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  1. Article: Acute toxic effects of areca nut on central nervous system and liver: A case report.

    Mahdavi Mortazavi, Seyede Maryam / Ataollahi, Maryam / Mashhadiagha, Amirali / Moosavi, Seyed Ali / Moshfeghinia, Reze / Soheili, Marzieh

    Clinical case reports

    2023  Volume 11, Issue 10, Page(s) e7976

    Abstract: Areca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non-conclusive. ...

    Abstract Areca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non-conclusive. In the present case report, we investigated the hepatotoxicity of AN in a four-year-old Iranian girl who was transferred to our medical center with abdominal pain, vomiting, diarrhea, fever, and other symptoms such as hematuria, decreased mental status, multiple seizure episodes. After a comprehensive evaluation, it was concluded that these signs and symptoms were all attributed to AN consumption, which was given by her mother to control diarrhea. Eventually, the patient medical conditions were managed successfully, and she survived by intense medical care. In conclusion, we suggest AN should be considered a potential hepatotoxic agent.
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Large Volume Paracentesis in Patients with Liver Cirrhosis Temporarily Diminishes Blood Cell Count.

    Haghighat, Mahmood / Ataollahi, Maryam / Imanieh, Mohammad Hadi / Honar, Naser / Dehghani, Seyed Mohsen / Soheili, Marzieh / Mahdavi Mortazavi, Seyede Maryam

    Iranian journal of medical sciences

    2023  Volume 48, Issue 4, Page(s) 385–392

    Abstract: Background: Large-volume paracentesis is the preferred treatment for patients with severe and refractory ascites. Several complications were reported during therapeutical paracentesis. However, there are very few published studies on the change in blood ...

    Abstract Background: Large-volume paracentesis is the preferred treatment for patients with severe and refractory ascites. Several complications were reported during therapeutical paracentesis. However, there are very few published studies on the change in blood cell count after paracentesis. This study aimed to evaluate any changes in blood cell counts after ascites fluid drainage.
    Methods: This study was conducted on patients with severe ascites and chronic liver disease who underwent large-volume paracentesis at Namazi Hospital, in Shiraz, Iran, between March 2021 and February 2022. A data gathering form containing the patient's medical history, cause of cirrhosis, ascites fluid volume, as well as routine tests including primarily sodium, potassium, and basal creatinine, was filled out. Before and after the surgery, the total blood cell count was measured. Before the procedure, adjustment was made in the case of coagulopathy and albumin deficiency. The effect of factors such as the volume of drained fluid, splenomegaly, antibiotics, and steroid use was assessed on the changes in the number of blood cells. Using the JAMOVI 2.3.9 software, a paired
    Results: The study included 37 patients. After the paracentesis procedure, the number of blood cells significantly decreased in all groups (P<0.001). The followings are the amounts of each type of blood cells before and after the procedure: Platelet=153837±91862 and 115648±69136, red blood cells=3.53±0.784 and 3.22±0.705, white blood cells=12.3±7.78 and 8.6±5.5. None of the study variables, including drained volume, splenomegaly, antibiotics, and steroid use, were significant predictors of the changes in the blood cell count after paracentesis (P>0.001).
    Conclusion: The findings of the present study showed that children with tense ascites who had large-volume paracentesis might experience a sharp drop in blood cell count after the procedure, which was a transient physiological condition.
    MeSH term(s) Child ; Humans ; Paracentesis/adverse effects ; Paracentesis/methods ; Ascites/complications ; Ascites/therapy ; Splenomegaly/complications ; Liver Cirrhosis/complications ; Liver Cirrhosis/therapy ; Blood Cell Count ; Anti-Bacterial Agents ; Steroids
    Chemical Substances Anti-Bacterial Agents ; Steroids
    Language English
    Publishing date 2023-07-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 603872-4
    ISSN 1735-3688 ; 0253-0716
    ISSN (online) 1735-3688
    ISSN 0253-0716
    DOI 10.30476/IJMS.2022.95859.2743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis.

    Moradi, Yousef / Soheili, Marzieh / Dehghanbanadaki, Hojat / Moradi, Ghobad / Moradpour, Farhad / Mahdavi Mortazavi, Seyede Maryam / Gilzad Kohan, Hamed / Zareie, Mostafa

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    2022  Volume 25, Page(s) 183–192

    Abstract: Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19.: Methods: A comprehensive literature search was ... ...

    Abstract Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19.
    Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies.
    Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients.
    Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality.
    MeSH term(s) COVID-19 ; Dyspnea/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-06-20
    Publishing country Canada
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1422972-9
    ISSN 1482-1826 ; 1482-1826
    ISSN (online) 1482-1826
    ISSN 1482-1826
    DOI 10.18433/jpps32831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Monkeypox: Virology, Pathophysiology, Clinical Characteristics, Epidemiology, Vaccines, Diagnosis, and Treatments.

    Soheili, Marzieh / Nasseri, Sherko / Afraie, Maryam / Khateri, Sorour / Moradi, Yousef / Mahdavi Mortazavi, Seyede Maryam / Gilzad-Kohan, Hamed

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    2022  Volume 25, Page(s) 297–322

    Abstract: The World Health Organization, has declared the recent multiregional outbreak of monkeypox, a global public health emergency. Monkeypox is a zoonotic viral infection endemic to the west and central Africa. It belongs to the Poxviridae family, the ... ...

