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  1. AU="Mahboobe Hosseinikia"
  2. AU="Stone, G"
  3. AU="Seuthe, Leni Katharina"
  4. AU="Schuetz, Thomas J"
  5. AU="Thielen, Peter"
  6. AU="Anders Tveita"
  7. AU="Joseph O. Fadare"
  8. AU="Koech, O K"
  9. AU="Kapp, William"
  10. AU="Argañaraz, Gustavo A."
  11. AU="Winters, Adrienna"
  12. AU="Iman Mamdouh Talaat"
  13. AU="Benjamin Kingsley Harley"
  14. AU="Cirio, Maria Cecilia"
  15. AU="Rodriguez-Rodriguez, Alvaro Manuel"
  16. AU="Anna Maria Aloisi"
  17. AU="Na, Li"
  18. AU="Beatriz Aguiar Jordão Paranhos"
  19. AU="johnson, Michael"
  20. AU=Hunt S A
  21. AU="Gniazdowski, Victoria"
  22. AU="Griffin, Matthew E"
  23. AU="Bean, Paris"
  24. AU="Elomaa, Paula"
  25. AU="Robert Fowler"
  26. AU="Nielsen, Stine"
  27. AU="Chabartier, Cyrille"

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  1. Artikel ; Online: Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients

    Mojtaba Yousefi / Mohammadreza Sadriirani / Sara Mahmoodi / Bahar Samimi / Azizollah Pourmahmoudi / Mahboobe Hosseinikia / Omid Sadeghi / Narges Roustaei / Zaker Saeedinezhad / Juan Carlos Espín / Somaye Ansari / Seyed Bahman Panahande

    Complementary Therapies in Medicine, Vol 75, Iss , Pp 102958- (2023)

    A randomized and placebo-controlled trial

    2023  

    Abstract: Background: This study aimed to evaluate the effect of pomegranate juice intake on the inflammatory status and complete blood count in hospitalized Covid-19 patients. Methods: This randomized, double-blinded placebo-controlled trial included 48 patients ... ...

    Abstract Background: This study aimed to evaluate the effect of pomegranate juice intake on the inflammatory status and complete blood count in hospitalized Covid-19 patients. Methods: This randomized, double-blinded placebo-controlled trial included 48 patients with two parallel arms. In addition to the standard care provided at the hospital, the patients consumed 500 mL of whole pomegranate juice (PJ) daily or a placebo for 14 days. Inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR)) and complete blood count were determined at baseline and after the 14 days of intervention. Results: At the end of the intervention, a significant decreased was observed in primary outcomes [mean difference (95 %CI)] including IL-6 [5.24(0.87–9.61)], CRP [23.19(11.93–34.44)] and ESR [10.52(1.54–19.50)] in the PJ group vs. before the intervention. In addition, significant changes were also observed in the some of the secondary outcomes, including neutrophils, lymphocytes, platelets, platelets-to-lymphocyte(PLR) and neutrophils-to-lymphocyte (NLR) ratios (p < 0.05) in the PJ group compared to before the intervention. At the end of the intervention period, the mean change of IL-6 [− 7.09(−12.21 to − 1.96)], white blood cells [− 3.09(− 6.14 to − 0.05)], neutrophils [− 9.12(−18.08 to −0.15)], lymphocyte [7.05(0.17–13.92)], platelets [− 94.54(− 139.33 to − 49.75)], PLR [− 15.99(− 29.31 to − 2.67)], blood oxygen saturation [1.75(0.13–3.37)] and MCV [0.31(− 0.25 to 0.88)] levels were significantly different between groups while no difference was observed between the two groups in other blood indices. Conclusion: Our results suggest that pomegranate juice intake might slightly improve the inflammatory status and CBC outcomes of COVID-19 patients and it may be beneficial.
    Schlagwörter COVID-19 ; SARS-CoV-2 coronavirus ; Pomegranate ; Inflammation ; Complete blood count ; Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Effect of Curcumin on Lipid Profile, Oxidative Stress and Blood Glucose in Experimental Dexamethasone-Induced Diabetes in Rats

    Azizollah Pourmahmoudi / Mohammad Sharif Talebianpoor / Tahereh Vafaiee Nejad / Mahnaz Mozafari / Mohammad Shafee Talebianpoor / Mahboobe Hosseinikia

    Journal of Nutrition and Food Security, Vol 6, Iss 1, Pp 65-

    2021  Band 73

    Abstract: Background: The present study was conducted to evaluate the effect of curcumin as a flavonoid antioxidant on serum lipid profile, oxidative stress, and blood glucose in experimental models of type 2 diabetes (DM2). Methods: Subcutaneous daily injection ... ...

