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  1. Article ; Online: Cellular Immunity of

    Cinege, Gyöngyi / Fodor, Kinga / Magyar, Lilla B / Lipinszki, Zoltán / Hultmark, Dan / Andó, István

    Cells

    2024  Volume 13, Issue 7

    Abstract: Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes ... ...

    Abstract Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes of
    MeSH term(s) Animals ; Drosophila ; Parasites ; Cell Differentiation ; Phagocytosis ; Immunity, Cellular
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Distinctive features of

    Cinege, Gyöngyi / Magyar, Lilla B / Kovács, Henrietta / Varga, Viktória / Bodai, László / Zsindely, Nóra / Nagy, Gábor / Hegedűs, Zoltán / Hultmark, Dan / Andó, István

    Frontiers in immunology

    2023  Volume 14, Page(s) 1322381

    Abstract: Background: Insects have specialized cell types that participate in the elimination of parasites, for instance, the lamellocytes of the broadly studied species : Methods: Morphological, protein expressional, and functional features of blood cells ... ...

    Abstract Background: Insects have specialized cell types that participate in the elimination of parasites, for instance, the lamellocytes of the broadly studied species
    Methods: Morphological, protein expressional, and functional features of blood cells were revealed using epifluorescence and confocal microscopy. The respective hemocyte subpopulations were identified using monoclonal antibodies in indirect immunofluorescence assays. Fluorescein isothiocyanate (FITC)-labeled
    Results: D. ananassae
    Conclusion: Our observations provide insights into the broad repertoire of blood cell functions required for efficient defense reactions to maintain the homeostasis of the organism. The analysis of the differentiation and function of multinucleated giant hemocytes gives an insight into the diversification of the immune mechanisms.
    MeSH term(s) Animals ; Hemocytes ; Drosophila melanogaster ; Cell Differentiation ; Drosophila ; Blood Platelets ; Wasps ; Mammals
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1322381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evolution of insect innate immunity through domestication of bacterial toxins.

    Verster, Kirsten I / Cinege, Gyöngyi / Lipinszki, Zoltán / Magyar, Lilla B / Kurucz, Éva / Tarnopol, Rebecca L / Ábrahám, Edit / Darula, Zsuzsanna / Karageorgi, Marianthi / Tamsil, Josephine A / Akalu, Saron M / Andó, István / Whiteman, Noah K

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 16, Page(s) e2218334120

    Abstract: Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same genes have been horizontally transferred from phage ... ...

    Abstract Toxin cargo genes are often horizontally transferred by phages between bacterial species and are known to play an important role in the evolution of bacterial pathogenesis. Here, we show how these same genes have been horizontally transferred from phage or bacteria to animals and have resulted in novel adaptations. We discovered that two widespread bacterial genes encoding toxins of animal cells,
    MeSH term(s) Animals ; Domestication ; Bacterial Toxins/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Gene Transfer, Horizontal ; Wasps/metabolism ; Immunity, Innate/genetics
    Chemical Substances Bacterial Toxins
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2218334120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids.

    Cinege, Gyöngyi / Magyar, Lilla B / Kovács, Attila L / Lerner, Zita / Juhász, Gábor / Lukacsovich, David / Winterer, Jochen / Lukacsovich, Tamás / Hegedűs, Zoltán / Kurucz, Éva / Hultmark, Dan / Földy, Csaba / Andó, István

    Journal of innate immunity

    2021  Volume 14, Issue 4, Page(s) 335–354

    Abstract: Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating ... ...

    Abstract Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulating MGHs have high motility and the interaction with the parasitoid rapidly triggers encapsulation. However, structural and molecular mechanisms behind these processes remained elusive. Here, we used detailed ultrastructural analysis and live cell imaging of MGHs to study encapsulation in Drosophila ananassae after parasitoid wasp infection. We found dynamic structural changes, mainly driven by the formation of diverse vesicular systems and newly developed complex intracytoplasmic membrane structures, and abundant generation of giant cell exosomes in MGHs. In addition, we used RNA sequencing to study the transcriptomic profile of MGHs and activated plasmatocytes 72 h after infection, as well as the uninduced blood cells. This revealed that differentiation of MGHs was accompanied by broad changes in gene expression. Consistent with the observed structural changes, transcripts related to vesicular function, cytoskeletal organization, and adhesion were enriched in MGHs. In addition, several orphan genes encoding for hemolysin-like proteins, pore-forming toxins of prokaryotic origin, were expressed at high level, which may be important for parasitoid elimination. Our results reveal coordinated molecular and structural changes in the course of MGH differentiation and parasitoid encapsulation, providing a mechanistic model for a powerful innate immune response.
    MeSH term(s) Animals ; Drosophila ; Hemocytes ; Host-Parasite Interactions ; Immunity, Innate ; Transcriptome ; Wasps/genetics
    Language English
    Publishing date 2021-12-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000520110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus.

    Cinege, Gyöngyi / Lerner, Zita / Magyar, Lilla B / Soós, Bálint / Tóth, Renáta / Kristó, Ildikó / Vilmos, Péter / Juhász, Gábor / Kovács, Attila L / Hegedűs, Zoltán / Sensen, Christoph W / Kurucz, Éva / Andó, István

    Journal of innate immunity

    2019  Volume 12, Issue 3, Page(s) 257–272

    Abstract: Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during ... ...

    Abstract Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differentiate in Zaprionus indianus, an invasive species belonging to the vittiger subgroup of the family, highly resistant to a large number of parasitoid wasp species. We have classified the MGHs of Z. indianusas giant hemocytes belonging to a class of cells which also include elongated blood cells carrying a single nucleus and anuclear structures. They are involved in encapsulating parasites, originate from the lymph gland, can develop by cell fusion, and generally carry many nuclei, while possessing an elaborated system of canals and sinuses, resulting in a spongiform appearance. Their nuclei are all transcriptionally active and show accretion of genetic material. Multinucleation and accumulation of the genetic material in the giant hemocytes represents a two-stage amplification of the genome, while their spongy ultrastructure substantially increases the contact surface with the extracellular space. These features may furnish the giant hemocytes with a considerable metabolic advantage, hence contributing to the mechanism of the effective immune response.
    MeSH term(s) Animals ; Drosophilidae/genetics ; Drosophilidae/immunology ; Genome, Insect ; Giant Cells/immunology ; Hemocytes/immunology ; Immunity, Cellular
    Language English
    Publishing date 2019-09-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000502646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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