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  1. Book: Resistant hypertension treatments

    Mahfoud, Felix / Kjeldsen, Sverre E. / Daemen, Joost

    a new era in interventional medicine

    (EuroIntervention ; 9, Suppl. R)

    2013  

    Author's details [guest ed. Felix Mahfoud ; Sverre Kjeldsen ; Joost Daemen]
    Series title EuroIntervention ; 9, Suppl. R
    Collection
    Language English
    Size R160 S. : Ill., graph. Darst.
    Publisher Europa Digital & Publishing
    Publishing place Toulouse
    Publishing country France
    Document type Book
    HBZ-ID HT017704310
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Outcome data for renal denervation: craving the unattainable?

    Lauder, Lucas / Mahfoud, Felix

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01667-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Audio / Video ; Thesis: Untersuchung der Pulswelle des intrakraniellen Drucks als Parameter zur Bestimmung der für den cerebralen Perfusionsdruck optimalen Oberkörperlagerung

    Mahfoud, Felix

    2006  

    Author's details vorgelegt von Felix Mahfoud
    Language German
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2008
    Note Titel auf der Beil.
    HBZ-ID HT015626210
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Pulmonary artery denervation - the suspense continues?

    Mahfoud, Felix / Götzinger, Felix

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2023  Volume 19, Issue 8, Page(s) 623–624

    MeSH term(s) Humans ; Pulmonary Artery/surgery ; Denervation ; Hypertension, Pulmonary
    Language English
    Publishing date 2023-10-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-23-00033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adherence to antihypertensive medication in renal denervation trials: new studies, old problems?

    Lauder, Lucas / Mahfoud, Felix

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 11, Page(s) 2543–2544

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Denervation
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01389-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The current position of β-blockers in hypertension: guidelines and clinical practice.

    Mahfoud, Felix / Wang, Jiguang / Ray, Saumitra

    Current medical research and opinion

    2024  Volume 40, Issue sup1, Page(s) 25–32

    Abstract: The benefits of improved clinical outcomes through blood pressure (BP) reduction have been proven in multiple clinical trials and meta-analyses. The new (2023) guideline from the European Society of Hypertension (ESH) includes β-blockers within five main ...

    Abstract The benefits of improved clinical outcomes through blood pressure (BP) reduction have been proven in multiple clinical trials and meta-analyses. The new (2023) guideline from the European Society of Hypertension (ESH) includes β-blockers within five main classes of antihypertensive agents suitable for initiation of antihypertensive pharmacotherapy and for combination with other antihypertensive agents. This is in contrast to the 2018 edition of ESH guidelines that recommended β-blockers for use primarily in patients with compelling indications such as cardiovascular comorbidities, e.g. coronary heart disease, heart failure. This change was based on the fact that the magnitude of BP reduction is the most important factor for adverse cardiovascular outcomes, over and above the precise manner in which reduced BP is achieved. The ESH guideline also supports the use of β-blockers for patients with resting heart rate (>80 bpm); high resting heart rate is a sign of sympathetic overactivity, an important driver of adverse cardiac remodelling in the setting of hypertension and heart failure. Hypertension management guidelines support for the use of combination therapies for almost all patients with hypertension, ideally within a single-pill combination to optimise adherence to therapy. Where a β-blocker is prescribed, the inclusion of a dihydropyridine calcium channel blocker within a combination regimen is rational. These agents together reduce both peripheral and central BP, which epidemiological studies have shown is important for reducing the burden of premature morbidity and mortality associated with uncontrolled hypertension, especially strokes.
    MeSH term(s) Humans ; Adrenergic beta-Antagonists/therapeutic use ; Antihypertensive Agents/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Heart Failure/drug therapy ; Hypertension/drug therapy ; Hypotension/drug therapy ; Practice Guidelines as Topic
    Chemical Substances Adrenergic beta-Antagonists ; Antihypertensive Agents ; Calcium Channel Blockers
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2024.2318003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Medication adherence in hypertension: lessons learned from renal denervation trials.

    Fisher, Naomi D L / Mahfoud, Felix

    European journal of preventive cardiology

    2022  Volume 30, Issue 1, Page(s) 34–36

    MeSH term(s) Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Kidney ; Denervation ; Medication Adherence ; Sympathectomy/adverse effects ; Antihypertensive Agents/adverse effects ; Blood Pressure ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwac159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Renal denervation in the management of hypertension.

    Lauder, Lucas / Kandzari, David E / Lüscher, Thomas F / Mahfoud, Felix

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2024  Volume 20, Issue 8, Page(s) e467–e478

    Abstract: Arterial hypertension is a global leading cause of cardiovascular, cerebrovascular, and renal disease, as well as mortality. Although pharmacotherapy is safe and effective in lowering blood pressure (BP) and cardiovascular disease risk, BP control ... ...

    Abstract Arterial hypertension is a global leading cause of cardiovascular, cerebrovascular, and renal disease, as well as mortality. Although pharmacotherapy is safe and effective in lowering blood pressure (BP) and cardiovascular disease risk, BP control remains poor, and the mortality rates associated with high BP have been steadily increasing. Device-based therapies have been investigated to overcome barriers to pharmacotherapy, including non-adherence and low rates of persistence to daily medications. Among these device-based therapies, catheter-based renal denervation (RDN) has been most extensively examined over the past 15 years. In this state-of-the-art article, we summarise the rationale for RDN, review the available evidence, provide recommendations for a safe procedure, and discuss the role of RDN in current guidelines and clinical practice.
    MeSH term(s) Humans ; Blood Pressure ; Antihypertensive Agents/therapeutic use ; Sympathectomy/adverse effects ; Sympathectomy/methods ; Treatment Outcome ; Hypertension/drug therapy ; Kidney/surgery ; Denervation
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2024-04-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-23-00836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What Is the Relevance of Low Standing Blood Pressure?

    Buder, Felix / Mahfoud, Felix / Böhm, Michael / Haring, Bernhard

    American journal of hypertension

    2023  Volume 36, Issue 11, Page(s) 586–587

    MeSH term(s) Humans ; Blood Pressure/physiology ; Posture/physiology ; Hypotension
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpad074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Management of Resistant Hypertension.

    Lauder, Lucas / Mahfoud, Felix / Böhm, Michael

    Annual review of medicine

    2023  Volume 75, Page(s) 443–457

    Abstract: Resistant hypertension (RH) is a severe form of hypertension associated with increased cardiovascular risk. Although true RH affects less than 10% of the patients receiving antihypertensive therapy, the absolute number is high and continues to increase. ... ...

    Abstract Resistant hypertension (RH) is a severe form of hypertension associated with increased cardiovascular risk. Although true RH affects less than 10% of the patients receiving antihypertensive therapy, the absolute number is high and continues to increase. The workup of these patients requires screening for secondary hypertension and pseudoresistance, including poor adherence to prescribed medicines and the white-coat phenomenon. The treatment of RH consists of lifestyle modifications and pharmacological therapies. Lifestyle modifications include dietary adjustments, weight loss, physical activity, and limiting alcohol consumption; pharmacological therapies include diuretics, mineralocorticoid receptor antagonists, beta blockers, angiotensin receptor-neprilysin inhibitors, and others. Over the last 15 years, interventional approaches have emerged as adjunct treatment options; we highlight catheter-based renal denervation. This review summarizes the rationales and latest clinical evidence and, based thereon, proposes an updated algorithm for the management of RH.
    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Hypertension/drug therapy ; Life Style
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-050922-052605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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