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  1. Article ; Online: The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis

    Masoud Nouri-Vaskeh / Payam Hashemi / Naser Hataminia / Yalda Yazdani / Mahkameh Nasirian / Leila Alizadeh

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    a randomized double-blind controlled trial

    2024  Volume 8

    Abstract: Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic dysfunction of the liver defined as an abnormal accumulation of fat within the liver without secondary triggers like alcohol consumption or viral hepatitis. Piperine, the bio-active ... ...

    Abstract Abstract Non-alcoholic fatty liver disease (NAFLD) is a metabolic dysfunction of the liver defined as an abnormal accumulation of fat within the liver without secondary triggers like alcohol consumption or viral hepatitis. Piperine, the bio-active ingredient of black pepper, can exert a significant function in treatment of individuals with NAFLDand early cirrhosis. We investigated the impact of piperine consumption with a duration of 12 weeks on patients with NAFLD and early cirrhosis compared toplacebo consumption. In a double-blind study, patients with NAFLD and early stage of cirrhosis were haphazardly distributed into case and control groups. They were prescribed a placebo and 5 mg of piperine for 12 weeks, respectively. The demographic and laboratory parameters of individuals were assessed as the baseline and after the duration of piperine intake. Piperine with a daily dosage of 5 mg could significantly decrease hepatic enzymes and glucose, and alleviate dyslipidemia in the case arm rather than the control arm. Moreover, HOMA levels and insulin resistance were reduced in case participants compared to the control counterparts. In the absence of approved medicinal intervention for patients with NAFLD, and regarding the favorable impact of piperine on NAFLD more studies on this subject are warranted.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Evaluation of D-dimer Test Correlation with Lung Perfusion-Ventilation Scan in Patients Suspected Pulmonary Embolism

    Mahkameh Nasirian / Esmaeil Gharepapagh / Ashraf Fakhari / Mohammad Reza Ghaffari Bavil / Neda Gilani

    Iranian South Medical Journal, Vol 25, Iss 6, Pp 519-

    2023  Volume 530

    Abstract: Background: Pulmonary embolism refers to the blockage of pulmonary arteries or a condition in which blood flow to the lungs is interrupted by a blood or fat clot. This phenomenon eventually leads to ische-mia and respiratory failure, which, without ... ...

    Abstract Background: Pulmonary embolism refers to the blockage of pulmonary arteries or a condition in which blood flow to the lungs is interrupted by a blood or fat clot. This phenomenon eventually leads to ische-mia and respiratory failure, which, without diagnosis and treatment, will result in the lungs losing their efficiency. Along with other diagnostic methods such as CT angiography and the D-dimer test, nuclear medicine scans are very helpful in embolism cases as a non-invasive diagnostic method. Specifically, the purpose of this study is to compare D-dimer tests with perfusion-ventilation scans in patients suspected of having pulmonary embo-lisms. Materials and Methods: According to the Nuclear Medicine Association protocol, 112 patients underwent lung scintigraphy (V/Q) with SPECT imaging systems (Siemens Ecam models). D-dimer tests were admin-istered to all patients before the scan, at the discretion of the attending physician. Data were collected and the distribution of embolism probability (normal, low, high, and intermediate probabilities) among refer-ring patients was evaluated using Modified PIOPED criteria. In addition, D-dimer test values were evalu-ated and compared with possible pulmonary embolism diagnoses and clinical conditions (age, surgery, pregnancy, and underlying diseases). Results: This study showed that 26.2% of patients with normal V/Q and 15.4% of patients with V/Q with a low probability of embolism had positive D-dimer tests. Accordingly, patients with intermediate and high probabilities of pulmonary embolism had 33.3% and 50% positive D-dimer tests, respectively. Addi-tionally, the results of the studies showed that the correlation with D-dimers negative (positive) in individ-uals less than or equal to 60 years, who had a normal scan and a low, intermediate, or high embolism probability was 74% (26%), 92.3% (7.7%), 83.3% (16.7%), and 0% (100%) respectively. Over 60-year-olds showed the same correlation with 73.3% (26.7%), 76.9% (23.1%), 55.6% (44.4%), and 100% (0%) respectively. ...
    Keywords d-dimer ; perfusion-ventilation scan ; pulmonary embolism ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Bushehr University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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