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Artikel ; Online: Assessing IgE sensitization profiles to birch and timothy grass pollen allergens in birch pollen allergic blood donors using an oligoplex specific IgE assay.

Mahmood, Faiza / Nissen-Meyer, Lise Sofie Haug / Hetland, Geir / Nentwich, Ivo

Scandinavian journal of clinical and laboratory investigation

2023 Band 83, Heft 7, Seite(n) 444–447

Abstract: IgE sensitization profiles to single birch allergens in birch-sensitized patients differ among European countries. The aim of this study was to determine the distribution of specific IgE antibodies to major and minor birch pollen allergens in a ... ...

Abstract	IgE sensitization profiles to single birch allergens in birch-sensitized patients differ among European countries. The aim of this study was to determine the distribution of specific IgE antibodies to major and minor birch pollen allergens in a population of allergic Norwegian individuals by using a birch allergic blood donor population as a surrogate sample. Sixty blood donors were recruited and sampled based on birch allergy symptoms such as rhinitis, rhinoconjunctivitis and/or mild asthma in previous seasons. All sera were collected before start of the pollen season and tested using a line blot assay (Euroimmun AG, Lübeck, Germany) for IgE to birch and timothy pollen. Both extracts, single allergens, and cross-reacting carbohydrate determinants (CCD) were analysed. Only donors with specific IgE to birch and/or timothy grass were further evaluated. Specific IgE to birch pollen extract was found in 52 sera, and sensitization to timothy grass in 40 sera. Specific IgE to Bet v 1 was predominant in contrast to Bet v 4 which was absent. However, sensitization to the minor allergens Bet v 2 and 6 was always found together with high levels of IgE to Bet v 1. Subjects sensitized to the profilin Bet v 2 from birch were also sensitized to Phl p 12 from timothy grass. In conclusion, there was predominantly Bet v 1 sensitization in this cohort and low sensitization to minor allergens and cross-reactive allergens (Bet v 2, Bet v 4, Phl p 7 and Phl p 12).
Mesh-Begriff(e)	Humans ; Betula ; Phleum ; Blood Donors ; Immunoglobulin E ; Hypersensitivity/diagnosis ; Pollen ; Allergens ; Cross Reactions
Chemische Substanzen	Immunoglobulin E (37341-29-0) ; Allergens
Sprache	Englisch
Erscheinungsdatum	2023-11-30
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2023.2255972
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A novel HLA-DQA1 allele, DQA1*01:05:03, identified in a patient with suspected celiac disease.

Mahmood, Faiza / Saether, Per C

HLA

2020 Band 96, Heft 1, Seite(n) 117–118

Abstract: A novel HLA-DQA1 allele, officially named DQA1*01:05:03 by the WHO Nomenclature Committee, was identified in a Norwegian patient with suspected celiac disease. The allele was sequenced by next-generation sequencing and is identical to DQA1*01:05:01:01 ... ...

Abstract	A novel HLA-DQA1 allele, officially named DQA101:05:03 by the WHO Nomenclature Committee, was identified in a Norwegian patient with suspected celiac disease. The allele was sequenced by next-generation sequencing and is identical to DQA101:05:01:01 with the exception of one synonymous nucleotide substitution in exon two.
Mesh-Begriff(e)	Alleles ; Celiac Disease/diagnosis ; Celiac Disease/genetics ; Exons/genetics ; HLA-DQ alpha-Chains/genetics ; Humans
Chemische Substanzen	HLA-DQ alpha-Chains ; HLA-DQA1 antigen
Sprache	Englisch
Erscheinungsdatum	2020-02-28
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.13836
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: <i>Agaricus blazei</i>-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial

Mahmood, Faiza / Hetland, Geir / Nentwich, Ivo / Mirlashari, Mohammad Reza / Ghiasvand, Reza / Nissen-Meyer, Lise Sofie Haug

Nutrients. 2019 Oct. 02, v. 11, no. 10

2019

Abstract: Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma. Sixty recruited donors ... ...

