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  1. Article ; Online: Copper nitroprusside: An innovative approach for targeted cancer therapy via ROS modulation.

    Asif, Kanwal / Adeel, Muhammad / Mahbubur Rahman, Md / Bartoletti, Michele / Brezar, Simona Kranjc / Cemazar, Maja / Canzonieri, Vincenzo / Rizzolio, Flavio / Caligiuri, Isabella

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116017

    Abstract: The clinical application of nanomaterials for chemodynamic therapy (CDT), which generate multiple reactive oxygen species (ROS), presents significant challenges. These challenges arise due to insufficient levels of endogenous hydrogen peroxide and ... ...

    Abstract The clinical application of nanomaterials for chemodynamic therapy (CDT), which generate multiple reactive oxygen species (ROS), presents significant challenges. These challenges arise due to insufficient levels of endogenous hydrogen peroxide and catalytic ions necessary to initiate Fenton reactions. As a result, sophisticated additional delivery systems are required. In this study, a novel bimetallic copper (II) pentacyanonitrosylferrate (Cu(II)NP, Cu[Fe(CN) 5 NO]) material was developed to address these limitations. This material functions as a multiple ROS generator at tumoral sites by self-inducing hydrogen peroxide and producing peroxynitrite (ONOO
    MeSH term(s) Humans ; Copper ; Hydrogen Peroxide ; Nitroprusside ; Reactive Oxygen Species ; Neoplasms
    Chemical Substances Copper (789U1901C5) ; Hydrogen Peroxide (BBX060AN9V) ; Nitroprusside (169D1260KM) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.116017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Evaluation of safety and anti-obesity effects of DWP16001 in naturally obese dogs

    Rhee, Beomseok / Mahbubur, Rahman Md / Jin, Changfan / Choi, Ji-Soo / Lim, Hyun-Woo / Huh, Wan / Pak, Chun-sŏk / Han, Jumi / Kim, Sokho / Lee, Youngwon / Park, Jinho

    BMC Vet Res. 2022 Dec., v. 18, no. 1 p.237-237

    2022  

    Abstract: BACKGROUND: The aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), ... ...

    Abstract BACKGROUND: The aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), and three treated groups; DWP0.2 group, DWP0.5 group, and DWP1 group. OC group fed with food for maintenance and treated groups were fed with food for maintenance with 0.2 mg/kg DWP16001, 0.5 mg/kg DWP16001 and 1 mg/kg DWP16001, respectively. The food for maintenance was provided to dogs as 2 RER (Resting energy requirement) in kcal and DWP16001-supplemented food was administered once a day for 8 weeks. RESULTS: Body condition score, body weight, and fat thickness were significantly reduced (P < 0.05) in the DWP0.2 group compared with the OC group, respectively without affecting the food consumption. At the 10ᵗʰ week the food consumption rate was 101.35 ± 2.56, 166.59 ± 4.72, 98.47 ± 1.44 and 123.15 ± 2.45% compared with initial food consumption rate. Body fat percentage, chest and waist circumference, blood glucose, and insulin were reduced compared to OC group but not significantly different from those of the OC group during experimental period. Serum alanine aminotransferase, alkaline phosphatase, creatine phosphokinase, and creatinine were significantly reduced in DWP0.2 group on 8 weeks. Serum cholesterol and triglycerides were reduced but not significantly. No specific adverse effects were observed throughout the experiment, and hematological parameters were unchanged. The results indicate that DWP16001 was not harmful to the dogs in our study and might have anti-obesity effects in naturally obese dogs. CONCLUSIONS: The above results and discussion suggest that DWP16001 is safe and might have anti-obesity effects in naturally obese dogs.
    Keywords alanine transaminase ; alkaline phosphatase ; blood glucose ; blood serum ; body condition ; body weight ; chest ; cholesterol ; creatine kinase ; creatinine ; energy ; fat thickness ; food consumption ; insulin ; sodium glucose cotransporter-2 inhibitors ; waist circumference
    Language English
    Dates of publication 2022-12
    Size p. 237.
    Publishing place BioMed Central
    Document type Article ; Online
    ZDB-ID 2191675-5
    ISSN 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-022-03324-2
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Evaluation of safety and anti-obesity effects of DWP16001 in naturally obese dogs.