    Abstract Background: The present study was conducted to evaluate the effect of curcumin as a flavonoid antioxidant on serum lipid profile, oxidative stress, and blood glucose in experimental models of type 2 diabetes (DM2). Methods: Subcutaneous daily injection of dexamethasone (5 mg/kg/day) for a month was performed to induce DM2. For this purpose, 28 adult male Wistar rats were divided into four groups: healthy control group received dexamethasone carrier containing normal saline + ethanol 4% , diabetic control group took 5 mg/kg/day dexamethasone, diabetic group 1 underwent the treatment with 50 mg/kg/day curcumin, and diabetic group 2 underwent treatment with 100 mg/kg/day curcumin. Seven days after dexamethasone injection, curcumin (50 and 100 mg/kg/day) was administrated intraperitoneally for 23 days. At the end of one month, the fasting blood sugar (FBS) level was measured and recorded by glucometer. Later, after a 30-day period, the animals were anesthetized with ether and their blood samples were collected from the heart puncture to measure their serum triglyceride (TG), high density lipoprotein cholrsterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and malondialdehyde (MDA). Results: The findings showed that curcumin could decrease FBS (P < 0.05), LDL-C (P < 0.01), TG (P < 0.001), and MDA (P < 0.001) and increase HDL-C (P < 0.001) at the end of 30 days. Conclusion: These effects of curcumin can be mediated by increasing either the pancreatic secretion of insulin or releasing from insulin bonds as well as enhancing insulin receptor sensitivity. Moreover, it may prevent the glucose absorption, reduce the activity of 3-hydroxy- 3-methyl glutaryl- CoA reductase (HMG-CoA), or improve the function of liver and pancreas through potent antioxidant properties.
    Schlagwörter curcumin ; diabetes ; dexamethasone ; rat ; Agriculture ; S ; Nutrition. Foods and food supply ; TX341-641
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Shahid Sadoughi University of Medical Sciences and Health Services
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Effects of pomegranate juice (Punica Granatum) on inflammatory biomarkers and complete blood count in patients with COVID-19

    Mojtaba Yousefi / Mohammadreza Sadriirani / Azizollah PourMahmoudi / Sara Mahmoodi / Bahar Samimi / Mahboobe Hosseinikia / Zaker Saeedinezhad / Seyed Bahman Panahande

    Trials, Vol 22, Iss 1, Pp 1-

    a structured summary of a study protocol for a randomized clinical trial

    2021  Band 3

    Abstract: Abstract Objectives This study is conducted to investigate efficacy of pomegranate juice on inflammatory biomarkers, C-reactive protein (CRP), interleukin 6(IL-6), erythrocyte sedimentation rate (ESR) and complete blood count (CBC) in hospitalized ... ...