    Abstract The World Health Organization, has declared the recent multiregional outbreak of monkeypox, a global public health emergency. Monkeypox is a zoonotic viral infection endemic to the west and central Africa. It belongs to the Poxviridae family, the Chordopoxvirinae subfamily, and the Orthopoxvirus genus. The Poxviridae family generally consists of complex, large, enveloped, and linear double-stranded DNA viruses. The initial clinical symptoms of monkeypox are often fever, severe headache, lymphadenopathy, myalgia, and fatigue. The skin lesions typically erupt within 1-3 days of the onset of fever. The rash tends to be more localized on the face and extremities than on the trunk. Monkeypox is often a self-limiting infection, and symptoms last from 2 to 4 weeks. It is isolated from various species, but the exact natural host is uncertain. Monkeypox is transmitted by close contact with infected humans or animals. Currently, no specific medication is available for monkeypox, and the existing therapeutics are the anti-viral agents approved for smallpox infection, including tecovirimat, cidofovir, and brincidofovir. Additionally, the U.S. Food and Drug Administration has approved Vaccinia Immune Globulin Intravenous for treating vaccination complications. It is diagnosed by PCR. There are currently two vaccines licensed by the U.S. Food and Drug Administration. According to the WHO guidance, the first-generation smallpox vaccines held in national reserves of some countries are not recommended as they do not meet the current safety and manufacturing standards. The interim guidance indicates that new and safer (second- and third generation) vaccines for smallpox, may be beneficial for monkeypox prevention, including JYNNEOS, which has been approved for the prevention of monkeypox. Human monkeypox was first reported in 1970. Since then, it has caused several outbreaks, mainly in central and west Africa. The first monkeypox outbreak outside of Africa occurred in the United States in 2003, linked to contact with infected pet prairie dogs. More recently (2018-2021), monkeypox cases have been reported in travelers from Nigeria to the United Kingdom, Israel, Singapore, and the US. Since May 2022, multiple monkeypox cases have been confirmed in several non-endemic countries, raising the concern of an emerging global pandemic. This review is an updated overview of our current state of knowledge regarding monkeypox virology, pathophysiology, clinical characteristics, epidemiology, vaccines, diagnosis, and treatment options.
    MeSH term(s) Animals ; Cidofovir ; DNA ; Humans ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Smallpox ; United States ; Vaccines
    Chemical Substances Vaccines ; DNA (9007-49-2) ; Cidofovir (JIL713Q00N)
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1422972-9
    ISSN 1482-1826 ; 1482-1826
    ISSN (online) 1482-1826
    ISSN 1482-1826
    DOI 10.18433/jpps33138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Evaluation of Outcomes and Complications of Large Volume Paracentesis without Albumin and Coagulopathy Therapy in Pediatrics with Severe Ascites.

    Haghighat, Mahmoud / Honar, Naser / Imanieh, Mohammad Hadi / Ataollahi, Maryam / Dehghani, Seyed Mohsen / Shahramian, Iraj / Karbasian, Fereshteh / Komeily Fard, Hamideh / Soheili, Marzieh / Mahdavi Mortazavi, Seyede Maryam

    Medical journal of the Islamic Republic of Iran

    2023  Volume 37, Page(s) 45

    Abstract: Background: Large-volume paracentesis has become the first treatment choice for patients with severe and refractory ascites. The studies have reported several complications after therapeutic paracentesis. But there are few published data on the ... ...

    Abstract Background: Large-volume paracentesis has become the first treatment choice for patients with severe and refractory ascites. The studies have reported several complications after therapeutic paracentesis. But there are few published data on the complications with or without Albumin therapy. We aimed to analyze the safety and complications of large-volume paracentesis in children with or without albumin therapy.
    Methods: This study was conducted on children with severe ascites with chronic liver disease who underwent large-volume paracentesis. They were divided into albumin-infused and albumin non-infused groups. In the case of coagulopathy, no adjustment was made. Albumin was not administered after the procedure. The outcomes were monitored to evaluate the complications. To compare two groups, a t-test was utilized, and the ANOVA test was used to compare several groups. If the requirements for using these tests were not met, Mann-Whitney and Kruskal-Wallis tests were applied.
    Results: Decreased heart rate was observed in all time intervals and was meaningful six days after paracentesis. MAP also decreased statistically at 48 hours and six days after the procedure (
    Conclusion: Children having tense ascites with thrombocytopenia, prolonged PT, Child-Pugh class C, and encephalopathy can undergo large-volume paracentesis without any complication. Albumin administration before the procedure in patients with low levels of Albumin (<2.9) can effectively overcome the problems of tachycardia and increased mean arterial pressure. There will be no need for Albumin administration after paracentesis.
    Language English
    Publishing date 2023-05-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 1095990-7
    ISSN 1016-1430
    ISSN 1016-1430
    DOI 10.47176/mjiri.37.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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