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  1. Article: Fungal Colonization and Infections—Interactions with Other Human Diseases

    Mahalingam, Shanmuga S. / Jayaraman, Sangeetha / Pandiyan, Pushpa

    Pathogens. 2022 Feb. 06, v. 11, no. 2

    2022  

    Abstract: Candida albicans is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infections ... ...

    Abstract Candida albicans is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infections to fulminant sepsis with 70% mortality rates. Fungi influence at least several diseases, in part by mechanisms such as the production of pro-carcinogenic agents, molecular mimicking, and triggering of the inflammation cascade. These processes impact the interactions among human pathogenic and resident fungi, the bacteriome in various organs/tissues, and the host immune system, dictating the outcomes of invasive infections, metabolic diseases, and cancer. Although mechanistic investigations are at stages of infancy, recent studies have advanced our understanding of host–fungal interactions, their role in immune homeostasis, and their associated pathologies. This review summarizes the role of C. albicans and other opportunistic fungi, specifically their association with various diseases, providing a glimpse at the recent developments and our current knowledge in the context of inflammatory-bowel disease (IBD), cancers, and COVID-19. Two of the most common human diseases where fungal interactions have been previously well-studied are cancer and IBD. Here we also discuss the emerging role of fungi in the ongoing and evolving pandemic of COVID-19, as it is relevant to current health affairs.
    Keywords COVID-19 infection ; Candida albicans ; bacteriome ; candidemia ; candidiasis ; fungi ; homeostasis ; humans ; immune system ; infancy ; inflammation ; mortality ; mucosa ; pandemic ; pathogens
    Language English
    Dates of publication 2022-0206
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020212
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Fungal Colonization and Infections-Interactions with Other Human Diseases.

    Mahalingam, Shanmuga S / Jayaraman, Sangeetha / Pandiyan, Pushpa

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2022-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020212
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  3. Article ; Online: Recognition and Chaperoning by Pex19, Followed by Trafficking and Membrane Insertion of the Peroxisome Proliferation Protein, Pex11.

    Zientara-Rytter, Katarzyna M / Mahalingam, Shanmuga S / Farré, Jean-Claude / Carolino, Krypton / Subramani, Suresh

    Cells

    2022  Volume 11, Issue 1

    Abstract: Pex11, an abundant peroxisomal membrane protein (PMP), is required for division of peroxisomes and is robustly imported to peroxisomal membranes. We present a comprehensive analysis of how ... ...

    Abstract Pex11, an abundant peroxisomal membrane protein (PMP), is required for division of peroxisomes and is robustly imported to peroxisomal membranes. We present a comprehensive analysis of how the
    MeSH term(s) Amino Acid Sequence ; Cell Proliferation ; Humans ; Membrane Proteins/metabolism ; Molecular Chaperones/metabolism
    Chemical Substances Membrane Proteins ; Molecular Chaperones ; PEX11A protein, human ; PEX19 protein, human (157153-79-2)
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11010157
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  4. Article: Balancing the Opposing Principles That Govern Peroxisome Homeostasis

    Mahalingam, Shanmuga S / Shukla, Nandini / Farré, Jean-Claude / Zientara-Rytter, Katarzyna / Subramani, Suresh

    Trends in biochemical sciences. 2021 Mar., v. 46, no. 3

    2021  

    Abstract: Despite major advances in our understanding of players and mechanisms involved in peroxisome biogenesis and peroxisome degradation, very few studies have focused on unraveling the multi-layered connections between, and the coordination of, these two ... ...

    Abstract Despite major advances in our understanding of players and mechanisms involved in peroxisome biogenesis and peroxisome degradation, very few studies have focused on unraveling the multi-layered connections between, and the coordination of, these two opposing processes that regulate peroxisome homeostasis. The intersection between these processes also provides exciting avenues for future research. This review highlights the links between peroxisome biogenesis and degradation, incorporating an integrative approach that is critical not only for a mechanistic understanding, but also for manipulating the balance between these processes in relevant disease models.
    Keywords biogenesis ; disease models ; homeostasis
    Language English
    Dates of publication 2021-03
    Size p. 200-212.
    Publishing place Elsevier Ltd
    Document type Article
    Note NALT-AP-4-rerunAP2-fuzzy
    ZDB-ID 194220-7
    ISSN 0968-0004 ; 0376-5067
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.09.006
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    In stock of ZB MED Bonn / Germany

    Z 78/716: Show issues

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  5. Article ; Online: Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway.

    Manikanta, Kurnegala / Paul, Manoj / Sandesha, Vaddaragudisalu D / Mahalingam, Shanmuga S / Ramesh, Thimmasandra Narayan / Harishkumar, Krishnegowda / Koundinya, Shashank S / Naveen, Shivanna / Kemparaju, Kempaiah / Girish, Kesturu S

    Biochemistry. Biokhimiia

    2024  Volume 89, Issue 3, Page(s) 417–430

    Abstract: Platelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative stress is known to mediate various health complications, including cardiovascular diseases and other health ... ...

