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  1. Article ; Online: Pentosan Polysulfate Maculopathy-We Need to Know More.

    Maguire, Maureen G

    JAMA ophthalmology

    2023  Volume 141, Issue 3, Page(s) 266–267

    MeSH term(s) Humans ; Pentosan Sulfuric Polyester/adverse effects ; Macular Degeneration/chemically induced ; Macular Degeneration/diagnosis ; Macular Degeneration/drug therapy ; Retinal Diseases
    Chemical Substances Pentosan Sulfuric Polyester (37300-21-3)
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2022.6158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Best Practices for the Design of Clinical Trials Related to the Visual System.

    Maguire, Maureen G

    Annual review of vision science

    2021  Volume 7, Page(s) 867–886

    Abstract: Clinical trials for conditions affecting the visual system need to not only conform to the guidelines for all clinical trials, but also accommodate the possibility of both eyes of a single patient qualifying for the trial. In this review, I present the ... ...

    Abstract Clinical trials for conditions affecting the visual system need to not only conform to the guidelines for all clinical trials, but also accommodate the possibility of both eyes of a single patient qualifying for the trial. In this review, I present the interplay of the key components in the design of a clinical trial, along with the modifications or options that may be available for trials addressing ocular conditions. Examples drawn from published reports of the design and results of clinical trials of ocular conditions are provided to illustrate application of the design principles. Current approaches to data analysis and reporting of trials are outlined, and the oversight and regulatory procedures to protect participants in clinical trials are discussed.
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2805730-2
    ISSN 2374-4650 ; 2374-4642
    ISSN (online) 2374-4650
    ISSN 2374-4642
    DOI 10.1146/annurev-vision-093019-113930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dose Response in Antivascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Is It Only the Number of Injections?

    Maguire, Maureen G

    Retina (Philadelphia, Pa.)

    2021  Volume 41, Issue 6, Page(s) 1141–1142

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Endothelial Growth Factors ; Humans ; Macular Degeneration/drug therapy ; Ranibizumab/therapeutic use
    Chemical Substances Angiogenesis Inhibitors ; Endothelial Growth Factors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2021-01-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1724: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: No Red Flags for Risk of Retinal Vascular Occlusion After mRNA COVID-19 Vaccination.

    Jampol, Lee M / Maguire, Maureen G

    JAMA ophthalmology

    2023  Volume 141, Issue 5, Page(s) 447–448

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/etiology ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.0925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Steps Forward in Analyzing Optical Coherence Tomography in Age-Related Macular Degeneration-Capitalizing on the Power of Artificial Intelligence.

    Maguire, Maureen G

    JAMA ophthalmology

    2020  Volume 138, Issue 7, Page(s) 747–748

    MeSH term(s) Artificial Intelligence ; Biomarkers ; Disease Progression ; Humans ; Macular Degeneration/diagnostic imaging ; Tomography, Optical Coherence
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.1385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessing Intereye Symmetry and Its Implications for Study Design.

    Maguire, Maureen G

    Investigative ophthalmology & visual science

    2020  Volume 61, Issue 6, Page(s) 27

    MeSH term(s) Animals ; Biomedical Research/methods ; Humans ; Nerve Fibers/pathology ; Ophthalmology ; Retinal Diseases/diagnosis ; Retinal Ganglion Cells/cytology
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.61.6.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 45: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: New Section on Using Data from Vision Research.

    Maguire, Maureen G

    Investigative ophthalmology & visual science

    2020  Volume 61, Issue 6, Page(s) 26

    MeSH term(s) Biomedical Research/statistics & numerical data ; Humans ; Ophthalmology ; Periodicals as Topic ; Vision Disorders/diagnosis
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.61.6.26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease.

    Asbell, Penny A / Maguire, Maureen G

    JAMA ophthalmology

    2022  Volume 140, Issue 7, Page(s) 714–715

    MeSH term(s) Dietary Supplements ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/drug therapy ; Fatty Acids, Omega-3/therapeutic use ; Humans ; Tears
    Chemical Substances Fatty Acids, Omega-3
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2022.1821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Updated Methods for Assessing the Risk of Progression to Late Age-Related Macular Degeneration.

    Maguire, Maureen G

    JAMA ophthalmology

    2019  Volume 137, Issue 7, Page(s) 745–746

    MeSH term(s) Demography ; Disease Progression ; Humans ; Macular Degeneration
    Language English
    Publishing date 2019-04-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.0918
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  10. Article ; Online: Changes in activity impairment and work productivity after treatment for vitreous hemorrhage due to proliferative diabetic retinopathy: Secondary outcomes from a randomized controlled trial (DRCR Retina Network Protocol AB).

    Beaulieu, Wesley T / Maguire, Maureen G / Antoszyk, Andrew N

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0293543

    Abstract: Background: Vitreous hemorrhage from proliferative diabetic retinopathy can cause severe vision loss. DRCR Retina Network Protocol AB was a randomized clinical trial comparing intravitreal aflibercept versus vitrectomy with panretinal photocoagulation ... ...

    Abstract Background: Vitreous hemorrhage from proliferative diabetic retinopathy can cause severe vision loss. DRCR Retina Network Protocol AB was a randomized clinical trial comparing intravitreal aflibercept versus vitrectomy with panretinal photocoagulation and found no difference in the average rate of visual recovery over 104 weeks. Herein, we describe patient-reported outcome measures from Protocol AB.
    Methods: Secondary analysis of a multicenter (39 sites) randomized clinical trial. The Work Productivity and Activity Impairment Questionnaire was administered at 4, 12, 24, 36, 52, 68, 84, and 104 weeks. Main outcomes were mean change in activity impairment and work productivity loss over 24 and 104 weeks (area under the curve).
    Results: Mean (SD) activity impairment at baseline was 58% (27%) in the aflibercept group (N = 99) and 56% (30%) in the vitrectomy group (N = 105). The mean reduction in activity impairment from baseline over 24 weeks was 21% (25%) in the aflibercept group and 27% (31%) in the vitrectomy group (adjusted difference = -6.8% [95% CI, -12.7% to -0.9%], P = .02); over 104 weeks, the adjusted mean difference was -3.1% (95% CI, -9.2% to 3.0%, P = .31). Mean work productivity loss at baseline was 51% (28%) in the aflibercept group (N = 44) and 58% (30%) in the vitrectomy group (N = 43). The mean reduction in work productivity loss from baseline over 24 weeks (area under the curve) was 19% (23%) in the aflibercept group and 31% (24%) in the vitrectomy group (adjusted difference = -8.3% [95% CI, -16.8% to 0.2%], P = .06); over 104 weeks, the adjusted mean difference was -9.1% (95% CI, -18.4% to 0.2%, P = .05).
    Conclusions: Participants with vitreous hemorrhage from proliferative diabetic retinopathy had less activity impairment over 24 weeks when treated initially with vitrectomy and panretinal photocoagulation versus intravitreal aflibercept. The trend was similar for work productivity but not statistically significant. By 104 weeks, the improvements were similar in the two treatment groups.
    Trial registration: ClinicalTrials.gov NCT02858076.
    MeSH term(s) Humans ; Angiogenesis Inhibitors/therapeutic use ; Diabetes Mellitus/drug therapy ; Diabetic Retinopathy/therapy ; Diabetic Retinopathy/drug therapy ; Intravitreal Injections ; Retina ; Visual Acuity ; Vitreous Hemorrhage/etiology ; Vitreous Hemorrhage/surgery
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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