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Article ; Online: Clinical and pathological overview of endometrial endometrioid carcinoma.

Maher, Mohamed / Zeches, Breann Angelica / Mohamed, Anas

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2024 Volume 34, Issue 4, Page(s) 645–647

MeSH term(s)	Female ; Humans ; Carcinoma, Endometrioid/pathology ; Endometrial Hyperplasia/pathology ; Endometrial Neoplasms/therapy ; Endometrial Neoplasms/pathology ; Endometrium/pathology
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-004382
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Zs.A 3198: Show issues

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Article ; Online: FROM SHARING TO SELLING: CHALLENGES AND OPPORTUNITIES OF ESTABLISHING A DIGITAL HEALTH DATA MARKETPLACE USING BLOCKCHAIN TECHNOLOGIES.

Maher, Mohamed A / Khan, Imtiaz A

Blockchain in healthcare today

2022 Volume 5

Abstract: During the COVID-19 pandemic, we witnessed how sharing of biological and biomedical data facilitated researchers, medical practitioners, and policymakers to tackle the pandemic on a global scale. Despite the growing use of electronic health records (EHRs) ...

Abstract	During the COVID-19 pandemic, we witnessed how sharing of biological and biomedical data facilitated researchers, medical practitioners, and policymakers to tackle the pandemic on a global scale. Despite the growing use of electronic health records (EHRs) by medical practitioners and wearable digital gadgets by individuals, 80% of health and medical data remain unused, adding little value to the work of researchers and medical practitioners. Legislative constraints related to health data sharing, centralized siloed design of traditional data management systems, and most importantly, lack of incentivization models are thought to be the underpinning bottlenecks for sharing health data. With the advent of the General Data Protection Regulation (GDPR) of the European Union (EU) and the development of technologies like blockchain and distributed ledger technologies (DLTs), it is now possible to create a new paradigm of data sharing by changing the incentivization model from current authoritative or altruistic form to a shared economic model where financial incentivization will be the main driver for data sharing. This can be achieved by setting up a digital health data marketplace (DHDM). Here, we review papers that proposed technical models or implemented frameworks that use blockchain-like technologies for health data. We seek to understand and compare different technical challenges associated with implementing and optimizing the DHDM operation outlined in these articles. We also examine legal limitations in the context of the EU and other countries such as the USA to accommodate any compliance requirement for such a marketplace. Last but not least, we review papers that investigated the short-, medium-, and long-term socioeconomic impact of such a marketplace on a wide range of stakeholders.
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2573-8240
ISSN (online)	2573-8240
DOI	10.30953/bhty.v5.184
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Article ; Online: Anatomical and radiographic distribution of hepatic artery and biliary duct system applied to biochemical parameters indicative to hepatobiliary disease in Egyptian donkey (Equus asinus).

Maher, Mohamed Ahmed / Ahmad, Ismail M

Anatomia, histologia, embryologia

2022 Volume 51, Issue 3, Page(s) 355–365

Abstract: The current study was performed on ten adult Egyptian donkeys of both sexes for anatomical and radiographic studies in addition to six other donkeys for enzymatic, biochemical and statistical analysis. The aim was to illustrate the normal hepatic ... ...