Abstract	Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma. Sixty recruited donors were randomized in a placebo-controlled, double-blinded study with pre-seasonal, 7-week, oral supplementation with the AbM-based extract AndosanTM. Before and after the pollen season, questionnaires were answered for allergic rhino-conjunctivitis, asthma, and medication; serum IgE was measured, and Bet v 1-induced basophil activation was determined by CD63 expression. The reported general allergy and asthma symptoms and medication were significantly reduced in the AbM compared to the placebo group during pollen season. During the season, there was significant reduction in specific IgE anti-Bet v 1 and anti-t3 (birch pollen extract) levels in the AbM compared with the placebo group. While the maximal allergen concentrations needed for eliciting basophil activation before the season, changed significantly in the placebo group to lower concentrations (i.e., enhanced sensitization) after the season, these concentrations remained similar in the AndosanTM AbM extract group. Hence, the prophylactic effect of oral supplementation before the season with the AbM-based AndosanTM extract on aeroallergen-induced allergy was associated with reduced specific IgE levels during the season and basophils becoming less sensitive to allergen activation.
Schlagwörter	Agaricus subrufescens ; Betula ; allergens ; asthma ; basophils ; blood donors ; blood serum ; drug therapy ; hay fever ; immunoglobulin E ; mice ; models ; mushrooms ; placebos ; pollen ; protective effect ; questionnaires ; randomized clinical trials
Sprache	Englisch
Erscheinungsverlauf	2019-1002
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11102339
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies

Hetland, Geir / Tangen, Jon-Magnus / Mahmood, Faiza / Mirlashari, Mohammad Reza / Nissen-Meyer, Lise Sofie Haug / Nentwich, Ivo / Therkelsen, Stig Palm / Tjønnfjord, Geir Erland / Johnson, Egil

Nutrients. 2020 May 08, v. 12, no. 5

2020

Abstract: Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine. ... ...

Abstract	Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine. Special focus has been on their antitumor effects, but the mushrooms’ anti-inflammatory and antiallergic properties have also been investigated. The antitumor mechanisms were either direct tumor attack, e.g., apoptosis and metastatic suppression, or indirect defense, e.g., inhibited tumor neovascularization and T helper cell (Th) 1 immune response. The anti-inflammatory mechanisms were a reduction in proinflammatory cytokines, oxidative stress and changed gut microbiota, and the antiallergic mechanism was amelioration of a skewed Th1/Th2 balance. Since a predominant Th2 milieu is also found in cancer, which quite often is caused by a local chronic inflammation, the three conditions—tumor, inflammation and allergy—seem to be linked. Further mechanisms for HE were increased nerve and beneficial gut microbiota growth, and oxidative stress regulation. The medicinal mushrooms AbM, HE and GF appear to be safe, and can, in fact, increase longevity in animal models, possibly due to reduced tumorigenesis and oxidation. This article reviews preclinical and clinical findings with these mushrooms and the mechanisms behind them.
Schlagwörter	Agaricus subrufescens ; CD4-positive T-lymphocytes ; Erinaceus ; Grifola frondosa ; Hericium ; angiogenesis ; animal models ; anti-allergic agents ; antineoplastic activity ; apoptosis ; carcinogenesis ; clinical trials ; cytokines ; immune response ; inflammation ; intestinal microorganisms ; longevity ; medicinal fungi ; metastasis ; mushrooms ; neoplasms ; nerve tissue ; nutrients ; oxidation ; oxidative stress ; traditional medicine
Sprache	Englisch
Erscheinungsverlauf	2020-0508
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
Anmerkung	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12051339
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

Kononova, Natalia / Sikkeland, Liv Ingunn Bjoner / Mahmood, Faiza / Vistnes, Maria / Kongerud, Johny / Einvik, Gunnar / Søyseth, Vidar

BMC pulmonary medicine

2019 Band 19, Heft 1, Seite(n) 90

Abstract: Background: Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV: Methods: The study, conducted from 2003 to 2005, included 120 healthy Norwegian ... ...

Abstract	Background: Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV Methods: The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examination. From 2015 to 2016, 62 (52%) participants agreed to a follow-up examination that did not include induced sputum examination. Those with a FEV Results: The mean dFEV Conclusions: In this cohort of presumably healthy subjects, we found no associations between sputum inflammatory cells or mediators and dFEV
Mesh-Begriff(e)	Adult ; Aged ; Cytokines/analysis ; Female ; Forced Expiratory Volume ; Healthy Volunteers ; Humans ; Inflammation Mediators/analysis ; Lung/physiology ; Male ; Middle Aged ; Multivariate Analysis ; Norway ; Regression Analysis ; Spirometry ; Sputum/chemistry ; Vital Capacity
Chemische Substanzen	Cytokines ; Inflammation Mediators
Sprache	Englisch
Erscheinungsdatum	2019-05-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-018-0765-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Agaricus blazei

Mahmood, Faiza / Hetland, Geir / Nentwich, Ivo / Mirlashari, Mohammad Reza / Ghiasvand, Reza / Nissen-Meyer, Lise Sofie Haug

Nutrients

2019 Band 11, Heft 10

Abstract: ... ...