    Abstract Abstract Objectives This study is conducted to investigate efficacy of pomegranate juice on inflammatory biomarkers, C-reactive protein (CRP), interleukin 6(IL-6), erythrocyte sedimentation rate (ESR) and complete blood count (CBC) in hospitalized patients with mild to moderate coronavirus disease 2019 (COVID- 19). Trial Design This is a randomized, placebo-controlled, double-blind, parallel 2-arm (1:1 ratio) clinical trial. Participants Patients with COVID-19 admitted to hospitals in Yasuj City, Kohgiluyeh and Boyer-Ahmad Province, Iran. Inclusion Criteria Informed consent Patients 18 years of age or older Diagnosis of COVID-19 based on real-time polymerase chain reaction (RT-PCR) test Exclusion Criteria Pregnancy or lactation Immunoglobulin A (IgA) level <61 mg/dl Disseminated intravascular coagulation or any other types of coagulopathy Severe congestive heart failure Participation in any clinical trial within 30 days prior to enrollment in this RCT Other contraindications determined by the specialist. Intervention and Comparator Intervention: 500 ml pomegranate juice and standard of care hospital treatment for COVID-19 Comparator: matching placebo containing 500 ml of red water and standard of care hospital treatment for COVID-19 Both intervention and comparator to be taken twice a day, after lunch and dinner, for 14 days. Criteria for Discontinuing Transfer of patients to intensive care unit (ICU) Death Unwillingness to continue participating in the study Main Outcomes The main outcomes of this study are levels of inflammatory biomarkers, CRP, IL-6, ESR, and CBC after 14 days of treatment. Randomization Eligible patients will be randomly assigned into the intervention or control group in a 1:1 ratio. Randomization will be performed based on 8 permuted blocks with block sizes of 6 and they will be stratified according to sex and age categories. Randomization sequences will be prepared by the trial’s pharmacist using computer-generated random numbers. Blinding (Masking) This study is a double-blind clinical ...
    Schlagwörter COVID-19 ; Randomized Controlled Trial ; Protocol ; Pomegranate Juice ; CRP ; IL-6 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Evaluation of the Antimicrobial Effects of Satureja Montana Essential Oil Alone and in Combination with Nisin on Escherichia Coli and Staphylococcus Aureus

    Sajjad Babaei / Arezoo Moradi / Mahboobe Hosseinikia / Omid Mansouri Zaveleh / Zohreh Amiri / Nasrollah Sohrabi

    Journal of Research in Medical and Dental Science, Vol 6, Iss 2, Pp 54-

    2018  Band 60

    Abstract: With ongoing use of preservative chemical compounds in the food industry, in addition to the challenge of microbial resistance, also there is growing concerns over side effects of these compounds. So, the use of herbal essential oils in food ... ...

    Abstract With ongoing use of preservative chemical compounds in the food industry, in addition to the challenge of microbial resistance, also there is growing concerns over side effects of these compounds. So, the use of herbal essential oils in food preservatives with much less side effects and sometimes even positive effects, has been considered. Therefore, in the present study, the antibacterial effects of Nisin and Satureja montana essential oil have been studied separately and in combination on standard strains of Escherichia coli and Staphylococcus aureus, that are important bacteria in food microbial contamination. Constituents analysis of Satureja essential oil was performed by GC/MS. Antimicrobial susceptibility testing as Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) was performed by Broth micro dilution method and evaluation of interactions between the compounds, was performed by calculating FIC index (Fractional Inhibitory Concentration) method. Antimicrobial susceptibility test showed that MIC and MBC of Satureja montana essential oil and Nisin on S.aureus were 1.25mg/ml and ≤7.8I.U/ml, respectively. and MIC and MBC of Satureja montana and Nisin on E.coli were <10mg/ml and 1000 I.U/ml, respectively. Results of FIC index revealed that antibacterial effects of Satureja montana in combination with Nisin on E.coli O157 , synergistically increased. While, antibacterial effect of the above mentioned compounds on S.aureus was indifferent. Present study showed a significant improvement in the antibacterial effects of Satureja montana essential oil in combination with Nisin on E.coli compared to S.aureus. The effect of Nisin alone on gram-negative bacteria is weak and now faces the challenge of microbial resistance. However, obtaining a stable combination of herbal essential oils containing antimicrobial agents such as Carvacrol for use in food preservation, can be a good point for further research and development.
    Schlagwörter Food Preservative ; Herbal Essential Oils ; Nisin ; Satureja Montana ; MIC ; MBC ; FIC ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag Amber Publication
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine

    Roghayeh Hosseinikia / Mohammad Reza Nikbakht / Ali Asghar Moghaddam / Ahmad Tajehmiri / Mahboobe Hosseinikia / Farhad Oubari / Mahin Nikougoftar Zarif / Yahya Pasdar / Kamran Mansouri

    International Journal of Hematology-Oncology and Stem Cell Research, Vol 11, Iss

    2016  Band 1

    Abstract: Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in ... ...

    Abstract Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic.
    Schlagwörter MSCs ; Immunomodulation ; Cell therapy ; Regeneration medicine ; Soluble factors ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-12-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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