Abstract	The current study was performed on ten adult Egyptian donkeys of both sexes for anatomical and radiographic studies in addition to six other donkeys for enzymatic, biochemical and statistical analysis. The aim was to illustrate the normal hepatic arterial and biliary distribution using different anatomic techniques and radiographic imaging besides, establishing an accurate laboratory profile specific for donkeys that used as standard indicators for hepatobiliary dysfunction. The right branch of the hepatic artery in donkey forms a curved arch erupting five branches, unlike the left branch that erupts six branches, being the direct continuation of the main hepatic artery. The caudate lobe artery either originated from the hepatic artery or its right division. The common hepatic duct represented a very clear enlargement called 'gall tank' at its terminal pouring intestinal end and compensating absence of gall bladder, cystic and common bile ducts. The intrahepatic biliary distribution is characterized by a segmental ramification into dorsal, intermediate, and ventral branches of bile ductules especially noticed in the undivided right lobe and left lateral lobe. The quadrate lobe is divided according to its biliary drainage into right and left parts where the former is drained by the left hepatic duct while the latter is drained through a branch from R. lobi medialis sinistri. The serum enzymatic activity was slightly similar to that of the horse while some biochemical parameters differentiating the donkey from the horse such as lowered total bilirubin, serum bile acids, and higher triglycerides, blood urea and prolonged prothrombin time.
MeSH term(s)	Animals ; Digestive System Diseases/veterinary ; Egypt ; Equidae ; Female ; Hepatic Artery/diagnostic imaging ; Horse Diseases ; Horses ; Liver/diagnostic imaging ; Male
Language	English
Publishing date	2022-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	537922-2
ISSN	1439-0264 ; 0340-2096 ; 0044-4294
ISSN (online)	1439-0264
ISSN	0340-2096 ; 0044-4294
DOI	10.1111/ahe.12794
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Article ; Online: Methotrexate treatment for peritoneal trophoblastic implants after laparoscopic salpingectomy and secondary laparoscopic excision of ectopic pregnancy.

Maher, Mohamed A / Fairley, Helen / Khatri, Pinky / Khunda, Aethele

BMJ case reports

2024 Volume 17, Issue 1

Abstract: Ectopic pregnancy is a one of the primary causes of maternal mortality in first trimester. The most common site of ectopic pregnancy is the fallopian tube. Surgical management of tubal ectopic pregnancy includes salpingotomy or salpingectomy. Persistent ... ...

Abstract	Ectopic pregnancy is a one of the primary causes of maternal mortality in first trimester. The most common site of ectopic pregnancy is the fallopian tube. Surgical management of tubal ectopic pregnancy includes salpingotomy or salpingectomy. Persistent ectopic pregnancy can happen after salpingotomy due to incomplete removal of ectopic tissue. However, it is very rare after salpingectomy. In our case, the patient had right-sided salpingectomy and histology confirmed right-sided tubal ectopic pregnancy. She presented 19 days' later with abdominal pain, haemoperitoneum and persistent high beta-HCG (B-HCG). A second laparoscopy was done and tissue implants were removed from the surface of the right ovary and the omentum, which were confirmed to be products of conception on histology. The pain settled postoperative. However, B-HCG remained high postoperative. Subsequently, methotrexate treatment was given leading to full resolution of the pregnancy with one dose.
MeSH term(s)	Pregnancy ; Female ; Humans ; Methotrexate/therapeutic use ; Pregnancy, Ectopic/drug therapy ; Pregnancy, Ectopic/surgery ; Pregnancy, Tubal/surgery ; Salpingectomy/adverse effects ; Laparoscopy/adverse effects
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-257693
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Article ; Online: Ovarian steroid cell tumors.

Maher, Mohamed / Zeches, Breann Angelica / Mohamed, Anas

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 10, Page(s) 1660–1662

MeSH term(s)	Female ; Humans ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Sex Cord-Gonadal Stromal Tumors/pathology ; Steroids
Chemical Substances	Steroids
Language	English
Publishing date	2023-10-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-004256
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Zs.A 3198: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Lymphedematous Fibroepithelial Polyp Without Associated Condom Catheter Use: A Case Report With Review of the Literature.

Zeches, Breann A / Maher, Mohamed / Alomari, Ahmed K

The American Journal of dermatopathology

2023 Volume 45, Issue 7, Page(s) 466–469

Abstract: Abstract: Lymphedematous fibroepithelial polyps are rare proliferations involving the glans penis typically associated with chronic condom catheter usage. To the best of our knowledge, less than 20 cases have been reported in the literature with ... ...

