Article ; Online: Baicalein and Αlpha-Tocopherol Inhibit Toll-like Receptor Pathways in Cisplatin-Induced Nephrotoxicity.
Molecules (Basel, Switzerland)
2022 Volume 27, Issue 7
Abstract: Cisplatin (CP) is a conventional chemotherapeutic agent with serious adverse effects. Its toxicity was linked to the stimulation of oxidative stress and inflammation. As a result, this study explored the protective effect of baicalein and alpha- ... ...
| Abstract | Cisplatin (CP) is a conventional chemotherapeutic agent with serious adverse effects. Its toxicity was linked to the stimulation of oxidative stress and inflammation. As a result, this study explored the protective effect of baicalein and alpha-tocopherol in nephrotoxicity induced by cisplatin. Until receiving an intraperitoneal injection of CP (3 mg/kg BW), rats were given baicalein orally 100 mg/kg for seven days or/and a single intraperitoneal injection of α-tocopherol 250 mg/kg. Renal function was tested to explore whether baicalein and α-tocopherol have any beneficial effects; blood urea nitrogen (BUN), serum creatinine, malondialdehyde (MDA) content, antioxidant activity biomarkers and histopathology of renal tissue, oxidative stress biomarkers, inflammatory response markers, and histopathological features of kidney architecture were measured. Cisplatin treatment resulted in extreme renal failure, as measured by high serum creatinine and BUN levels and severe renal changes. Cisplatin therapy resulted in increased lipid peroxidation and decreased glutathione and superoxide dismutase levels, reflecting oxidative stress. Upon treatment with α-tocopherol, baicalein, and combined therapy, there was augmentation in the antioxidant status as well as a reduction in IL-6, NF-κB, TNF, TLR2, and TLR4 and a significant increase in Keap-1 and NRF-2. The combined treatment was the most effective and the nearest to the normal status. These findings suggest that baicalein and α-tocopherol may be useful in preventing cisplatin-induced nephrotoxicity. |
|---|---|
| MeSH term(s) | Animals ; Antineoplastic Agents/pharmacology ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Biomarkers/metabolism ; Blood Urea Nitrogen ; Cisplatin/pharmacology ; Creatinine/metabolism ; Flavanones ; Kidney ; Oxidative Stress ; Rats ; Renal Insufficiency/metabolism ; Renal Insufficiency/pathology ; Tocopherols/pharmacology ; Toll-Like Receptors/metabolism ; alpha-Tocopherol/metabolism ; alpha-Tocopherol/pharmacology |
| Chemical Substances | Antineoplastic Agents ; Antioxidants ; Biomarkers ; Flavanones ; Toll-Like Receptors ; baicalein (49QAH60606) ; Creatinine (AYI8EX34EU) ; alpha-Tocopherol (H4N855PNZ1) ; Cisplatin (Q20Q21Q62J) ; Tocopherols (R0ZB2556P8) |
| Language | English |
| Publishing date | 2022-03-28 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 1413402-0 |
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 |
| ISSN (online) | 1420-3049 |
| ISSN | 1431-5165 ; 1420-3049 |
| DOI | 10.3390/molecules27072179 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.MO 81: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.