent infection with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a patient with untreated human immunodeficiency virus (HIV).

Zhabokritsky, Alice / Mubareka, Samira / Kozak, Robert A / Maguire, Finlay / Yip, Lily / Yip, Paul / Powis, Jeff

Infection control and hospital epidemiology

2022 Volume 44, Issue 2, Page(s) 350–351

MeSH term(s)	Humans ; HIV ; SARS-CoV-2 ; COVID-19 ; Persistent Infection ; Virus Diseases ; HIV Infections/complications
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Letter
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2022.140
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Article ; Online: Use of whole genome sequencing to identify low-frequency mutations in SARS-CoV-2 patients treated with remdesivir.

Nirmalarajah, Kuganya / Yim, Winfield / Aftanas, Patryk / Li, Angel X / Shigayeva, Altynay / Yip, Lily / Zhong, Zoe / McGeer, Allison J / Maguire, Finlay / Mubareka, Samira / Kozak, Robert

Influenza and other respiratory viruses

2023 Volume 17, Issue 9, Page(s) e13179

Abstract: Background: Remdesivir (RDV) has been shown to reduce hospitalization and mortality in COVID-19 patients. Resistance mutations caused by RDV are rare and have been predominantly reported in patients who are on prolonged therapy and immunocompromised. We ...

Abstract	Background: Remdesivir (RDV) has been shown to reduce hospitalization and mortality in COVID-19 patients. Resistance mutations caused by RDV are rare and have been predominantly reported in patients who are on prolonged therapy and immunocompromised. We investigate the effects of RDV treatment on intra-host SARS-CoV-2 diversity and low-frequency mutations in moderately ill hospitalized COVID-19 patients and compare them to patients without RDV treatment. Methods: From March 2020 to April 2022, sequential collections of nasopharyngeal and mid-turbinate swabs were obtained from 14 patients with and 30 patients without RDV treatment. Demographic and clinical data on all patients were reviewed. A total of 109 samples were sequenced and mutation analyses were performed. Results: Previously reported drug resistant mutations in nsp12 were not identified during short courses of RDV therapy. In genes encoding and surrounding the replication complex (nsp6-nsp14), low-frequency minority variants were detected in 7/14 (50%) and 18/30 (60%) patients with and without RDV treatment, respectively. We did not detect significant differences in within-host diversity and positive selection between the RDV-treated and untreated groups. Conclusions: Minimal intra-host variability and stochastic low-frequency variants detected in moderately ill patients suggests little selective pressure in patients receiving short courses of RDV. The barrier to RDV resistance is high in patients with moderate disease. Patients undergoing short regimens of RDV therapy should continue to be monitored.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19 ; COVID-19 Drug Treatment ; Mutation ; Whole Genome Sequencing
Chemical Substances	remdesivir (3QKI37EEHE)
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.13179
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Article ; Online: Organelle evolution: a mosaic of 'mitochondrial' functions.

Maguire, Finlay / Richards, Thomas A

Current biology : CB

2014 Volume 24, Issue 11, Page(s) R518–20

Abstract: An ancient endosymbiosis of an α-proteobacterium produced a diverse range of organelles including mitochondria. Reconstruction of the Pygsuia biforma proteome adds to the mosaic of functional systems present in mitochondrial-related organelles and ... ...

Abstract	An ancient endosymbiosis of an α-proteobacterium produced a diverse range of organelles including mitochondria. Reconstruction of the Pygsuia biforma proteome adds to the mosaic of functional systems present in mitochondrial-related organelles and demonstrates the role of horizontal gene transfer.
MeSH term(s)	Eukaryota/genetics ; Eukaryota/metabolism ; Organelles/metabolism ; Proteome ; Sulfur/metabolism
Chemical Substances	Proteome ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2014-06-02
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2014.03.075
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