Abstract	Abstract: Lymphedematous fibroepithelial polyps are rare proliferations involving the glans penis typically associated with chronic condom catheter usage. To the best of our knowledge, less than 20 cases have been reported in the literature with relatively similar clinical presentation. Herein, we report a case of lymphedematous fibroepithelial polyp not associated with condom usage in a 74-year-old man treated with surgical excision. On histopathological examination, the lesion displayed a hypocellular proliferation of spindled and stellate fibroblasts with intermixed Touton-like giant cells embedded within an edematous stroma with thickened vasculature. Immunohistochemical profiling exhibits strong immunoreactivity for smooth muscle actin, weak positivity for factor XIIIa, and no reactivity for CD34 or desmin. We also conducted a review of the reported range of clinical and histopathological features of this entity in addition to the various hypotheses regarding its pathogenesis. We hope to increase awareness and accurate diagnosis of this entity, which could affect clinical management.
MeSH term(s)	Male ; Humans ; Aged ; Condoms/adverse effects ; Polyps/etiology ; Polyps/surgery ; Penis/pathology ; Skin Neoplasms/pathology ; Catheters/adverse effects ; Lymphedema/pathology
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000002462
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Zs.A 1518: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Relationship between High-density Lipoprotein Cholesterol and Insulin Resistance in Non-diabetic Chronic Kidney Disease Patients.

El-Hendy, Yasser Abdel-Monem / Ismail, Mabrouk Ibrahim / Borai, Maher Mohamed / Abdelhamid, Walid Ahmed Ragab

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2024 Volume 34, Issue 4, Page(s) 323–330

Abstract: Insulin resistance is linked to cardiovascular disease (CVD), even in non-diabetic patients. Therefore, insulin resistance contributes to the development of CVDs, which are the most important cause of morbidity and mortality in chronic kidney disease ( ... ...

Abstract	Insulin resistance is linked to cardiovascular disease (CVD), even in non-diabetic patients. Therefore, insulin resistance contributes to the development of CVDs, which are the most important cause of morbidity and mortality in chronic kidney disease (CKD) and patients receiving dialysis replacement therapy. Furthermore, CKD greatly affects the enzyme activities responsible for the metabolism of high-density lipoprotein (HDL), causing an abnormal composition and function of HDL, which results in the loss of the anti-inflammatory effect of HDL and its protective effect against CVD. The study aimed to find the relationship between HDL-C, inflammation, and insulin resistance in nondiabetic CKD patients undergoing different modalities of treatment. This prospective cross-sectional comparative study included 80 subjects divided into the control group (20 healthy participants), Group 1 (15 predialysis CKD patients on conservative treatment), Group 2 (10 peritoneal dialysis patients), and Group 3 (35 hemodialysis patients). A full history, medical examination, and a laboratory investigation were carried out on all subjects from June 2018 to June 2019. The patient groups had significantly lower HDL and higher serum insulin than the control group. HDL was negatively correlated with the Homeostatic Model Assessment of Insulin Resistance. There was a strong negative association between HDL and insulin resistance in CKD patients. Therefore, lifestyle modifications and dyslipidemia treatment in CKD might help to prevent cardiovascular events even in nondiabetic nonobese CKD patients.
MeSH term(s)	Humans ; Cholesterol, HDL ; Insulin Resistance ; Cross-Sectional Studies ; Prospective Studies ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Lipoproteins, HDL ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control
Chemical Substances	Cholesterol, HDL ; Lipoproteins, HDL
Language	English
Publishing date	2024-02-12
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.395448
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Zs.A 4735: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Anatomical and radiographic distribution of hepatic artery and biliary duct system applied to biochemical parameters indicative to hepatobiliary disease in Egyptian donkey (Equus asinus)

Maher, Mohamed Ahmed / Ahmad, Ismail M.