    Abstract Platelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative stress is known to mediate various health complications, including cardiovascular diseases and other health complications. To date, several synthetic molecules have displayed antiplatelet activity; however, their uses are associated with bleeding and other adverse effects. The commercially available curcumin is generally a mixture of three curcuminoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Although crude curcumin is known to inhibit platelet aggregation, the effect of purified curcumin on platelet apoptosis, activation, and aggregation remains unclear. Therefore, in this study, curcumin was purified from a crude curcumin mixture and the effects of this preparation on the oxidative stress-induced platelet apoptosis and activation was evaluated. 2,2'-Azobis(2-methylpropionamidine) dihydrochloride (AAPH) compound was used as an inducer of oxidative stress. Purified curcumin restored AAPH-induced platelet apoptotic markers like reactive oxygen species, intracellular calcium level, mitochondrial membrane potential, cardiolipin peroxidation, cytochrome c release from mitochondria to the cytosol, and phosphatidyl serine externalization. Further, it inhibited the agonist-induced platelet activation and aggregation, demonstrating its antiplatelet activity. Western blot analysis confirms protective effect of the purified curcumin against oxidative stress-induced platelet apoptosis and activation via downregulation of MAPKs protein activation, including ASK1, JNK, and p-38. Together, these results suggest that the purified curcumin could be a potential therapeutic bioactive molecule to treat the oxidative stress-induced platelet activation, apoptosis, and associated complications.
    MeSH term(s) Curcumin/pharmacology ; Curcumin/analogs & derivatives ; Curcumin/chemistry ; Apoptosis/drug effects ; Oxidative Stress/drug effects ; MAP Kinase Kinase Kinase 5/metabolism ; Humans ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; MAP Kinase Signaling System/drug effects ; Reactive Oxygen Species/metabolism ; Platelet Activation/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Platelet Aggregation/drug effects
    Chemical Substances Curcumin (IT942ZTH98) ; MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; MAP3K5 protein, human (EC 2.7.11.25) ; Reactive Oxygen Species ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297924030039
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Balancing the Opposing Principles That Govern Peroxisome Homeostasis.

    Mahalingam, Shanmuga S / Shukla, Nandini / Farré, Jean-Claude / Zientara-Rytter, Katarzyna / Subramani, Suresh

    Trends in biochemical sciences

    2020  Volume 46, Issue 3, Page(s) 200–212

    Abstract: Despite major advances in our understanding of players and mechanisms involved in peroxisome biogenesis and peroxisome degradation, very few studies have focused on unraveling the multi-layered connections between, and the coordination of, these two ... ...

    Abstract Despite major advances in our understanding of players and mechanisms involved in peroxisome biogenesis and peroxisome degradation, very few studies have focused on unraveling the multi-layered connections between, and the coordination of, these two opposing processes that regulate peroxisome homeostasis. The intersection between these processes also provides exciting avenues for future research. This review highlights the links between peroxisome biogenesis and degradation, incorporating an integrative approach that is critical not only for a mechanistic understanding, but also for manipulating the balance between these processes in relevant disease models.
    MeSH term(s) Homeostasis ; Metabolic Networks and Pathways ; Peroxisomes/metabolism
    Language English
    Publishing date 2020-10-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.09.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Peroxisome biogenesis, membrane contact sites, and quality control.

    Farré, Jean-Claude / Mahalingam, Shanmuga S / Proietto, Marco / Subramani, Suresh

    EMBO reports

    2018  Volume 20, Issue 1

    Abstract: Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer and signaling. We review here the current status of the different co- ... ...

    Abstract Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer and signaling. We review here the current status of the different co-existing modes of biogenesis of peroxisomal membrane proteins demonstrating the fascinating adaptability in their targeting and sorting pathways. While earlier studies focused on peroxisomes as autonomous organelles, the necessity of the ER and potentially even mitochondria as sources of peroxisomal membrane proteins and lipids has come to light in recent years. Additionally, the intimate physical juxtaposition of peroxisomes with other organelles has transitioned from being viewed as random encounters to a growing appreciation of the expanding roles of such inter-organellar membrane contact sites in metabolic and regulatory functions. Peroxisomal quality control mechanisms have also come of age with a variety of mechanisms operating both during biogenesis and in the cellular response to environmental cues.
    MeSH term(s) Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Eukaryotic Cells/metabolism ; Homeostasis/genetics ; Humans ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Metabolic Networks and Pathways/genetics ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Oxidation-Reduction ; Peroxisomes/genetics ; Peroxisomes/metabolism
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2018-12-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201846864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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