Abstract	Since
Mesh-Begriff(e)	Administration, Oral ; Adult ; Agaricus ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/adverse effects ; Anti-Allergic Agents/isolation & purification ; Basophils/drug effects ; Basophils/immunology ; Betula/immunology ; Blood Donors ; Complex Mixtures/administration & dosage ; Complex Mixtures/adverse effects ; Complex Mixtures/isolation & purification ; Conjunctivitis, Allergic/diagnosis ; Conjunctivitis, Allergic/drug therapy ; Conjunctivitis, Allergic/immunology ; Double-Blind Method ; Female ; Humans ; Immunoglobulin E/blood ; Male ; Middle Aged ; Norway ; Plant Extracts/administration & dosage ; Plant Extracts/adverse effects ; Plant Extracts/isolation & purification ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/diagnosis ; Rhinitis, Allergic, Seasonal/drug therapy ; Rhinitis, Allergic, Seasonal/immunology ; Time Factors ; Treatment Outcome ; Young Adult
Chemische Substanzen	AndoSan ; Anti-Allergic Agents ; Complex Mixtures ; Plant Extracts ; Immunoglobulin E (37341-29-0)
Sprache	Englisch
Erscheinungsdatum	2019-10-02
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11102339
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: In vitro

Anjum, Muhammad Sohail / Mehmood, Azra / Mahmood, Faiza / Ali, Muhammad / Tarrar, Moazzam Nazir / Khan, Shaheen N / Riazuddin, Sheikh

Journal of biosciences

2018 Band 43, Heft 4, Seite(n) 649–659

Abstract: Glucose-induced oxidative stress in the diabetic pancreas directly affects viability and the consequent therapeutic outcome of transplanted stem cells. Pretreatment of stem cells with growth factors induces tolerance in them against various stresses ( ... ...

Abstract	Glucose-induced oxidative stress in the diabetic pancreas directly affects viability and the consequent therapeutic outcome of transplanted stem cells. Pretreatment of stem cells with growth factors induces tolerance in them against various stresses (hypoxia, thermal or hyperglycaemic). This study investigated the effect of pretreatment on insulin-producing cells (IPCs) differentiated from adipose-derived mesenchymal stem cells (ADMSCs), with a combination of stromal cell-derived factor 1 alpha (SDF1 α) and basic fibroblast growth factor (bFGF) against hyperglycaemic stress (17 or 33 mM glucose). The results showed that IPCs pretreated with a combination of SDF1α and bFGF exhibited maximally alleviated apoptosis, senescence and cell damage with a concomitantly increased release of insulin, enhanced cell proliferation and greater upregulation of Insulin 1, Insulin 2, Ngn3, Pdx1 and Nkx6.2 when stressed with 33 mM glucose. These findings may offer an improved therapeutic outcome for the treatment of diabetes.
Mesh-Begriff(e)	Adipose Tissue/cytology ; Adipose Tissue/drug effects ; Animals ; Apoptosis/drug effects ; Cell Differentiation/drug effects ; Cell Hypoxia/drug effects ; Cell Proliferation/drug effects ; Chemokine CXCL12/metabolism ; Chemokine CXCL12/pharmacology ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Fibroblast Growth Factor 2/pharmacology ; Glucose/administration & dosage ; Glucose/toxicity ; Humans ; Insulin/biosynthesis ; Insulin/metabolism ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Intercellular Signaling Peptides and Proteins/pharmacology ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Oxidative Stress/drug effects ; Pancreas/metabolism ; Pancreas/pathology ; Rats
Chemische Substanzen	CXCL12 protein, rat ; Chemokine CXCL12 ; Insulin ; Intercellular Signaling Peptides and Proteins ; Fibroblast Growth Factor 2 (103107-01-3) ; Glucose (IY9XDZ35W2)
Sprache	Englisch
Erscheinungsdatum	2018-09-12
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antitumor, Anti-Inflammatory and Antiallergic Effects of

Hetland, Geir / Tangen, Jon-Magnus / Mahmood, Faiza / Mirlashari, Mohammad Reza / Nissen-Meyer, Lise Sofie Haug / Nentwich, Ivo / Therkelsen, Stig Palm / Tjønnfjord, Geir Erland / Johnson, Egil

Nutrients

2020 Band 12, Heft 5

Abstract: Since the 1980s, medicinal effects have been documented in scientific studies with the ... ...