Anatomia, histologia, embryologia. 2022 May, v. 51, no. 3

2022

Abstract	The current study was performed on ten adult Egyptian donkeys of both sexes for anatomical and radiographic studies in addition to six other donkeys for enzymatic, biochemical and statistical analysis. The aim was to illustrate the normal hepatic arterial and biliary distribution using different anatomic techniques and radiographic imaging besides, establishing an accurate laboratory profile specific for donkeys that used as standard indicators for hepatobiliary dysfunction. The right branch of the hepatic artery in donkey forms a curved arch erupting five branches, unlike the left branch that erupts six branches, being the direct continuation of the main hepatic artery. The caudate lobe artery either originated from the hepatic artery or its right division. The common hepatic duct represented a very clear enlargement called ‘gall tank’ at its terminal pouring intestinal end and compensating absence of gall bladder, cystic and common bile ducts. The intrahepatic biliary distribution is characterized by a segmental ramification into dorsal, intermediate, and ventral branches of bile ductules especially noticed in the undivided right lobe and left lateral lobe. The quadrate lobe is divided according to its biliary drainage into right and left parts where the former is drained by the left hepatic duct while the latter is drained through a branch from R. lobi medialis sinistri. The serum enzymatic activity was slightly similar to that of the horse while some biochemical parameters differentiating the donkey from the horse such as lowered total bilirubin, serum bile acids, and higher triglycerides, blood urea and prolonged prothrombin time.
Keywords	Equus asinus ; adults ; asses ; bile ; bilirubin ; blood serum ; drainage ; enzyme activity ; gall bladder ; hepatic artery ; horses ; intestines ; prothrombin ; radiography ; statistical analysis ; urea
Language	English
Dates of publication	2022-05
Size	p. 355-365.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	537922-2
ISSN	1439-0264 ; 0340-2096 ; 0044-4294
ISSN (online)	1439-0264
ISSN	0340-2096 ; 0044-4294
DOI	10.1111/ahe.12794
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Instance-based Label Smoothing For Better Calibrated Classification Networks

Maher, Mohamed / Kull, Meelis

2021

Abstract: Label smoothing is widely used in deep neural networks for multi-class classification. While it enhances model generalization and reduces overconfidence by aiming to lower the probability for the predicted class, it distorts the predicted probabilities ... ...

Abstract	Label smoothing is widely used in deep neural networks for multi-class classification. While it enhances model generalization and reduces overconfidence by aiming to lower the probability for the predicted class, it distorts the predicted probabilities of other classes resulting in poor class-wise calibration. Another method for enhancing model generalization is self-distillation where the predictions of a teacher network trained with one-hot labels are used as the target for training a student network. We take inspiration from both label smoothing and self-distillation and propose two novel instance-based label smoothing approaches, where a teacher network trained with hard one-hot labels is used to determine the amount of per class smoothness applied to each instance. The assigned smoothing factor is non-uniformly distributed along with the classes according to their similarity with the actual class. Our methods show better generalization and calibration over standard label smoothing on various deep neural architectures and image classification datasets. Comment: 8 pages, 3 figures, ICMLA 2021
Keywords	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2021-10-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis.

Samy, Asmaa / Maher, Mohamed A / Abdelsalam, Nehal Adel / Badr, Eman

Scientific reports

2022 Volume 12, Issue 1, Page(s) 11934

Abstract: COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus evolve, a complete comprehension of the disease and drug targets becomes a decisive duty. The Omicron variant, for example, has a notably high transmission ... ...

Abstract	COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus evolve, a complete comprehension of the disease and drug targets becomes a decisive duty. The Omicron variant, for example, has a notably high transmission rate verified in 155 countries. We performed integrative transcriptomic and network analyses to identify drug targets and diagnostic biomarkers and repurpose FDA-approved drugs for SARS-CoV-2. Upon the enrichment of 464 differentially expressed genes, pathways regulating the host cell cycle were significant. Regulatory and interaction networks featured hsa-mir-93-5p and hsa-mir-17-5p as blood biomarkers while hsa-mir-15b-5p as an antiviral agent. MYB, RRM2, ERG, CENPF, CIT, and TOP2A are potential drug targets for treatment. HMOX1 is suggested as a prognostic biomarker. Enhancing HMOX1 expression by neem plant extract might be a therapeutic alternative. We constructed a drug-gene network for FDA-approved drugs to be repurposed against the infection. The key drugs retrieved were members of anthracyclines, mitotic inhibitors, anti-tumor antibiotics, and CDK1 inhibitors. Additionally, hydroxyquinone and digitoxin are potent TOP2A inhibitors. Hydroxyurea, cytarabine, gemcitabine, sotalol, and amiodarone can also be redirected against COVID-19. The analysis enforced the repositioning of fluorouracil and doxorubicin, especially that they have multiple drug targets, hence less probability of resistance.
MeSH term(s)	Biomarkers ; COVID-19/drug therapy ; Drug Repositioning ; Host Microbial Interactions ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; SARS-CoV-2
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-15898-w
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