    Rhee, Beomseok / Mahbubur, Rahman Md / Jin, Changfan / Choi, Ji-Soo / Lim, Hyun-Woo / Huh, Wan / Park, Joon Seok / Han, Jumi / Kim, Sokho / Lee, Youngwon / Park, Jinho

    BMC veterinary research

    2022  Volume 18, Issue 1, Page(s) 237

    Abstract: Background: The aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), ...

    Abstract Background: The aim of this study was to investigate the anti-obesity effects of DWP16001, a sodium-glucose cotransporter-2 (SGLT2 inhibitor), in naturally obese dogs. A total of 20 dogs were divided into four equal groups: one obese control (OC group), and three treated groups; DWP0.2 group, DWP0.5 group, and DWP1 group. OC group fed with food for maintenance and treated groups were fed with food for maintenance with 0.2 mg/kg DWP16001, 0.5 mg/kg DWP16001 and 1 mg/kg DWP16001, respectively. The food for maintenance was provided to dogs as 2 RER (Resting energy requirement) in kcal and DWP16001-supplemented food was administered once a day for 8 weeks.
    Results: Body condition score, body weight, and fat thickness were significantly reduced (P < 0.05) in the DWP0.2 group compared with the OC group, respectively without affecting the food consumption. At the 10
    Conclusions: The above results and discussion suggest that DWP16001 is safe and might have anti-obesity effects in naturally obese dogs.
    MeSH term(s) Animals ; Blood Glucose ; Body Weight ; Dog Diseases/drug therapy ; Dogs ; Insulin ; Obesity/drug therapy ; Obesity/veterinary ; Triglycerides
    Chemical Substances Blood Glucose ; Insulin ; Triglycerides
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191675-5
    ISSN 1746-6148 ; 1746-6148
    ISSN (online) 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-022-03324-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Identification of

    Abdul Hannan, M D / Mahbubur Rahman, M D / Nurunnabi Mondal, M D / Suzan Chandra, Deb / Chowdhury, Gazlima / Tofazzal Islam, M D

    Polish journal of microbiology

    2019  Volume 68, Issue 4, Page(s) 429–438

    Abstract: Penaeus monodon: Penaeus ... ...

    Abstract Penaeus monodon
    Penaeus monodon
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; DNA, Bacterial/genetics ; Food Preservation ; Food Preservatives/pharmacology ; Microbial Sensitivity Tests ; Penaeidae/growth & development ; Penaeidae/microbiology ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; RNA, Ribosomal, 16S/genetics ; Shellfish/microbiology ; Vibrio alginolyticus/drug effects ; Vibrio alginolyticus/genetics ; Vibrio alginolyticus/growth & development ; Vibrio alginolyticus/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; DNA, Bacterial ; Food Preservatives ; Plant Extracts ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-10-31
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2234080-4
    ISSN 2544-4646 ; 1733-1331
    ISSN (online) 2544-4646
    ISSN 1733-1331
    DOI 10.33073/pjm-2019-042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: mSieve: Differential Behavioral Privacy in Time Series of Mobile Sensor Data.

    Saleheen, Nazir / Chakraborty, Supriyo / Ali, Nasir / Mahbubur Rahman, Md / Hossain, Syed Monowar / Bari, Rummana / Buder, Eugene / Srivastava, Mani / Kumar, Santosh

    Proceedings of the ... ACM International Conference on Ubiquitous Computing . UbiComp (Conference)

    2016  Volume 2016, Page(s) 706–717

    Abstract: Differential privacy concepts have been successfully used to protect anonymity of individuals in population-scale analysis. Sharing of mobile sensor data, especially physiological data, raise different privacy challenges, that of protecting private ... ...

    Abstract Differential privacy concepts have been successfully used to protect anonymity of individuals in population-scale analysis. Sharing of mobile sensor data, especially physiological data, raise different privacy challenges, that of protecting private behaviors that can be revealed from time series of sensor data. Existing privacy mechanisms rely on noise addition and data perturbation. But the accuracy requirement on inferences drawn from physiological data, together with well-established limits within which these data values occur, render traditional privacy mechanisms inapplicable. In this work, we define a new behavioral privacy metric based on differential privacy and propose a novel data substitution mechanism to protect behavioral privacy. We evaluate the efficacy of our scheme using 660 hours of ECG, respiration, and activity data collected from 43 participants and demonstrate that it is possible to retain meaningful utility, in terms of inference accuracy (90%), while simultaneously preserving the privacy of sensitive behaviors.
    Language English
    Publishing date 2016-11-11
    Publishing country United States
    Document type Journal Article
    DOI 10.1145/2971648.2971753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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