Abstract	Since the 1980s, medicinal effects have been documented in scientific studies with the related
Mesh-Begriff(e)	Agaricus/chemistry ; Animals ; Anti-Allergic Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Basidiomycota/chemistry ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cytokines/metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Grifola/chemistry ; Hericium/chemistry ; Humans ; Inflammation Mediators/metabolism ; Mice ; Neoplasms/blood supply ; Neoplasms/drug therapy ; Neovascularization, Pathologic ; Oxidative Stress/drug effects ; Rats ; T-Lymphocytes, Helper-Inducer/immunology
Chemische Substanzen	Anti-Allergic Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Biological Products ; Cytokines ; Inflammation Mediators
Sprache	Englisch
Erscheinungsdatum	2020-05-08
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12051339
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes.

Mousavi, Seyed Ali / Mahmood, Faiza / Aandahl, Astrid / Knutsen, Teresa Risopatron / Llohn, Abid Hussain

BioMed research international

2015 Band 2015, Seite(n) 241784

Abstract: Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF) elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements. ... ...

Abstract	Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF) elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements. Methods. A total of 196 patients (124 males and 72 females) who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study. Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (≥150 g/L) baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve iron depletion than those who had lower (<150 g/L) baseline hemoglobin, regardless of whether baseline SF was below or above 1000 µg/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for transferrin saturation between male subgroups with SF above 1000 µg/L. Similar differences were observed when females with higher (≥138 g/L) baseline hemoglobin were compared with those with lower (<138 g/L) baseline hemoglobin. Conclusion. Dividing C282Y-homozygous patients into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations.
Mesh-Begriff(e)	Adult ; Aged ; Female ; Ferritins/blood ; Hemochromatosis/blood ; Hemochromatosis/genetics ; Hemochromatosis/therapy ; Hemochromatosis Protein ; Hemoglobins/analysis ; Histocompatibility Antigens Class I/genetics ; Humans ; Male ; Membrane Proteins/genetics ; Middle Aged ; Phlebotomy ; Retrospective Studies ; Young Adult
Chemische Substanzen	HFE protein, human ; Hemochromatosis Protein ; Hemoglobins ; Histocompatibility Antigens Class I ; Membrane Proteins ; Ferritins (9007-73-2)
Sprache	Englisch
Erscheinungsdatum	2015-08-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2015/241784
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Resistance of polio to its eradication in Pakistan

Sher Zunaira / Mahmood Faiza / Shakeel Saleha / Khan Muhammad / Shah Masaud / Sarwar Muhammad / Sumrin Aleena

Virology Journal, Vol 8, Iss 1, p

2011 Band 457

Abstract: Abstract Background This study is based on EPI (Expanded Program on Immunization) immunization surveys and surveillance of polio, its challenges in immunization and the way forward to overcome these challenges. Methods Several Government documents, ... ...

Abstract	Abstract Background This study is based on EPI (Expanded Program on Immunization) immunization surveys and surveillance of polio, its challenges in immunization and the way forward to overcome these challenges. Methods Several Government documents, survey reports and unpublished program documents were studied and online search was made to find information on EPI Pakistan. SPSS 16 and Microsoft Excel 2007 were used for the statistical analysis. Results Immunization against polio is higher in urban areas as compared to rural areas. Marked variation in vaccination has been observed in different provinces of Pakistan in the last decade. Secondly 10-20% of the children who have received their first dose of trivalent polio vaccine were deprived of their 2 nd and 3 rd dose because of poor performance of EPI and Lack of information about immunization. Conclusion In spite of numerous successes, such as the addition of new vaccines and raising immunization to over 100% in some areas, EPI is still struggling to reach its polio eradication goals. Inadequate service delivery, lack of information about immunization and limited number of vaccinators were found to be the key reason for poor performance of immunization and for large number of cases reported each year due to the deficiency of second and third booster dose.
Schlagwörter	Polio ; immunization ; vaccines ; EPI ; Pakistan ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Sprache	Englisch
Erscheinungsdatum	2011-10-01T00:00:00Z
Verlag	BioMed Central
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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